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Items: 21

1.

Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation.

Harischandra DS, Ghaisas S, Zenitsky G, Jin H, Kanthasamy A, Anantharam V, Kanthasamy AG.

Front Neurosci. 2019 Jun 26;13:654. doi: 10.3389/fnins.2019.00654. eCollection 2019. Review.

2.

Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.

Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, Anantharam V, Kanthasamy AG, Kanthasamy A.

J Exp Med. 2019 Jun 3;216(6):1411-1430. doi: 10.1084/jem.20182191. Epub 2019 Apr 29.

PMID:
31036561
3.

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.

Harischandra DS, Rokad D, Neal ML, Ghaisas S, Manne S, Sarkar S, Panicker N, Zenitsky G, Jin H, Lewis M, Huang X, Anantharam V, Kanthasamy A, Kanthasamy AG.

Sci Signal. 2019 Mar 12;12(572). pii: eaau4543. doi: 10.1126/scisignal.aau4543.

PMID:
30862700
4.

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells.

Sarkar S, Rokad D, Malovic E, Luo J, Harischandra DS, Jin H, Anantharam V, Huang X, Lewis M, Kanthasamy A, Kanthasamy AG.

Sci Signal. 2019 Jan 8;12(563). pii: eaat9900. doi: 10.1126/scisignal.aat9900.

5.

Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes.

Neal M, Luo J, Harischandra DS, Gordon R, Sarkar S, Jin H, Anantharam V, Désaubry L, Kanthasamy A, Kanthasamy A.

Glia. 2018 Oct;66(10):2137-2157. doi: 10.1002/glia.23467. Epub 2018 Sep 12.

PMID:
30277602
6.

Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes.

Sarkar S, Malovic E, Harischandra DS, Ngwa HA, Ghosh A, Hogan C, Rokad D, Zenitsky G, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A.

Neurotoxicology. 2018 Jan;64:204-218. doi: 10.1016/j.neuro.2017.05.009. Epub 2017 May 21.

7.

Exosomes in Toxicology: Relevance to Chemical Exposure and Pathogenesis of Environmentally Linked Diseases.

Harischandra DS, Ghaisas S, Rokad D, Kanthasamy AG.

Toxicol Sci. 2017 Jul 1;158(1):3-13. doi: 10.1093/toxsci/kfx074. Review.

8.

Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal neurotoxicity.

Harischandra DS, Ghaisas S, Rokad D, Zamanian M, Jin H, Anantharam V, Kimber M, Kanthasamy A, Kanthasamy AG.

Neurotoxicology. 2018 Jan;64:267-277. doi: 10.1016/j.neuro.2017.04.007. Epub 2017 Apr 24.

9.

Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation.

Rokad D, Ghaisas S, Harischandra DS, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

Brain Res Bull. 2017 Jul;133:60-70. doi: 10.1016/j.brainresbull.2016.12.003. Epub 2016 Dec 16.

10.

Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration.

Gordon R, Neal ML, Luo J, Langley MR, Harischandra DS, Panicker N, Charli A, Jin H, Anantharam V, Woodruff TM, Zhou QY, Kanthasamy AG, Kanthasamy A.

Nat Commun. 2016 Oct 5;7:12932. doi: 10.1038/ncomms12932.

11.

Copper-induced structural conversion templates prion protein oligomerization and neurotoxicity.

Yen CF, Harischandra DS, Kanthasamy A, Sivasankar S.

Sci Adv. 2016 Jul 1;2(7):e1600014. doi: 10.1126/sciadv.1600014. eCollection 2016 Jul.

12.

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease.

Gordon R, Singh N, Lawana V, Ghosh A, Harischandra DS, Jin H, Hogan C, Sarkar S, Rokad D, Panicker N, Anantharam V, Kanthasamy AG, Kanthasamy A.

Neurobiol Dis. 2016 Sep;93:96-114. doi: 10.1016/j.nbd.2016.04.008. Epub 2016 May 2.

13.

Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease.

Ghosh A, Langley MR, Harischandra DS, Neal ML, Jin H, Anantharam V, Joseph J, Brenza T, Narasimhan B, Kanthasamy A, Kalyanaraman B, Kanthasamy AG.

J Neuroimmune Pharmacol. 2016 Jun;11(2):259-78. doi: 10.1007/s11481-016-9650-4. Epub 2016 Feb 2.

14.

Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson's disease.

Ay M, Jin H, Harischandra DS, Asaithambi A, Kanthasamy A, Anantharam V, Kanthasamy AG.

J Neurochem. 2015 Oct;135(2):402-15. doi: 10.1111/jnc.13261. Epub 2015 Aug 28.

15.

Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease.

Panicker N, Saminathan H, Jin H, Neal M, Harischandra DS, Gordon R, Kanthasamy K, Lawana V, Sarkar S, Luo J, Anantharam V, Kanthasamy AG, Kanthasamy A.

J Neurosci. 2015 Jul 8;35(27):10058-77. doi: 10.1523/JNEUROSCI.0302-15.2015.

16.

Targeted toxicants to dopaminergic neuronal cell death.

Jin H, Kanthasamy A, Harischandra DS, Anantharam V, Rana A, Kanthasamy A.

Methods Mol Biol. 2015;1254:239-52. doi: 10.1007/978-1-4939-2152-2_18.

PMID:
25431070
17.

α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease.

Harischandra DS, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

Toxicol Sci. 2015 Feb;143(2):454-68. doi: 10.1093/toxsci/kfu247. Epub 2014 Nov 21.

18.

Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease.

Jin H, Kanthasamy A, Harischandra DS, Kondru N, Ghosh A, Panicker N, Anantharam V, Rana A, Kanthasamy AG.

J Biol Chem. 2014 Dec 12;289(50):34743-67. doi: 10.1074/jbc.M114.576702. Epub 2014 Oct 23.

19.

Role of proteolytic activation of protein kinase Cδ in the pathogenesis of prion disease.

Harischandra DS, Kondru N, Martin DP, Kanthasamy A, Jin H, Anantharam V, Kanthasamy AG.

Prion. 2014 Jan-Feb;8(1):143-53.

20.

The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease.

Ghosh A, Saminathan H, Kanthasamy A, Anantharam V, Jin H, Sondarva G, Harischandra DS, Qian Z, Rana A, Kanthasamy AG.

J Biol Chem. 2013 Jul 26;288(30):21955-71. doi: 10.1074/jbc.M112.444224. Epub 2013 Jun 10.

21.

Effect of divalent metals on the neuronal proteasomal system, prion protein ubiquitination and aggregation.

Kanthasamy AG, Choi C, Jin H, Harischandra DS, Anantharam V, Kanthasamy A.

Toxicol Lett. 2012 Nov 15;214(3):288-95. doi: 10.1016/j.toxlet.2012.09.008. Epub 2012 Sep 17.

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