Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 216


Transcriptional profiling of the murine airway response to acute ozone exposure.

Tovar A, Smith GJ, Thomas JM, Crouse WL, Harkema JR, Kelada SNP.

Toxicol Sci. 2019 Oct 18. pii: kfz219. doi: 10.1093/toxsci/kfz219. [Epub ahead of print]


Innate Lymphoid Cell-Dependent Airway Epithelial and Inflammatory Responses to Inhaled Ozone: A New Paradigm in Pathogenesis.

Harkema JR, Wagner JG.

Toxicol Pathol. 2019 Sep 19:192623319873872. doi: 10.1177/0192623319873872. [Epub ahead of print]


Correction: Silica-Triggered Autoimmunity in Lupus-Prone Mice Blocked by Docosahexaenoic Acid Consumption.

Bates MA, Brandenberger C, Langohr IM, Kumagai K, Lock AL, Harkema JR, Holian A, Pestka JJ.

PLoS One. 2019 Jul 24;14(7):e0220469. doi: 10.1371/journal.pone.0220469. eCollection 2019.


Mapping of Dynamic Transcriptome Changes Associated With Silica-Triggered Autoimmune Pathogenesis in the Lupus-Prone NZBWF1 Mouse.

Bates MA, Benninghoff AD, Gilley KN, Holian A, Harkema JR, Pestka JJ.

Front Immunol. 2019 Mar 29;10:632. doi: 10.3389/fimmu.2019.00632. eCollection 2019.


Neighborhood air pollution and household environmental health as it relates to respiratory health and healthcare utilization among elderly persons with asthma.

Arnetz BB, Arnetz J, Harkema JR, Morishita M, Slonager K, Sudan S, Jamil H.

J Asthma. 2019 Feb 27:1-12. doi: 10.1080/02770903.2018.1545856. [Epub ahead of print]


The Endothelin-A Receptor Antagonist Zibotentan Induces Damage to the Nasal Olfactory Epithelium Possibly Mediated in Part through Type 2 Innate Lymphoid Cells.

Esvelt MA, Freeman ZT, Pearson AT, Harkema JR, Clines GT, Clines KL, Dyson MC, Hoenerhoff MJ.

Toxicol Pathol. 2019 Feb;47(2):150-164. doi: 10.1177/0192623318816295. Epub 2018 Dec 30.


Sex Differences in Renal Inflammation and Injury in High-Fat Diet-Fed Dahl Salt-Sensitive Rats.

Fernandes R, Garver H, Harkema JR, Galligan JJ, Fink GD, Xu H.

Hypertension. 2018 Nov;72(5):e43-e52. doi: 10.1161/HYPERTENSIONAHA.118.11485.


Dietary Docosahexaenoic Acid Prevents Silica-Induced Development of Pulmonary Ectopic Germinal Centers and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse.

Bates MA, Akbari P, Gilley KN, Wagner JG, Li N, Kopec AK, Wierenga KA, Jackson-Humbles D, Brandenberger C, Holian A, Benninghoff AD, Harkema JR, Pestka JJ.

Front Immunol. 2018 Sep 12;9:2002. doi: 10.3389/fimmu.2018.02002. eCollection 2018.


Effect of Ambient Fine Particulate Matter Air Pollution and Colder Outdoor Temperatures on High-Density Lipoprotein Function.

Mathew AV, Yu J, Guo Y, Byun J, Chen YE, Wang L, Liu M, Bard RL, Morishita M, Huang W, Li J, Harkema JR, Rajagopalan S, Pennathur S, Brook RD.

Am J Cardiol. 2018 Aug 15;122(4):565-570. doi: 10.1016/j.amjcard.2018.04.061. Epub 2018 Jul 11.


Short-Term Blood Pressure Responses to Ambient Fine Particulate Matter Exposures at the Extremes of Global Air Pollution Concentrations.

Huang W, Wang L, Li J, Liu M, Xu H, Liu S, Chen J, Zhang Y, Morishita M, Bard RL, Harkema JR, Rajagopalan S, Brook RD.

Am J Hypertens. 2018 Apr 13;31(5):590-599. doi: 10.1093/ajh/hpx216.


Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice.

Nault R, Fader KA, Harkema JR, Zacharewski T.

PLoS One. 2017 Sep 18;12(9):e0184842. doi: 10.1371/journal.pone.0184842. eCollection 2017.


Imipramine blocks acute silicosis in a mouse model.

Biswas R, Trout KL, Jessop F, Harkema JR, Holian A.

Part Fibre Toxicol. 2017 Sep 11;14(1):36. doi: 10.1186/s12989-017-0217-1.


Innate Lymphoid Cells Mediate Pulmonary Eosinophilic Inflammation, Airway Mucous Cell Metaplasia, and Type 2 Immunity in Mice Exposed to Ozone.

