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Integration of Wnt and FGF signaling in the Xenopus gastrula at TCF and Ets binding sites shows the importance of short-range repression by TCF in patterning the marginal zone.

Kjolby RAS, Truchado-Garcia M, Iruvanti S, Harland RM.

Development. 2019 Aug 9;146(15). pii: dev179580. doi: 10.1242/dev.179580.


A chromosome-scale genome assembly and dense genetic map for Xenopus tropicalis.

Mitros T, Lyons JB, Session AM, Jenkins J, Shu S, Kwon T, Lane M, Ng C, Grammer TC, Khokha MK, Grimwood J, Schmutz J, Harland RM, Rokhsar DS.

Dev Biol. 2019 Aug 1;452(1):8-20. doi: 10.1016/j.ydbio.2019.03.015. Epub 2019 Apr 10.


Alternative polyadenylation coordinates embryonic development, sexual dimorphism and longitudinal growth in Xenopus tropicalis.

Zhou X, Zhang Y, Michal JJ, Qu L, Zhang S, Wildung MR, Du W, Pouchnik DJ, Zhao H, Xia Y, Shi H, Ji G, Davis JF, Smith GD, Griswold MD, Harland RM, Jiang Z.

Cell Mol Life Sci. 2019 Jun;76(11):2185-2198. doi: 10.1007/s00018-019-03036-1. Epub 2019 Feb 7.


Na+/H+ Exchangers Are Required for the Development and Function of Vertebrate Mucociliary Epithelia.

Sun DI, Tasca A, Haas M, Baltazar G, Harland RM, Finkbeiner WE, Walentek P.

Cells Tissues Organs. 2018;205(5-6):279-292. doi: 10.1159/000492973. Epub 2018 Oct 9.


Katanin-like protein Katnal2 is required for ciliogenesis and brain development in Xenopus embryos.

Willsey HR, Walentek P, Exner CRT, Xu Y, Lane AB, Harland RM, Heald R, Santama N.

Dev Biol. 2018 Oct 15;442(2):276-287. doi: 10.1016/j.ydbio.2018.08.002. Epub 2018 Aug 8.


A new view of embryo development and regeneration.

Harland RM.

Science. 2018 Jun 1;360(6392):967-968. doi: 10.1126/science.aat8413. No abstract available.


A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates.

Plouhinec JL, Medina-Ruiz S, Borday C, Bernard E, Vert JP, Eisen MB, Harland RM, Monsoro-Burq AH.

PLoS Biol. 2017 Oct 19;15(10):e2004045. doi: 10.1371/journal.pbio.2004045. eCollection 2017 Oct.


Emergent cellular self-organization and mechanosensation initiate follicle pattern in the avian skin.

Shyer AE, Rodrigues AR, Schroeder GG, Kassianidou E, Kumar S, Harland RM.

Science. 2017 Aug 25;357(6353):811-815. doi: 10.1126/science.aai7868. Epub 2017 Jul 13.


Editorial: The Xenopus laevis genome.

Harland RM, Gilchrist MJ.

Dev Biol. 2017 Jun 15;426(2):139-142. doi: 10.1016/j.ydbio.2017.04.016. Epub 2017 Apr 27. No abstract available.


sall1 and sall4 repress pou5f3 family expression to allow neural patterning, differentiation, and morphogenesis in Xenopus laevis.

Exner CRT, Kim AY, Mardjuki SM, Harland RM.

Dev Biol. 2017 May 1;425(1):33-43. doi: 10.1016/j.ydbio.2017.03.015. Epub 2017 Mar 18.


Deletion of the sclerotome-enriched lncRNA PEAT augments ribosomal protein expression.

Stafford DA, Dichmann DS, Chang JK, Harland RM.

Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):101-106. doi: 10.1073/pnas.1612069113. Epub 2016 Dec 16.


Genome evolution in the allotetraploid frog Xenopus laevis.

Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A, Takahashi S, Fukui A, Hikosaka A, Suzuki A, Kondo M, van Heeringen SJ, Quigley I, Heinz S, Ogino H, Ochi H, Hellsten U, Lyons JB, Simakov O, Putnam N, Stites J, Kuroki Y, Tanaka T, Michiue T, Watanabe M, Bogdanovic O, Lister R, Georgiou G, Paranjpe SS, van Kruijsbergen I, Shu S, Carlson J, Kinoshita T, Ohta Y, Mawaribuchi S, Jenkins J, Grimwood J, Schmutz J, Mitros T, Mozaffari SV, Suzuki Y, Haramoto Y, Yamamoto TS, Takagi C, Heald R, Miller K, Haudenschild C, Kitzman J, Nakayama T, Izutsu Y, Robert J, Fortriede J, Burns K, Lotay V, Karimi K, Yasuoka Y, Dichmann DS, Flajnik MF, Houston DW, Shendure J, DuPasquier L, Vize PD, Zorn AM, Ito M, Marcotte EM, Wallingford JB, Ito Y, Asashima M, Ueno N, Matsuda Y, Veenstra GJ, Fujiyama A, Harland RM, Taira M, Rokhsar DS.

Nature. 2016 Oct 20;538(7625):336-343. doi: 10.1038/nature19840.


Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis.

Walentek P, Quigley IK, Sun DI, Sajjan UK, Kintner C, Harland RM.

Elife. 2016 Sep 13;5. pii: e17557. doi: 10.7554/eLife.17557.


Noggin is required for first pharyngeal arch differentiation in the frog Xenopus tropicalis.

Young JJ, Kjolby RAS, Wu G, Wong D, Hsu SW, Harland RM.

Dev Biol. 2017 Jun 15;426(2):245-254. doi: 10.1016/j.ydbio.2016.06.034. Epub 2016 Jun 27.


Accurate Profiling of Gene Expression and Alternative Polyadenylation with Whole Transcriptome Termini Site Sequencing (WTTS-Seq).

Zhou X, Li R, Michal JJ, Wu XL, Liu Z, Zhao H, Xia Y, Du W, Wildung MR, Pouchnik DJ, Harland RM, Jiang Z.

Genetics. 2016 Jun;203(2):683-97. doi: 10.1534/genetics.116.188508. Epub 2016 Apr 20.


Genome-wide identification of Wnt/β-catenin transcriptional targets during Xenopus gastrulation.

Kjolby RAS, Harland RM.

Dev Biol. 2017 Jun 15;426(2):165-175. doi: 10.1016/j.ydbio.2016.03.021. Epub 2016 Apr 16.


ATP4 and ciliation in the neuroectoderm and endoderm of Xenopus embryos and tadpoles.

Walentek P, Hagenlocher C, Beyer T, Müller C, Feistel K, Schweickert A, Harland RM, Blum M.

Data Brief. 2015 Apr 20;4:22-31. doi: 10.1016/j.dib.2015.04.003. eCollection 2015 Sep.


Whole transcriptome analysis with sequencing: methods, challenges and potential solutions.

Jiang Z, Zhou X, Li R, Michal JJ, Zhang S, Dodson MV, Zhang Z, Harland RM.

Cell Mol Life Sci. 2015 Sep;72(18):3425-39. doi: 10.1007/s00018-015-1934-y. Epub 2015 May 28. Review.


ATP4a is required for development and function of the Xenopus mucociliary epidermis - a potential model to study proton pump inhibitor-associated pneumonia.

Walentek P, Beyer T, Hagenlocher C, Müller C, Feistel K, Schweickert A, Harland RM, Blum M.

Dev Biol. 2015 Dec 15;408(2):292-304. doi: 10.1016/j.ydbio.2015.03.013. Epub 2015 Apr 4.


Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation.

Ray A, Singh PN, Sohaskey ML, Harland RM, Bandyopadhyay A.

Development. 2015 Mar 15;142(6):1169-79. doi: 10.1242/dev.110940.


The alternative splicing regulator Tra2b is required for somitogenesis and regulates splicing of an inhibitory Wnt11b isoform.

Dichmann DS, Walentek P, Harland RM.

Cell Rep. 2015 Feb 3;10(4):527-36. doi: 10.1016/j.celrep.2014.12.046. Epub 2015 Jan 22.


Sp8 regulates inner ear development.

Chung HA, Medina-Ruiz S, Harland RM.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6329-34. doi: 10.1073/pnas.1319301111. Epub 2014 Apr 10.


