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Items: 1 to 50 of 58

1.

LC-MS/MS analysis of the central energy and carbon metabolites in biological samples following derivatization by dimethylaminophenacyl bromide.

Willacey CCW, Naaktgeboren M, Lucumi Moreno E, Wegrzyn AB, van der Es D, Karu N, Fleming RMT, Harms AC, Hankemeier T.

J Chromatogr A. 2019 Jul 31:460413. doi: 10.1016/j.chroma.2019.460413. [Epub ahead of print]

2.

Mechanistic and Quantitative Understanding of Pharmacokinetics in Zebrafish Larvae through Nanoscale Blood Sampling and Metabolite Modeling of Paracetamol.

Van Wijk RC, Krekels EHJ, Kantae V, Ordas A, Kreling T, Harms AC, Hankemeier T, Spaink HP, van der Graaf PH.

J Pharmacol Exp Ther. 2019 Oct;371(1):15-24. doi: 10.1124/jpet.119.260299. Epub 2019 Aug 1.

PMID:
31371482
3.

Publisher Correction: Menstrual cycle rhythmicity: metabolic patterns in healthy women.

Draper CF, Duisters K, Weger B, Chakrabarti A, Harms AC, Brennan L, Hankemeier T, Goulet L, Konz T, Martin FP, Moco S, van der Greef J.

Sci Rep. 2019 Apr 3;9(1):5797. doi: 10.1038/s41598-019-41392-x.

4.

The influence of neuronal electrical activity on the mammalian central clock metabolome.

Buijink MR, van Weeghel M, Gülersönmez MC, Harms AC, Rohling JHT, Meijer JH, Hankemeier T, Michel S.

Metabolomics. 2018 Sep 17;14(10):122. doi: 10.1007/s11306-018-1423-z.

5.

Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae.

van Wijk RC, Krekels EHJ, Kantae V, Harms AC, Hankemeier T, van der Graaf PH, Spaink HP.

Sci Rep. 2019 Feb 15;9(1):2149. doi: 10.1038/s41598-019-38530-w.

6.

High Fat Diet Increases Circulating Endocannabinoids Accompanied by Increased Synthesis Enzymes in Adipose Tissue.

Kuipers EN, Kantae V, Maarse BCE, van den Berg SM, van Eenige R, Nahon KJ, Reifel-Miller A, Coskun T, de Winther MPJ, Lutgens E, Kooijman S, Harms AC, Hankemeier T, van der Stelt M, Rensen PCN, Boon MR.

Front Physiol. 2019 Jan 10;9:1913. doi: 10.3389/fphys.2018.01913. eCollection 2018.

7.

Persistent metabolic changes in HIV-infected patients during the first year of combination antiretroviral therapy.

Peltenburg NC, Schoeman JC, Hou J, Mora F, Harms AC, Lowe SH, Bierau J, Bakker JA, Verbon A, Hankemeier T, Boonstra A.

Sci Rep. 2018 Nov 16;8(1):16947. doi: 10.1038/s41598-018-35271-0.

8.

Baseline metabolic profiles of early rheumatoid arthritis patients achieving sustained drug-free remission after initiating treat-to-target tocilizumab, methotrexate, or the combination: insights from systems biology.

Teitsma XM, Yang W, Jacobs JWG, Pethö-Schramm A, Borm MEA, Harms AC, Hankemeier T, van Laar JM, Bijlsma JWJ, Lafeber FPJG.

Arthritis Res Ther. 2018 Oct 15;20(1):230. doi: 10.1186/s13075-018-1729-2.

9.

Menstrual cycle rhythmicity: metabolic patterns in healthy women.

Draper CF, Duisters K, Weger B, Chakrabarti A, Harms AC, Brennan L, Hankemeier T, Goulet L, Konz T, Martin FP, Moco S, van der Greef J.

Sci Rep. 2018 Oct 1;8(1):14568. doi: 10.1038/s41598-018-32647-0. Erratum in: Sci Rep. 2019 Apr 3;9(1):5797.

