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Items: 41

1.

Differential inhibition of APOBEC3 DNA-mutator isozymes by fluoro- versus non-fluoro-substituted 2'-deoxyzebularine embedded in single-stranded DNA.

Kvach MV, Barzak FM, Harjes S, Schares HAM, Kurup HM, Jones KF, Sutton L, Donahue J, D'Aquila RT, Jameson GB, Harki DA, Krause KL, Harjes E, Filichev V.

Chembiochem. 2019 Oct 21. doi: 10.1002/cbic.201900505. [Epub ahead of print]

PMID:
31633265
2.

Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2'-Deoxyzebularine Analogues.

Kvach MV, Barzak FM, Harjes S, Schares HAM, Jameson GB, Ayoub AM, Moorthy R, Aihara H, Harris RS, Filichev VV, Harki DA, Harjes E.

Biochemistry. 2019 Feb 5;58(5):391-400. doi: 10.1021/acs.biochem.8b00858. Epub 2018 Nov 28.

3.

Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor.

Divakaran A, Talluri SK, Ayoub AM, Mishra NK, Cui H, Widen JC, Berndt N, Zhu JY, Carlson AS, Topczewski JJ, Schonbrunn EK, Harki DA, Pomerantz WCK.

J Med Chem. 2018 Oct 25;61(20):9316-9334. doi: 10.1021/acs.jmedchem.8b01248. Epub 2018 Oct 16.

4.

Determinants of Oligonucleotide Selectivity of APOBEC3B.

Wagner JR, Demir Ö, Carpenter MA, Aihara H, Harki DA, Harris RS, Amaro RE.

J Chem Inf Model. 2019 May 28;59(5):2264-2273. doi: 10.1021/acs.jcim.8b00427. Epub 2018 Sep 10.

PMID:
30130104
5.

4-Cyanoindole-2'-deoxyribonucleoside (4CIN): A Universal Fluorescent Nucleoside Analogue.

Passow KT, Harki DA.

Org Lett. 2018 Jul 20;20(14):4310-4313. doi: 10.1021/acs.orglett.8b01746. Epub 2018 Jul 10.

6.

SN-38 Conjugated Gold Nanoparticles Activated by Ewing Sarcoma Specific mRNAs Exhibit In Vitro and In Vivo Efficacy.

Naumann JA, Widen JC, Jonart LA, Ebadi M, Tang J, Gordon DJ, Harki DA, Gordon PM.

Bioconjug Chem. 2018 Apr 18;29(4):1111-1118. doi: 10.1021/acs.bioconjchem.7b00774. Epub 2018 Feb 19.

PMID:
29412642
7.

Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles.

Widen JC, Kempema AM, Baur JW, Skopec HM, Edwards JT, Brown TJ, Brown DA, Meece FA, Harki DA.

ChemMedChem. 2018 Feb 20;13(4):303-311. doi: 10.1002/cmdc.201700752. Epub 2018 Jan 19.

8.

APOBEC Enzymes as Targets for Virus and Cancer Therapy.

Olson ME, Harris RS, Harki DA.

Cell Chem Biol. 2018 Jan 18;25(1):36-49. doi: 10.1016/j.chembiol.2017.10.007. Epub 2017 Nov 16. Review.

9.

Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers.

Dulin D, Arnold JJ, van Laar T, Oh HS, Lee C, Perkins AL, Harki DA, Depken M, Cameron CE, Dekker NH.

Cell Rep. 2017 Oct 24;21(4):1063-1076. doi: 10.1016/j.celrep.2017.10.005.

10.

Rapid, Microwave Accelerated Synthesis of [1,2,4]Triazolo[3,4-b][1,3,4]oxadiazoles from 4-Acylamino-1,2,4-Triazoles.

Breunig SL, Olson ME, Harki DA.

Tetrahedron Lett. 2016 Sep 7;57(36):4056-4060. doi: 10.1016/j.tetlet.2016.07.082. Epub 2016 Jul 29.

11.

Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile.

Widen JC, Kempema AM, Villalta PW, Harki DA.

ACS Chem Biol. 2017 Jan 20;12(1):102-113. doi: 10.1021/acschembio.6b00751. Epub 2016 Nov 28.

12.

Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.

Jackson PA, Widen JC, Harki DA, Brummond KM.

J Med Chem. 2017 Feb 9;60(3):839-885. doi: 10.1021/acs.jmedchem.6b00788. Epub 2016 Dec 20.

13.

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.

