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Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.

Rozbesky D, Robinson RA, Jain V, Renner M, Malinauskas T, Harlos K, Siebold C, Jones EY.

Nat Commun. 2019 Aug 15;10(1):3691. doi: 10.1038/s41467-019-11683-y.


Evidence of commitment to research partnerships? Results of two web reviews.

de Moissac D, Bowen S, Botting I, Graham ID, MacLeod M, Harlos K, Songok CM, Bohémier M.

Health Res Policy Syst. 2019 Jul 30;17(1):73. doi: 10.1186/s12961-019-0475-5.


Primary care reform in Manitoba, Canada, 2011-15: Balancing accountability and acceptability.

Kreindler SA, Metge C, Struthers A, Harlos K, Charette C, Bapuji S, Beaudin P, Botting I, Katz A, Zinnick S.

Health Policy. 2019 Jun;123(6):532-537. doi: 10.1016/j.healthpol.2019.03.014. Epub 2019 Mar 27.


Pushing for partnership: physician engagement and resistance in primary care renewal.

Kreindler SA, Struthers A, Metge CJ, Charette C, Harlos K, Beaudin P, Bapuji SB, Botting I, Francois J.

J Health Organ Manag. 2019 Mar 28;33(2):126-140. doi: 10.1108/JHOM-05-2018-0141. Epub 2019 Feb 7.


The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins.

El Omari K, Li S, Kotecha A, Walter TS, Bignon EA, Harlos K, Somerharju P, De Haas F, Clare DK, Molin M, Hurtado F, Li M, Grimes JM, Bamford DH, Tischler ND, Huiskonen JT, Stuart DI, Roine E.

Nat Commun. 2019 Feb 19;10(1):846. doi: 10.1038/s41467-019-08728-7.


Insights from the crystal structure of the chicken CREB3 bZIP suggest that members of the CREB3 subfamily transcription factors may be activated in response to oxidative stress.

Sabaratnam K, Renner M, Paesen G, Harlos K, Nair V, Owens RJ, Grimes JM.

Protein Sci. 2019 Apr;28(4):779-787. doi: 10.1002/pro.3573. Epub 2019 Feb 6.


A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus.

Allen ER, Krumm SA, Raghwani J, Halldorsson S, Elliott A, Graham VA, Koudriakova E, Harlos K, Wright D, Warimwe GM, Brennan B, Huiskonen JT, Dowall SD, Elliott RM, Pybus OG, Burton DR, Hewson R, Doores KJ, Bowden TA.

Cell Rep. 2018 Dec 26;25(13):3750-3758.e4. doi: 10.1016/j.celrep.2018.12.001.


Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.

Walters LC, Harlos K, Brackenridge S, Rozbesky D, Barrett JR, Jain V, Walter TS, O'Callaghan CA, Borrow P, Toebes M, Hansen SG, Sacha JB, Abdulhaqq S, Greene JM, Früh K, Marshall E, Picker LJ, Jones EY, McMichael AJ, Gillespie GM.

Nat Commun. 2018 Nov 13;9(1):4833. doi: 10.1038/s41467-018-07304-9.


Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance.

Yogavel M, Nettleship JE, Sharma A, Harlos K, Jamwal A, Chaturvedi R, Sharma M, Jain V, Chhibber-Goel J, Sharma A.

J Biol Chem. 2018 Sep 28;293(39):14962-14972. doi: 10.1074/jbc.RA118.004558. Epub 2018 Aug 13.


Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.

Walters LC, Harlos K, Brackenridge S, Rozbesky D, Barrett JR, Jain V, Walter TS, O'Callaghan CA, Borrow P, Toebes M, Hansen SG, Sacha JB, Abdulhaqq S, Greene JM, Früh K, Marshall E, Picker LJ, Jones EY, McMichael AJ, Gillespie GM.

Nat Commun. 2018 Aug 7;9(1):3137. doi: 10.1038/s41467-018-05459-z. Erratum in: Nat Commun. 2018 Nov 13;9(1):4833.


Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6.

Zhao Y, Ren J, Lu W, Harlos K, Jones EY.

FEBS Lett. 2018 Sep;592(18):3152-3162. doi: 10.1002/1873-3468.13212. Epub 2018 Aug 24.


Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite.

