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Items: 19

1.

Mutation update on ACAT1 variants associated with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency.

Abdelkreem E, Harijan RK, Yamaguchi S, Wierenga RK, Fukao T.

Hum Mutat. 2019 Jul 3. doi: 10.1002/humu.23831. [Epub ahead of print]

PMID:
31268215
2.

Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase.

Harijan RK, Hoff O, Ducati RG, Firestone RS, Hirsch BM, Evans GB, Schramm VL, Tyler PC.

J Med Chem. 2019 Apr 11;62(7):3286-3296. doi: 10.1021/acs.jmedchem.8b01642. Epub 2019 Mar 28.

PMID:
30860833
3.

Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase.

Ducati RG, Harijan RK, Cameron SA, Tyler PC, Evans GB, Schramm VL.

ACS Chem Biol. 2018 Nov 16;13(11):3173-3183. doi: 10.1021/acschembio.8b00781. Epub 2018 Oct 19.

4.

Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels.

Harijan RK, Zoi I, Antoniou D, Schwartz SD, Schramm VL.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6209-E6216. doi: 10.1073/pnas.1805416115. Epub 2018 Jun 18.

5.

Genetic resistance to purine nucleoside phosphorylase inhibition in Plasmodium falciparum.

Ducati RG, Namanja-Magliano HA, Harijan RK, Fajardo JE, Fiser A, Daily JP, Schramm VL.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2114-2119. doi: 10.1073/pnas.1525670115. Epub 2018 Feb 12.

6.

Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase.

Harris LD, Harijan RK, Ducati RG, Evans GB, Hirsch BM, Schramm VL.

ACS Chem Biol. 2018 Jan 19;13(1):152-160. doi: 10.1021/acschembio.7b00601. Epub 2017 Dec 14.

7.

Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.

Namanja-Magliano HA, Evans GB, Harijan RK, Tyler PC, Schramm VL.

Biochemistry. 2017 Sep 26;56(38):5090-5098. doi: 10.1021/acs.biochem.7b00576. Epub 2017 Sep 7.

8.

Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase.

Harijan RK, Zoi I, Antoniou D, Schwartz SD, Schramm VL.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6456-6461. doi: 10.1073/pnas.1704786114. Epub 2017 Jun 5.

9.

Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1.

Harijan RK, Kiema TR, Syed SM, Qadir I, Mazet M, Bringaud F, Michels PAM, Wierenga RK.

Protein Eng Des Sel. 2017 Mar 1;30(3):225-233. doi: 10.1093/protein/gzw080.

PMID:
28062645
10.

The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism.

Harijan RK, Mazet M, Kiema TR, Bouyssou G, Alexson SE, Bergmann U, Moreau P, Michels PA, Bringaud F, Wierenga RK.

Proteins. 2016 Aug;84(8):1075-96. doi: 10.1002/prot.25054. Epub 2016 May 9.

PMID:
27093562
11.

Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatis.

Janardan N, Harijan RK, Kiema TR, Wierenga RK, Murthy MR.

Acta Crystallogr D Biol Crystallogr. 2015 Dec 1;71(Pt 12):2479-93. doi: 10.1107/S1399004715019331. Epub 2015 Nov 27.

PMID:
26627655
12.

The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities.

Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK.

Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3212-25. doi: 10.1107/S1399004714023827. Epub 2014 Nov 22.

PMID:
25478839
13.

Phylogenetic relationships and classification of thiolases and thiolase-like proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis.

Anbazhagan P, Harijan RK, Kiema TR, Janardan N, Murthy MR, Michels PA, Juffer AH, Wierenga RK.

Tuberculosis (Edinb). 2014 Jul;94(4):405-12. doi: 10.1016/j.tube.2014.03.003. Epub 2014 Apr 4.

PMID:
24825023
14.

Development of MLPA for human ACAT1 gene and identification of a heterozygous Alu-mediated deletion of exons 3 and 4 in a patient with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency.

Fukao T, Aoyama Y, Murase K, Hori T, Harijan RK, Wierenga RK, Boneh A, Kondo N.

Mol Genet Metab. 2013 Sep-Oct;110(1-2):184-7. doi: 10.1016/j.ymgme.2013.07.004. Epub 2013 Jul 14.

PMID:
23920042
15.

Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop.

Harijan RK, Kiema TR, Karjalainen MP, Janardan N, Murthy MR, Weiss MS, Michels PA, Wierenga RK.

Biochem J. 2013 Oct 1;455(1):119-30. doi: 10.1042/BJ20130669.

PMID:
23909465
16.

Crystal structure of a monomeric thiolase-like protein type 1 (TLP1) from Mycobacterium smegmatis.

Janardan N, Harijan RK, Wierenga RK, Murthy MR.

PLoS One. 2012;7(7):e41894. doi: 10.1371/journal.pone.0041894. Epub 2012 Jul 26.

17.

Structural and mutational studies on substrate specificity and catalysis of Salmonella typhimurium D-cysteine desulfhydrase.

Bharath SR, Bisht S, Harijan RK, Savithri HS, Murthy MR.

PLoS One. 2012;7(5):e36267. doi: 10.1371/journal.pone.0036267. Epub 2012 May 4.

18.

The characterization and evolutionary relationships of a trypanosomal thiolase.

Mazet M, Harijan RK, Kiema TR, Haapalainen AM, Morand P, Morales J, Bringaud F, Wierenga RK, Michels PA.

Int J Parasitol. 2011 Oct;41(12):1273-83. doi: 10.1016/j.ijpara.2011.07.009. Epub 2011 Aug 26.

PMID:
21907205
19.

Cloning, expression, purification and preliminary X-ray diffraction studies of a putative Mycobacterium smegmatis thiolase.

Janardan N, Paul A, Harijan RK, Wierenga RK, Murthy MR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):817-20. doi: 10.1107/S1744309111019324. Epub 2011 Jun 30.

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