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Items: 41


Pan-Specific Prediction of Peptide-MHC Class I Complex Stability, a Correlate of T Cell Immunogenicity.

Rasmussen M, Fenoy E, Harndahl M, Kristensen AB, Nielsen IK, Nielsen M, Buus S.

J Immunol. 2016 Aug 15;197(4):1517-24. doi: 10.4049/jimmunol.1600582. Epub 2016 Jul 8.


HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma.

Thuring C, Follin E, Geironson L, Freyhult E, Junghans V, Harndahl M, Buus S, Paulsson KM.

Br J Cancer. 2015 Dec 1;113(11):1640. doi: 10.1038/bjc.2015.387. No abstract available.


A combined prediction strategy increases identification of peptides bound with high affinity and stability to porcine MHC class I molecules SLA-1*04:01, SLA-2*04:01, and SLA-3*04:01.

Pedersen LE, Rasmussen M, Harndahl M, Nielsen M, Buus S, Jungersen G.

Immunogenetics. 2016 Feb;68(2):157-65. doi: 10.1007/s00251-015-0883-9. Epub 2015 Nov 14.


HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma.

Thuring C, Follin E, Geironson L, Freyhult E, Junghans V, Harndahl M, Buus S, Paulsson KM.

Br J Cancer. 2015 Sep 15;113(6):952-62. doi: 10.1038/bjc.2015.297. Epub 2015 Aug 27. Erratum in: Br J Cancer. 2015 Dec 1;113(11):1640.


CD8+ TCR Bias and Immunodominance in HIV-1 Infection.

Kløverpris HN, McGregor R, McLaren JE, Ladell K, Harndahl M, Stryhn A, Carlson JM, Koofhethile C, Gerritsen B, Keşmir C, Chen F, Riddell L, Luzzi G, Leslie A, Walker BD, Ndung'u T, Buus S, Price DA, Goulder PJ.

J Immunol. 2015 Jun 1;194(11):5329-45. doi: 10.4049/jimmunol.1400854. Epub 2015 Apr 24.


Uncovering the peptide-binding specificities of HLA-C: a general strategy to determine the specificity of any MHC class I molecule.

Rasmussen M, Harndahl M, Stryhn A, Boucherma R, Nielsen LL, Lemonnier FA, Nielsen M, Buus S.

J Immunol. 2014 Nov 15;193(10):4790-802. doi: 10.4049/jimmunol.1401689. Epub 2014 Oct 13.


Characterization of binding specificities of bovine leucocyte class I molecules: impacts for rational epitope discovery.

Hansen AM, Rasmussen M, Svitek N, Harndahl M, Golde WT, Barlow J, Nene V, Buus S, Nielsen M.

Immunogenetics. 2014 Dec;66(12):705-18. doi: 10.1007/s00251-014-0802-5. Epub 2014 Sep 4.


HIV subtype influences HLA-B*07:02-associated HIV disease outcome.

Kløverpris HN, Adland E, Koyanagi M, Stryhn A, Harndahl M, Matthews PC, Shapiro R, Walker BD, Ndung'u T, Brander C, Takiguchi M, Buus S, Goulder P.

AIDS Res Hum Retroviruses. 2014 May;30(5):468-75. doi: 10.1089/AID.2013.0197. Epub 2013 Oct 4.


Tapasin facilitation of natural HLA-A and -B allomorphs is strongly influenced by peptide length, depends on stability, and separates closely related allomorphs.

Geironson L, Thuring C, Harndahl M, Rasmussen M, Buus S, Røder G, Paulsson KM.

J Immunol. 2013 Oct 1;191(7):3939-47. doi: 10.4049/jimmunol.1201741. Epub 2013 Aug 26.


HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01.

Kløverpris HN, Stryhn A, Harndahl M, Payne R, Towers GJ, Chen F, Riddell L, Walker BD, Ndung'u T, Leslie A, Buus S, Goulder P.

J Virol. 2013 Oct;87(19):10889-94. doi: 10.1128/JVI.01122-13. Epub 2013 Jul 17.


