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Items: 45

1.

TAMing pancreatic cancer: combat with a double edged sword.

Lankadasari MB, Mukhopadhyay P, Mohammed S, Harikumar KB.

Mol Cancer. 2019 Mar 30;18(1):48. doi: 10.1186/s12943-019-0966-6. Review.

2.

Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus.

Mohammed S, Vineetha NS, James S, Aparna JS, Lankadasari MB, Allegood JC, Li QZ, Spiegel S, Harikumar KB.

FASEB J. 2019 Jun;33(6):7061-7071. doi: 10.1096/fj.201802535R. Epub 2019 Mar 6.

PMID:
30840833
3.

Acid Ceramidase: A Novel Therapeutic Target in Cancer.

Vijayan Y, Lankadasari MB, Harikumar KB.

Curr Top Med Chem. 2019;19(17):1512-1520. doi: 10.2174/1568026619666190227222930. Review.

PMID:
30827244
4.

Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine.

Lankadasari MB, Aparna JS, Mohammed S, James S, Aoki K, Binu VS, Nair S, Harikumar KB.

Theranostics. 2018 Jun 13;8(14):3824-3840. doi: 10.7150/thno.25308. eCollection 2018.

5.

Corrigendum: Sphingosine 1-Phosphate: A Novel Target for Lung Disorders.

Mohammed S, Harikumar KB.

Front Immunol. 2018 Jul 17;9:1628. doi: 10.3389/fimmu.2018.01628. eCollection 2018.

6.

The Origin and Functions of Exosomes in Cancer.

Rajagopal C, Harikumar KB.

Front Oncol. 2018 Mar 20;8:66. doi: 10.3389/fonc.2018.00066. eCollection 2018. Review.

7.

Enhanced expression of histone chaperone APLF associate with breast cancer.

Majumder A, Syed KM, Mukherjee A, Lankadasari MB, Azeez JM, Sreeja S, Harikumar KB, Pillai MR, Dutta D.

Mol Cancer. 2018 Mar 26;17(1):76. doi: 10.1186/s12943-018-0826-9.

8.

Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy.

Rajagopal C, Lankadasari MB, Aranjani JM, Harikumar KB.

Pharmacol Res. 2018 Apr;130:273-291. doi: 10.1016/j.phrs.2017.12.034. Epub 2018 Jan 4. Review.

PMID:
29305909
9.

Cardamonin inhibits colonic neoplasia through modulation of MicroRNA expression.

James S, Aparna JS, Paul AM, Lankadasari MB, Mohammed S, Binu VS, Santhoshkumar TR, Reshmi G, Harikumar KB.

Sci Rep. 2017 Oct 24;7(1):13945. doi: 10.1038/s41598-017-14253-8.

10.

Sphingosine 1-Phosphate: A Novel Target for Lung Disorders.

Mohammed S, Harikumar KB.

Front Immunol. 2017 Mar 14;8:296. doi: 10.3389/fimmu.2017.00296. eCollection 2017. Review. Erratum in: Front Immunol. 2018 Jul 17;9:1628.

11.

The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses.

Oskeritzian CA, Hait NC, Wedman P, Chumanevich A, Kolawole EM, Price MM, Falanga YT, Harikumar KB, Ryan JJ, Milstien S, Sabbadini R, Spiegel S.

J Allergy Clin Immunol. 2015 Apr;135(4):1008-18.e1. doi: 10.1016/j.jaci.2014.10.044. Epub 2014 Dec 13.

12.

K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.

Harikumar KB, Yester JW, Surace MJ, Oyeniran C, Price MM, Huang WC, Hait NC, Allegood JC, Yamada A, Kong X, Lazear HM, Bhardwaj R, Takabe K, Diamond MS, Luo C, Milstien S, Spiegel S, Kordula T.

Nat Immunol. 2014 Mar;15(3):231-8. doi: 10.1038/ni.2810. Epub 2014 Jan 26.

13.

Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

Liang J, Nagahashi M, Kim EY, Harikumar KB, Yamada A, Huang WC, Hait NC, Allegood JC, Price MM, Avni D, Takabe K, Kordula T, Milstien S, Spiegel S.

Cancer Cell. 2013 Jan 14;23(1):107-20. doi: 10.1016/j.ccr.2012.11.013. Epub 2012 Dec 27.

14.

A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.

Price MM, Oskeritzian CA, Falanga YT, Harikumar KB, Allegood JC, Alvarez SE, Conrad D, Ryan JJ, Milstien S, Spiegel S.

J Allergy Clin Immunol. 2013 Feb;131(2):501-11.e1. doi: 10.1016/j.jaci.2012.07.014. Epub 2012 Aug 30.

15.

Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics.

Van DN, Roberts CF, Marion JD, L├ępine S, Harikumar KB, Schreiter J, Dumur CI, Fang X, Spiegel S, Bell JK.

