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Items: 1 to 50 of 76

1.

Thermal Dissociation Assay for Time-Resolved Fluorescence Detection of Protein Post-Translational Modifications.

Eskonen V, Tong-Ochoa N, Valtonen S, Kopra K, Härmä H.

ACS Omega. 2019 Sep 24;4(15):16501-16507. doi: 10.1021/acsomega.9b02134. eCollection 2019 Oct 8.

2.

Immunoassays Based on Hot Electron-Induced Electrochemiluminescence at Disposable Cell Chips with Printed Electrodes.

Grönroos P; Nur-E-Habiba, Salminen K, Nissinen M, Tuomaala T, Miikki K, Zhang Q, Wei N, Kauppinen E, Eskola J, Härmä H, Kulmala S.

Sensors (Basel). 2019 Jun 19;19(12). pii: E2751. doi: 10.3390/s19122751.

3.

High-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors.

Manoharan GB, Kopra K, Eskonen V, Härmä H, Abankwa D.

Anal Biochem. 2019 May 1;572:25-32. doi: 10.1016/j.ab.2019.02.015. Epub 2019 Feb 27.

PMID:
30825429
4.

Homogeneous peptide-break assay for luminescent detection of enzymatic protein post-translational modification activity utilizing charged peptides.

Kopra K, Tong-Ochoa N, Laine M, Eskonen V, Koskinen PJ, Härmä H.

Anal Chim Acta. 2019 May 9;1055:126-132. doi: 10.1016/j.aca.2018.12.041. Epub 2018 Dec 28.

PMID:
30782363
5.

Label-Free Time-Gated Luminescent Detection Method for the Nucleotides with Varying Phosphate Content.

Kopra K, Seppälä T, Rabara D, Abreu-Blanco M, Kulmala S, Holderfield M, Härmä H.

Sensors (Basel). 2018 Nov 16;18(11). pii: E3989. doi: 10.3390/s18113989.

6.

Toward universal protein post-translational modification detection in high throughput format.

Härmä H, Tong-Ochoa N, van Adrichem AJ, Jelesarov I, Wennerberg K, Kopra K.

Chem Commun (Camb). 2018 Mar 15;54(23):2910-2913. doi: 10.1039/c7cc09575a.

7.

High-Throughput Dual Screening Method for Ras Activities and Inhibitors.

Kopra K, van Adrichem AJ, Salo-Ahen OMH, Peltonen J, Wennerberg K, Härmä H.

Anal Chem. 2017 Apr 18;89(8):4508-4516. doi: 10.1021/acs.analchem.6b04904. Epub 2017 Mar 29.

PMID:
28318223
8.

Luminometric Nanoparticle-Based Assay for High Sensitivity Detection of β-Amyloid Aggregation.

Pihlasalo S, Deguchi T, Virtamo M, Jacobino J, Chary K, López-Picón FR, Brunhofer-Bolzer G, Huttunen R, Fallarero A, Vuorela P, Härmä H.

Anal Chem. 2017 Feb 21;89(4):2398-2404. doi: 10.1021/acs.analchem.6b04266. Epub 2017 Feb 2.

PMID:
28219250
9.

Residual nanoparticle label immunosensor for wash-free C-reactive protein detection in blood.

Huttunen RJ, Näreoja T, Mariani L, Härmä H.

Biosens Bioelectron. 2016 Sep 15;83:54-9. doi: 10.1016/j.bios.2016.04.036. Epub 2016 Apr 13.

PMID:
27104585
10.

Luminometric Label Array for Quantification and Identification of Metal Ions.

Pihlasalo S, Montoya Perez I, Hollo N, Hokkanen E, Pahikkala T, Härmä H.

Anal Chem. 2016 May 17;88(10):5271-80. doi: 10.1021/acs.analchem.6b00453. Epub 2016 May 5.

PMID:
27086705
11.

Quantitative and discriminative analysis of nucleic acid samples using luminometric nonspecific nanoparticle methods.

Pihlasalo S, Mariani L, Härmä H.

Nanoscale. 2016 Mar 21;8(11):5902-11. doi: 10.1039/c5nr09252c. Epub 2016 Feb 25.

PMID:
26912463
12.

Homogeneous single-label tyrosine kinase activity assay for high throughput screening.

Tong-Ochoa N, Kopra K, Syrjänpää M, Legrand N, Härmä H.

Anal Chim Acta. 2015 Oct 15;897:96-101. doi: 10.1016/j.aca.2015.09.032. Epub 2015 Oct 8.

PMID:
26515010
13.

Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation.

