Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 38

1.

Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan.

Hu Z, Xia B, Postnikoff SD, Shen ZJ, Tomoiaga AS, Harkness TA, Seol JH, Li W, Chen K, Tyler JK.

Elife. 2018 Aug 17;7. pii: e35551. doi: 10.7554/eLife.35551.

2.

Activating the Anaphase Promoting Complex to Enhance Genomic Stability and Prolong Lifespan.

Harkness TAA.

Int J Mol Sci. 2018 Jun 27;19(7). pii: E1888. doi: 10.3390/ijms19071888. Review.

3.

Rapid Nuclear Exclusion of Hcm1 in Aging Saccharomyces cerevisiae Leads to Vacuolar Alkalization and Replicative Senescence.

Ghavidel A, Baxi K, Prusinkiewicz M, Swan C, Belak ZR, Eskiw CH, Carvalho CE, Harkness TA.

G3 (Bethesda). 2018 May 4;8(5):1579-1592. doi: 10.1534/g3.118.200161.

4.

Regulation of Lysosomal Function by the DAF-16 Forkhead Transcription Factor Couples Reproduction to Aging in Caenorhabditis elegans.

Baxi K, Ghavidel A, Waddell B, Harkness TA, de Carvalho CE.

Genetics. 2017 Sep;207(1):83-101. doi: 10.1534/genetics.117.204222. Epub 2017 Jul 10.

5.

The ubiquitin-conjugating enzyme, Ubc1, indirectly regulates SNF1 kinase activity via Forkhead-dependent transcription.

Jiao R, Lobanova L, Waldner A, Fu A, Xiao L, Harkness TA, Arnason TG.

Microb Cell. 2016 Nov 4;3(11):540-553. doi: 10.15698/mic2016.11.538.

6.

Novel Dimer Compounds That Bind α-Synuclein Can Rescue Cell Growth in a Yeast Model Overexpressing α-Synuclein. A Possible Prevention Strategy for Parkinson's Disease.

Kakish J, Allen KJ, Harkness TA, Krol ES, Lee JS.

ACS Chem Neurosci. 2016 Dec 21;7(12):1671-1680. doi: 10.1021/acschemneuro.6b00209. Epub 2016 Oct 7.

PMID:
27673434
7.

Mitotic degradation of yeast Fkh1 by the Anaphase Promoting Complex is required for normal longevity, genomic stability and stress resistance.

Malo ME, Postnikoff SD, Arnason TG, Harkness TA.

Aging (Albany NY). 2016 Apr;8(4):810-30. doi: 10.18632/aging.100949.

8.

A Genome Scale Screen for Mutants with Delayed Exit from Mitosis: Ire1-Independent Induction of Autophagy Integrates ER Homeostasis into Mitotic Lifespan.

Ghavidel A, Baxi K, Ignatchenko V, Prusinkiewicz M, Arnason TG, Kislinger T, Carvalho CE, Harkness TA.

PLoS Genet. 2015 Aug 6;11(8):e1005429. doi: 10.1371/journal.pgen.1005429. eCollection 2015 Aug.

9.

Living longer through mitochondrial housekeeping.

Harkness TA.

Cell Cycle. 2015;14(12):1770. doi: 10.1080/15384101.2015.1046792. No abstract available.

10.

The SNF1 Kinase Ubiquitin-associated Domain Restrains Its Activation, Activity, and the Yeast Life Span.

Jiao R, Postnikoff S, Harkness TA, Arnason TG.

J Biol Chem. 2015 Jun 19;290(25):15393-404. doi: 10.1074/jbc.M115.647032. Epub 2015 Apr 13.

11.

Replicative and chronological life-span assays.

Postnikoff SD, Harkness TA.

Methods Mol Biol. 2014;1163:223-7. doi: 10.1007/978-1-4939-0799-1_17.

PMID:
24841311
12.

TFPI1 mediates resistance to doxorubicin in breast cancer cells by inducing a hypoxic-like response.

Davies GF, Berg A, Postnikoff SD, Wilson HL, Arnason TG, Kusalik A, Harkness TA.

PLoS One. 2014 Jan 28;9(1):e84611. doi: 10.1371/journal.pone.0084611. eCollection 2014.

13.

The anaphase promoting complex regulates yeast lifespan and rDNA stability by targeting Fob1 for degradation.

Menzel J, Malo ME, Chan C, Prusinkiewicz M, Arnason TG, Harkness TA.

Genetics. 2014 Mar;196(3):693-709. doi: 10.1534/genetics.113.158949. Epub 2013 Dec 20.

14.

The spatiotemporal dynamics of longevity-defining cellular processes and its modulation by genetic, dietary, and pharmacological anti-aging interventions.

Titorenko VI, Harkness TA.

Front Physiol. 2012 Oct 31;3:419. doi: 10.3389/fphys.2012.00419. eCollection 2012. No abstract available.

15.

Mechanistic insights into aging, cell-cycle progression, and stress response.

Postnikoff SD, Harkness TA.

Front Physiol. 2012 Jun 4;3:183. doi: 10.3389/fphys.2012.00183. eCollection 2012.

16.

The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex.

Postnikoff SD, Malo ME, Wong B, Harkness TA.

PLoS Genet. 2012;8(3):e1002583. doi: 10.1371/journal.pgen.1002583. Epub 2012 Mar 15.

17.

Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells.