Kumagai K, Lewandowski RP, Jackson-Humbles DN, Buglak N, Li N, White K, Van Dyken SJ, Wagner JG, Harkema JR.

Toxicol Pathol. 2017 Aug;45(6):692-704. doi: 10.1177/0192623317728135. Epub 2017 Sep 11.


Altered thymocyte and T cell development in neonatal mice with hyperoxia-induced lung injury.

Angusamy S, Mansour T, Abdulmageed M, Han R, Schutte BC, LaPres J, Harkema JR, Omar SA.

J Perinat Med. 2018 May 24;46(4):441-449. doi: 10.1515/jpm-2016-0234.


2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism.

Fader KA, Nault R, Zhang C, Kumagai K, Harkema JR, Zacharewski TR.

Sci Rep. 2017 Jul 19;7(1):5921. doi: 10.1038/s41598-017-05656-8.


Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome.

Carll AP, Crespo SM, Filho MS, Zati DH, Coull BA, Diaz EA, Raimundo RD, Jaeger TNG, Ricci-Vitor AL, Papapostolou V, Lawrence JE, Garner DM, Perry BS, Harkema JR, Godleski JJ.

Part Fibre Toxicol. 2017 May 25;14(1):16. doi: 10.1186/s12989-017-0196-2.


Correction: Silica-Triggered Autoimmunity in Lupus-Prone Mice Blocked by Docosahexaenoic Acid Consumption.

Bates MA, Brandenberger C, Langohr IM, Kumagai K, Lock AL, Harkema JR, Holian A, Pestka JJ.

PLoS One. 2017 Feb 6;12(2):e0171877. doi: 10.1371/journal.pone.0171877. eCollection 2017.


Strain Differences in a Murine Model of Air Pollutant-induced Nonatopic Asthma and Rhinitis.

Harkema JR, Hotchkiss LA, Vetter NA, Jackson-Humbles DN, Lewandowski RP, Wagner JG.

Toxicol Pathol. 2017 Jan;45(1):161-171. doi: 10.1177/0192623316674274. Epub 2016 Nov 15.


National Institute of Environmental Health Sciences: 50 Years of Advancing Science and Improving Lung Health.

Antony VB, Redlich CA, Pinkerton KE, Balmes J, Harkema JR.

Am J Respir Crit Care Med. 2016 Nov 15;194(10):1190-1195.


From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis.

Nault R, Fader KA, Kopec AK, Harkema JR, Zacharewski TR, Luyendyk JP.

Toxicol Sci. 2016 Dec;154(2):381-391. Epub 2016 Sep 9.


Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis.

Nault R, Fader KA, Ammendolia DA, Dornbos P, Potter D, Sharratt B, Kumagai K, Harkema JR, Lunt SY, Matthews J, Zacharewski T.

Toxicol Sci. 2016 Dec;154(2):253-266. Epub 2016 Aug 25.


Silica-Triggered Autoimmunity in Lupus-Prone Mice Blocked by Docosahexaenoic Acid Consumption.

Bates MA, Brandenberger C, Langohr II, Kumagai K, Lock AL, Harkema JR, Holian A, Pestka JJ.

PLoS One. 2016 Aug 11;11(8):e0160622. doi: 10.1371/journal.pone.0160622. eCollection 2016. Erratum in: PLoS One. 2017 Feb 6;12 (2):e0171877. PLoS One. 2019 Jul 24;14(7):e0220469.


Repeated ozone exposure exacerbates insulin resistance and activates innate immune response in genetically susceptible mice.

Zhong J, Allen K, Rao X, Ying Z, Braunstein Z, Kankanala SR, Xia C, Wang X, Bramble LA, Wagner JG, Lewandowski R, Sun Q, Harkema JR, Rajagopalan S.

Inhal Toxicol. 2016 Aug;28(9):383-92. doi: 10.1080/08958378.2016.1179373. Epub 2016 May 31.


Subacute inhalation exposure to ozone induces systemic inflammation but not insulin resistance in a diabetic mouse model.

Ying Z, Allen K, Zhong J, Chen M, Williams KM, Wagner JG, Lewandowski R, Sun Q, Rajagopalan S, Harkema JR.

Inhal Toxicol. 2016;28(4):155-63. doi: 10.3109/08958378.2016.1146808.


Ozone-Induced Nasal Type 2 Immunity in Mice Is Dependent on Innate Lymphoid Cells.

Kumagai K, Lewandowski R, Jackson-Humbles DN, Li N, Van Dyken SJ, Wagner JG, Harkema JR.

Am J Respir Cell Mol Biol. 2016 Jun;54(6):782-91. doi: 10.1165/rcmb.2015-0118OC.


Evaluation of the mode of action of mouse lung tumors induced by 4-methylimidazole.

