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Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum.

van der Laan T, Kloots T, Beekman M, Kindt A, Dubbelman AC, Harms A, van Duijn CM, Slagboom PE, Hankemeier T.

Sci Rep. 2019 Aug 26;9(1):12370. doi: 10.1038/s41598-019-48876-w.


Inter-and intra-subject variability of potential plasma and urine metabolite and protein biomarkers in healthy human volunteers.

Duisters K, Ogino S, Andou T, Ito K, Akabane T, Harms A, Moerland M, Hashimoto Y, Ando A, Ohtsu Y, Wada N, Yukinaga H, Meulman J, Kobayashi H, Kobayashi N, Suzumura K, Hankemeier T.

Clin Pharmacol Ther. 2019 Aug 10. doi: 10.1002/cpt.1606. [Epub ahead of print]


LC-MS/MS analysis of the central energy and carbon metabolites in biological samples following derivatization by dimethylaminophenacyl bromide.

Willacey CCW, Naaktgeboren M, Lucumi Moreno E, Wegrzyn AB, van der Es D, Karu N, Fleming RMT, Harms AC, Hankemeier T.

J Chromatogr A. 2019 Jul 31:460413. doi: 10.1016/j.chroma.2019.460413. [Epub ahead of print]


Mechanistic and Quantitative Understanding of Pharmacokinetics in Zebrafish Larvae through Nanoscale Blood Sampling and Metabolite Modeling of Paracetamol.

Van Wijk RC, Krekels EHJ, Kantae V, Ordas A, Kreling T, Harms AC, Hankemeier T, Spaink HP, van der Graaf PH.

J Pharmacol Exp Ther. 2019 Oct;371(1):15-24. doi: 10.1124/jpet.119.260299. Epub 2019 Aug 1.


Spatial and Temporal Heterogeneity of Panel-Based Tumor Mutational Burden in Pulmonary Adenocarcinoma: Separating Biology From Technical Artifacts.

Kazdal D, Endris V, Allgäuer M, Kriegsmann M, Leichsenring J, Volckmar AL, Harms A, Kirchner M, Kriegsmann K, Neumann O, Brandt R, Talla SB, Rempel E, Ploeger C, von Winterfeld M, Christopoulos P, Merino DM, Stewart M, Allen J, Bischoff H, Meister M, Muley T, Herth F, Penzel R, Warth A, Winter H, Fröhling S, Peters S, Swanton C, Thomas M, Schirmacher P, Budczies J, Stenzinger A.

J Thorac Oncol. 2019 Jul 23. pii: S1556-0864(19)30563-5. doi: 10.1016/j.jtho.2019.07.006. [Epub ahead of print]


Spatial control of the GTPase MglA by localized RomR-RomX GEF and MglB GAP activities enables Myxococcus xanthus motility.

Szadkowski D, Harms A, Carreira LAM, Wigbers M, Potapova A, Wuichet K, Keilberg D, Gerland U, Søgaard-Andersen L.

Nat Microbiol. 2019 Aug;4(8):1344-1355. doi: 10.1038/s41564-019-0451-4. Epub 2019 May 20.


Publisher Correction: Definitions and guidelines for research on antibiotic persistence.

Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A.

Nat Rev Microbiol. 2019 Jul;17(7):460. doi: 10.1038/s41579-019-0207-4.


Variant classification in precision oncology.

Leichsenring J, Horak P, Kreutzfeldt S, Heining C, Christopoulos P, Volckmar AL, Neumann O, Kirchner M, Ploeger C, Budczies J, Heilig CE, Hutter B, Fröhlich M, Uhrig S, Kazdal D, Allgäuer M, Harms A, Rempel E, Lehmann U, Thomas M, Pfarr N, Azoitei N, Bonzheim I, Marienfeld R, Möller P, Werner M, Fend F, Boerries M, von Bubnoff N, Lassmann S, Longerich T, Bitzer M, Seufferlein T, Malek N, Weichert W, Schirmacher P, Penzel R, Endris V, Brors B, Klauschen F, Glimm H, Fröhling S, Stenzinger A.