Shi K, Carpenter MA, Banerjee S, Shaban NM, Kurahashi K, Salamango DJ, McCann JL, Starrett GJ, Duffy JV, Demir Ö, Amaro RE, Harki DA, Harris RS, Aihara H.

Nat Struct Mol Biol. 2017 Feb;24(2):131-139. doi: 10.1038/nsmb.3344. Epub 2016 Dec 19.

14.

Reassessing APOBEC3G Inhibition by HIV-1 Vif-Derived Peptides.

Richards CM, Li M, Perkins AL, Rathore A, Harki DA, Harris RS.

J Mol Biol. 2017 Jan 6;429(1):88-96. doi: 10.1016/j.jmb.2016.11.012. Epub 2016 Nov 22.

15.

Alkyne Ligation Handles: Propargylation of Hydroxyl, Sulfhydryl, Amino, and Carboxyl Groups via the Nicholas Reaction.

Wells SM, Widen JC, Harki DA, Brummond KM.

Org Lett. 2016 Sep 16;18(18):4566-9. doi: 10.1021/acs.orglett.6b02088. Epub 2016 Aug 29.

16.

Synthesis of a peptide-universal nucleotide antigen: towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes.

Perkins AL, Peterson KL, Beito TG, Flatten KS, Kaufmann SH, Harki DA.

Org Biomol Chem. 2016 Apr 26;14(17):4103-9. doi: 10.1039/c5ob02049b.

17.

Catch and Release DNA Decoys: Capture and Photochemical Dissociation of NF-κB Transcription Factors.

Struntz NB, Harki DA.

ACS Chem Biol. 2016 Jun 17;11(6):1631-8. doi: 10.1021/acschembio.6b00130. Epub 2016 Apr 7.

18.

Immunodetection of human topoisomerase I-DNA covalent complexes.

Patel AG, Flatten KS, Peterson KL, Beito TG, Schneider PA, Perkins AL, Harki DA, Kaufmann SH.

Nucleic Acids Res. 2016 Apr 7;44(6):2816-26. doi: 10.1093/nar/gkw109. Epub 2016 Feb 24.

19.

The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches.

Richards C, Albin JS, Demir Ö, Shaban NM, Luengas EM, Land AM, Anderson BD, Holten JR, Anderson JS, Harki DA, Amaro RE, Harris RS.

Cell Rep. 2015 Dec 1;13(9):1781-8. doi: 10.1016/j.celrep.2015.10.067. Epub 2015 Nov 25.

20.

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle.

Kerr JP, Robison P, Shi G, Bogush AI, Kempema AM, Hexum JK, Becerra N, Harki DA, Martin SS, Raiteri R, Prosser BL, Ward CW.

Nat Commun. 2015 Oct 8;6:8526. doi: 10.1038/ncomms9526.

21.

Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries.

Olson ME, Abate-Pella D, Perkins AL, Li M, Carpenter MA, Rathore A, Harris RS, Harki DA.

J Med Chem. 2015 Sep 24;58(18):7419-30. doi: 10.1021/acs.jmedchem.5b00930. Epub 2015 Sep 11.

22.

Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.

Kempema AM, Widen JC, Hexum JK, Andrews TE, Wang D, Rathe SK, Meece FA, Noble KE, Sachs Z, Largaespada DA, Harki DA.

Bioorg Med Chem. 2015 Aug 1;23(15):4737-45. doi: 10.1016/j.bmc.2015.05.037. Epub 2015 May 30.

23.

Parthenolide prodrug LC-1 slows growth of intracranial glioma.

Hexum JK, Becker CM, Kempema AM, Ohlfest JR, Largaespada DA, Harki DA.

Bioorg Med Chem Lett. 2015 Jun 15;25(12):2493-5. doi: 10.1016/j.bmcl.2015.04.058. Epub 2015 Apr 25.

PMID:
25978958
24.

EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer.

Brand LJ, Olson ME, Ravindranathan P, Guo H, Kempema AM, Andrews TE, Chen X, Raj GV, Harki DA, Dehm SM.

Oncotarget. 2015 Feb 28;6(6):3811-24.

25.

A redox economical synthesis of bioactive 6,12-guaianolides.

Wen B, Hexum JK, Widen JC, Harki DA, Brummond KM.

Org Lett. 2013 Jun 7;15(11):2644-7. doi: 10.1021/ol400904y. Epub 2013 May 10.

26.

Cell surface markers of cancer stem cells: diagnostic macromolecules and targets for drug delivery.