Das P, Babbar P, Malhotra N, Sharma M, Jachak GR, Gonnade RG, Shanmugam D, Harlos K, Yogavel M, Sharma A, Reddy DS.

J Med Chem. 2018 Jul 12;61(13):5664-5678. doi: 10.1021/acs.jmedchem.8b00565. Epub 2018 Jun 4.


Structures of monomeric and oligomeric forms of the Toxoplasma gondii perforin-like protein 1.

Ni T, Williams SI, Rezelj S, Anderluh G, Harlos K, Stansfeld PJ, Gilbert RJC.

Sci Adv. 2018 Mar 21;4(3):eaaq0762. doi: 10.1126/sciadv.aaq0762. eCollection 2018 Mar.


Effectiveness of implementation interventions in improving physician adherence to guideline recommendations in heart failure: a systematic review.

Shanbhag D, Graham ID, Harlos K, Haynes RB, Gabizon I, Connolly SJ, Van Spall HGC.

BMJ Open. 2018 Mar 6;8(3):e017765. doi: 10.1136/bmjopen-2017-017765. Review.


Shielding and activation of a viral membrane fusion protein.

Halldorsson S, Li S, Li M, Harlos K, Bowden TA, Huiskonen JT.

Nat Commun. 2018 Jan 24;9(1):349. doi: 10.1038/s41467-017-02789-2.


Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.

Jain V, Yogavel M, Kikuchi H, Oshima Y, Hariguchi N, Matsumoto M, Goel P, Touquet B, Jumani RS, Tacchini-Cottier F, Harlos K, Huston CD, Hakimi MA, Sharma A.

Structure. 2017 Oct 3;25(10):1495-1505.e6. doi: 10.1016/j.str.2017.07.015. Epub 2017 Aug 31.


Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope.

Rissanen I, Stass R, Zeltina A, Li S, Hepojoki J, Harlos K, Gilbert RJC, Huiskonen JT, Bowden TA.

J Virol. 2017 Oct 13;91(21). pii: e00378-17. doi: 10.1128/JVI.00378-17. Print 2017 Nov 1.


Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization.

Zeltina A, Krumm SA, Sahin M, Struwe WB, Harlos K, Nunberg JH, Crispin M, Pinschewer DD, Doores KJ, Bowden TA.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7031-7036. doi: 10.1073/pnas.1702127114. Epub 2017 Jun 19.


High-speed fixed-target serial virus crystallography.

Roedig P, Ginn HM, Pakendorf T, Sutton G, Harlos K, Walter TS, Meyer J, Fischer P, Duman R, Vartiainen I, Reime B, Warmer M, Brewster AS, Young ID, Michels-Clark T, Sauter NK, Kotecha A, Kelly J, Rowlands DJ, Sikorsky M, Nelson S, Damiani DS, Alonso-Mori R, Ren J, Fry EE, David C, Stuart DI, Wagner A, Meents A.

Nat Methods. 2017 Aug;14(8):805-810. doi: 10.1038/nmeth.4335. Epub 2017 Jun 19.


Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.

Mpakali A, Saridakis E, Harlos K, Zhao Y, Kokkala P, Georgiadis D, Giastas P, Papakyriakou A, Stratikos E.

J Med Chem. 2017 Apr 13;60(7):2963-2972. doi: 10.1021/acs.jmedchem.6b01890. Epub 2017 Apr 3.


A Two-Tailed Phosphopeptide Crystallizes to Form a Lamellar Structure.

Pellach M, Mondal S, Harlos K, Mance D, Baldus M, Gazit E, Shimon LJ.

Angew Chem Int Ed Engl. 2017 Mar 13;56(12):3252-3255. doi: 10.1002/anie.201609877. Epub 2017 Feb 13.


Toremifene interacts with and destabilizes the Ebola virus glycoprotein.

Zhao Y, Ren J, Harlos K, Jones DM, Zeltina A, Bowden TA, Padilla-Parra S, Fry EE, Stuart DI.

Nature. 2016 Jul 7;535(7610):169-172. doi: 10.1038/nature18615. Epub 2016 Jun 29.


A Molecular-Level Account of the Antigenic Hantaviral Surface.

Li S, Rissanen I, Zeltina A, Hepojoki J, Raghwani J, Harlos K, Pybus OG, Huiskonen JT, Bowden TA.

