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Items: 46

1.

Breast cancer in neurofibromatosis 1: survival and risk of contralateral breast cancer in a five country cohort study.

Evans DGR, Kallionpää RA, Clementi M, Trevisson E, Mautner VF, Howell SJ, Lewis L, Zehou O, Peltonen S, Brunello A, Harkness EF, Wolkenstein P, Peltonen J.

Genet Med. 2019 Sep 9. doi: 10.1038/s41436-019-0651-6. [Epub ahead of print]

PMID:
31495828
2.

Incidence of mosaicism in 1055 de novo NF2 cases: much higher than previous estimates with high utility of next-generation sequencing.

Evans DG, Hartley CL, Smith PT, King AT, Bowers NL, Tobi S, Wallace AJ, Perry M, Anup R, Lloyd SKW, Rutherford SA, Hammerbeck-Ward C, Pathmanaban ON, Stapleton E, Freeman SR, Kellett M, Halliday D, Parry A, Gair JJ, Axon P, Laitt R, Thomas O, Afridi SK, Obholzer R; English Specialist NF research group, Duff C, Stivaros SM, Vassallo G, Harkness EF, Smith MJ.

Genet Med. 2019 Jul 5. doi: 10.1038/s41436-019-0598-7. [Epub ahead of print]

PMID:
31273341
3.

A case-control evaluation of 143 single nucleotide polymorphisms for breast cancer risk stratification with classical factors and mammographic density.

Brentnall AR, van Veen EM, Harkness EF, Rafiq S, Byers H, Astley SM, Sampson S, Howell A, Newman WG, Cuzick J, Evans DGR.

Int J Cancer. 2019 Jun 28. doi: 10.1002/ijc.32541. [Epub ahead of print]

PMID:
31251818
4.

Breast cancer pathology and stage are better predicted by risk stratification models that include mammographic density and common genetic variants.

Evans DGR, Harkness EF, Brentnall AR, van Veen EM, Astley SM, Byers H, Sampson S, Southworth J, Stavrinos P, Howell SJ, Maxwell AJ, Howell A, Newman WG, Cuzick J.

Breast Cancer Res Treat. 2019 Jul;176(1):141-148. doi: 10.1007/s10549-019-05210-2. Epub 2019 Apr 2.

5.

Genome-wide association study of germline variants and breast cancer-specific mortality.