Spalt-like 4 promotes posterior neural fates via repression of pou5f3 family members in Xenopus.

Young JJ, Kjolby RA, Kong NR, Monica SD, Harland RM.

Development. 2014 Apr;141(8):1683-93. doi: 10.1242/dev.099374.


Follistatin interacts with Noggin in the development of the axial skeleton.

Stafford DA, Monica SD, Harland RM.

Mech Dev. 2014 Feb;131:78-85.


Pax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers.

Plouhinec JL, Roche DD, Pegoraro C, Figueiredo AL, Maczkowiak F, Brunet LJ, Milet C, Vert JP, Pollet N, Harland RM, Monsoro-Burq AH.

Dev Biol. 2014 Feb 15;386(2):461-72. doi: 10.1016/j.ydbio.2013.12.010. Epub 2013 Dec 17.


Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner.

Collette NM, Yee CS, Murugesh D, Sebastian A, Taher L, Gale NW, Economides AN, Harland RM, Loots GG.

Dev Biol. 2013 Nov 1;383(1):90-105. doi: 10.1016/j.ydbio.2013.08.015. Epub 2013 Aug 29.


Interrogating transcriptional regulatory sequences in Tol2-mediated Xenopus transgenics.

Loots GG, Bergmann A, Hum NR, Oldenburg CE, Wills AE, Hu N, Ovcharenko I, Harland RM.

PLoS One. 2013 Jul 16;8(7):e68548. doi: 10.1371/journal.pone.0068548. Print 2013.


Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.

Huang X, McGann JC, Liu BY, Hannoush RN, Lill JR, Pham V, Newton K, Kakunda M, Liu J, Yu C, Hymowitz SG, Hongo JA, Wynshaw-Boris A, Polakis P, Harland RM, Dixit VM.

Science. 2013 Mar 22;339(6126):1441-5. doi: 10.1126/science.1232253. Epub 2013 Jan 31.


Targeted gene disruption with engineered zinc-finger nucleases (ZFNs).

Young JJ, Harland RM.

Methods Mol Biol. 2012;917:129-41. doi: 10.1007/978-1-61779-992-1_7.


Targeted deletion of Sost distal enhancer increases bone formation and bone mass.

Collette NM, Genetos DC, Economides AN, Xie L, Shahnazari M, Yao W, Lane NE, Harland RM, Loots GG.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14092-7. doi: 10.1073/pnas.1207188109. Epub 2012 Aug 10.


fus/TLS orchestrates splicing of developmental regulators during gastrulation.

Dichmann DS, Harland RM.

Genes Dev. 2012 Jun 15;26(12):1351-63. doi: 10.1101/gad.187278.112.


Isolation of DNA from red blood cells in Xenopus.

Sive HL, Grainger RM, Harland RM.

Cold Spring Harb Protoc. 2012 Jan 1;2012(1):129-32. doi: 10.1101/pdb.prot067462.


Xenopus research: metamorphosed by genetics and genomics.

Harland RM, Grainger RM.

Trends Genet. 2011 Dec;27(12):507-15. doi: 10.1016/j.tig.2011.08.003. Epub 2011 Oct 1. Review.


Development and initial characterization of a HAPPY panel for mapping the X. tropicalis genome.

Jiang Z, Michal JJ, Beckman KB, Lyons JB, Zhang M, Pan Z, Rokhsar DS, Harland RM.

Int J Biol Sci. 2011;7(7):1037-44. Epub 2011 Aug 24.


Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases.

Young JJ, Cherone JM, Doyon Y, Ankoudinova I, Faraji FM, Lee AH, Ngo C, Guschin DY, Paschon DE, Miller JC, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Harland RM, Zeitler B.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7052-7. doi: 10.1073/pnas.1102030108. Epub 2011 Apr 6.


Cooperative activity of noggin and gremlin 1 in axial skeleton development.

Stafford DA, Brunet LJ, Khokha MK, Economides AN, Harland RM.

Development. 2011 Mar;138(5):1005-14. doi: 10.1242/dev.051938.


A revised model of Xenopus dorsal midline development: differential and separable requirements for Notch and Shh signaling.

Peyrot SM, Wallingford JB, Harland RM.

