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Items: 49

1.

Enhanced protein production using HBV X protein (HBx), and synergy when used in combination with XBP1s in BHK21 cells.

Jin F, Kretschmer PJ, Harkins RN, Hermiston TW.

Biotechnol Bioeng. 2010 Feb 1;105(2):341-9. doi: 10.1002/bit.22536.

PMID:
19739082
2.

Development and validation of an improved inducer-regulator protein complex in the pBRES-regulated expression system.

Levitsky K, Szymanski P, Jin F, Meurer-Ogden JA, Harkins RN.

Hum Gene Ther. 2008 Nov;19(11):1273-82. doi: 10.1089/hum.2008.082.

PMID:
19000019
3.

Directed evolution generates a novel oncolytic virus for the treatment of colon cancer.

Kuhn I, Harden P, Bauzon M, Chartier C, Nye J, Thorne S, Reid T, Ni S, Lieber A, Fisher K, Seymour L, Rubanyi GM, Harkins RN, Hermiston TW.

PLoS One. 2008 Jun 18;3(6):e2409. doi: 10.1371/journal.pone.0002409.

4.

Characterization of virus-like particle assembly for DNA delivery using asymmetrical flow field-flow fractionation and light scattering.

Citkowicz A, Petry H, Harkins RN, Ast O, Cashion L, Goldmann C, Bringmann P, Plummer K, Larsen BR.

Anal Biochem. 2008 May 15;376(2):163-72. doi: 10.1016/j.ab.2008.02.011. Epub 2008 Feb 19.

PMID:
18342613
5.

Effect of viral dose on neutralizing antibody response and transgene expression after AAV1 vector re-administration in mice.

Petry H, Brooks A, Orme A, Wang P, Liu P, Xie J, Kretschmer P, Qian HS, Hermiston TW, Harkins RN.

Gene Ther. 2008 Jan;15(1):54-60. Epub 2007 Oct 25.

PMID:
17960164
6.

Regulated expression of the interferon-beta gene in mice.

Harkins RN, Szymanski P, Petry H, Brooks A, Qian HS, Schaefer C, Kretschmer PJ, Orme A, Wang P, Rubanyi GM, Hermiston TW.

Gene Ther. 2008 Jan;15(1):1-11. Epub 2007 Jul 19.

PMID:
17637794
7.

Development and validation of a robust and versatile one-plasmid regulated gene expression system.

Szymanski P, Kretschmer PJ, Bauzon M, Jin F, Qian HS, Rubanyi GM, Harkins RN, Hermiston TW.

Mol Ther. 2007 Jul;15(7):1340-7. Epub 2007 May 1.

8.

Mx1 and IP-10: biomarkers to measure IFN-beta activity in mice following gene-based delivery.

Petry H, Cashion L, Szymanski P, Ast O, Orme A, Gross C, Bauzon M, Brooks A, Schaefer C, Gibson H, Qian H, Rubanyi GM, Harkins RN.

J Interferon Cytokine Res. 2006 Oct;26(10):699-705.

PMID:
17032164
9.

Gene-based delivery of IFN-beta is efficacious in a murine model of experimental allergic encephalomyelitis.

Schaefer C, Hidalgo TR, Cashion L, Petry H, Brooks A, Szymanski P, Qian HS, Gross C, Wang P, Liu P, Goldman C, Rubanyi GM, Harkins RN.

J Interferon Cytokine Res. 2006 Jul;26(7):449-54.

PMID:
16800783
10.

Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle.

Brooks AR, Harkins RN, Wang P, Qian HS, Liu P, Rubanyi GM.

J Gene Med. 2004 Apr;6(4):395-404.

PMID:
15079814
11.

Homologue scanning mutagenesis of heregulin reveals receptor specific binding epitopes.

Harris A, Adler M, Brink J, Lin R, Foehr M, Ferrer M, Langton-Webster BC, Harkins RN, Thompson SA.

Biochem Biophys Res Commun. 1998 Oct 9;251(1):220-4.

PMID:
9790934
12.
13.

Reconstitution of a high affinity binding site for type I interferons.

Russell-Harde D, Pu H, Betts M, Harkins RN, Perez HD, Croze E.

J Biol Chem. 1995 Nov 3;270(44):26033-6.

14.

Heregulin activation of extracellular acidification in mammary carcinoma cells is associated with expression of HER2 and HER3.

Chan SD, Antoniucci DM, Fok KS, Alajoki ML, Harkins RN, Thompson SA, Wada HG.