Escala-Garcia M, Guo Q, Dörk T, Canisius S, Keeman R, Dennis J, Beesley J, Lecarpentier J, Bolla MK, Wang Q, Abraham J, Andrulis IL, Anton-Culver H, Arndt V, Auer PL, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bernstein L, Blomqvist C, Boeckx B, Bojesen SE, Bonanni B, Børresen-Dale AL, Brauch H, Brenner H, Brentnall A, Brinton L, Broberg P, Brock IW, Brucker SY, Burwinkel B, Caldas C, Caldés T, Campa D, Canzian F, Carracedo A, Carter BD, Castelao JE, Chang-Claude J, Chanock SJ, Chenevix-Trench G, Cheng TD, Chin SF, Clarke CL; NBCS Collaborators, Cordina-Duverger E, Couch FJ, Cox DG, Cox A, Cross SS, Czene K, Daly MB, Devilee P, Dunn JA, Dunning AM, Durcan L, Dwek M, Earl HM, Ekici AB, Eliassen AH, Ellberg C, Engel C, Eriksson M, Evans DG, Figueroa J, Flesch-Janys D, Flyger H, Gabrielson M, Gago-Dominguez M, Galle E, Gapstur SM, García-Closas M, García-Sáenz JA, Gaudet MM, George A, Georgoulias V, Giles GG, Glendon G, Goldgar DE, González-Neira A, Alnæs GIG, Grip M, Guénel P, Haeberle L, Hahnen E, Haiman CA, Håkansson N, Hall P, Hamann U, Hankinson S, Harkness EF, Harrington PA, Hart SN, Hartikainen JM, Hein A, Hillemanns P, Hiller L, Holleczek B, Hollestelle A, Hooning MJ, Hoover RN, Hopper JL, Howell A, Huang G, Humphreys K, Hunter DJ, Janni W, John EM, Jones ME, Jukkola-Vuorinen A, Jung A, Kaaks R, Kabisch M, Kaczmarek K, Kerin MJ, Khan S, Khusnutdinova E, Kiiski JI, Kitahara CM, Knight JA, Ko YD, Koppert LB, Kosma VM, Kraft P, Kristensen VN, Krüger U, Kühl T, Lambrechts D, Le Marchand L, Lee E, Lejbkowicz F, Li L, Lindblom A, Lindström S, Linet M, Lissowska J, Lo WY, Loibl S, Lubiński J, Lux MP, MacInnis RJ, Maierthaler M, Maishman T, Makalic E, Mannermaa A, Manoochehri M, Manoukian S, Margolin S, Martinez ME, Mavroudis D, McLean C, Meindl A, Middha P, Miller N, Milne RL, Moreno F, Mulligan AM, Mulot C, Nassir R, Neuhausen SL, Newman WT, Nielsen SF, Nordestgaard BG, Norman A, Olsson H, Orr N, Pankratz VS, Park-Simon TW, Perez JIA, Pérez-Barrios C, Peterlongo P, Petridis C, Pinchev M, Prajzendanc K, Prentice R, Presneau N, Prokofieva D, Pylkäs K, Rack B, Radice P, Ramachandran D, Rennert G, Rennert HS, Rhenius V, Romero A, Roylance R, Saloustros E, Sawyer EJ, Schmidt DF, Schmutzler RK, Schneeweiss A, Schoemaker MJ, Schumacher F, Schwentner L, Scott RJ, Scott C, Seynaeve C, Shah M, Simard J, Smeets A, Sohn C, Southey MC, Swerdlow AJ, Talhouk A, Tamimi RM, Tapper WJ, Teixeira MR, Tengström M, Terry MB, Thöne K, Tollenaar RAEM, Tomlinson I, Torres D, Truong T, Turman C, Turnbull C, Ulmer HU, Untch M, Vachon C, van Asperen CJ, van den Ouweland AMW, van Veen EM, Wendt C, Whittemore AS, Willett W, Winqvist R, Wolk A, Yang XR, Zhang Y, Easton DF, Fasching PA, Nevanlinna H, Eccles DM, Pharoah PDP, Schmidt MK.

Br J Cancer. 2019 Mar;120(6):647-657. doi: 10.1038/s41416-019-0393-x. Epub 2019 Feb 21.

6.

Prediction of reader estimates of mammographic density using convolutional neural networks.

Ionescu GV, Fergie M, Berks M, Harkness EF, Hulleman J, Brentnall AR, Cuzick J, Evans DG, Astley SM.

J Med Imaging (Bellingham). 2019 Jul;6(3):031405. doi: 10.1117/1.JMI.6.3.031405. Epub 2019 Jan 31.

PMID:
30746393
7.

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.