10.

Gene Expression of Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight.

Nahon KJ, Kantae V, den Haan R, Hanssen MJW, Harms AC, van der Stelt M, Hankemeier T, Jazet IM, van Marken Lichtenbelt WD, Rensen PCN, Boon MR.

Obesity (Silver Spring). 2018 Aug;26(8):1332-1337. doi: 10.1002/oby.22245. Epub 2018 Aug 1.

11.

Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress.

Schoeman JC, Harms AC, van Weeghel M, Berger R, Vreeken RJ, Hankemeier T.

Anal Bioanal Chem. 2018 Apr;410(10):2551-2568. doi: 10.1007/s00216-018-0912-2. Epub 2018 Mar 2.

12.

A metabolomics study of Qiliqiangxin in a rat model of heart failure: a reverse pharmacology approach.

Fu J, Chang L, Harms AC, Jia Z, Wang H, Wei C, Qiao L, Tian S, Hankemeier T, Wu Y, Wang M.

Sci Rep. 2018 Feb 27;8(1):3688. doi: 10.1038/s41598-018-22074-6.

13.

Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes.

van Eyk HJ, van Schinkel LD, Kantae V, Dronkers CEA, Westenberg JJM, de Roos A, Lamb HJ, Jukema JW, Harms AC, Hankemeier T, van der Stelt M, Jazet IM, Rensen PCN, Smit JWA.

Nutr Diabetes. 2018 Jan 17;8(1):6. doi: 10.1038/s41387-017-0016-7.

14.

Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition.

Kootte RS, Levin E, Salojärvi J, Smits LP, Hartstra AV, Udayappan SD, Hermes G, Bouter KE, Koopen AM, Holst JJ, Knop FK, Blaak EE, Zhao J, Smidt H, Harms AC, Hankemeijer T, Bergman JJGHM, Romijn HA, Schaap FG, Olde Damink SWM, Ackermans MT, Dallinga-Thie GM, Zoetendal E, de Vos WM, Serlie MJ, Stroes ESG, Groen AK, Nieuwdorp M.

Cell Metab. 2017 Oct 3;26(4):611-619.e6. doi: 10.1016/j.cmet.2017.09.008.

15.

Blood-based metabolic signatures in Alzheimer's disease.

de Leeuw FA, Peeters CFW, Kester MI, Harms AC, Struys EA, Hankemeier T, van Vlijmen HWT, van der Lee SJ, van Duijn CM, Scheltens P, Demirkan A, van de Wiel MA, van der Flier WM, Teunissen CE.

Alzheimers Dement (Amst). 2017 Sep 6;8:196-207. doi: 10.1016/j.dadm.2017.07.006. eCollection 2017.

16.

Amine Metabolism Is Influenced by Dietary Protein Source.

Kar SK, Jansman AJM, Schokker D, Kruijt L, Harms AC, Wells JM, Smits MA.

Front Nutr. 2017 Sep 1;4:41. doi: 10.3389/fnut.2017.00041. eCollection 2017.

17.

Multivariate pharmacokinetic/pharmacodynamic (PKPD) analysis with metabolomics shows multiple effects of remoxipride in rats.

van den Brink WJ, Elassaiss-Schaap J, Gonzalez-Amoros B, Harms AC, van der Graaf PH, Hankemeier T, de Lange ECM.

Eur J Pharm Sci. 2017 Nov 15;109:431-440. doi: 10.1016/j.ejps.2017.08.031. Epub 2017 Sep 4.

18.

A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes.

Liu J, van Klinken JB, Semiz S, van Dijk KW, Verhoeven A, Hankemeier T, Harms AC, Sijbrands E, Sheehan NA, van Duijn CM, Demirkan A.

Diabetes. 2017 Nov;66(11):2915-2926. doi: 10.2337/db17-0199. Epub 2017 Aug 28.

19.

Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study.

