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Synthetic small molecule analogues of the immunomodulatory Acanthocheilonema viteae product ES-62 promote metabolic homeostasis during obesity in a mouse model.

Lumb FE, Crowe J, Doonan J, Suckling CJ, Selman C, Harnett MM, Harnett W.

Mol Biochem Parasitol. 2019 Dec;234:111232. doi: 10.1016/j.molbiopara.2019.111232. Epub 2019 Oct 18.


The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis.

Doonan J, Tarafdar A, Pineda MA, Lumb FE, Crowe J, Khan AM, Hoskisson PA, Harnett MM, Harnett W.

Nat Commun. 2019 Apr 5;10(1):1554. doi: 10.1038/s41467-019-09361-0.


Failure of the Anti-Inflammatory Parasitic Worm Product ES-62 to Provide Protection in Mouse Models of Type I Diabetes, Multiple Sclerosis, and Inflammatory Bowel Disease.

Doonan J, Thomas D, Wong MH, Ramage HJ, Al-Riyami L, Lumb FE, Bell KS, Fairlie-Clarke KJ, Suckling CJ, Michelsen KS, Jiang HR, Cooke A, Harnett MM, Harnett W.

Molecules. 2018 Oct 17;23(10). pii: E2669. doi: 10.3390/molecules23102669.


Protection Against Arthritis by the Parasitic Worm Product ES-62, and Its Drug-Like Small Molecule Analogues, Is Associated With Inhibition of Osteoclastogenesis.

Doonan J, Lumb FE, Pineda MA, Tarafdar A, Crowe J, Khan AM, Suckling CJ, Harnett MM, Harnett W.

Front Immunol. 2018 May 14;9:1016. doi: 10.3389/fimmu.2018.01016. eCollection 2018.


Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis.

Suckling CJ, Mukherjee S, Khalaf AI, Narayan A, Scott FJ, Khare S, Dhakshinamoorthy S, Harnett MM, Harnett W.

Acta Trop. 2018 Sep;185:212-218. doi: 10.1016/j.actatropica.2018.05.015. Epub 2018 May 23.


IL-33/ST2 signalling and crosstalk with FcεRI and TLR4 is targeted by the parasitic worm product, ES-62.

Ball DH, Al-Riyami L, Harnett W, Harnett MM.

Sci Rep. 2018 Mar 14;8(1):4497. doi: 10.1038/s41598-018-22716-9.


Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling.

Suckling CJ, Alam S, Olson MA, Saikh KU, Harnett MM, Harnett W.

Sci Rep. 2018 Feb 1;8(1):2123. doi: 10.1038/s41598-018-20388-z.


Can Parasitic Worms Cure the Modern World's Ills?

Harnett MM, Harnett W.

Trends Parasitol. 2017 Sep;33(9):694-705. doi: 10.1016/ Epub 2017 Jun 9. Review.


Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62.

Lumb FE, Doonan J, Bell KS, Pineda MA, Corbet M, Suckling CJ, Harnett MM, Harnett W.

Sci Rep. 2017 May 10;7(1):1704. doi: 10.1038/s41598-017-01651-1.


From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home.

Harnett MM, Pineda MA, Latré de Laté P, Eason RJ, Besteiro S, Harnett W, Langsley G.

Biomed J. 2017 Feb;40(1):9-22. doi: 10.1016/ Epub 2017 Mar 22. Review.


Parasite excretory-secretory products and their effects on metabolic syndrome.

Crowe J, Lumb FE, Harnett MM, Harnett W.

Parasite Immunol. 2017 May;39(5). doi: 10.1111/pim.12410. Epub 2017 Mar 26. Review.


The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ.

Eason RJ, Bell KS, Marshall FA, Rodgers DT, Pineda MA, Steiger CN, Al-Riyami L, Harnett W, Harnett MM.

Sci Rep. 2016 Nov 21;6:37276. doi: 10.1038/srep37276.


Testing small molecule analogues of the Acanthocheilonema viteae immunomodulator ES-62 against clinically relevant allergens.

Janicova L, Rzepecka J, Rodgers DT, Doonan J, Bell KS, Lumb FE, Suckling CJ, Harnett MM, Harnett W.

Parasite Immunol. 2016 Jun;38(6):340-51. doi: 10.1111/pim.12322.


The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma.

Coltherd JC, Rodgers DT, Lawrie RE, Al-Riyami L, Suckling CJ, Harnett W, Harnett MM.

Sci Rep. 2016 Jan 14;6:19224. doi: 10.1038/srep19224.


The role of individual protein kinase C isoforms in mouse mast cell function and their targeting by the immunomodulatory parasitic worm product, ES-62.