J Biol Chem. 1995 Sep 22;270(38):22608-13.

15.

Homology model of human interferon-alpha 8 and its receptor complex.

Seto MH, Harkins RN, Adler M, Whitlow M, Church WB, Croze E.

Protein Sci. 1995 Apr;4(4):655-70.

16.

Interaction of transforming growth factor alpha with the epidermal growth factor receptor: binding kinetics and differential mobility within the bound TGF-alpha.

Hoyt DW, Harkins RN, Debanne MT, O'Connor-McCourt M, Sykes BD.

Biochemistry. 1994 Dec 27;33(51):15283-92.

PMID:
7803391
17.

Differential expression of two genes for 1-aminocyclopropane-1-carboxylate synthase in tomato fruits.

Olson DC, White JA, Edelman L, Harkins RN, Kende H.

Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5340-4.

18.

TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas.

Jhappan C, Stahle C, Harkins RN, Fausto N, Smith GH, Merlino GT.

Cell. 1990 Jun 15;61(6):1137-46.

PMID:
2350785
19.

The estrogen-responsive 110K and 74K rat uterine secretory proteins are structurally related to complement component C3.

Kuivanen PC, Capulong RB, Harkins RN, DeSombre ER.

Biochem Biophys Res Commun. 1989 Feb 15;158(3):898-905.

PMID:
2645873
20.

Purification of multiplication-stimulating activity carrier protein.

Smith GL, Lyons RM, Harkins RN, Knauer DJ.

Methods Enzymol. 1987;146:270-7. No abstract available.

PMID:
2446106
21.

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors.

Yarden Y, Escobedo JA, Kuang WJ, Yang-Feng TL, Daniel TO, Tremble PM, Chen EY, Ando ME, Harkins RN, Francke U, et al.

Nature. 1986 Sep 18-24;323(6085):226-32.

PMID:
3020426
22.

The avian beta-adrenergic receptor: primary structure and membrane topology.

Yarden Y, Rodriguez H, Wong SK, Brandt DR, May DC, Burnier J, Harkins RN, Chen EY, Ramachandran J, Ullrich A, et al.

Proc Natl Acad Sci U S A. 1986 Sep;83(18):6795-9.

23.

Topology of signal recognition particle receptor in endoplasmic reticulum membrane.

Lauffer L, Garcia PD, Harkins RN, Coussens L, Ullrich A, Walter P.

Nature. 1985 Nov 28-Dec 4;318(6044):334-8.

PMID:
2999608
24.

Primary structure of human lymphotoxin derived from 1788 lymphoblastoid cell line.

Aggarwal BB, Henzel WJ, Moffat B, Kohr WJ, Harkins RN.

J Biol Chem. 1985 Feb 25;260(4):2334-44.

25.

Human tumor necrosis factor. Production, purification, and characterization.

Aggarwal BB, Kohr WJ, Hass PE, Moffat B, Spencer SA, Henzel WJ, Bringman TS, Nedwin GE, Goeddel DV, Harkins RN.

J Biol Chem. 1985 Feb 25;260(4):2345-54.

26.

Structure of human factor VIII.

Vehar GA, Keyt B, Eaton D, Rodriguez H, O'Brien DP, Rotblat F, Oppermann H, Keck R, Wood WI, Harkins RN, Tuddenham EG, Lawn RM, Capon DJ.

Nature. 1984 Nov 22-28;312(5992):337-42.

PMID:
6438527
27.

Design and operation of a completely automated Beckman microsequencer.

Rodriguez H, Kohr WJ, Harkins RN.

Anal Biochem. 1984 Aug 1;140(2):538-47.

PMID:
6486438
28.

Cloning, nucleotide sequence, and expression in Escherichia coli of the exotoxin A structural gene of Pseudomonas aeruginosa.

Gray GL, Smith DH, Baldridge JS, Harkins RN, Vasil ML, Chen EY, Heyneker HL.

Proc Natl Acad Sci U S A. 1984 May;81(9):2645-9.

29.

Effects of bacteria-produced human alpha, beta, and gamma interferons on in vitro immune functions.

Shalaby MR, Weck PK, Rinderknecht E, Harkins RN, Frane JW, Ross MJ.

Cell Immunol. 1984 Apr 1;84(2):380-92.

PMID:
6231112
30.

Biological and antigenic similarities of murine interferon-gamma and macrophage-activating factor.

Svedersky LP, Benton CV, Berger WH, Rinderknecht E, Harkins RN, Palladino MA.