Šolman M, Ligabue A, Blaževitš O, Jaiswal A, Zhou Y, Liang H, Lectez B, Kopra K, Guzmán C, Härmä H, Hancock JF, Aittokallio T, Abankwa D.

Elife. 2015 Aug 14;4:e08905. doi: 10.7554/eLife.08905.

14.

Lanthanide Label Array Method for Identification and Adulteration of Honey and Cacao.

Härmä H, Peltomaa R, Pihlasalo S.

Anal Chem. 2015 Jul 7;87(13):6451-4. doi: 10.1021/acs.analchem.5b01101. Epub 2015 Jun 23.

PMID:
26102618
15.

Method for determination of polyethylene glycol molecular weight.

Pihlasalo S, Hänninen P, Härmä H.

Anal Chem. 2015 Apr 7;87(7):3918-22. doi: 10.1021/acs.analchem.5b00736. Epub 2015 Mar 27.

PMID:
25783500
16.

Quenching resonance energy transfer (QRET): a single-label technique for inhibitor screening and interaction studies.

Kopra K, Härmä H.

N Biotechnol. 2015 Dec 25;32(6):575-80. doi: 10.1016/j.nbt.2015.02.007. Epub 2015 Feb 23. Review.

PMID:
25721971
17.

GTP-specific fab fragment-based GTPase activity assay.

Kopra K, Rozwandowicz-Jansen A, Syrjänpää M, Blaževitš O, Ligabue A, Veltel S, Lamminmäki U, Abankwa D, Härmä H.

Anal Chem. 2015 Mar 17;87(6):3527-34. doi: 10.1021/acs.analchem.5b00117. Epub 2015 Mar 3.

PMID:
25707436
18.

A homogeneous quenching resonance energy transfer assay for the kinetic analysis of the GTPase nucleotide exchange reaction.

Kopra K, Ligabue A, Wang Q, Syrjänpää M, Blaževitš O, Veltel S, van Adrichem AJ, Hänninen P, Abankwa D, Härmä H.

Anal Bioanal Chem. 2014 Jul;406(17):4147-56. doi: 10.1007/s00216-014-7795-7. Epub 2014 Apr 24.

PMID:
24760397
19.

Non-competitive aptamer-based quenching resonance energy transfer assay for homogeneous growth factor quantification.

Kopra K, Syrjänpää M, Hänninen P, Härmä H.

Analyst. 2014 Apr 21;139(8):2016-23. doi: 10.1039/c3an01814h.

PMID:
24611155
20.

Simple nanoparticle-based luminometric method for molecular weight determination of polymeric compounds.

Pihlasalo S, Virtamo M, Legrand N, Hänninen P, Härmä H.

Anal Chem. 2014 Jan 21;86(2):1038-44. doi: 10.1021/ac401797m. Epub 2013 Dec 30.

PMID:
24328326
21.

Kinetics of bioconjugate nanoparticle label binding in a sandwich-type immunoassay.

Näreoja T, Ebner A, Gruber HJ, Taskinen B, Kienberger F, Hänninen PE, Hytönen VP, Hinterdorfer P, Härmä H.

Anal Bioanal Chem. 2014 Jan;406(2):493-503. doi: 10.1007/s00216-013-7474-0. Epub 2013 Nov 22.

PMID:
24264621
22.

High-throughput screening of colonization samples for methicillin-resistant Staphylococcus aureus.

Stenholm T, Hakanen AJ, Hakanen E, Härmä H, Österblad M, Vuopio J, Hänninen PE, Huovinen P, Rankakokko-Jalava K, Kotilainen P.

Scand J Infect Dis. 2013 Dec;45(12):922-9. doi: 10.3109/00365548.2013.831182. Epub 2013 Oct 3.

PMID:
24090458
23.

Stable and highly fluorescent europium(III) chelates for time-resolved immunoassays.

Wang Q, Nchimi Nono K, Syrjänpää M, Charbonnière LJ, Hovinen J, Härmä H.

Inorg Chem. 2013 Aug 5;52(15):8461-6. doi: 10.1021/ic400384f. Epub 2013 Jul 9.

PMID:
23837738
24.

A homogeneous single-label quenching resonance energy transfer assay for a δ-opioid receptor-ligand using intact cells.

Kopra K, Shweta, Martikkala E, Hänninen P, Petäjä-Repo U, Härmä H.

Analyst. 2013 Sep 7;138(17):4907-14. doi: 10.1039/c3an00736g. Epub 2013 Jun 26.

PMID:
23800721
25.

Luminescence stability improvement in liposome-based homogeneous luminescence resonance energy transfer.