Mavaddat N, Michailidou K, Dennis J, Lush M, Fachal L, Lee A, Tyrer JP, Chen TH, Wang Q, Bolla MK, Yang X, Adank MA, Ahearn T, Aittomäki K, Allen J, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Auer PL, Auvinen P, Barrdahl M, Beane Freeman LE, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bernstein L, Blomqvist C, Bogdanova NV, Bojesen SE, Bonanni B, Børresen-Dale AL, Brauch H, Bremer M, Brenner H, Brentnall A, Brock IW, Brooks-Wilson A, Brucker SY, Brüning T, Burwinkel B, Campa D, Carter BD, Castelao JE, Chanock SJ, Chlebowski R, Christiansen H, Clarke CL, Collée JM, Cordina-Duverger E, Cornelissen S, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Devilee P, Dörk T, Dos-Santos-Silva I, Dumont M, Durcan L, Dwek M, Eccles DM, Ekici AB, Eliassen AH, Ellberg C, Engel C, Eriksson M, Evans DG, Fasching PA, Figueroa J, Fletcher O, Flyger H, Försti A, Fritschi L, Gabrielson M, Gago-Dominguez M, Gapstur SM, García-Sáenz JA, Gaudet MM, Georgoulias V, Giles GG, Gilyazova IR, Glendon G, Goldberg MS, Goldgar DE, González-Neira A, Grenaker Alnæs GI, Grip M, Gronwald J, Grundy A, Guénel P, Haeberle L, Hahnen E, Haiman CA, Håkansson N, Hamann U, Hankinson SE, Harkness EF, Hart SN, He W, Hein A, Heyworth J, Hillemanns P, Hollestelle A, Hooning MJ, Hoover RN, Hopper JL, Howell A, Huang G, Humphreys K, Hunter DJ, Jakimovska M, Jakubowska A, Janni W, John EM, Johnson N, Jones ME, Jukkola-Vuorinen A, Jung A, Kaaks R, Kaczmarek K, Kataja V, Keeman R, Kerin MJ, Khusnutdinova E, Kiiski JI, Knight JA, Ko YD, Kosma VM, Koutros S, Kristensen VN, Krüger U, Kühl T, Lambrechts D, Le Marchand L, Lee E, Lejbkowicz F, Lilyquist J, Lindblom A, Lindström S, Lissowska J, Lo WY, Loibl S, Long J, Lubiński J, Lux MP, MacInnis RJ, Maishman T, Makalic E, Maleva Kostovska I, Mannermaa A, Manoukian S, Margolin S, Martens JWM, Martinez ME, Mavroudis D, McLean C, Meindl A, Menon U, Middha P, Miller N, Moreno F, Mulligan AM, Mulot C, Muñoz-Garzon VM, Neuhausen SL, Nevanlinna H, Neven P, Newman WG, Nielsen SF, Nordestgaard BG, Norman A, Offit K, Olson JE, Olsson H, Orr N, Pankratz VS, Park-Simon TW, Perez JIA, Pérez-Barrios C, Peterlongo P, Peto J, Pinchev M, Plaseska-Karanfilska D, Polley EC, Prentice R, Presneau N, Prokofyeva D, Purrington K, Pylkäs K, Rack B, Radice P, Rau-Murthy R, Rennert G, Rennert HS, Rhenius V, Robson M, Romero A, Ruddy KJ, Ruebner M, Saloustros E, Sandler DP, Sawyer EJ, Schmidt DF, Schmutzler RK, Schneeweiss A, Schoemaker MJ, Schumacher F, Schürmann P, Schwentner L, Scott C, Scott RJ, Seynaeve C, Shah M, Sherman ME, Shrubsole MJ, Shu XO, Slager S, Smeets A, Sohn C, Soucy P, Southey MC, Spinelli JJ, Stegmaier C, Stone J, Swerdlow AJ, Tamimi RM, Tapper WJ, Taylor JA, Terry MB, Thöne K, Tollenaar RAEM, Tomlinson I, Truong T, Tzardi M, Ulmer HU, Untch M, Vachon CM, van Veen EM, Vijai J, Weinberg CR, Wendt C, Whittemore AS, Wildiers H, Willett W, Winqvist R, Wolk A, Yang XR, Yannoukakos D, Zhang Y, Zheng W, Ziogas A; ABCTB Investigators; kConFab/AOCS Investigators; NBCS Collaborators, Dunning AM, Thompson DJ, Chenevix-Trench G, Chang-Claude J, Schmidt MK, Hall P, Milne RL, Pharoah PDP, Antoniou AC, Chatterjee N, Kraft P, García-Closas M, Simard J, Easton DF.

Am J Hum Genet. 2019 Jan 3;104(1):21-34. doi: 10.1016/j.ajhg.2018.11.002. Epub 2018 Dec 13.

8.

Identifying the deficiencies of current diagnostic criteria for neurofibromatosis 2 using databases of 2777 individuals with molecular testing.

Evans DG, King AT, Bowers NL, Tobi S, Wallace AJ, Perry M, Anup R, Lloyd SKL, Rutherford SA, Hammerbeck-Ward C, Pathmanaban ON, Stapleton E, Freeman SR, Kellett M, Halliday D, Parry A, Gair JJ, Axon P, Laitt R, Thomas O, Afridi S, Ferner RE, Harkness EF, Smith MJ; English Specialist NF2 Research Group.

