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Items: 1 to 50 of 110

1.

Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway.

Benson HE, Watterson S, Sharman JL, Mpamhanga CP, Parton A, Southan C, Harmar AJ, Ghazal P.

Br J Pharmacol. 2017 Dec;174(23):4362-4382. doi: 10.1111/bph.14037. Epub 2017 Nov 26.

2.

The Concise Guide to PHARMACOLOGY 2013/14: enzymes.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators.

Br J Pharmacol. 2013 Dec;170(8):1797-867. doi: 10.1111/bph.12451.

3.

The Concise Guide to PHARMACOLOGY 2013/14: transporters.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators.

Br J Pharmacol. 2013 Dec;170(8):1706-96. doi: 10.1111/bph.12450.

4.

The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators.

Br J Pharmacol. 2013 Dec;170(8):1676-705. doi: 10.1111/bph.12449.

5.

The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators.

Br J Pharmacol. 2013 Dec;170(8):1652-75. doi: 10.1111/bph.12448.

6.

The Concise Guide to PHARMACOLOGY 2013/14: ion channels.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators.

Br J Pharmacol. 2013 Dec;170(8):1607-51. doi: 10.1111/bph.12447.

7.

The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators.

Br J Pharmacol. 2013 Dec;170(8):1582-606. doi: 10.1111/bph.12446.

8.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

9.

The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators.

Br J Pharmacol. 2013 Dec;170(8):1459-581. doi: 10.1111/bph.12445.

10.

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands.

Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, Davenport AP, McGrath JC, Peters JA, Southan C, Spedding M, Yu W, Harmar AJ; NC-IUPHAR.

Nucleic Acids Res. 2014 Jan;42(Database issue):D1098-106. doi: 10.1093/nar/gkt1143. Epub 2013 Nov 14.

11.

Evolving pharmacology of orphan GPCRs: IUPHAR Commentary.

Davenport AP, Harmar AJ.

Br J Pharmacol. 2013 Oct;170(4):693-5. doi: 10.1111/bph.12339.

12.

International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands.

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ.

Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. Print 2013 Jul. Review.

13.

IUPHAR-DB: updated database content and new features.

Sharman JL, Benson HE, Pawson AJ, Lukito V, Mpamhanga CP, Bombail V, Davenport AP, Peters JA, Spedding M, Harmar AJ; NC-IUPHAR.

Nucleic Acids Res. 2013 Jan;41(Database issue):D1083-8. doi: 10.1093/nar/gks960. Epub 2012 Oct 18.

14.

GuideToPharmacology.org--an update.

Alexander SP, Benson HE, Davenport A, Mathie A, McGrath IJ, Pawson AJ, Peters JA, Sharman JL, Spedding M, Harmar AJ.

Br J Pharmacol. 2012 Oct;167(4):697-8. doi: 10.1111/j.1476-5381.2012.02141.x. No abstract available.

15.

How to use the IUPHAR receptor database to navigate pharmacological data.

Mpamhanga CP, Sharman JL, Harmar AJ; NC-IUPHAR.

Methods Mol Biol. 2012;897:15-29. doi: 10.1007/978-1-61779-909-9_2.

PMID:
22674159
16.

Activation of thiazide-sensitive co-transport by angiotensin II in the cyp1a1-Ren2 hypertensive rat.

Ashek A, Menzies RI, Mullins LJ, Bellamy CO, Harmar AJ, Kenyon CJ, Flatman PW, Mullins JJ, Bailey MA.

PLoS One. 2012;7(4):e36311. doi: 10.1371/journal.pone.0036311. Epub 2012 Apr 27.

17.

Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1.

Harmar AJ, Fahrenkrug J, Gozes I, Laburthe M, May V, Pisegna JR, Vaudry D, Vaudry H, Waschek JA, Said SI.

Br J Pharmacol. 2012 May;166(1):4-17. doi: 10.1111/j.1476-5381.2012.01871.x. Review.

18.

Diurnal expression of the thrombopoietin gene is regulated by CLOCK.

Tracey CJ, Pan X, Catterson JH, Harmar AJ, Hussain MM, Hartley PS.

J Thromb Haemost. 2012 Apr;10(4):662-9. doi: 10.1111/j.1538-7836.2012.04643.x.

19.

IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data.

Sharman JL, Mpamhanga CP, Spedding M, Germain P, Staels B, Dacquet C, Laudet V, Harmar AJ; NC-IUPHAR.

Nucleic Acids Res. 2011 Jan;39(Database issue):D534-8. doi: 10.1093/nar/gkq1062. Epub 2010 Nov 17.

20.

Dietary modulation of Drosophila sleep-wake behaviour.

Catterson JH, Knowles-Barley S, James K, Heck MM, Harmar AJ, Hartley PS.