Pihlasalo S, Granberg J, Hänninen P, Peltonen J, Härmä H.

Anal Biochem. 2013 Sep 1;440(1):6-8. doi: 10.1016/j.ab.2013.05.004. Epub 2013 May 20.

PMID:
23702341
26.

Fuzzy liquid analysis by an array of nonspecifically interacting reagents: the taste of fluorescence.

Hänninen PE, Siivonen JJ, Väisänen PI, Tiittanen SA, Lehmusto MM, Teimonen T, Törnkvist N, Sandell MA, Knaapila AJ, Mundill P, Härmä HJ.

J Am Chem Soc. 2013 May 22;135(20):7422-5. doi: 10.1021/ja401726d. Epub 2013 May 8.

PMID:
23651080
27.

Application of paper-supported printed gold electrodes for impedimetric immunosensor development.

Ihalainen P, Majumdar H, Viitala T, Törngren B, Närjeoja T, Määttänen A, Sarfraz J, Härmä H, Yliperttula M, Österbacka R, Peltonen J.

Biosensors (Basel). 2012 Dec 27;3(1):1-17. doi: 10.3390/bios3010001. eCollection 2013 Mar.

28.

Protein quantification using resonance energy transfer between donor nanoparticles and acceptor quantum dots.

Härmä H, Pihlasalo S, Cywinski PJ, Mikkonen P, Hammann T, Löhmannsröben HG, Hänninen P.

Anal Chem. 2013 Mar 5;85(5):2921-6. doi: 10.1021/ac303586n. Epub 2013 Feb 21.

PMID:
23391291
29.

Nonspecific particle-based method with two-photon excitation detection for sensitive protein quantification and cell counting.

Pihlasalo S, Engbert A, Martikkala E, Ylander P, Hänninen P, Härmä H.

Anal Chem. 2013 Mar 5;85(5):2689-96. doi: 10.1021/ac303069f. Epub 2013 Feb 20.

PMID:
23384281
30.

Multiparametric homogeneous method for identification of ligand binding to G protein-coupled receptors: receptor-ligand binding and β-arrestin assay.

Kopra K, Kainulainen M, Mikkonen P, Rozwandowicz-Jansen A, Hänninen P, Härmä H.

Anal Chem. 2013 Feb 19;85(4):2276-81. doi: 10.1021/ac303215r. Epub 2013 Feb 6.

PMID:
23330639
31.
32.

Method for estimation of protein isoelectric point.

Pihlasalo S, Auranen L, Hänninen P, Härmä H.

Anal Chem. 2012 Oct 2;84(19):8253-8. doi: 10.1021/ac301569b. Epub 2012 Sep 18.

PMID:
22946671
33.
34.

Time-resolved fluorescence immunoassay for C-reactive protein using colloidal semiconducting nanoparticles.

Härmä H, Toivonen J, Soini JT, Hänninen P, Parak WJ.

Sensors (Basel). 2011;11(12):11335-42. doi: 10.3390/s111211335. Epub 2011 Nov 28.

35.

Sensitive luminometric method for protein quantification in bacterial cell lysate based on particle adsorption and dissociation of chelated europium.

Pihlasalo S, Kulmala A, Rozwandowicz-Jansen A, Hänninen P, Härmä H.

Anal Chem. 2012 Feb 7;84(3):1386-93. doi: 10.1021/ac202417j. Epub 2012 Jan 10.

PMID:
22242711
36.

Homogeneous single-label biochemical Ras activation assay using time-resolved luminescence.

Martikkala E, Veltel S, Kirjavainen J, Rozwandowicz-Jansen A, Lamminmäki U, Hänninen P, Härmä H.

Anal Chem. 2011 Dec 15;83(24):9230-3. doi: 10.1021/ac202723h. Epub 2011 Nov 18.

PMID:
22098697
37.

Glucose response of near-infrared alginate-based microsphere sensors under dynamic reversible conditions.

Chaudhary A, Harma H, Hanninen P, McShane MJ, Srivastava R.

Diabetes Technol Ther. 2011 Aug;13(8):827-35. doi: 10.1089/dia.2011.0057. Epub 2011 May 13.

38.

Single-label time-resolved luminescence assay for estrogen receptor--ligand binding.

Huttunen R, Shweta, Martikkala E, Lahdenranta M, Virta P, Hänninen P, Härmä H.

Anal Biochem. 2011 Aug 1;415(1):27-31. doi: 10.1016/j.ab.2011.03.038. Epub 2011 Apr 6.

PMID:
21477578
39.