Genet Med. 2019 Jul;21(7):1525-1533. doi: 10.1038/s41436-018-0384-y. Epub 2018 Dec 7.

PMID:
30523344
9.

Schwannomatosis: a genetic and epidemiological study.

Evans DG, Bowers NL, Tobi S, Hartley C, Wallace AJ, King AT, Lloyd SKW, Rutherford SA, Hammerbeck-Ward C, Pathmanaban ON, Freeman SR, Ealing J, Kellett M, Laitt R, Thomas O, Halliday D, Ferner R, Taylor A, Duff C, Harkness EF, Smith MJ.

J Neurol Neurosurg Psychiatry. 2018 Nov;89(11):1215-1219. doi: 10.1136/jnnp-2018-318538. Epub 2018 Jun 16.

PMID:
29909380
10.

Exploring the prediction performance for breast cancer risk based on volumetric mammographic density at different thresholds.

Wang C, Brentnall AR, Cuzick J, Harkness EF, Evans DG, Astley S.

Breast Cancer Res. 2018 Jun 8;20(1):49. doi: 10.1186/s13058-018-0979-x.

11.

Penetrance estimates for BRCA1, BRCA2 (also applied to Lynch syndrome) based on presymptomatic testing: a new unbiased method to assess risk?

Evans DG, Woodward E, Harkness EF, Howell A, Plaskocinska I, Maher ER, Tischkowitz MD, Lalloo F.

J Med Genet. 2018 Jul;55(7):442-448. doi: 10.1136/jmedgenet-2017-105223. Epub 2018 Feb 26.

PMID:
29483236
12.

A comparison of five methods of measuring mammographic density: a case-control study.

Astley SM, Harkness EF, Sergeant JC, Warwick J, Stavrinos P, Warren R, Wilson M, Beetles U, Gadde S, Lim Y, Jain A, Bundred S, Barr N, Reece V, Brentnall AR, Cuzick J, Howell T, Evans DG.

Breast Cancer Res. 2018 Feb 5;20(1):10. doi: 10.1186/s13058-018-0932-z.

13.

Breast cancer risk in a screening cohort of Asian and white British/Irish women from Manchester UK.

Evans DG, Brentnall AR, Harvie M, Astley S, Harkness EF, Stavrinos P, Donnelly LS, Sampson S, Idries F, Watterson D, Cuzick J, Wilson M, Jain A, Harrison F, Maxwell AJ, Howell A.

BMC Public Health. 2018 Jan 25;18(1):178. doi: 10.1186/s12889-018-5090-9.

14.

Use of Single-Nucleotide Polymorphisms and Mammographic Density Plus Classic Risk Factors for Breast Cancer Risk Prediction.

van Veen EM, Brentnall AR, Byers H, Harkness EF, Astley SM, Sampson S, Howell A, Newman WG, Cuzick J, Evans DGR.

JAMA Oncol. 2018 Apr 1;4(4):476-482. doi: 10.1001/jamaoncol.2017.4881.

15.

Young age at first pregnancy does protect against early onset breast cancer in BRCA1 and BRCA2 mutation carriers.

Evans DG, Harkness EF, Howel S, Woodward ER, Howell A, Lalloo F.

Breast Cancer Res Treat. 2018 Feb;167(3):779-785. doi: 10.1007/s10549-017-4557-1. Epub 2017 Nov 7.

16.

A novel and fully automated mammographic texture analysis for risk prediction: results from two case-control studies.

Wang C, Brentnall AR, Cuzick J, Harkness EF, Evans DG, Astley S.

Breast Cancer Res. 2017 Oct 18;19(1):114. doi: 10.1186/s13058-017-0906-6.

17.

Pathology update to the Manchester Scoring System based on testing in over 4000 families.

Evans DG, Harkness EF, Plaskocinska I, Wallace AJ, Clancy T, Woodward ER, Howell TA, Tischkowitz M, Lalloo F.

J Med Genet. 2017 Oct;54(10):674-681. doi: 10.1136/jmedgenet-2017-104584. Epub 2017 May 10.

PMID:
28490612
18.

Evaluation of Kinect 3D Sensor for Healthcare Imaging.