Carbon anhydrase IX specific immune responses in patients with metastatic renal cell carcinoma potentially cured by interleukin-2 based immunotherapy.

Rasmussen S, Donskov F, Pedersen JW, Wandall HH, Buus S, Harndahl M, Braendstrup P, Claesson MH, Pedersen AE.

Immunopharmacol Immunotoxicol. 2013 Aug;35(4):487-96. doi: 10.3109/08923973.2013.802802. Epub 2013 Jun 27.


HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective.

Kløverpris HN, Stryhn A, Harndahl M, Carlson JM, Leslie AJ, Chen F, Riddell L, Mulenga J, Walker BD, Ndung'u T, Buus S, Goulder P.

AIDS. 2013 Jul 17;27(11):1717-23. doi: 10.1097/QAD.0b013e32836146cd.


Peptide pool immunization and CD8+ T cell reactivity.

Rasmussen SB, Harndahl MN, Stryhn A, Buus S, Claesson MH.

Immunol Lett. 2013 Mar;151(1-2):48-53. doi: 10.1016/j.imlet.2013.02.006. Epub 2013 Mar 13.


Cancer associated aberrant protein O-glycosylation can modify antigen processing and immune response.

Madsen CB, Petersen C, Lavrsen K, Harndahl M, Buus S, Clausen H, Pedersen AE, Wandall HH.

PLoS One. 2012;7(11):e50139. doi: 10.1371/journal.pone.0050139. Epub 2012 Nov 26.


Identification of peptides from foot-and-mouth disease virus structural proteins bound by class I swine leukocyte antigen (SLA) alleles, SLA-1*0401 and SLA-2*0401.

Pedersen LE, Harndahl M, Nielsen M, Patch JR, Jungersen G, Buus S, Golde WT.

Anim Genet. 2013 Jun;44(3):251-8. doi: 10.1111/j.1365-2052.2012.02400.x. Epub 2012 Sep 18.


Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope.

Matthews PC, Koyanagi M, Kløverpris HN, Harndahl M, Stryhn A, Akahoshi T, Gatanaga H, Oka S, Juarez Molina C, Valenzuela Ponce H, Avila Rios S, Cole D, Carlson J, Payne RP, Ogwu A, Bere A, Ndung'u T, Gounder K, Chen F, Riddell L, Luzzi G, Shapiro R, Brander C, Walker B, Sewell AK, Reyes Teran G, Heckerman D, Hunter E, Buus S, Takiguchi M, Goulder PJ.

J Virol. 2012 Dec;86(23):12643-54. doi: 10.1128/JVI.01381-12. Epub 2012 Sep 12.


MUC4-specific CTLs.

Madsen CB, Jess P, Harndahl M, Wandall HH, Pedersen AE.

Immunopharmacol Immunotoxicol. 2013 Feb;35(1):202-3. doi: 10.3109/08923973.2012.719525. Epub 2012 Sep 7. No abstract available.


HIV control through a single nucleotide on the HLA-B locus.

Kløverpris HN, Harndahl M, Leslie AJ, Carlson JM, Ismail N, van der Stok M, Huang KH, Chen F, Riddell L, Steyn D, Goedhals D, van Vuuren C, Frater J, Walker BD, Carrington M, Ndung'u T, Buus S, Goulder P.

J Virol. 2012 Nov;86(21):11493-500. doi: 10.1128/JVI.01020-12. Epub 2012 Aug 15.


Peptide-MHC class I stability is a better predictor than peptide affinity of CTL immunogenicity.

Harndahl M, Rasmussen M, Roder G, Dalgaard Pedersen I, Sørensen M, Nielsen M, Buus S.

Eur J Immunol. 2012 Jun;42(6):1405-16. doi: 10.1002/eji.201141774.


Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire.

Ostrov DA, Grant BJ, Pompeu YA, Sidney J, Harndahl M, Southwood S, Oseroff C, Lu S, Jakoncic J, de Oliveira CA, Yang L, Mei H, Shi L, Shabanowitz J, English AM, Wriston A, Lucas A, Phillips E, Mallal S, Grey HM, Sette A, Hunt DF, Buus S, Peters B.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9959-64. doi: 10.1073/pnas.1207934109. Epub 2012 May 29.