Int J Cancer. 2019 Apr 22. doi: 10.1002/ijc.32358. [Epub ahead of print]


Birth and Resuscitation of (p)ppGpp Induced Antibiotic Tolerant Persister Cells.

Svenningsen MS, Veress A, Harms A, Mitarai N, Semsey S.

Sci Rep. 2019 Apr 15;9(1):6056. doi: 10.1038/s41598-019-42403-7.


Definitions and guidelines for research on antibiotic persistence.

Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A.

Nat Rev Microbiol. 2019 Jul;17(7):441-448. doi: 10.1038/s41579-019-0196-3. Review. Erratum in: Nat Rev Microbiol. 2019 Apr 29;:.


Publisher Correction: Menstrual cycle rhythmicity: metabolic patterns in healthy women.

Draper CF, Duisters K, Weger B, Chakrabarti A, Harms AC, Brennan L, Hankemeier T, Goulet L, Konz T, Martin FP, Moco S, van der Greef J.

Sci Rep. 2019 Apr 3;9(1):5797. doi: 10.1038/s41598-019-41392-x.


Swallowing Function in Survivors of Oropharyngeal Cancer Is Associated With Advanced T Classification.

Harms A, Kansara S, Stach C, Richardson PA, Chen G, Lai S, Sikora AG, Parke R, Donovan D, Chiao E, Skinner H, Sandulache VC.

Ann Otol Rhinol Laryngol. 2019 Aug;128(8):696-703. doi: 10.1177/0003489419839091. Epub 2019 Mar 27.


The influence of neuronal electrical activity on the mammalian central clock metabolome.

Buijink MR, van Weeghel M, Gülersönmez MC, Harms AC, Rohling JHT, Meijer JH, Hankemeier T, Michel S.

Metabolomics. 2018 Sep 17;14(10):122. doi: 10.1007/s11306-018-1423-z.


Agreement of CK5/6, p40, and p63 immunoreactivity in non-small cell lung cancer.

Kriegsmann K, Cremer M, Zgorzelski C, Harms A, Muley T, Winter H, Kazdal D, Warth A, Kriegsmann M.

Pathology. 2019 Apr;51(3):240-245. doi: 10.1016/j.pathol.2018.11.009. Epub 2019 Feb 21.


NUT carcinoma in a nutshell: A diagnosis to be considered more frequently.

Albrecht T, Harms A, Roessler S, Goeppert B.

Pathol Res Pract. 2019 Jun;215(6):152347. doi: 10.1016/j.prp.2019.01.043. Epub 2019 Jan 30.


Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae.

van Wijk RC, Krekels EHJ, Kantae V, Harms AC, Hankemeier T, van der Graaf PH, Spaink HP.

Sci Rep. 2019 Feb 15;9(1):2149. doi: 10.1038/s41598-019-38530-w.


Crowd Controlled-Host Quorum Sensing Drives Phage Decision.

Harms A, Diard M.

Cell Host Microbe. 2019 Feb 13;25(2):179-181. doi: 10.1016/j.chom.2019.01.016.


High Fat Diet Increases Circulating Endocannabinoids Accompanied by Increased Synthesis Enzymes in Adipose Tissue.

Kuipers EN, Kantae V, Maarse BCE, van den Berg SM, van Eenige R, Nahon KJ, Reifel-Miller A, Coskun T, de Winther MPJ, Lutgens E, Kooijman S, Harms AC, Hankemeier T, van der Stelt M, Rensen PCN, Boon MR.

Front Physiol. 2019 Jan 10;9:1913. doi: 10.3389/fphys.2018.01913. eCollection 2018.


Subclonal evolution of pulmonary adenocarcinomas delineated by spatially distributed somatic mitochondrial mutations.

Kazdal D, Harms A, Endris V, Penzel R, Oliveira C, Kriegsmann M, Longuespée R, Winter H, Schneider MA, Muley T, Pfarr N, Weichert W, Stenzinger A, Warth A.