PLoS One. 2010 Aug 10;5(8):e12062. doi: 10.1371/journal.pone.0012062.

21.

Circadian control of mouse heart rate and blood pressure by the suprachiasmatic nuclei: behavioral effects are more significant than direct outputs.

Sheward WJ, Naylor E, Knowles-Barley S, Armstrong JD, Brooker GA, Seckl JR, Turek FW, Holmes MC, Zee PC, Harmar AJ.

PLoS One. 2010 Mar 22;5(3):e9783. doi: 10.1371/journal.pone.0009783.

22.

The neurotransmitter VIP expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VPAC2 receptors or directs them toward a neuronal fate via VPAC1 receptors.

Zaben M, Sheward WJ, Shtaya A, Abbosh C, Harmar AJ, Pringle AK, Gray WP.

Stem Cells. 2009 Oct;27(10):2539-51. doi: 10.1002/stem.184.

23.

Timed feeding of mice modulates light-entrained circadian rhythms of reticulated platelet abundance and plasma thrombopoietin and affects gene expression in megakaryocytes.

Hartley PS, Sheward J, Scholefield E, French K, Horn JM, Holmes MC, Harmar AJ.

Br J Haematol. 2009 Jul;146(2):185-92. doi: 10.1111/j.1365-2141.2009.07722.x. Epub 2009 May 4.

PMID:
19438469
24.

Sex influences the effect of a lifelong increase in serotonin transporter function on cerebral metabolism.

Dawson N, Ferrington L, Olverman HJ, Harmar AJ, Kelly PA.

J Neurosci Res. 2009 Aug 1;87(10):2375-85. doi: 10.1002/jnr.22062.

PMID:
19326435
25.

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.

Harmar AJ, Hills RA, Rosser EM, Jones M, Buneman OP, Dunbar DR, Greenhill SD, Hale VA, Sharman JL, Bonner TI, Catterall WA, Davenport AP, Delagrange P, Dollery CT, Foord SM, Gutman GA, Laudet V, Neubig RR, Ohlstein EH, Olsen RW, Peters J, Pin JP, Ruffolo RR, Searls DB, Wright MW, Spedding M.

Nucleic Acids Res. 2009 Jan;37(Database issue):D680-5. doi: 10.1093/nar/gkn728. Epub 2008 Oct 23.

26.

Food-entrained rhythmic expression of PER2 and BMAL1 in murine megakaryocytes does not correlate with circadian rhythms in megakaryopoiesis.

Hartley PS, John Sheward W, French K, Horn JM, Holmes MC, Harmar AJ.

J Thromb Haemost. 2008 Jul;6(7):1144-52. doi: 10.1111/j.1538-7836.2008.02978.x. Epub 2008 Jul 1.

27.

Evidence that genetic variation in 5-HT transporter expression is linked to changes in 5-HT2A receptor function.

Jennings KA, Sheward WJ, Harmar AJ, Sharp T.

Neuropharmacology. 2008 Apr;54(5):776-83. doi: 10.1016/j.neuropharm.2007.12.001. Epub 2007 Dec 14.

PMID:
18241894
28.

Entrainment to feeding but not to light: circadian phenotype of VPAC2 receptor-null mice.

Sheward WJ, Maywood ES, French KL, Horn JM, Hastings MH, Seckl JR, Holmes MC, Harmar AJ.

J Neurosci. 2007 Apr 18;27(16):4351-8.

29.

Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission.

Jennings KA, Loder MK, Sheward WJ, Pei Q, Deacon RM, Benson MA, Olverman HJ, Hastie ND, Harmar AJ, Shen S, Sharp T.

J Neurosci. 2006 Aug 30;26(35):8955-64.

30.

Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice.

Lang B, Song B, Davidson W, MacKenzie A, Smith N, McCaig CD, Harmar AJ, Shen S.

J Clin Invest. 2006 Jul;116(7):1924-34.

31.

Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signaling.

Maywood ES, Reddy AB, Wong GK, O'Neill JS, O'Brien JA, McMahon DG, Harmar AJ, Okamura H, Hastings MH.

Curr Biol. 2006 Mar 21;16(6):599-605.

32.

International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function.

Davenport AP, Bonner TI, Foord SM, Harmar AJ, Neubig RR, Pin JP, Spedding M, Kojima M, Kangawa K.

Pharmacol Rev. 2005 Dec;57(4):541-6. Review.

PMID:
16382107
33.

VIP receptors control excitability of suprachiasmatic nuclei neurones.

Pakhotin P, Harmar AJ, Verkhratsky A, Piggins H.

Pflugers Arch. 2006 Apr;452(1):7-15. Epub 2005 Nov 8.

PMID:
16283205
34.

Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease.

Lawrie A, Spiekerkoetter E, Martinez EC, Ambartsumian N, Sheward WJ, MacLean MR, Harmar AJ, Schmidt AM, Lukanidin E, Rabinovitch M.