FASEB J. 2012 Aug;26(8):3188-98. doi: 10.1096/fj.11-202333. Epub 2012 Apr 24.

16.

Extracellular and intracellular sphingosine-1-phosphate in cancer.

Yester JW, Tizazu E, Harikumar KB, Kordula T.

Cancer Metastasis Rev. 2011 Dec;30(3-4):577-97. doi: 10.1007/s10555-011-9305-0. Review.

PMID:
22002715
17.

Sphingosine-1-phosphate signaling and its role in disease.

Maceyka M, Harikumar KB, Milstien S, Spiegel S.

Trends Cell Biol. 2012 Jan;22(1):50-60. doi: 10.1016/j.tcb.2011.09.003. Epub 2011 Oct 14. Review.

18.

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.

Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, Maceyka M, Jiang H, Luo C, Kordula T, Milstien S, Spiegel S.

Nature. 2010 Jun 24;465(7301):1084-8. doi: 10.1038/nature09128.

19.

Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products.

Harikumar KB, Sung B, Tharakan ST, Pandey MK, Joy B, Guha S, Krishnan S, Aggarwal BB.

Mol Cancer Res. 2010 May;8(5):751-61. doi: 10.1158/1541-7786.MCR-09-0565. Epub 2010 May 11.

20.

A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.

Harikumar KB, Kunnumakkara AB, Ochi N, Tong Z, Deorukhkar A, Sung B, Kelland L, Jamieson S, Sutherland R, Raynham T, Charles M, Bagherzadeh A, Foxton C, Boakes A, Farooq M, Maru D, Diagaradjane P, Matsuo Y, Sinnett-Smith J, Gelovani J, Krishnan S, Aggarwal BB, Rozengurt E, Ireson CR, Guha S.

Mol Cancer Ther. 2010 May;9(5):1136-46. doi: 10.1158/1535-7163.MCT-09-1145. Epub 2010 May 4. Erratum in: Mol Cancer Ther. 2010 Jul;9(7):2153. Bagherazadeh, Azadeh [corrected to Bagherzadeh, Azadeh].

21.

Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.

Takabe K, Kim RH, Allegood JC, Mitra P, Ramachandran S, Nagahashi M, Harikumar KB, Hait NC, Milstien S, Spiegel S.

J Biol Chem. 2010 Apr 2;285(14):10477-86. doi: 10.1074/jbc.M109.064162. Epub 2010 Jan 28.

22.

Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.

Harikumar KB, Sung B, Pandey MK, Guha S, Krishnan S, Aggarwal BB.

Mol Pharmacol. 2010 May;77(5):818-27. doi: 10.1124/mol.109.062760. Epub 2010 Jan 26.

23.

Inhibition of IkB kinase and NF-kappaB by a novel synthetic compound SK 2009.

Anchoori RK, Harikumar KB, Batchu VR, Aggarwal BB, Khan SR.

Bioorg Med Chem. 2010 Jan 1;18(1):229-35. doi: 10.1016/j.bmc.2009.10.065. Epub 2009 Nov 4.

24.

Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer.

Harikumar KB, Kunnumakkara AB, Sethi G, Diagaradjane P, Anand P, Pandey MK, Gelovani J, Krishnan S, Guha S, Aggarwal BB.

Int J Cancer. 2010 Jul 15;127(2):257-68. doi: 10.1002/ijc.25041. Erratum in: Int J Cancer. 2015 Dec 15;137(12):E21.

25.

Inhibition of viral carcinogenesis by Phyllanthus amarus.

Harikumar KB, Kuttan G, Kuttan R.

Integr Cancer Ther. 2009 Sep;8(3):254-60. doi: 10.1177/1534735409340162. Erratum in: Integr Cancer Ther. 2010 Mar;9(1):122.

PMID:
19815595
26.

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S.

Science. 2009 Sep 4;325(5945):1254-7. doi: 10.1126/science.1176709. Erratum in: Science. 2009 Oct 16;326(5951):366.

27.

Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.

Aggarwal BB, Kunnumakkara AB, Harikumar KB, Gupta SR, Tharakan ST, Koca C, Dey S, Sung B.

Ann N Y Acad Sci. 2009 Aug;1171:59-76. doi: 10.1111/j.1749-6632.2009.04911.x. Review.

28.

Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.

Kunnumakkara AB, Diagaradjane P, Anand P, Harikumar KB, Deorukhkar A, Gelovani J, Guha S, Krishnan S, Aggarwal BB.

Int J Cancer. 2009 Nov 1;125(9):2187-97. doi: 10.1002/ijc.24593. Erratum in: Int J Cancer. 2010 Feb 1;126(3):799. Kuzhuvelil, Harikumar B [corrected to Harikumar, Kuzhuvelil B].

29.

Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis.

Aggarwal BB, Van Kuiken ME, Iyer LH, Harikumar KB, Sung B.