Pöhlmann ST, Harkness EF, Taylor CJ, Astley SM.

J Med Biol Eng. 2016;36(6):857-870. doi: 10.1007/s40846-016-0184-2. Epub 2016 Dec 9.

19.

Intensive breast screening in BRCA2 mutation carriers is associated with reduced breast cancer specific and all cause mortality.

Evans DG, Harkness EF, Howell A, Wilson M, Hurley E, Holmen MM, Tharmaratnam KU, Hagen AI, Lim Y, Maxwell AJ, Moller P.

Hered Cancer Clin Pract. 2016 Apr 14;14:8. doi: 10.1186/s13053-016-0048-3. eCollection 2016.

20.

Breast cancer risk feedback to women in the UK NHS breast screening population.

Evans DG, Donnelly LS, Harkness EF, Astley SM, Stavrinos P, Dawe S, Watterson D, Fox L, Sergeant JC, Ingham S, Harvie MN, Wilson M, Beetles U, Buchan I, Brentnall AR, French DP, Cuzick J, Howell A.

Br J Cancer. 2016 Apr 26;114(9):1045-52. doi: 10.1038/bjc.2016.56. Epub 2016 Mar 29.

21.

Mammographic density adds accuracy to both the Tyrer-Cuzick and Gail breast cancer risk models in a prospective UK screening cohort.

Brentnall AR, Harkness EF, Astley SM, Donnelly LS, Stavrinos P, Sampson S, Fox L, Sergeant JC, Harvie MN, Wilson M, Beetles U, Gadde S, Lim Y, Jain A, Bundred S, Barr N, Reece V, Howell A, Cuzick J, Evans DG.

Breast Cancer Res. 2015 Dec 1;17(1):147. doi: 10.1186/s13058-015-0653-5.

22.

The Contribution of Whole Gene Deletions and Large Rearrangements to the Mutation Spectrum in Inherited Tumor Predisposing Syndromes.

Smith MJ, Urquhart JE, Harkness EF, Miles EK, Bowers NL, Byers HJ, Bulman M, Gokhale C, Wallace AJ, Newman WG, Evans DG.

Hum Mutat. 2016 Mar;37(3):250-6. doi: 10.1002/humu.22938. Epub 2016 Jan 11.

PMID:
26615784
23.

Lynch syndrome caused by MLH1 mutations is associated with an increased risk of breast cancer: a cohort study.

Harkness EF, Barrow E, Newton K, Green K, Clancy T, Lalloo F, Hill J, Evans DG.

J Med Genet. 2015 Aug;52(8):553-6. doi: 10.1136/jmedgenet-2015-103216. Epub 2015 Jun 22.

PMID:
26101330
24.

The BRCA2 polymorphic stop codon: stuff or nonsense?

Higgs JE, Harkness EF, Bowers NL, Howard E, Wallace AJ, Lalloo F, Newman WG, Evans DG.

J Med Genet. 2015 Sep;52(9):642-5. doi: 10.1136/jmedgenet-2015-103206. Epub 2015 Jun 3.

PMID:
26041759
25.

Using read codes to identify patients with irritable bowel syndrome in general practice: a database study.

Harkness EF, Grant L, O'Brien SJ, Chew-Graham CA, Thompson DG.

BMC Fam Pract. 2013 Dec 2;14:183. doi: 10.1186/1471-2296-14-183.

26.

GP perspectives of irritable bowel syndrome--an accepted illness, but management deviates from guidelines: a qualitative study.

Harkness EF, Harrington V, Hinder S, O'Brien SJ, Thompson DG, Beech P, Chew-Graham CA.

BMC Fam Pract. 2013 Jun 27;14:92. doi: 10.1186/1471-2296-14-92.

27.

On-site mental health workers delivering psychological therapy and psychosocial interventions to patients in primary care: effects on the professional practice of primary care providers.

Harkness EF, Bower PJ.

Cochrane Database Syst Rev. 2009 Jan 21;(1):CD000532. doi: 10.1002/14651858.CD000532.pub2. Review.

PMID:
19160181
28.

Predicting the onset of knee pain: results from a 2-year prospective study of new workers.