Lung Cancer. 2018 Dec;126:80-88. doi: 10.1016/j.lungcan.2018.10.024. Epub 2018 Oct 29.


Persistent metabolic changes in HIV-infected patients during the first year of combination antiretroviral therapy.

Peltenburg NC, Schoeman JC, Hou J, Mora F, Harms AC, Lowe SH, Bierau J, Bakker JA, Verbon A, Hankemeier T, Boonstra A.

Sci Rep. 2018 Nov 16;8(1):16947. doi: 10.1038/s41598-018-35271-0.


Glial GLP1R: A novel neuroprotector?

Schonhoff AM, Harms AS.

Mov Disord. 2018 Dec;33(12):1877. doi: 10.1002/mds.27547. Epub 2018 Nov 14. No abstract available.


Global DNA methylation reflects spatial heterogeneity and molecular evolution of lung adenocarcinomas.

Dietz S, Lifshitz A, Kazdal D, Harms A, Endris V, Winter H, Stenzinger A, Warth A, Sill M, Tanay A, Sültmann H.

Int J Cancer. 2019 Mar 1;144(5):1061-1072. doi: 10.1002/ijc.31939. Epub 2018 Dec 3.


Baseline metabolic profiles of early rheumatoid arthritis patients achieving sustained drug-free remission after initiating treat-to-target tocilizumab, methotrexate, or the combination: insights from systems biology.

Teitsma XM, Yang W, Jacobs JWG, Pethö-Schramm A, Borm MEA, Harms AC, Hankemeier T, van Laar JM, Bijlsma JWJ, Lafeber FPJG.

Arthritis Res Ther. 2018 Oct 15;20(1):230. doi: 10.1186/s13075-018-1729-2.


Menstrual cycle rhythmicity: metabolic patterns in healthy women.

Draper CF, Duisters K, Weger B, Chakrabarti A, Harms AC, Brennan L, Hankemeier T, Goulet L, Konz T, Martin FP, Moco S, van der Greef J.

Sci Rep. 2018 Oct 1;8(1):14568. doi: 10.1038/s41598-018-32647-0. Erratum in: Sci Rep. 2019 Apr 3;9(1):5797.


Expression of HMB45, MelanA and SOX10 is rare in non-small cell lung cancer.

Kriegsmann M, Kriegsmann K, Harms A, Longuespée R, Zgorzelski C, Leichsenring J, Muley T, Winter H, Kazdal D, Goeppert B, Warth A.

Diagn Pathol. 2018 Sep 11;13(1):68. doi: 10.1186/s13000-018-0751-7.


Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate.

Kaddurah-Daouk R, Hankemeier T, Scholl EH, Baillie R, Harms A, Stage C, Dalhoff KP, Jűrgens G, Taboureau O, Nzabonimpa GS, Motsinger-Reif AA, Thomsen R, Linnet K, Rasmussen HB; INDICES Consortium; Pharmacometabolomics Research Network.

CPT Pharmacometrics Syst Pharmacol. 2018 Aug;7(8):525-533. doi: 10.1002/psp4.12309.


Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson's disease.

Williams GP, Schonhoff AM, Jurkuvenaite A, Thome AD, Standaert DG, Harms AS.

J Neuroinflammation. 2018 Aug 30;15(1):244. doi: 10.1186/s12974-018-1286-2.


SLING: a tool to search for linked genes in bacterial datasets.

Horesh G, Harms A, Fino C, Parts L, Gerdes K, Heinz E, Thomson NR.

Nucleic Acids Res. 2018 Nov 30;46(21):e128. doi: 10.1093/nar/gky738.


Gene Expression of Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight.

Nahon KJ, Kantae V, den Haan R, Hanssen MJW, Harms AC, van der Stelt M, Hankemeier T, Jazet IM, van Marken Lichtenbelt WD, Rensen PCN, Boon MR.

Obesity (Silver Spring). 2018 Aug;26(8):1332-1337. doi: 10.1002/oby.22245. Epub 2018 Aug 1.