Dev Biol. 2011 Apr 15;352(2):254-66. doi: 10.1016/j.ydbio.2011.01.021. Epub 2011 Jan 27.


Microinjection of RNA and preparation of secreted proteins from Xenopus oocytes.

Sive HL, Grainger RM, Harland RM.

Cold Spring Harb Protoc. 2010 Dec 1;2010(12):pdb.prot5538. doi: 10.1101/pdb.prot5538.


Calibration of the injection volume for microinjection of Xenopus oocytes and embryos.

Sive HL, Grainger RM, Harland RM.

Cold Spring Harb Protoc. 2010 Dec 1;2010(12):pdb.prot5537. doi: 10.1101/pdb.prot5537.


Microinjection of Xenopus oocytes.

Sive HL, Grainger RM, Harland RM.

Cold Spring Harb Protoc. 2010 Dec 1;2010(12):pdb.prot5536. doi: 10.1101/pdb.prot5536.


Defolliculation of Xenopus oocytes.

Sive HL, Grainger RM, Harland RM.

Cold Spring Harb Protoc. 2010 Dec 1;2010(12):pdb.prot5535. doi: 10.1101/pdb.prot5535.


Isolation of Xenopus oocytes.

Sive HL, Grainger RM, Harland RM.

Cold Spring Harb Protoc. 2010 Dec 1;2010(12):pdb.prot5534. doi: 10.1101/pdb.prot5534.


Microinjection of Xenopus embryos.

Sive HL, Grainger RM, Harland RM.

Cold Spring Harb Protoc. 2010 Dec 1;2010(12):pdb.ip81. doi: 10.1101/pdb.ip81.


Nkx6 genes pattern the frog neural plate and Nkx6.1 is necessary for motoneuron axon projection.

Dichmann DS, Harland RM.

Dev Biol. 2011 Jan 15;349(2):378-86. doi: 10.1016/j.ydbio.2010.10.030. Epub 2010 Oct 28.


Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice.

Sohaskey ML, Jiang Y, Zhao JJ, Mohr A, Roemer F, Harland RM.

J Cell Biol. 2010 May 3;189(3):511-25. doi: 10.1083/jcb.201003006.


The genome of the Western clawed frog Xenopus tropicalis.

Hellsten U, Harland RM, Gilchrist MJ, Hendrix D, Jurka J, Kapitonov V, Ovcharenko I, Putnam NH, Shu S, Taher L, Blitz IL, Blumberg B, Dichmann DS, Dubchak I, Amaya E, Detter JC, Fletcher R, Gerhard DS, Goodstein D, Graves T, Grigoriev IV, Grimwood J, Kawashima T, Lindquist E, Lucas SM, Mead PE, Mitros T, Ogino H, Ohta Y, Poliakov AV, Pollet N, Robert J, Salamov A, Sater AK, Schmutz J, Terry A, Vize PD, Warren WC, Wells D, Wills A, Wilson RK, Zimmerman LB, Zorn AM, Grainger R, Grammer T, Khokha MK, Richardson PM, Rokhsar DS.

Science. 2010 Apr 30;328(5978):633-6. doi: 10.1126/science.1183670.


Genetic evidence that SOST inhibits WNT signaling in the limb.

Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG.

Dev Biol. 2010 Jun 15;342(2):169-79. doi: 10.1016/j.ydbio.2010.03.021. Epub 2010 Mar 30.


Endocytosis is required for efficient apical constriction during Xenopus gastrulation.

Lee JY, Harland RM.

Curr Biol. 2010 Feb 9;20(3):253-8. doi: 10.1016/j.cub.2009.12.021. Epub 2010 Jan 21.


Lymph heart musculature is under distinct developmental control from lymphatic endothelium.

Peyrot SM, Martin BL, Harland RM.

Dev Biol. 2010 Mar 15;339(2):429-38. doi: 10.1016/j.ydbio.2010.01.002. Epub 2010 Jan 11.


BMP antagonists and FGF signaling contribute to different domains of the neural plate in Xenopus.

Wills AE, Choi VM, Bennett MJ, Khokha MK, Harland RM.

Dev Biol. 2010 Jan 15;337(2):335-50. doi: 10.1016/j.ydbio.2009.11.008. Epub 2009 Nov 10.

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