Evaluation of the TPX MRSA assay for the detection of methicillin-resistant Staphylococcus aureus.

Stenholm T, Hakanen AJ, Salmenlinna S, Pihlasalo S, Härmä H, Hänninen PE, Huovinen P, Vuopio J, Kotilainen P.

Eur J Clin Microbiol Infect Dis. 2011 Oct;30(10):1237-43. doi: 10.1007/s10096-011-1218-x. Epub 2011 Apr 2.

PMID:
21461657
40.

A homogeneous single-label time-resolved fluorescence cAMP assay.

Martikkala E, Rozwandowicz-Jansen A, Hänninen P, Petäjä-Repo U, Härmä H.

J Biomol Screen. 2011 Mar;16(3):356-62. doi: 10.1177/1087057110397356. Epub 2011 Feb 22.

PMID:
21343601
41.

Multiparametric luminescence method for quantitative cell surface protein expression analysis and imaging.

Huttunen R, Soini J, Härkönen P, Hänninen P, Härmä H.

J Immunol Methods. 2011 Mar 31;367(1-2):40-6. doi: 10.1016/j.jim.2011.01.008. Epub 2011 Jan 28.

PMID:
21277303
42.

High sensitivity luminescence nanoparticle assay for the detection of protein aggregation.

Pihlasalo S, Kirjavainen J, Hänninen P, Härmä H.

Anal Chem. 2011 Feb 15;83(4):1163-6. doi: 10.1021/ac1026385. Epub 2011 Jan 19.

PMID:
21247196
43.

Sensitive fluorometric nanoparticle assays for cell counting and viability.

Pihlasalo S, Pellonperä L, Martikkala E, Hänninen P, Härmä H.

Anal Chem. 2010 Nov 15;82(22):9282-8. doi: 10.1021/ac1017869. Epub 2010 Oct 18.

PMID:
20954745
44.

Rapid detection of trace amounts of surfactants using nanoparticles in fluorometric assays.

Härmä H, Laakso S, Pihlasalo S, Hänninen P, Faure B, Rana S, Bergström L.

Nanoscale. 2010 Jan;2(1):69-71. doi: 10.1039/b9nr00172g. Epub 2009 Nov 16.

PMID:
20648365
45.

Characterization of immune responses to capsid protein p24 of human immunodeficiency virus type 1 and implications for detection.

Tang S, Zhao J, Wang A, Viswanath R, Harma H, Little RF, Yarchoan R, Stramer SL, Nyambi PN, Lee S, Wood O, Wong EY, Wang X, Hewlett IK.

Clin Vaccine Immunol. 2010 Aug;17(8):1244-51. doi: 10.1128/CVI.00066-10. Epub 2010 Jun 9.

46.

Homogeneous GTP binding assay employing QRET technology.

Rozwandowicz-Jansen A, Laurila J, Martikkala E, Frang H, Hemmilä I, Scheinin M, Hänninen P, Härmä H.

J Biomol Screen. 2010 Mar;15(3):261-7. doi: 10.1177/1087057109358921. Epub 2010 Jan 26.

PMID:
20103692
47.

Internalization of coxsackievirus A9 is mediated by {beta}2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin.

Heikkilä O, Susi P, Tevaluoto T, Härmä H, Marjomäki V, Hyypiä T, Kiljunen S.

J Virol. 2010 Apr;84(7):3666-81. doi: 10.1128/JVI.01340-09. Epub 2010 Jan 20.

48.

Comparison of homogeneous single-label fluorometric binding assays: fluorescence polarization and dual-parametric quenching resonance energy transfer technique.

Härmä H, Sarrail G, Kirjavainen J, Martikkala E, Hemmilä I, Hänninen P.

Anal Chem. 2010 Feb 1;82(3):892-7. doi: 10.1021/ac902044n.

PMID:
20047278
49.

A new simple cell-based homogeneous time-resolved fluorescence QRET technique for receptor-ligand interaction screening.

Härmä H, Rozwandowicz-Jansen A, Martikkala E, Frang H, Hemmilä I, Sahlberg N, Fey V, Perälä M, Hänninen P.

J Biomol Screen. 2009 Sep;14(8):936-43. doi: 10.1177/1087057109341657. Epub 2009 Aug 14.

PMID:
19684287
50.

Evaluation of glucose sensitive affinity binding assay entrapped in fluorescent dissolved-core alginate microspheres.

Chaudhary A, Raina M, Harma H, Hanninen P, McShane MJ, Srivastava R.

Biotechnol Bioeng. 2009 Dec 15;104(6):1075-85. doi: 10.1002/bit.22500.

PMID:
19655392

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