High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor.

van der Aart LT, Spijksma GK, Harms A, Vollmer W, Hankemeier T, van Wezel GP.

J Bacteriol. 2018 Sep 24;200(20). pii: e00290-18. doi: 10.1128/JB.00290-18. Print 2018 Oct 15.


Combined Immunohistochemistry after Mass Spectrometry Imaging for Superior Spatial Information.

Kriegsmann K, Longuespée R, Hundemer M, Zgorzelski C, Casadonte R, Schwamborn K, Weichert W, Schirmacher P, Harms A, Kazdal D, Leichsenring J, Stenzinger A, Warth A, Fresnais M, Kriegsmann J, Kriegsmann M.

Proteomics Clin Appl. 2019 Jan;13(1):e1800035. doi: 10.1002/prca.201800035. Epub 2018 Aug 21.


Computed tomography and histopathological findings after embolization with inherently radiopaque 40μm-microspheres, standard 40μm-microspheres and iodized oil in a porcine liver model.

Vollherbst DF, Gockner T, Do T, Holzer K, Mogler C, Flechsig P, Harms A, Schlett CL, Pereira PL, Richter GM, Kauczor HU, Sommer CM.

PLoS One. 2018 Jul 9;13(7):e0198911. doi: 10.1371/journal.pone.0198911. eCollection 2018.


Molecular dissection of large cell carcinomas of the lung with null immunophenotype.

Harms A, Endris V, Winter H, Kriegsmann M, Stenzinger A, Schirmacher P, Warth A, Kazdal D.

Pathology. 2018 Aug;50(5):530-535. doi: 10.1016/j.pathol.2018.03.005. Epub 2018 Jun 27.


A feasibility study of brain-targeted treatment for people with painful knee osteoarthritis in tertiary care.

Harms A, Heredia-Rizo AM, Moseley GL, Hau R, Stanton TR.

Physiother Theory Pract. 2018 Jun 11:1-15. doi: 10.1080/09593985.2018.1482391. [Epub ahead of print]


Inherently Radiopaque Narrow-Size-Calibrated Microspheres: Proof of Principle in a Pig Embolization Model.

Sommer CM, Harms A, Do TD, Gockner TL, Kriegsmann M, Schlett CL, Holzer K, Vollherbst D, Warth A, Pereira PL, Eichwald V, Jugold M, Kauczor HU, Flechsig P.

Cardiovasc Intervent Radiol. 2018 Sep;41(9):1404-1411. doi: 10.1007/s00270-018-1986-0. Epub 2018 Jun 1.


Impact of Computer-Aided CT and PET Analysis on Non-invasive T Staging in Patients with Lung Cancer and Atelectasis.

Flechsig P, Rastgoo R, Kratochwil C, Martin O, Holland-Letz T, Harms A, Kauczor HU, Haberkorn U, Giesel FL.

Mol Imaging Biol. 2018 Dec;20(6):1044-1052. doi: 10.1007/s11307-018-1196-9.


PD-L1 expression in large cell neuroendocrine carcinoma of the lung.

Eichhorn F, Harms A, Warth A, Muley T, Winter H, Eichhorn ME.

Lung Cancer. 2018 Apr;118:76-82. doi: 10.1016/j.lungcan.2018.02.003. Epub 2018 Feb 6.


Strategies to assess and optimize stability of endogenous amines during cerebrospinal fluid sampling.

Noga MJ, Zielman R, van Dongen RM, Bos S, Harms A, Terwindt GM, van den Maagdenberg AMJM, Hankemeier T, Ferrari MD.

Metabolomics. 2018;14(4):44. doi: 10.1007/s11306-018-1333-0. Epub 2018 Mar 5.


Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress.

Schoeman JC, Harms AC, van Weeghel M, Berger R, Vreeken RJ, Hankemeier T.

Anal Bioanal Chem. 2018 Apr;410(10):2551-2568. doi: 10.1007/s00216-018-0912-2. Epub 2018 Mar 2.


A metabolomics study of Qiliqiangxin in a rat model of heart failure: a reverse pharmacology approach.