J Exp Med. 1984 Mar 1;159(3):812-27.

31.

Human lymphotoxin. Production by a lymphoblastoid cell line, purification, and initial characterization.

Aggarwal BB, Moffat B, Harkins RN.

J Biol Chem. 1984 Jan 10;259(1):686-91.

32.

A comparison of the structure and activity of cat and trout muscle pyruvate kinases.

Harkins RN, Nocton JC, Russell MP, Fothergill LA, Muirhead H.

Eur J Biochem. 1983 Nov 2;136(2):341-6.

33.
34.

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli.

Pennica D, Holmes WE, Kohr WJ, Harkins RN, Vehar GA, Ward CA, Bennett WF, Yelverton E, Seeburg PH, Heyneker HL, Goeddel DV, Collen D.

Nature. 1983 Jan 20;301(5897):214-21. No abstract available.

PMID:
6337343
35.

Purification of peptides that contain methionine residues.

Kyte J, Degen J, Harkins RN.

Methods Enzymol. 1983;91:367-77. No abstract available.

PMID:
6304453
36.

Characterization of intact and trypsin-digested biosynthetic human growth hormone by high-pressure liquid chromatography.

Kohr WJ, Keck R, Harkins RN.

Anal Biochem. 1982 May 15;122(2):348-59. No abstract available.

PMID:
7051893
37.

The amino acid sequence of yeast phosphoglycerate mutase.

Fothergill LA, Harkins RN.

Proc R Soc Lond B Biol Sci. 1982 Apr 22;215(1198):19-44.

PMID:
6127696
38.

Purified human growth hormone from E. coli is biologically active.

Olson KC, Fenno J, Lin N, Harkins RN, Snider C, Kohr WH, Ross MJ, Fodge D, Prender G, Stebbing N.

Nature. 1981 Oct 1;293(5831):408-11. No abstract available.

PMID:
7024824
39.

Structure and activity of phosphoglycerate mutase.

Winn SI, Watson HC, Harkins RN, Fothergill LA.

Philos Trans R Soc Lond B Biol Sci. 1981 Jun 26;293(1063):121-30. Review.

PMID:
6115412
40.

Trinitrobenzenesulphonic acid as a tool for isolating the reactive-lysine-containing peptide of pyruvate kinase [proceedings].

Russell MP, Harkins RN, Fothergill LA.

Biochem Soc Trans. 1979 Aug;7(4):714-5. No abstract available.

PMID:
478144
41.

M2 isozyme of pyruvate kinase from human kidney as the product of a separate gene: its purification and characterization.

Harkins RN, Black JA, Rittenberg MB.

Biochemistry. 1977 Aug 23;16(17):3831-7. No abstract available.

PMID:
409426
42.

Amino acid compositions and evolutionary relationships with protein families.

Black JA, Harkins RN.

J Theor Biol. 1977 May 21;66(2):281-95. No abstract available.

PMID:
196140
43.

Purification and characterization of human muscle pyruvate kinase.

Harkins RN, Black JA, Rittenberg MB.

Can J Biochem. 1977 Apr;55(4):301-7.

PMID:
404004
44.

Cat muscle pyruvate kinase: isolation of a reactive thiol-group-containing peptide [proceedings].

Harkins RN, Fothergill LA.

Biochem Soc Trans. 1977;5(3):772-4. No abstract available.

PMID:
902912
45.

The active site of yeast phosphoglycerate mutase.

Winn SI, Watson HC, Fothergill LA, Harkins RN.

Biochem Soc Trans. 1977;5(3):657-9. No abstract available.

PMID:
198264
46.

Non-random relationships among amino acids in protein sequences.

Black JA, Harkins RN, Stenzel P.

Int J Pept Protein Res. 1976;8(2):125-30.

PMID:
1270187
47.

Partial gene duplication and posterior pituitary peptide.

Black JA, Harkins RN.

J Mol Evol. 1975 Jun 9;5(1):47-55.

PMID:
1177326
48.

The terminal amino acids of protein sequences and protein maturation.

Black JA, Stenzel P, Harkins RN.

J Theor Biol. 1975 Mar;50(1):161-6. No abstract available.

PMID:
1127955
49.

The subunit structure of human muscle and human erythrocyte pyruvate kinase isozymes.

Peterson JS, Chern CJ, Harkins RN, Black JA.

FEBS Lett. 1974 Dec 1;49(1):73-7. No abstract available.

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