Jones GT, Harkness EF, Nahit ES, McBeth J, Silman AJ, Macfarlane GJ.

Ann Rheum Dis. 2007 Mar;66(3):400-6. Epub 2006 Aug 25.

29.

Is musculoskeletal pain more common now than 40 years ago?: Two population-based cross-sectional studies.

Harkness EF, Macfarlane GJ, Silman AJ, McBeth J.

Rheumatology (Oxford). 2005 Jul;44(7):890-5. Epub 2005 Mar 22.

PMID:
15784630
30.
31.

Mechanical and psychosocial factors predict new onset shoulder pain: a prospective cohort study of newly employed workers.

Harkness EF, Macfarlane GJ, Nahit ES, Silman AJ, McBeth J.

Occup Environ Med. 2003 Nov;60(11):850-7.

32.

The role of workplace low-level mechanical trauma, posture and environment in the onset of chronic widespread pain.

McBeth J, Harkness EF, Silman AJ, Macfarlane GJ.

Rheumatology (Oxford). 2003 Dec;42(12):1486-94. Epub 2003 Jul 16.

PMID:
12867586
33.

Risk factors for new-onset low back pain amongst cohorts of newly employed workers.

Harkness EF, Macfarlane GJ, Nahit ES, Silman AJ, McBeth J.

Rheumatology (Oxford). 2003 Aug;42(8):959-68. Epub 2003 Apr 16.

PMID:
12730508
34.

Generalised estimating equations and low back pain.

Harkness EF, Nahit ES, Macfarlane GJ, Silman AJ, McBeth J, Dunn G.

Occup Environ Med. 2003 May;60(5):378-80; author reply 380-1. No abstract available.

35.

Changing trends in incidence of lung cancer by histologic type in Scotland.

Harkness EF, Brewster DH, Kerr KM, Fergusson RJ, MacFarlane GJ.

Int J Cancer. 2002 Nov 10;102(2):179-83.

36.

Spiritual healing as a therapy for chronic pain: a randomized, clinical trial.

Abbot NC, Harkness EF, Stevinson C, Marshall FP, Conn DA, Ernst E.

Pain. 2001 Mar;91(1-2):79-89.

PMID:
11240080
37.

Location bias in controlled clinical trials of complementary/alternative therapies.

Pittler MH, Abbot NC, Harkness EF, Ernst E.

J Clin Epidemiol. 2000 May;53(5):485-9.

PMID:
10812320
38.

A randomized trial of distant healing for skin warts.

Harkness EF, Abbot NC, Ernst E.

Am J Med. 2000 Apr 15;108(6):448-52.

PMID:
10781776
39.

A pilot study to evaluate the effects of floatation spa treatment on patients with osteoarthritis.

Hill S, Eckett MJ, Paterson C, Harkness EF.

Complement Ther Med. 1999 Dec;7(4):235-8.

PMID:
10709308
40.

Articles on complementary medicine in the mainstream medical literature: an investigation of MEDLINE, 1966 through 1996.

Barnes J, Abbot NC, Harkness EF, Ernst E.

Arch Intern Med. 1999 Aug 9-23;159(15):1721-5.

PMID:
10448774
41.

Randomized, double-blind trial of chitosan for body weight reduction.

Pittler MH, Abbot NC, Harkness EF, Ernst E.

Eur J Clin Nutr. 1999 May;53(5):379-81.

PMID:
10369493
42.

Incidence of childhood leukaemia and non-Hodgkin's lymphoma in the vicinity of nuclear sites in Scotland, 1968-93.

Sharp L, Black RJ, Harkness EF, McKinney PA.

Occup Environ Med. 1996 Dec;53(12):823-31.

43.
44.

Registration quality and descriptive epidemiology of childhood brain tumours in Scotland 1975-90.

McKinney PA, Ironside JW, Harkness EF, Arango JC, Doyle D, Black RJ.

Br J Cancer. 1994 Nov;70(5):973-9.

45.
46.

Cancer incidence in a population potentially exposed to radium-226 at Dalgety Bay, Scotland.

Black RJ, Sharp L, Finlayson AR, Harkness EF.

Br J Cancer. 1994 Jan;69(1):140-3.

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