Cell Rep. 2016 Jun 28;16(1):278. doi: 10.1016/j.celrep.2016.06.039. Epub 2016 Jun 28. No abstract available.


Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion.

Halldorsson S, Behrens AJ, Harlos K, Huiskonen JT, Elliott RM, Crispin M, Brennan B, Bowden TA.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7154-9. doi: 10.1073/pnas.1603827113. Epub 2016 Jun 20.


Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development.

Ni T, Harlos K, Gilbert R.

Open Biol. 2016 May;6(5). pii: 160053. doi: 10.1098/rsob.160053. Epub 2016 May 4.


The crystal structure of human dopamine β-hydroxylase at 2.9 Å resolution.

Vendelboe TV, Harris P, Zhao Y, Walter TS, Harlos K, El Omari K, Christensen HE.

Sci Adv. 2016 Apr 8;2(4):e1500980. doi: 10.1126/sciadv.1500980. eCollection 2016 Apr.


A Molecular-Level Account of the Antigenic Hantaviral Surface.

Li S, Rissanen I, Zeltina A, Hepojoki J, Raghwani J, Harlos K, Pybus OG, Huiskonen JT, Bowden TA.

Cell Rep. 2016 May 3;15(5):959-967. doi: 10.1016/j.celrep.2016.03.082. Epub 2016 Apr 21. Erratum in: Cell Rep. 2016 Jun 28;16(1):278.


Effectiveness of implementation strategies in improving physician adherence to guideline recommendations in heart failure: a systematic review protocol.

Van Spall HG, Shanbhag D, Gabizon I, Ibrahim Q, Graham ID, Harlos K, Haynes RB, Connolly SJ.

BMJ Open. 2016 Mar 31;6(3):e009364. doi: 10.1136/bmjopen-2015-009364.


Initiation of T cell signaling by CD45 segregation at 'close contacts'.

Chang VT, Fernandes RA, Ganzinger KA, Lee SF, Siebold C, McColl J, Jönsson P, Palayret M, Harlos K, Coles CH, Jones EY, Lui Y, Huang E, Gilbert RJC, Klenerman D, Aricescu AR, Davis SJ.

Nat Immunol. 2016 May;17(5):574-582. doi: 10.1038/ni.3392. Epub 2016 Mar 21.


Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions.

Zhao Y, Ren J, Harlos K, Stuart DI.

FEBS Lett. 2016 Mar;590(5):605-12. doi: 10.1002/1873-3468.12089. Epub 2016 Feb 23.


Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling.

Zeev-Ben-Mordehai T, Weberruß M, Lorenz M, Cheleski J, Hellberg T, Whittle C, El Omari K, Vasishtan D, Dent KC, Harlos K, Franzke K, Hagen C, Klupp BG, Antonin W, Mettenleiter TC, Grünewald K.

Cell Rep. 2015 Dec 29;13(12):2645-52. doi: 10.1016/j.celrep.2015.11.008. Epub 2015 Dec 17.


Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing.

Mpakali A, Saridakis E, Harlos K, Zhao Y, Papakyriakou A, Kokkala P, Georgiadis D, Stratikos E.

J Immunol. 2015 Sep 15;195(6):2842-51. doi: 10.4049/jimmunol.1501103. Epub 2015 Aug 10.


Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.

Chang TH, Hsieh FL, Zebisch M, Harlos K, Elegheert J, Jones EY.

Elife. 2015 Jul 9;4. doi: 10.7554/eLife.06554.


New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM.

Fadel F, Zhao Y, Cachau R, Cousido-Siah A, Ruiz FX, Harlos K, Howard E, Mitschler A, Podjarny A.

Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1455-70. doi: 10.1107/S139900471500783X. Epub 2015 Jun 30.


Improved crystallization and diffraction of caffeine-induced death suppressor protein 1 (Cid1).

Yates LA, Durrant BP, Barber M, Harlos K, Fleurdépine S, Norbury CJ, Gilbert RJ.

Acta Crystallogr F Struct Biol Commun. 2015 Mar;71(Pt 3):346-53. doi: 10.1107/S2053230X15001351. Epub 2015 Feb 21.


Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states.

Skálová T, Bláha J, Harlos K, Dušková J, Koval' T, Stránský J, Hašek J, Vaněk O, Dohnálek J.