Andrews TE, Wang D, Harki DA.

Drug Deliv Transl Res. 2013 Apr;3(2):121-42. doi: 10.1007/s13346-012-0075-1.

PMID:
25787981
27.

Small-molecule APOBEC3G DNA cytosine deaminase inhibitors based on a 4-amino-1,2,4-triazole-3-thiol scaffold.

Olson ME, Li M, Harris RS, Harki DA.

ChemMedChem. 2013 Jan;8(1):112-7. doi: 10.1002/cmdc.201200411. Epub 2012 Nov 23.

28.

Inhibition of guanosine monophosphate synthetase by the substrate enantiomer L-XMP.

Struntz NB, Hu T, White BR, Olson ME, Harki DA.

Chembiochem. 2012 Nov 26;13(17):2517-20. doi: 10.1002/cbic.201200503. Epub 2012 Oct 23. No abstract available.

29.

Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling.

Hexum JK, Tello-Aburto R, Struntz NB, Harned AM, Harki DA.

ACS Med Chem Lett. 2012 Jun 14;3(6):459-464. Epub 2012 May 11.

30.

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.

Li M, Shandilya SM, Carpenter MA, Rathore A, Brown WL, Perkins AL, Harki DA, Solberg J, Hook DJ, Pandey KK, Parniak MA, Johnson JR, Krogan NJ, Somasundaran M, Ali A, Schiffer CA, Harris RS.

ACS Chem Biol. 2012 Mar 16;7(3):506-17. doi: 10.1021/cb200440y. Epub 2012 Jan 17.

31.

Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide.

Zhang Y, Sicot G, Cui X, Vogel M, Wuertzer CA, Lezon-Geyda K, Wheeler J, Harki DA, Muzikar KA, Stolper DA, Dervan PB, Perkins AS.

Biochemistry. 2011 Dec 6;50(48):10431-41. doi: 10.1021/bi200962u. Epub 2011 Nov 10.

32.

Oligomerization route to Py-Im polyamide macrocycles.

Chenoweth DM, Harki DA, Dervan PB.

Org Lett. 2009 Aug 20;11(16):3590-3. doi: 10.1021/ol901311m.

33.

Solution-phase synthesis of pyrrole-imidazole polyamides.

Chenoweth DM, Harki DA, Dervan PB.

J Am Chem Soc. 2009 May 27;131(20):7175-81. doi: 10.1021/ja901307m.

34.

Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.

Chenoweth DM, Harki DA, Phillips JW, Dose C, Dervan PB.

J Am Chem Soc. 2009 May 27;131(20):7182-8. doi: 10.1021/ja901309z.

35.

In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography.

Harki DA, Satyamurthy N, Stout DB, Phelps ME, Dervan PB.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13039-44. doi: 10.1073/pnas.0806308105. Epub 2008 Aug 27.

36.

Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase.

Zamyatkin DF, Parra F, Alonso JM, Harki DA, Peterson BR, Grochulski P, Ng KK.

J Biol Chem. 2008 Mar 21;283(12):7705-12. doi: 10.1074/jbc.M709563200. Epub 2008 Jan 9.

37.

Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues.

Graci JD, Too K, Smidansky ED, Edathil JP, Barr EW, Harki DA, Galarraga JE, Bollinger JM Jr, Peterson BR, Loakes D, Brown DM, Cameron CE.

Antimicrob Agents Chemother. 2008 Mar;52(3):971-9. doi: 10.1128/AAC.01056-07. Epub 2008 Jan 7.

38.

Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue.

Graci JD, Harki DA, Korneeva VS, Edathil JP, Too K, Franco D, Smidansky ED, Paul AV, Peterson BR, Brown DM, Loakes D, Cameron CE.

J Virol. 2007 Oct;81(20):11256-66. Epub 2007 Aug 8.

39.

Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase.

Harki DA, Graci JD, Edathil JP, Castro C, Cameron CE, Peterson BR.

Chembiochem. 2007 Aug 13;8(12):1359-62. No abstract available.

40.

Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases.

Harki DA, Graci JD, Galarraga JE, Chain WJ, Cameron CE, Peterson BR.

J Med Chem. 2006 Oct 19;49(21):6166-9.

41.

Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole.

Harki DA, Graci JD, Korneeva VS, Ghosh SK, Hong Z, Cameron CE, Peterson BR.

Biochemistry. 2002 Jul 23;41(29):9026-33.

PMID:
12119016

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