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Items: 21

1.

A pharmaceutical industry perspective on microphysiological kidney systems for evaluation of safety for new therapies.

Phillips JA, Grandhi TSP, Davis M, Gautier JC, Hariparsad N, Keller D, Sura R, Van Vleet TR.

Lab Chip. 2020 Feb 7;20(3):468-476. doi: 10.1039/c9lc00925f. Epub 2020 Jan 28.

PMID:
31989145
2.

Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization.

Fowler S, Chen WLK, Duignan DB, Gupta A, Hariparsad N, Kenny JR, Lai WG, Liras J, Phillips JA, Gan J.

Lab Chip. 2020 Feb 7;20(3):446-467. doi: 10.1039/c9lc00857h. Epub 2020 Jan 14.

PMID:
31932816
3.

Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates.

Ramsden D, Fung C, Hariparsad N, Kenny JR, Mohutsky M, Parrott NJ, Robertson S, Tweedie DJ.

Drug Metab Dispos. 2019 Oct;47(10):1206-1221. doi: 10.1124/dmd.119.087270. Epub 2019 Aug 22.

PMID:
31439574
4.

Assessment of Transporter-Mediated and Passive Hepatic Uptake Clearance Using Rifamycin-SV as a Pan-Inhibitor of Active Uptake.

Chothe PP, Wu SP, Ye Z, Hariparsad N.

Mol Pharm. 2018 Oct 1;15(10):4677-4688. doi: 10.1021/acs.molpharmaceut.8b00654. Epub 2018 Aug 27.

PMID:
29996058
5.

Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance.

Kenny JR, Ramsden D, Buckley DB, Dallas S, Fung C, Mohutsky M, Einolf HJ, Chen L, Dekeyser JG, Fitzgerald M, Goosen TC, Siu YA, Walsky RL, Zhang G, Tweedie D, Hariparsad N.

Drug Metab Dispos. 2018 Sep;46(9):1285-1303. doi: 10.1124/dmd.118.081927. Epub 2018 Jun 29.

PMID:
29959133
6.

Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.

Hariparsad N, Ramsden D, Palamanda J, Dekeyser JG, Fahmi OA, Kenny JR, Einolf H, Mohutsky M, Pardon M, Siu YA, Chen L, Sinz M, Jones B, Walsky R, Dallas S, Balani SK, Zhang G, Buckley D, Tweedie D.

Drug Metab Dispos. 2017 Oct;45(10):1049-1059. doi: 10.1124/dmd.116.074567. Epub 2017 Jun 23.

PMID:
28646080
7.

Quantitative Prediction of CYP3A4 Induction: Impact of Measured, Free, and Intracellular Perpetrator Concentrations from Human Hepatocyte Induction Studies on Drug-Drug Interaction Predictions.

Sun Y, Chothe PP, Sager JE, Tsao H, Moore A, Laitinen L, Hariparsad N.

Drug Metab Dispos. 2017 Jun;45(6):692-705. doi: 10.1124/dmd.117.075481. Epub 2017 Mar 23.

PMID:
28336578
8.

Evaluation of the Interplay between Uptake Transport and CYP3A4 Induction in Micropatterned Cocultured Hepatocytes.

Moore A, Chothe PP, Tsao H, Hariparsad N.

Drug Metab Dispos. 2016 Dec;44(12):1910-1919. Epub 2016 Sep 21.

PMID:
27655038
9.

VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions.

Zetterberg C, Maltais F, Laitinen L, Liao S, Tsao H, Chakilam A, Hariparsad N.

Drug Metab Dispos. 2016 Aug;44(8):1286-95. doi: 10.1124/dmd.116.071100. Epub 2016 Jun 13.

PMID:
27298338
10.

Application of Micropatterned Cocultured Hepatocytes to Evaluate the Inductive Potential and Degradation Rate of Major Xenobiotic Metabolizing Enzymes.

Dixit V, Moore A, Tsao H, Hariparsad N.

Drug Metab Dispos. 2016 Feb;44(2):250-61. doi: 10.1124/dmd.115.067173. Epub 2015 Dec 9.

PMID:
26658225
11.

Lack of a clinically meaningful pharmacokinetic effect of rifabutin on raltegravir: in vitro/in vivo correlation.

Brainard DM, Kassahun K, Wenning LA, Petry AS, Liu C, Lunceford J, Hariparsad N, Eisenhandler R, Norcross A, DeNoia EP, Stone JA, Wagner JA, Iwamoto M.

J Clin Pharmacol. 2011 Jun;51(6):943-50. doi: 10.1177/0091270010375959. Epub 2010 Sep 17.

PMID:
20852006
12.
13.

Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.

Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R.

Nucleic Acids Res. 2009 Mar;37(4):1160-73. doi: 10.1093/nar/gkn1047. Epub 2009 Jan 7.

14.

Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction.

Hariparsad N, Carr BA, Evers R, Chu X.

Drug Metab Dispos. 2008 Jun;36(6):1046-55. doi: 10.1124/dmd.108.020677. Epub 2008 Mar 10.

PMID:
18332078
15.

Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions.

Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD.

Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16.

PMID:
17639026
16.

In vitro LC-MS cocktail assays to simultaneously determine human cytochrome P450 activities.

Dixit V, Hariparsad N, Desai P, Unadkat JD.

Biopharm Drug Dispos. 2007 Jul;28(5):257-62.

PMID:
17443647
17.

In vitro methods in human drug biotransformation research: implications for cancer chemotherapy.

Hariparsad N, Sane RS, Strom SC, Desai PB.

Toxicol In Vitro. 2006 Mar;20(2):135-53. Epub 2005 Dec 15. Review.

PMID:
16359840
18.

Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital.

Hariparsad N, Nallani SC, Sane RS, Buckley DJ, Buckley AR, Desai PB.

J Clin Pharmacol. 2004 Nov;44(11):1273-81.

PMID:
15496645
19.

Dose-dependent induction of cytochrome P450 (CYP) 3A4 and activation of pregnane X receptor by topiramate.

Nallani SC, Glauser TA, Hariparsad N, Setchell K, Buckley DJ, Buckley AR, Desai PB.

Epilepsia. 2003 Dec;44(12):1521-8.

20.

Attitudes and practices of pharmacists towards emergency contraception in Durban, South Africa.

Hariparsad N.

Eur J Contracept Reprod Health Care. 2001 Jun;6(2):87-92.

PMID:
11518453
21.

Knowledge of emergency contraception among pharmacists and doctors in Durban, South Africa.

Hariparsad N.

Eur J Contracept Reprod Health Care. 2001 Mar;6(1):21-6.

PMID:
11334472

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