Designing bovine T cell vaccines via reverse immunology.

Nene V, Svitek N, Toye P, Golde WT, Barlow J, Harndahl M, Buus S, Nielsen M.

Ticks Tick Borne Dis. 2012 Jun;3(3):188-92. doi: 10.1016/j.ttbdis.2011.12.001. Epub 2012 Jan 9. Review.


Identification of a novel UTY-encoded minor histocompatibility antigen.

Mortensen BK, Rasmussen AH, Larsen ME, Larsen MV, Lund O, Braendstrup P, Harndahl M, Rasmussen M, Buus S, Stryhn A, Vindeløv L.

Scand J Immunol. 2012 Aug;76(2):141-50. doi: 10.1111/j.1365-3083.2012.02708.x.


HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control.

Kloverpris HN, Stryhn A, Harndahl M, van der Stok M, Payne RP, Matthews PC, Chen F, Riddell L, Walker BD, Ndung'u T, Buus S, Goulder P.

J Virol. 2012 Jan;86(2):919-29. doi: 10.1128/JVI.06150-11. Epub 2011 Nov 16.


Human leukocyte antigen (HLA) class I restricted epitope discovery in yellow fewer and dengue viruses: importance of HLA binding strength.

Lund O, Nascimento EJ, Maciel M Jr, Nielsen M, Larsen MV, Lundegaard C, Harndahl M, Lamberth K, Buus S, Salmon J, August TJ, Marques ET Jr.

PLoS One. 2011;6(10):e26494. doi: 10.1371/journal.pone.0026494. Epub 2011 Oct 19. Erratum in: PLoS One. 2011;6(11). doi:10.1371/annotation/254c9f39-1c6b-4f48-a947-b4ed931642e7.


Wildtype p53-specific antibody and T-cell responses in cancer patients.

Pedersen AE, Stryhn A, Justesen S, Harndahl M, Rasmussen S, Donskov F, Claesson MH, Pedersen JW, Wandall HH, Svane IM, Buus S.

J Immunother. 2011 Nov-Dec;34(9):629-40. doi: 10.1097/CJI.0b013e3182281381.


Porcine major histocompatibility complex (MHC) class I molecules and analysis of their peptide-binding specificities.

Pedersen LE, Harndahl M, Rasmussen M, Lamberth K, Golde WT, Lund O, Nielsen M, Buus S.

Immunogenetics. 2011 Dec;63(12):821-34. doi: 10.1007/s00251-011-0555-3. Epub 2011 Jul 8.


Tapasin discriminates peptide-human leukocyte antigen-A*02:01 complexes formed with natural ligands.

Roder G, Geironson L, Rasmussen M, Harndahl M, Buus S, Paulsson K.

J Biol Chem. 2011 Jun 10;286(23):20547-57. doi: 10.1074/jbc.M111.230151. Epub 2011 Apr 25.


HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703.

Matthews PC, Adland E, Listgarten J, Leslie A, Mkhwanazi N, Carlson JM, Harndahl M, Stryhn A, Payne RP, Ogwu A, Huang KH, Frater J, Paioni P, Kloverpris H, Jooste P, Goedhals D, van Vuuren C, Steyn D, Riddell L, Chen F, Luzzi G, Balachandran T, Ndung'u T, Buus S, Carrington M, Shapiro R, Heckerman D, Goulder PJ.

J Immunol. 2011 May 15;186(10):5675-86. doi: 10.4049/jimmunol.1003711. Epub 2011 Apr 15.


Real-time, high-throughput measurements of peptide-MHC-I dissociation using a scintillation proximity assay.

Harndahl M, Rasmussen M, Roder G, Buus S.

J Immunol Methods. 2011 Nov 30;374(1-2):5-12. doi: 10.1016/j.jim.2010.10.012. Epub 2010 Oct 31.


HLA class I binding 9mer peptides from influenza A virus induce CD4 T cell responses.

Wang M, Larsen MV, Nielsen M, Harndahl M, Justesen S, Dziegiel MH, Buus S, Tang ST, Lund O, Claesson MH.