Goldberg AA, Beach A, Davies GF, Harkness TA, Leblanc A, Titorenko VI.

Oncotarget. 2011 Oct;2(10):761-82.

18.

Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast.

Islam A, Turner EL, Menzel J, Malo ME, Harkness TA.

Cell Div. 2011 Jun 8;6(1):13. doi: 10.1186/1747-1028-6-13.

19.

A role for the anaphase promoting complex in hormone regulation.

Lindsay DL, Bonham-Smith PC, Postnikoff S, Gray GR, Harkness TA.

Planta. 2011 Jun;233(6):1223-35. doi: 10.1007/s00425-011-1374-3. Epub 2011 Feb 17.

PMID:
21327815
20.

The Saccharomyces cerevisiae anaphase-promoting complex interacts with multiple histone-modifying enzymes to regulate cell cycle progression.

Turner EL, Malo ME, Pisclevich MG, Dash MD, Davies GF, Arnason TG, Harkness TA.

Eukaryot Cell. 2010 Oct;9(10):1418-31. doi: 10.1128/EC.00097-10. Epub 2010 Aug 13.

21.

Longevity as a matter of housekeeping.

Harkness TA.

Aging (Albany NY). 2010 Jul;2(7):392. No abstract available.

22.

Troglitazone reverses the multiple drug resistance phenotype in cancer cells.

Davies GF, Juurlink BH, Harkness TA.

Drug Des Devel Ther. 2009 Sep 21;3:79-88.

23.

Troglitazone inhibits histone deacetylase activity in breast cancer cells.

Davies GF, Ross AR, Arnason TG, Juurlink BH, Harkness TA.

Cancer Lett. 2010 Feb 28;288(2):236-50. doi: 10.1016/j.canlet.2009.07.011. Epub 2009 Aug 20.

PMID:
19699029
24.

Phase 2 protein inducers in the diet promote healthier aging.

Noyan-Ashraf MH, Sadeghinejad Z, Davies GF, Ross AR, Saucier D, Harkness TA, Juurlink BH.

J Gerontol A Biol Sci Med Sci. 2008 Nov;63(11):1168-76.

PMID:
19038831
25.

Involvement of homologous recombination repair after proton-induced DNA damage.

Rostek C, Turner EL, Robbins M, Rightnar S, Xiao W, Obenaus A, Harkness TA.

Mutagenesis. 2008 Mar;23(2):119-29. doi: 10.1093/mutage/gem055. Epub 2008 Feb 10.

PMID:
18267950
26.

Decondensation of Xenopus sperm chromatin using Saccharomyces cerevisiae whole-cell extracts.

Harkness TA.

Can J Physiol Pharmacol. 2006 Mar-Apr;84(3-4):451-8.

PMID:
16902590
27.

Troglitazone overcomes doxorubicin-resistance in resistant K562 leukemia cells.

Davies GF, Roesler WJ, Juurlink BH, Harkness TA.

Leuk Lymphoma. 2005 Aug;46(8):1199-206.

PMID:
16085563
28.

Contribution of CAF-I to anaphase-promoting-complex-mediated mitotic chromatin assembly in Saccharomyces cerevisiae.

Harkness TA, Arnason TG, Legrand C, Pisclevich MG, Davies GF, Turner EL.

Eukaryot Cell. 2005 Apr;4(4):673-84.

29.

Novel interaction between Apc5p and Rsp5p in an intracellular signaling pathway in Saccharomyces cerevisiae.

Arnason TG, Pisclevich MG, Dash MD, Davies GF, Harkness TA.

Eukaryot Cell. 2005 Jan;4(1):134-46.

30.

A functional analysis reveals dependence on the anaphase-promoting complex for prolonged life span in yeast.

Harkness TA, Shea KA, Legrand C, Brahmania M, Davies GF.

Genetics. 2004 Oct;168(2):759-74.

31.
32.
33.

Chromatin assembly in a yeast whole-cell extract.

Schultz MC, Hockman DJ, Harkness TA, Garinther WI, Altheim BA.

Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9034-9.

34.

Disruption of the nuclear gene encoding the 20.8-kDa subunit of NADH: ubiquinone reductase of Neurospora mitochondria.

da Silva MV, Alves PC, Duarte M, Mota N, Lobo-da-Cunha A, Harkness TA, Nargang FE, Videira A.

Mol Gen Genet. 1996 Aug 27;252(1-2):177-83.

PMID:
8804391
36.

Disruption of the gene encoding the 78-kilodalton subunit of the peripheral arm of complex I in Neurospora crassa by repeat induced point mutation (RIP).

Harkness TA, Rothery RA, Weiner JH, Werner S, Azevedo JE, Videira A, Nargang FE.

Curr Genet. 1995 Mar;27(4):339-50.

PMID:
7614557
37.

A crucial role of the mitochondrial protein import receptor MOM19 for the biogenesis of mitochondria.

Harkness TA, Nargang FE, van der Klei I, Neupert W, Lill R.

J Cell Biol. 1994 Mar;124(5):637-48.

38.

Inactivation of the Neurospora crassa gene encoding the mitochondrial protein import receptor MOM19 by the technique of "sheltered RIP".

Harkness TA, Metzenberg RL, Schneider H, Lill R, Neupert W, Nargang FE.

Genetics. 1994 Jan;136(1):107-18.

Supplemental Content

Loading ...
Support Center