Cruzan G, Harkema JR, Hosako H, Wasil JM, Murray FJ.

Regul Toxicol Pharmacol. 2015 Nov;73(2):501-8. doi: 10.1016/j.yrtph.2015.10.006. Epub 2015 Oct 9.


Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.

Saini Y, Proper SP, Dornbos P, Greenwood KK, Kopec AK, Lynn SG, Grier E, Burgoon LD, Zacharewski TR, Thomas RS, Harkema JR, LaPres JJ.

PLoS One. 2015 Sep 30;10(9):e0139270. doi: 10.1371/journal.pone.0139270. eCollection 2015.


2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice.

Fader KA, Nault R, Ammendolia DA, Harkema JR, Williams KJ, Crawford RB, Kaminski NE, Potter D, Sharratt B, Zacharewski TR.

Toxicol Sci. 2015 Dec;148(2):567-80. doi: 10.1093/toxsci/kfv206. Epub 2015 Sep 16.


Inhalation exposure to ethylene induces eosinophilic rhinitis and nasal epithelial remodeling in Fischer 344 rats.

Brandenberger C, Hotchkiss JA, Krieger SM, Pottenger LH, Harkema JR.

Chem Biol Interact. 2015 Nov 5;241:66-75. doi: 10.1016/j.cbi.2015.09.001. Epub 2015 Sep 11.


Ozone-Induced Type 2 Immunity in Nasal Airways. Development and Lymphoid Cell Dependence in Mice.

Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-Humbles DN, Nault R, Zacharewski TR, Wagner JG, Harkema JR.

Am J Respir Cell Mol Biol. 2016 Mar;54(3):331-40. doi: 10.1165/rcmb.2015-0165OC.


Alterations of the Murine Gut Microbiome with Age and Allergic Airway Disease.

Vital M, Harkema JR, Rizzo M, Tiedje J, Brandenberger C.

J Immunol Res. 2015;2015:892568. doi: 10.1155/2015/892568. Epub 2015 May 18.


Silica Triggers Inflammation and Ectopic Lymphoid Neogenesis in the Lungs in Parallel with Accelerated Onset of Systemic Autoimmunity and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse.

Bates MA, Brandenberger C, Langohr I, Kumagai K, Harkema JR, Holian A, Pestka JJ.

PLoS One. 2015 May 15;10(5):e0125481. doi: 10.1371/journal.pone.0125481. eCollection 2015.


Development of a computational high-throughput tool for the quantitative examination of dose-dependent histological features.

Nault R, Colbry D, Brandenberger C, Harkema JR, Zacharewski TR.

Toxicol Pathol. 2015 Apr;43(3):366-75. doi: 10.1177/0192623314544379. Epub 2014 Oct 1.


The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures.

Morishita M, Bard RL, Wang L, Das R, Dvonch JT, Spino C, Mukherjee B, Sun Q, Harkema JR, Rajagopalan S, Brook RD.

J Expo Sci Environ Epidemiol. 2015 Mar-Apr;25(2):153-9. doi: 10.1038/jes.2014.62. Epub 2014 Sep 17.


CD36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure.

Rao X, Zhong J, Maiseyeu A, Gopalakrishnan B, Villamena FA, Chen LC, Harkema JR, Sun Q, Rajagopalan S.

Circ Res. 2014 Oct 10;115(9):770-780. doi: 10.1161/CIRCRESAHA.115.304666. Epub 2014 Sep 3.


Enhanced allergic airway disease in old mice is associated with a Th17 response.

Brandenberger C, Li N, Jackson-Humbles DN, Rockwell CE, Wagner JG, Harkema JR.

Clin Exp Allergy. 2014 Oct;44(10):1282-92. doi: 10.1111/cea.12388.


PM2.5-induced cardiovascular dysregulation in rats is associated with elemental carbon and temperature-resolved carbon subfractions.

Wagner JG, Kamal AS, Morishita M, Dvonch JT, Harkema JR, Rohr AC.

Part Fibre Toxicol. 2014 May 22;11:25. doi: 10.1186/1743-8977-11-25.


Exploration of the composition and sources of urban fine particulate matter associated with same-day cardiovascular health effects in Dearborn, Michigan.

Morishita M, Bard RL, Kaciroti N, Fitzner CA, Dvonch T, Harkema JR, Rajagopalan S, Brook RD.

J Expo Sci Environ Epidemiol. 2015 Mar-Apr;25(2):145-52. doi: 10.1038/jes.2014.35. Epub 2014 May 28.


Supplementation with γ-tocopherol attenuates endotoxin-induced airway neutrophil and mucous cell responses in rats.

Wagner JG, Birmingham NP, Jackson-Humbles D, Jiang Q, Harkema JR, Peden DB.