Bell KS, Al-Riyami L, Lumb FE, Britton GJ, Poole AW, Williams CM, Braun U, Leitges M, Harnett MM, Harnett W.

Immunol Lett. 2015 Nov;168(1):31-40. doi: 10.1016/j.imlet.2015.09.001. Epub 2015 Sep 3.


Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus.

Rodgers DT, Pineda MA, Suckling CJ, Harnett W, Harnett MM.

Lupus. 2015 Nov;24(13):1437-42. doi: 10.1177/0961203315591031. Epub 2015 Jun 17.


Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome.

Rzepecka J, Pineda MA, Al-Riyami L, Rodgers DT, Huggan JK, Lumb FE, Khalaf AI, Meakin PJ, Corbet M, Ashford ML, Suckling CJ, Harnett MM, Harnett W.

J Autoimmun. 2015 Jun;60:59-73. doi: 10.1016/j.jaut.2015.04.005. Epub 2015 May 11.


Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation.

Al-Riyami L, Rodgers DT, Rzepecka J, Pineda MA, Suckling CJ, Harnett MM, Harnett W.

Exp Parasitol. 2015 Nov;158:18-22. doi: 10.1016/j.exppara.2015.03.025. Epub 2015 Mar 30.


From the worm to the pill, the parasitic worm product ES-62 raises new horizons in the treatment of rheumatoid arthritis.

Pineda MA, Eason RJ, Harnett MM, Harnett W.

Lupus. 2015 Apr;24(4-5):400-11. doi: 10.1177/0961203314560004. Review.


The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model.

Aprahamian TR, Zhong X, Amir S, Binder CJ, Chiang LK, Al-Riyami L, Gharakhanian R, Harnett MM, Harnett W, Rifkin IR.

Int J Parasitol. 2015 Mar;45(4):203-7. doi: 10.1016/j.ijpara.2014.12.006. Epub 2015 Feb 7.


The parasitic worm product ES-62 targets myeloid differentiation factor 88-dependent effector mechanisms to suppress antinuclear antibody production and proteinuria in MRL/lpr mice.

Rodgers DT, McGrath MA, Pineda MA, Al-Riyami L, Rzepecka J, Lumb F, Harnett W, Harnett MM.

Arthritis Rheumatol. 2015 Apr;67(4):1023-35. doi: 10.1002/art.39004.


Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties.

Rzepecka J, Coates ML, Saggar M, Al-Riyami L, Coltherd J, Tay HK, Huggan JK, Janicova L, Khalaf AI, Siebeke I, Suckling CJ, Harnett MM, Harnett W.

Int J Parasitol. 2014 Aug;44(9):669-74. doi: 10.1016/j.ijpara.2014.05.001. Epub 2014 Jun 12.


ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae.

Pineda MA, Lumb F, Harnett MM, Harnett W.

Mol Biochem Parasitol. 2014 Mar-Apr;194(1-2):1-8. doi: 10.1016/j.molbiopara.2014.03.003. Epub 2014 Mar 23. Review.


Lessons from helminth infections: ES-62 highlights new interventional approaches in rheumatoid arthritis.

Pineda MA, Al-Riyami L, Harnett W, Harnett MM.

Clin Exp Immunol. 2014 Jul;177(1):13-23. doi: 10.1111/cei.12252. Review.


ES-62 protects against collagen-induced arthritis by resetting interleukin-22 toward resolution of inflammation in the joints.

Pineda MA, Rodgers DT, Al-Riyami L, Harnett W, Harnett MM.

Arthritis Rheumatol. 2014 Jun;66(6):1492-503. doi: 10.1002/art.38392.


Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis.

Al-Riyami L, Pineda MA, Rzepecka J, Huggan JK, Khalaf AI, Suckling CJ, Scott FJ, Rodgers DT, Harnett MM, Harnett W.

J Med Chem. 2013 Dec 27;56(24):9982-10002. doi: 10.1021/jm401251p. Epub 2013 Nov 25.


Mast Cell Subsets and Their Functional Modulation by the Acanthocheilonema viteae Product ES-62.

Ball DH, Tay HK, Bell KS, Coates ML, Al-Riyami L, Rzepecka J, Harnett W, Harnett MM.

J Parasitol Res. 2013;2013:961268. doi: 10.1155/2013/961268. Epub 2013 Feb 7.


Reply: To PMID 22729944.

Harnett W, Harnett MM.

Arthritis Rheum. 2013 May;65(5):1403-4. doi: 10.1002/art.37886. No abstract available.


Mitogen-activated protein kinases as therapeutic targets for rheumatoid arthritis.

Paunovic V, Harnett MM.

Drugs. 2013 Feb;73(2):101-15. doi: 10.1007/s40265-013-0014-6. Review.


The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype.