Fu J, Chang L, Harms AC, Jia Z, Wang H, Wei C, Qiao L, Tian S, Hankemeier T, Wu Y, Wang M.

Sci Rep. 2018 Feb 27;8(1):3688. doi: 10.1038/s41598-018-22074-6.


Analysis of the proliferative activity in lung adenocarcinomas with specific driver mutations.

Kriegsmann M, Harms A, Kazdal D, Fischer S, Stenzinger A, Leichsenring J, Penzel R, Longuespée R, Kriegsmann K, Muley T, Safi S, Warth A.

Pathol Res Pract. 2018 Mar;214(3):408-416. doi: 10.1016/j.prp.2017.12.018. Epub 2018 Jan 2.


Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology.

Harms A, Brodersen DE, Mitarai N, Gerdes K.

Mol Cell. 2018 Jun 7;70(5):768-784. doi: 10.1016/j.molcel.2018.01.003. Epub 2018 Feb 3. Review.


Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes.

van Eyk HJ, van Schinkel LD, Kantae V, Dronkers CEA, Westenberg JJM, de Roos A, Lamb HJ, Jukema JW, Harms AC, Hankemeier T, van der Stelt M, Jazet IM, Rensen PCN, Smit JWA.

Nutr Diabetes. 2018 Jan 17;8(1):6. doi: 10.1038/s41387-017-0016-7.


Role of conventional immunomarkers, HNF4-α and SATB2, in the differential diagnosis of pulmonary and colorectal adenocarcinomas.

Kriegsmann M, Harms A, Longuespée R, Muley T, Winter H, Kriegsmann K, Kazdal D, Goeppert B, Pathil A, Warth A.

Histopathology. 2018 May;72(6):997-1006. doi: 10.1111/his.13455. Epub 2018 Feb 20.


Prophages and Growth Dynamics Confound Experimental Results with Antibiotic-Tolerant Persister Cells.

Harms A, Fino C, Sørensen MA, Semsey S, Gerdes K.

MBio. 2017 Dec 12;8(6). pii: e01964-17. doi: 10.1128/mBio.01964-17.


Bactofilin-mediated organization of the ParABS chromosome segregation system in Myxococcus xanthus.

Lin L, Osorio Valeriano M, Harms A, Søgaard-Andersen L, Thanbichler M.

Nat Commun. 2017 Nov 28;8(1):1817. doi: 10.1038/s41467-017-02015-z.


α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.

Harms AS, Delic V, Thome AD, Bryant N, Liu Z, Chandra S, Jurkuvenaite A, West AB.

Acta Neuropathol Commun. 2017 Nov 21;5(1):85. doi: 10.1186/s40478-017-0494-9.


Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease.

Harms AS, Thome AD, Yan Z, Schonhoff AM, Williams GP, Li X, Liu Y, Qin H, Benveniste EN, Standaert DG.

Exp Neurol. 2018 Feb;300:179-187. doi: 10.1016/j.expneurol.2017.11.010. Epub 2017 Nov 16.


A bacterial toxin-antitoxin module is the origin of inter-bacterial and inter-kingdom effectors of Bartonella.

Harms A, Liesch M, Körner J, Québatte M, Engel P, Dehio C.

PLoS Genet. 2017 Oct 26;13(10):e1007077. doi: 10.1371/journal.pgen.1007077. eCollection 2017 Oct.


Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition.

Kootte RS, Levin E, Salojärvi J, Smits LP, Hartstra AV, Udayappan SD, Hermes G, Bouter KE, Koopen AM, Holst JJ, Knop FK, Blaak EE, Zhao J, Smidt H, Harms AC, Hankemeijer T, Bergman JJGHM, Romijn HA, Schaap FG, Olde Damink SWM, Ackermans MT, Dallinga-Thie GM, Zoetendal E, de Vos WM, Serlie MJ, Stroes ESG, Groen AK, Nieuwdorp M.

Cell Metab. 2017 Oct 3;26(4):611-619.e6. doi: 10.1016/j.cmet.2017.09.008.

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