Free Radic Biol Med. 2014 Mar;68:101-9. doi: 10.1016/j.freeradbiomed.2013.11.024. Epub 2013 Dec 11.


Long-term exposure to concentrated ambient PM2.5 increases mouse blood pressure through abnormal activation of the sympathetic nervous system: a role for hypothalamic inflammation.

Ying Z, Xu X, Bai Y, Zhong J, Chen M, Liang Y, Zhao J, Liu D, Morishita M, Sun Q, Spino C, Brook RD, Harkema JR, Rajagopalan S.

Environ Health Perspect. 2014 Jan;122(1):79-86. doi: 10.1289/ehp.1307151. Epub 2013 Nov 15.


Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury.

Proper SP, Saini Y, Greenwood KK, Bramble LA, Downing NJ, Harkema JR, Lapres JJ.

Toxicol Sci. 2014 Feb;137(2):447-57. doi: 10.1093/toxsci/kft253. Epub 2013 Nov 11.


Cardiovascular depression in rats exposed to inhaled particulate matter and ozone: effects of diet-induced metabolic syndrome.

Wagner JG, Allen K, Yang HY, Nan B, Morishita M, Mukherjee B, Dvonch JT, Spino C, Fink GD, Rajagopalan S, Sun Q, Brook RD, Harkema JR.

Environ Health Perspect. 2014 Jan;122(1):27-33. doi: 10.1289/ehp.1307085. Epub 2013 Oct 29.


Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice.

Liu C, Xu X, Bai Y, Wang TY, Rao X, Wang A, Sun L, Ying Z, Gushchina L, Maiseyeu A, Morishita M, Sun Q, Harkema JR, Rajagopalan S.

Environ Health Perspect. 2014 Jan;122(1):17-26. doi: 10.1289/ehp.1306841. Epub 2013 Oct 22.


Ambient fine particulate matter and ozone exposures induce inflammation in epicardial and perirenal adipose tissues in rats fed a high fructose diet.

Sun L, Liu C, Xu X, Ying Z, Maiseyeu A, Wang A, Allen K, Lewandowski RP, Bramble LA, Morishita M, Wagner JG, Dvonch J, Sun Z, Yan X, Brook RD, Rajagopalan S, Harkema JR, Sun Q, Fan Z.

Part Fibre Toxicol. 2013 Aug 22;10:43. doi: 10.1186/1743-8977-10-43.


Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice.

Kopec AK, Boverhof DR, Nault R, Harkema JR, Tashiro C, Potter D, Sharratt B, Chittim B, Zacharewski TR.

Toxicol Sci. 2013 Oct;135(2):465-75. doi: 10.1093/toxsci/kft156. Epub 2013 Jul 17.


Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice.

Brandenberger C, Rowley NL, Jackson-Humbles DN, Zhang Q, Bramble LA, Lewandowski RP, Wagner JG, Chen W, Kaplan BL, Kaminski NE, Baker GL, Worden RM, Harkema JR.

Part Fibre Toxicol. 2013 Jul 1;10:26. doi: 10.1186/1743-8977-10-26.


Interlaboratory evaluation of rodent pulmonary responses to engineered nanomaterials: the NIEHS Nano GO Consortium.

Bonner JC, Silva RM, Taylor AJ, Brown JM, Hilderbrand SC, Castranova V, Porter D, Elder A, Oberdörster G, Harkema JR, Bramble LA, Kavanagh TJ, Botta D, Nel A, Pinkerton KE.

Environ Health Perspect. 2013 Jun;121(6):676-82. doi: 10.1289/ehp.1205693. Epub 2013 May 6.


Loss of Cftr function exacerbates the phenotype of Na(+) hyperabsorption in murine airways.

Livraghi-Butrico A, Kelly EJ, Wilkinson KJ, Rogers TD, Gilmore RC, Harkema JR, Randell SH, Boucher RC, O'Neal WK, Grubb BR.

Am J Physiol Lung Cell Mol Physiol. 2013 Apr 1;304(7):L469-80. doi: 10.1152/ajplung.00150.2012. Epub 2013 Feb 1.


Cannabidiol (CBD) enhances lipopolysaccharide (LPS)-induced pulmonary inflammation in C57BL/6 mice.

Karmaus PW, Wagner JG, Harkema JR, Kaminski NE, Kaplan BL.

J Immunotoxicol. 2013 Jul-Sep;10(3):321-8. doi: 10.3109/1547691X.2012.741628. Epub 2012 Nov 23.


Divergent effects of urban particulate air pollution on allergic airway responses in experimental asthma: a comparison of field exposure studies.

Wagner JG, Morishita M, Keeler GJ, Harkema JR.

Environ Health. 2012 Jul 6;11:45. doi: 10.1186/1476-069X-11-45.

Supplemental Content

Loading ...
Support Center