Circ Res. 2005 Aug 5;97(3):227-35. Epub 2005 Jul 7.

PMID:
16002749
35.

International Union of Pharmacology. XLVI. G protein-coupled receptor list.

Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP, Spedding M, Harmar AJ.

Pharmacol Rev. 2005 Jun;57(2):279-88. Review.

PMID:
15914470
36.

Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons.

Aton SJ, Colwell CS, Harmar AJ, Waschek J, Herzog ED.

Nat Neurosci. 2005 Apr;8(4):476-83. Epub 2005 Mar 6.

37.

Clinical endocrinology and metabolism. Receptors for gut peptides.

Harmar AJ.

Best Pract Res Clin Endocrinol Metab. 2004 Dec;18(4):463-75. Review.

PMID:
15533770
38.

Mice overexpressing human caspase 3 appear phenotypically normal but exhibit increased apoptosis and larger lesion volumes in response to transient focal cerebral ischaemia.

Kerr LE, McGregor AL, Amet LE, Asada T, Spratt C, Allsopp TE, Harmar AJ, Shen S, Carlson G, Logan N, Kelly JS, Sharkey J.

Cell Death Differ. 2004 Oct;11(10):1102-11.

39.

Transgenic approach reveals expression of the VPAC2 receptor in phenotypically defined neurons in the mouse suprachiasmatic nucleus and in its efferent target sites.

Kalló I, Kalamatianos T, Wiltshire N, Shen S, Sheward WJ, Harmar AJ, Coen CW.

Eur J Neurosci. 2004 Apr;19(8):2201-11.

PMID:
15090046
40.

Distribution of the VPAC2 receptor in peripheral tissues of the mouse.

Harmar AJ, Sheward WJ, Morrison CF, Waser B, Gugger M, Reubi JC.

Endocrinology. 2004 Mar;145(3):1203-10. Epub 2003 Nov 14.

PMID:
14617572
41.

A hVIPR transgene as a novel tool for the analysis of circadian function in the mouse suprachiasmatic nucleus.

King VM, Chahad-Ehlers S, Shen S, Harmar AJ, Maywood ES, Hastings MH.

Eur J Neurosci. 2003 Jun;17(11):822-32.

PMID:
12814356
42.
43.

A hVIPR transgene as a novel tool for the analysis of circadian function in the mouse suprachiasmatic nucleus.

King VM, Chahad-Ehlers S, Shen S, Harmar AJ, Maywood ES, Hastings MH.

Eur J Neurosci. 2003 Feb;17(4):822-32. Corrected and republished in: Eur J Neurosci. 2003 Jun;17(11):822-32.

PMID:
12603272
44.

The mouse VPAC2 receptor confers suprachiasmatic nuclei cellular rhythmicity and responsiveness to vasoactive intestinal polypeptide in vitro.

Cutler DJ, Haraura M, Reed HE, Shen S, Sheward WJ, Morrison CF, Marston HM, Harmar AJ, Piggins HD.

Eur J Neurosci. 2003 Jan;17(2):197-204.

PMID:
12542655
45.

The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei.

Harmar AJ, Marston HM, Shen S, Spratt C, West KM, Sheward WJ, Morrison CF, Dorin JR, Piggins HD, Reubi JC, Kelly JS, Maywood ES, Hastings MH.

Cell. 2002 May 17;109(4):497-508.

46.

Family-B G-protein-coupled receptors.

Harmar AJ.

Genome Biol. 2001;2(12):REVIEWS3013. Epub 2001 Nov 23. Review.

47.

Enhanced delayed-type hypersensitivity and diminished immediate-type hypersensitivity in mice lacking the inducible VPAC(2) receptor for vasoactive intestinal peptide.

Goetzl EJ, Voice JK, Shen S, Dorsam G, Kong Y, West KM, Morrison CF, Harmar AJ.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13854-9. Epub 2001 Nov 6.

48.

Overexpression of the human VPAC2 receptor in the suprachiasmatic nucleus alters the circadian phenotype of mice.

Shen S, Spratt C, Sheward WJ, Kallo I, West K, Morrison CF, Coen CW, Marston HM, Harmar AJ.

Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11575-80.

49.

Refined mapping of the human serotonin transporter (SLC6A4) gene within 17q11 adjacent to the CPD and NF1 genes.

Shen S, Battersby S, Weaver M, Clark E, Stephens K, Harmar AJ.

Eur J Hum Genet. 2000 Jan;8(1):75-8.

50.

Domains determining agonist selectivity in chimaeric VIP2 (VPAC2)/PACAP (PAC1) receptors.

Lutz EM, MacKenzie CJ, Johnson M, West K, Morrow JA, Harmar AJ, Mitchell R.

Br J Pharmacol. 1999 Oct;128(4):934-40.

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