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):578-91. doi: 10.1107/S1399004714027928. Epub 2015 Feb 26.


Structural basis of latrophilin-FLRT interaction.

Jackson VA, del Toro D, Carrasquero M, Roversi P, Harlos K, Klein R, Seiradake E.

Structure. 2015 Apr 7;23(4):774-81. doi: 10.1016/j.str.2015.01.013. Epub 2015 Feb 26.


Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity.

Yates LA, Durrant BP, Fleurdépine S, Harlos K, Norbury CJ, Gilbert RJ.

Nucleic Acids Res. 2015 Mar 11;43(5):2968-79. doi: 10.1093/nar/gkv122. Epub 2015 Feb 20.


FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development.

Seiradake E, del Toro D, Nagel D, Cop F, Härtl R, Ruff T, Seyit-Bremer G, Harlos K, Border EC, Acker-Palmer A, Jones EY, Klein R.

Neuron. 2014 Oct 22;84(2):370-85. doi: 10.1016/j.neuron.2014.10.008. Epub 2014 Oct 22.


The impact of organisational factors on horizontal bullying and turnover intentions in the nursing workplace.

Blackstock S, Harlos K, Macleod ML, Hardy CL.

J Nurs Manag. 2015 Nov;23(8):1106-14. doi: 10.1111/jonm.12260. Epub 2014 Nov 5.


Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1.

El Omari K, Iourin O, Kadlec J, Sutton G, Harlos K, Grimes JM, Stuart DI.

Nat Commun. 2014 Sep 16;5:4874. doi: 10.1038/ncomms5874.


Pushing the limits of sulfur SAD phasing: de novo structure solution of the N-terminal domain of the ectodomain of HCV E1.

El Omari K, Iourin O, Kadlec J, Fearn R, Hall DR, Harlos K, Grimes JM, Stuart DI.

Acta Crystallogr D Biol Crystallogr. 2014 Aug;70(Pt 8):2197-203. doi: 10.1107/S139900471401339X. Epub 2014 Jul 25.


Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae.

Leyrat C, Renner M, Harlos K, Huiskonen JT, Grimes JM.

Elife. 2014 May 19;3:e02674. doi: 10.7554/eLife.02674.


Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1.

Zhao Y, Malinauskas T, Harlos K, Jones EY.

Structure. 2014 Apr 8;22(4):612-20. doi: 10.1016/j.str.2014.01.009. Epub 2014 Feb 27.


Structure and self-assembly of the calcium binding matrix protein of human metapneumovirus.

Leyrat C, Renner M, Harlos K, Huiskonen JT, Grimes JM.

Structure. 2014 Jan 7;22(1):136-48. doi: 10.1016/j.str.2013.10.013. Epub 2013 Dec 5.


Solution and crystallographic structures of the central region of the phosphoprotein from human metapneumovirus.

Leyrat C, Renner M, Harlos K, Grimes JM.

PLoS One. 2013 Nov 4;8(11):e80371. doi: 10.1371/journal.pone.0080371. eCollection 2013.


Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 postfusion architecture with extensive glycosylation.

Parsy ML, Harlos K, Huiskonen JT, Bowden TA.

J Virol. 2013 Dec;87(23):13070-5. doi: 10.1128/JVI.02298-13. Epub 2013 Sep 18.


Mining the management literature for insights into implementing evidence-based change in healthcare.

Harlos K, Tetroe J, Graham ID, Bird M, Robinson N.

Healthc Policy. 2012 Aug;8(1):33-48. Review.


Structurally encoded intraclass differences in EphA clusters drive distinct cell responses.

Seiradake E, Schaupp A, del Toro Ruiz D, Kaufmann R, Mitakidis N, Harlos K, Aricescu AR, Klein R, Jones EY.

Nat Struct Mol Biol. 2013 Aug;20(8):958-64. doi: 10.1038/nsmb.2617. Epub 2013 Jun 30.


Bacteriophage P23-77 capsid protein structures reveal the archetype of an ancient branch from a major virus lineage.

Rissanen I, Grimes JM, Pawlowski A, Mäntynen S, Harlos K, Bamford JK, Stuart DI.

Structure. 2013 May 7;21(5):718-26. doi: 10.1016/j.str.2013.02.026. Epub 2013 Apr 25.

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