PLoS One. 2010 May 7;5(5):e10533. doi: 10.1371/journal.pone.0010533.


The outermost N-terminal region of tapasin facilitates folding of major histocompatibility complex class I.

Roder G, Geironson L, Darabi A, Harndahl M, Schafer-Nielsen C, Skjødt K, Buus S, Paulsson K.

Eur J Immunol. 2009 Oct;39(10):2682-94. doi: 10.1002/eji.200939364.


Functional recombinant MHC class II molecules and high-throughput peptide-binding assays.

Justesen S, Harndahl M, Lamberth K, Nielsen LL, Buus S.

Immunome Res. 2009 May 5;5:2. doi: 10.1186/1745-7580-5-2.


Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance.

Tenzer S, Wee E, Burgevin A, Stewart-Jones G, Friis L, Lamberth K, Chang CH, Harndahl M, Weimershaus M, Gerstoft J, Akkad N, Klenerman P, Fugger L, Jones EY, McMichael AJ, Buus S, Schild H, van Endert P, Iversen AK.

Nat Immunol. 2009 Jun;10(6):636-46. doi: 10.1038/ni.1728. Epub 2009 May 3.


Modified human beta 2-microglobulin (desLys(58)) displays decreased affinity for the heavy chain of MHC class I and induces nitric oxide production and apoptosis.

Wang M, Harhaji L, Lamberth K, Harndahl M, Buus S, Heegaard NH, Claesson MH, Nissen MH.

Scand J Immunol. 2009 Mar;69(3):203-12. doi: 10.1111/j.1365-3083.2008.02213.x.


Peptide binding to HLA class I molecules: homogenous, high-throughput screening, and affinity assays.

Harndahl M, Justesen S, Lamberth K, Røder G, Nielsen M, Buus S.

J Biomol Screen. 2009 Feb;14(2):173-80. doi: 10.1177/1087057108329453. Epub 2009 Feb 4.


MHC-I-restricted epitopes conserved among variola and other related orthopoxviruses are recognized by T cells 30 years after vaccination.

Tang ST, Wang M, Lamberth K, Harndahl M, Dziegiel MH, Claesson MH, Buus S, Lund O.

Arch Virol. 2008;153(10):1833-44. doi: 10.1007/s00705-008-0194-7. Epub 2008 Sep 12.


The peptide-binding specificity of HLA-A*3001 demonstrates membership of the HLA-A3 supertype.

Lamberth K, Røder G, Harndahl M, Nielsen M, Lundegaard C, Schafer-Nielsen C, Lund O, Buus S.

Immunogenetics. 2008 Nov;60(11):633-43. doi: 10.1007/s00251-008-0317-z. Epub 2008 Sep 4.


NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11.

Lundegaard C, Lamberth K, Harndahl M, Buus S, Lund O, Nielsen M.

Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W509-12. doi: 10.1093/nar/gkn202. Epub 2008 May 7.


NetMHCpan, a method for quantitative predictions of peptide binding to any HLA-A and -B locus protein of known sequence.

Nielsen M, Lundegaard C, Blicher T, Lamberth K, Harndahl M, Justesen S, Røder G, Peters B, Sette A, Lund O, Buus S.

PLoS One. 2007 Aug 29;2(8):e796.


CTL epitopes for influenza A including the H5N1 bird flu; genome-, pathogen-, and HLA-wide screening.

Wang M, Lamberth K, Harndahl M, Røder G, Stryhn A, Larsen MV, Nielsen M, Lundegaard C, Tang ST, Dziegiel MH, Rosenkvist J, Pedersen AE, Buus S, Claesson MH, Lund O.

Vaccine. 2007 Apr 12;25(15):2823-31. Epub 2006 Dec 29.


A community resource benchmarking predictions of peptide binding to MHC-I molecules.

Peters B, Bui HH, Frankild S, Nielson M, Lundegaard C, Kostem E, Basch D, Lamberth K, Harndahl M, Fleri W, Wilson SS, Sidney J, Lund O, Buus S, Sette A.

PLoS Comput Biol. 2006 Jun 9;2(6):e65. Epub 2006 Jun 9.

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