Liu J, Semiz S, van der Lee SJ, van der Spek A, Verhoeven A, van Klinken JB, Sijbrands E, Harms AC, Hankemeier T, van Dijk KW, van Duijn CM, Demirkan A.

Metabolomics. 2017;13(9):104. doi: 10.1007/s11306-017-1239-2. Epub 2017 Jul 28.

20.

Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men.

Kantae V, Nahon KJ, Straat ME, Bakker LEH, Harms AC, van der Stelt M, Hankemeier T, Jazet IM, Boon MR, Rensen PCN.

Sci Rep. 2017 Aug 8;7(1):7558. doi: 10.1038/s41598-017-07980-5.

21.

Fetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants.

Schoeman JC, Moutloatse GP, Harms AC, Vreeken RJ, Scherpbier HJ, Van Leeuwen L, Kuijpers TW, Reinecke CJ, Berger R, Hankemeier T, Bunders MJ.

J Infect Dis. 2017 Aug 15;216(4):436-446. doi: 10.1093/infdis/jix291.

22.

Metabolic network failures in Alzheimer's disease: A biochemical road map.

Toledo JB, Arnold M, Kastenmüller G, Chang R, Baillie RA, Han X, Thambisetty M, Tenenbaum JD, Suhre K, Thompson JW, John-Williams LS, MahmoudianDehkordi S, Rotroff DM, Jack JR, Motsinger-Reif A, Risacher SL, Blach C, Lucas JE, Massaro T, Louie G, Zhu H, Dallmann G, Klavins K, Koal T, Kim S, Nho K, Shen L, Casanova R, Varma S, Legido-Quigley C, Moseley MA, Zhu K, Henrion MYR, van der Lee SJ, Harms AC, Demirkan A, Hankemeier T, van Duijn CM, Trojanowski JQ, Shaw LM, Saykin AJ, Weiner MW, Doraiswamy PM, Kaddurah-Daouk R; Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium.

Alzheimers Dement. 2017 Sep;13(9):965-984. doi: 10.1016/j.jalz.2017.01.020. Epub 2017 Mar 22.

23.

Role of amino acids in rheumatoid arthritis studied by metabolomics.

He M, Harms AC, van Wijk E, Wang M, Berger R, Koval S, Hankemeier T, van der Greef J.

Int J Rheum Dis. 2019 Jan;22(1):38-46. doi: 10.1111/1756-185X.13062. Epub 2017 Mar 22.

PMID:
28328075
24.

Endometriosis is associated with aberrant metabolite profiles in plasma.

Letsiou S, Peterse DP, Fassbender A, Hendriks MM, van den Broek NJ, Berger R, O DF, Vanhie A, Vodolazkaia A, Van Langendonckt A, Donnez J, Harms AC, Vreeken RJ, Groothuis PG, Dolmans MM, Brenkman AB, D'Hooghe TM.

Fertil Steril. 2017 Mar;107(3):699-706.e6. doi: 10.1016/j.fertnstert.2016.12.032.

PMID:
28259259
25.

Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy.

Kantae V, Krekels EHJ, Esdonk MJV, Lindenburg P, Harms AC, Knibbe CAJ, Van der Graaf PH, Hankemeier T.

Metabolomics. 2017;13(1):9. doi: 10.1007/s11306-016-1143-1. Epub 2016 Dec 19.

26.

Quantitative profiling of endocannabinoids and related N-acylethanolamines in human CSF using nano LC-MS/MS.

Kantae V, Ogino S, Noga M, Harms AC, van Dongen RM, Onderwater GL, van den Maagdenberg AM, Terwindt GM, van der Stelt M, Ferrari MD, Hankemeier T.

J Lipid Res. 2017 Mar;58(3):615-624. doi: 10.1194/jlr.D070433. Epub 2016 Dec 20.

27.

Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment.

Fu J, Cuppen BV, Welsing PM, van Wietmarschen H, Harms AC, Berger R, Koval S, Fritsch-Stork RD, Bijlsma JW, Hankemeier T, van der Greef J, Lafeber FP.