Exp Biol Med (Maywood). 2009 Aug;234(8):825-49. doi: 10.3181/0902-MR-78. Epub 2009 Jun 2. Review.

30.
31.

Phyllanthus amarus inhibits cell growth and induces apoptosis in Dalton's lymphoma ascites cells through activation of caspase-3 and downregulation of Bcl-2.

Harikumar KB, Kuttan G, Kuttan R.

Integr Cancer Ther. 2009 Jun;8(2):190-4. doi: 10.1177/1534735408330713. Epub 2009 Feb 17.

PMID:
19223368
32.

The guggul for chronic diseases: ancient medicine, modern targets.

Shishodia S, Harikumar KB, Dass S, Ramawat KG, Aggarwal BB.

Anticancer Res. 2008 Nov-Dec;28(6A):3647-64. Review.

33.

Resveratrol addiction: to die or not to die.

Shakibaei M, Harikumar KB, Aggarwal BB.

Mol Nutr Food Res. 2009 Jan;53(1):115-28. doi: 10.1002/mnfr.200800148. Review.

PMID:
19072742
34.

Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis.

Anand P, Kunnumakkara AB, Harikumar KB, Ahn KS, Badmaev V, Aggarwal BB.

Cancer Res. 2008 Nov 1;68(21):8861-70. doi: 10.1158/0008-5472.CAN-08-1902. Retraction in: Cancer Res. 2018 Sep 1;78(17):5187.

35.

Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.

Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB.

Blood. 2009 Feb 26;113(9):2003-13. doi: 10.1182/blood-2008-04-151944. Epub 2008 Oct 24.

36.

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.

Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, Tharakan ST, Misra K, Priyadarsini IK, Rajasekharan KN, Aggarwal BB.

Biochem Pharmacol. 2008 Dec 1;76(11):1590-611. doi: 10.1016/j.bcp.2008.08.008. Epub 2008 Aug 19. Review.

PMID:
18775680
37.

Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer.

Tong Z, Kunnumakkara AB, Wang H, Matsuo Y, Diagaradjane P, Harikumar KB, Ramachandran V, Sung B, Chakraborty A, Bresalier RS, Logsdon C, Aggarwal BB, Krishnan S, Guha S.

Cancer Res. 2008 Aug 1;68(15):6100-8. doi: 10.1158/0008-5472.CAN-08-0540.

38.

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.

Aggarwal BB, Harikumar KB.

Int J Biochem Cell Biol. 2009 Jan;41(1):40-59. doi: 10.1016/j.biocel.2008.06.010. Epub 2008 Jul 9. Review.

39.

Cancer is a preventable disease that requires major lifestyle changes.

Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB.

Pharm Res. 2008 Sep;25(9):2097-116. doi: 10.1007/s11095-008-9661-9. Epub 2008 Jul 15. Review. Erratum in: Pharm Res. 2008 Sep;25(9):2200. Kunnumakara, Ajaikumar B [corrected to Kunnumakkara, Ajaikumar B].

40.

Potential of spice-derived phytochemicals for cancer prevention.

Aggarwal BB, Kunnumakkara AB, Harikumar KB, Tharakan ST, Sung B, Anand P.

Planta Med. 2008 Oct;74(13):1560-9. doi: 10.1055/s-2008-1074578. Epub 2008 Jul 8. Review.

PMID:
18612945
41.

Resveratrol: a multitargeted agent for age-associated chronic diseases.

Harikumar KB, Aggarwal BB.

Cell Cycle. 2008 Apr 15;7(8):1020-35. Epub 2008 Feb 15. Review.

PMID:
18414053
42.

Toxicity profile of lutein and lutein ester isolated from marigold flowers (Tagetes erecta).

Harikumar KB, Nimita CV, Preethi KC, Kuttan R, Shankaranarayana ML, Deshpande J.

Int J Toxicol. 2008 Jan-Feb;27(1):1-9. doi: 10.1080/10915810701876265.

PMID:
18293208
43.

An extract of Phyllanthus amarus protects mouse chromosomes and intestine from radiation induced damages.

Harikumar KB, Kuttan R.

J Radiat Res. 2007 Nov;48(6):469-76. Epub 2007 Sep 29.

44.

Proapoptotic and antitumor activities of the HMG-CoA reductase inhibitor, lovastatin, against Dalton's lymphoma ascites tumor in mice.

Ajith TA, Harikumar KB, Thasna H, Sabu MC, Babitha NV.

Clin Chim Acta. 2006 Apr;366(1-2):322-8. Epub 2005 Dec 27.

PMID:
16380106
45.

A preliminary assessment of the acute and subchronic toxicity profile of phase2: an alpha-amylase inhibitor.

Harikumar KB, Jesil AM, Sabu MC, Kuttan R.

Int J Toxicol. 2005 Mar-Apr;24(2):95-102.

PMID:
16036768

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