Rzepecka J, Siebeke I, Coltherd JC, Kean DE, Steiger CN, Al-Riyami L, McSharry C, Harnett MM, Harnett W.

Int J Parasitol. 2013 Mar;43(3-4):211-23. doi: 10.1016/j.ijpara.2012.12.001. Epub 2013 Jan 3.


The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites.

Pineda MA, McGrath MA, Smith PC, Al-Riyami L, Rzepecka J, Gracie JA, Harnett W, Harnett MM.

Arthritis Rheum. 2012 Oct;64(10):3168-78. doi: 10.1002/art.34581.


Immune complex-mediated co-ligation of the BCR with FcγRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of systemic lupus erythematosus.

Paunovic V, Carter NA, Thalhamer T, Blair D, Gordon B, Lacey E, Michie AM, Harnett MM.

J Autoimmun. 2012 Dec;39(4):332-46. doi: 10.1016/j.jaut.2012.04.006. Epub 2012 May 28.


Laser scanning cytometry: capturing the immune system in situ.

McGrath MA, Morton AM, Harnett MM.

Methods Cell Biol. 2011;102:231-60. doi: 10.1016/B978-0-12-374912-3.00009-2.


Effect of prolonged in vivo administration of progesterone in pregnancy on myometrial gene expression, peripheral blood leukocyte activation, and circulating steroid hormone levels.

Norman JE, Yuan M, Anderson L, Howie F, Harold G, Young A, Jordan F, McInnes I, Harnett MM.

Reprod Sci. 2011 May;18(5):435-46. doi: 10.1177/1933719110395404.


The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88.

Puneet P, McGrath MA, Tay HK, Al-Riyami L, Rzepecka J, Moochhala SM, Pervaiz S, Harnett MM, Harnett W, Melendez AJ.

Nat Immunol. 2011 Apr;12(4):344-51. doi: 10.1038/ni.2004. Epub 2011 Feb 27. Retraction in: Nat Immunol. 2011 Aug;12(8):804.


Helminth-derived immunomodulators: can understanding the worm produce the pill?

Harnett W, Harnett MM.

Nat Rev Immunol. 2010 Apr;10(4):278-84. doi: 10.1038/nri2730. Epub 2010 Mar 12. Review.


Immunomodulatory activity and therapeutic potential of the filarial nematode secreted product, ES-62.

Harnett W, Harnett MM.

Adv Exp Med Biol. 2009;666:88-94. Review.


The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease.

Harnett MM, Melendez AJ, Harnett W.

Clin Exp Immunol. 2010 Mar;159(3):256-67. doi: 10.1111/j.1365-2249.2009.04064.x. Epub 2009 Dec 1.


Leukocytes are primed in peripheral blood for activation during term and preterm labour.

Yuan M, Jordan F, McInnes IB, Harnett MM, Norman JE.

Mol Hum Reprod. 2009 Nov;15(11):713-24. doi: 10.1093/molehr/gap054. Epub 2009 Jul 23.


Fluorescence-based assays as tools for understanding immunologic processes.

Leonardo SM, Harnett MM, Lerch-Gaggl AF, Gauld SB.

Ann Allergy Asthma Immunol. 2009 Jan;102(1):84-90. doi: 10.1016/S1081-1206(10)60113-5. No abstract available.


Lymphocyte hyporesponsiveness during filarial nematode infection.

Harnett W, Harnett MM.

Parasite Immunol. 2008 Sep;30(9):447-53. doi: 10.1111/j.1365-3024.2008.01045.x. Review.


Parasitic nematode modulation of allergic disease.

Harnett W, Harnett MM.

Curr Allergy Asthma Rep. 2008 Sep;8(5):392-7. Review.


Therapeutic immunomodulators from nematode parasites.

Harnett W, Harnett MM.

Expert Rev Mol Med. 2008 Jun 19;10:e18. doi: 10.1017/S1462399408000720. Review.


MAPKs and their relevance to arthritis and inflammation.

Thalhamer T, McGrath MA, Harnett MM.

Rheumatology (Oxford). 2008 Apr;47(4):409-14. doi: 10.1093/rheumatology/kem297. Epub 2008 Jan 10. Review.


Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivo.

Marshall FA, Watson KA, Garside P, Harnett MM, Harnett W.

Immunology. 2008 Mar;123(3):411-25. Epub 2007 Oct 23.


Inhibition of Fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes.

Melendez AJ, Harnett MM, Pushparaj PN, Wong WS, Tay HK, McSharry CP, Harnett W.

Nat Med. 2007 Nov;13(11):1375-81. Epub 2007 Oct 21.


Laser scanning cytometry: understanding the immune system in situ.

Harnett MM.

Nat Rev Immunol. 2007 Nov;7(11):897-904. Review.


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