Inflammopharmacology. 2016 Dec;24(6):397-402. Epub 2016 Sep 28.

28.

Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude.

Kantae V, Krekels EH, Ordas A, González O, van Wijk RC, Harms AC, Racz PI, van der Graaf PH, Spaink HP, Hankemeier T.

Zebrafish. 2016 Dec;13(6):504-510. Epub 2016 Sep 15.

29.

Exploring the Inflammatory Metabolomic Profile to Predict Response to TNF-α Inhibitors in Rheumatoid Arthritis.

Cuppen BV, Fu J, van Wietmarschen HA, Harms AC, Koval S, Marijnissen AC, Peeters JJ, Bijlsma JW, Tekstra J, van Laar JM, Hankemeier T, Lafeber FP, van der Greef J; all Society for Rheumatology Research Utrecht investigators.

PLoS One. 2016 Sep 15;11(9):e0163087. doi: 10.1371/journal.pone.0163087. eCollection 2016.

30.

Metabolomics profiling of the free and total oxidised lipids in urine by LC-MS/MS: application in patients with rheumatoid arthritis.

Fu J, Schoeman JC, Harms AC, van Wietmarschen HA, Vreeken RJ, Berger R, Cuppen BV, Lafeber FP, van der Greef J, Hankemeier T.

Anal Bioanal Chem. 2016 Sep;408(23):6307-19. doi: 10.1007/s00216-016-9742-2. Epub 2016 Jul 12.

31.

Metabolic characterization of the natural progression of chronic hepatitis B.

Schoeman JC, Hou J, Harms AC, Vreeken RJ, Berger R, Hankemeier T, Boonstra A.

Genome Med. 2016 Jun 10;8(1):64. doi: 10.1186/s13073-016-0318-8.

32.

Serum-Based Oxylipins Are Associated with Outcomes in Primary Prevention Implantable Cardioverter Defibrillator Patients.

Zhang Y, Guallar E, Blasco-Colmenares E, Harms AC, Vreeken RJ, Hankemeier T, Tomaselli GF, Cheng A.

PLoS One. 2016 Jun 9;11(6):e0157035. doi: 10.1371/journal.pone.0157035. eCollection 2016.

33.

Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma.

He M, van Wijk E, Berger R, Wang M, Strassburg K, Schoeman JC, Vreeken RJ, van Wietmarschen H, Harms AC, Kobayashi M, Hankemeier T, van der Greef J.

Mediators Inflamm. 2015;2015:543541. doi: 10.1155/2015/543541. Epub 2015 Oct 29.

34.

Quantitative profiling of oxylipins in plasma and atherosclerotic plaques of hypercholesterolemic rabbits.

Bojic LA, McLaren DG, Harms AC, Hankemeier T, Dane A, Wang SP, Rosa R, Previs SF, Johns DG, Castro-Perez JM.

Anal Bioanal Chem. 2016 Jan;408(1):97-105. doi: 10.1007/s00216-015-9105-4. Epub 2015 Oct 28.

PMID:
26511226
35.

Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study.

Ellero-Simatos S, Beitelshees AL, Lewis JP, Yerges-Armstrong LM, Georgiades A, Dane A, Harms AC, Strassburg K, Guled F, Hendriks MM, Horenstein RB, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R; Pharmacometabolomics Research Network.

J Am Heart Assoc. 2015 Oct 26;4(10):e002203. doi: 10.1161/JAHA.115.002203.

36.

Serum amine-based metabolites and their association with outcomes in primary prevention implantable cardioverter-defibrillator patients.

Zhang Y, Blasco-Colmenares E, Harms AC, London B, Halder I, Singh M, Dudley SC, Gutmann R, Guallar E, Hankemeier T, Tomaselli GF, Cheng A.

Europace. 2016 Sep;18(9):1383-90. doi: 10.1093/europace/euv342. Epub 2015 Oct 25.

37.

First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach.

Koster MP, Vreeken RJ, Harms AC, Dane AD, Kuc S, Schielen PC, Hankemeier T, Berger R, Visser GH, Pennings JL.

Dis Markers. 2015;2015:857108. doi: 10.1155/2015/857108. Epub 2015 Jun 4.

38.

Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability.

Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sànchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R.

CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.

39.

Metabolomics profiling for identification of novel potential markers in early prediction of preeclampsia.

Kuc S, Koster MP, Pennings JL, Hankemeier T, Berger R, Harms AC, Dane AD, Schielen PC, Visser GH, Vreeken RJ.

PLoS One. 2014 May 29;9(5):e98540. doi: 10.1371/journal.pone.0098540. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e106358.

40.

Integrating metabolomics profiling measurements across multiple biobanks.

Dane AD, Hendriks MM, Reijmers TH, Harms AC, Troost J, Vreeken RJ, Boomsma DI, van Duijn CM, Slagboom EP, Hankemeier T.

Anal Chem. 2014 May 6;86(9):4110-4. doi: 10.1021/ac404191a. Epub 2014 Apr 16.

PMID:
24650176
41.

Discovery and validation of colonic tumor-associated proteins via metabolic labeling and stable isotopic dilution.

Huttlin EL, Chen X, Barrett-Wilt GA, Hegeman AD, Halberg RB, Harms AC, Newton MA, Dove WF, Sussman MR.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17235-40. doi: 10.1073/pnas.0909282106. Epub 2009 Sep 23.

42.

Stable isotope assisted assignment of elemental compositions for metabolomics.

Hegeman AD, Schulte CF, Cui Q, Lewis IA, Huttlin EL, Eghbalnia H, Harms AC, Ulrich EL, Markley JL, Sussman MR.

Anal Chem. 2007 Sep 15;79(18):6912-21. Epub 2007 Aug 21.

PMID:
17708672
43.

Implications of 15N-metabolic labeling for automated peptide identification in Arabidopsis thaliana.

Nelson CJ, Huttlin EL, Hegeman AD, Harms AC, Sussman MR.

Proteomics. 2007 Apr;7(8):1279-92.

PMID:
17443642
44.

Comparison of full versus partial metabolic labeling for quantitative proteomics analysis in Arabidopsis thaliana.

Huttlin EL, Hegeman AD, Harms AC, Sussman MR.

Mol Cell Proteomics. 2007 May;6(5):860-81. Epub 2007 Feb 9.

46.

A quantitative analysis of Arabidopsis plasma membrane using trypsin-catalyzed (18)O labeling.

Nelson CJ, Hegeman AD, Harms AC, Sussman MR.

Mol Cell Proteomics. 2006 Aug;5(8):1382-95. Epub 2006 Apr 24.

47.

High-throughput purification and quality assurance of Arabidopsis thaliana proteins for eukaryotic structural genomics.

Jeon WB, Aceti DJ, Bingman CA, Vojtik FC, Olson AC, Ellefson JM, McCombs JE, Sreenath HK, Blommel PG, Seder KD, Burns BT, Geetha HV, Harms AC, Sabat G, Sussman MR, Fox BG, Phillips GN Jr.

J Struct Funct Genomics. 2005;6(2-3):143-7.

PMID:
16211511
48.

An isotope labeling strategy for quantifying the degree of phosphorylation at multiple sites in proteins.

Hegeman AD, Harms AC, Sussman MR, Bunner AE, Harper JF.

J Am Soc Mass Spectrom. 2004 May;15(5):647-53.

49.

Disulfide connectivity of recombinant C-terminal region of human thrombospondin 2.

Misenheimer TM, Hahr AJ, Harms AC, Annis DS, Mosher DF.

J Biol Chem. 2001 Dec 7;276(49):45882-7. Epub 2001 Oct 4.

50.

Advances in the mass spectrometry of hemoglobin adducts: global analysis of the covalent binding of butadiene monoxide.

Moll TS, Harms AC, Elfarra AA.

Chem Biol Interact. 2001 Jun 1;135-136:667-74.

PMID:
11397420

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