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Items: 1 to 50 of 74

1.

Harnessing epithelial homeostatic mechanisms to fight cancer.

Lahvic JL, Hariharan IK.

Mol Biol Cell. 2019 Jul 1;30(14):1641-1644. doi: 10.1091/mbc.E19-03-0177.

PMID:
31246542
2.

The BMP2/4 ortholog Dpp can function as an inter-organ signal that regulates developmental timing.

Setiawan L, Pan X, Woods AL, O'Connor MB, Hariharan IK.

Life Sci Alliance. 2018 Nov 19;1(6):e201800216. doi: 10.26508/lsa.201800216. eCollection 2018 Dec.

3.

CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs.

Worley MI, Alexander LA, Hariharan IK.

Elife. 2018 Jan 26;7. pii: e30391. doi: 10.7554/eLife.30391.

4.

Ras Brakes for Hippo.

Sumabat TM, Hariharan IK.

Dev Cell. 2017 Sep 25;42(6):561-562. doi: 10.1016/j.devcel.2017.09.009.

5.

Imaginal disc regeneration takes flight.

Hariharan IK, Serras F.

Curr Opin Cell Biol. 2017 Oct;48:10-16. doi: 10.1016/j.ceb.2017.03.005. Epub 2017 Apr 1. Review.

6.

Size regulation blossoms in Kobe.

Hariharan IK.

Development. 2016 Aug 1;143(15):2691-5. doi: 10.1242/dev.137240. Review.

7.

Plexins function in epithelial repair in both Drosophila and zebrafish.

Yoo SK, Pascoe HG, Pereira T, Kondo S, Jacinto A, Zhang X, Hariharan IK.

Nat Commun. 2016 Jul 25;7:12282. doi: 10.1038/ncomms12282.

8.

Persistence of RNAi-Mediated Knockdown in Drosophila Complicates Mosaic Analysis Yet Enables Highly Sensitive Lineage Tracing.

Bosch JA, Sumabat TM, Hariharan IK.

Genetics. 2016 May;203(1):109-18. doi: 10.1534/genetics.116.187062. Epub 2016 Mar 16.

9.

Localized epigenetic silencing of a damage-activated WNT enhancer limits regeneration in mature Drosophila imaginal discs.

Harris RE, Setiawan L, Saul J, Hariharan IK.

Elife. 2016 Feb 3;5. pii: e11588. doi: 10.7554/eLife.11588.

10.

Organ Size Control: Lessons from Drosophila.

Hariharan IK.

Dev Cell. 2015 Aug 10;34(3):255-65. doi: 10.1016/j.devcel.2015.07.012. Review.

11.

Indeterminate Growth: Could It Represent the Ancestral Condition?

Hariharan IK, Wake DB, Wake MH.

Cold Spring Harb Perspect Biol. 2015 Jul 27;8(2):a019174. doi: 10.1101/cshperspect.a019174. Review.

12.

Energy stress tames the Hippo pathway.

Hariharan IK.

Nat Cell Biol. 2015 Apr;17(4):362-3. doi: 10.1038/ncb3141.

PMID:
25812520
13.

CoinFLP: a system for efficient mosaic screening and for visualizing clonal boundaries in Drosophila.

Bosch JA, Tran NH, Hariharan IK.

Development. 2015 Feb 1;142(3):597-606. doi: 10.1242/dev.114603.

14.

The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling.

Bosch JA, Sumabat TM, Hafezi Y, Pellock BJ, Gandhi KD, Hariharan IK.

Elife. 2014 Aug 8;3:e03383. doi: 10.7554/eLife.03383.

15.

TIE-DYE: a combinatorial marking system to visualize and genetically manipulate clones during development in Drosophila melanogaster.

Worley MI, Setiawan L, Hariharan IK.

Development. 2013 Aug;140(15):3275-84. doi: 10.1242/dev.096057. Epub 2013 Jun 19.

16.

The Drosophila ortholog of MLL3 and MLL4, trithorax related, functions as a negative regulator of tissue growth.

Kanda H, Nguyen A, Chen L, Okano H, Hariharan IK.

Mol Cell Biol. 2013 May;33(9):1702-10. doi: 10.1128/MCB.01585-12. Epub 2013 Mar 4.

17.

Regeneration and transdetermination in Drosophila imaginal discs.

Worley MI, Setiawan L, Hariharan IK.

Annu Rev Genet. 2012;46:289-310. doi: 10.1146/annurev-genet-110711-155637. Epub 2012 Aug 29. Review.

PMID:
22934642
18.

The hippo pathway.

Harvey KF, Hariharan IK.

Cold Spring Harb Perspect Biol. 2012 Aug 1;4(8):a011288. doi: 10.1101/cshperspect.a011288. Review. No abstract available.

19.

How growth abnormalities delay "puberty" in Drosophila.

Hariharan IK.

Sci Signal. 2012 Jun 19;5(229):pe27. doi: 10.1126/scisignal.2003238.

PMID:
22715466
20.

Differences in levels of the transmembrane protein Crumbs can influence cell survival at clonal boundaries.

Hafezi Y, Bosch JA, Hariharan IK.

Dev Biol. 2012 Aug 15;368(2):358-69. doi: 10.1016/j.ydbio.2012.06.001. Epub 2012 Jun 7.

21.

Identification and characterization of genes required for compensatory growth in Drosophila.

Gerhold AR, Richter DJ, Yu AS, Hariharan IK.

Genetics. 2011 Dec;189(4):1309-26. doi: 10.1534/genetics.111.132993. Epub 2011 Sep 16.

22.

A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability.

Reis T, Van Gilst MR, Hariharan IK.

PLoS Genet. 2010 Nov 11;6(11):e1001206. doi: 10.1371/journal.pgen.1001206.

23.

Inactivation of both Foxo and reaper promotes long-term adult neurogenesis in Drosophila.

Siegrist SE, Haque NS, Chen CH, Hay BA, Hariharan IK.

Curr Biol. 2010 Apr 13;20(7):643-8. doi: 10.1016/j.cub.2010.01.060. Epub 2010 Mar 25.

24.

The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila.

Herz HM, Madden LD, Chen Z, Bolduc C, Buff E, Gupta R, Davuluri R, Shilatifard A, Hariharan IK, Bergmann A.

Mol Cell Biol. 2010 May;30(10):2485-97. doi: 10.1128/MCB.01633-09. Epub 2010 Mar 8.

25.

Retinoids regulate a developmental checkpoint for tissue regeneration in Drosophila.

Halme A, Cheng M, Hariharan IK.

Curr Biol. 2010 Mar 9;20(5):458-63. doi: 10.1016/j.cub.2010.01.038.

26.

Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc.

Smith-Bolton RK, Worley MI, Kanda H, Hariharan IK.

Dev Cell. 2009 Jun;16(6):797-809. doi: 10.1016/j.devcel.2009.04.015.

27.

Mutation of the gene encoding the ubiquitin activating enzyme ubal causes tissue overgrowth in Drosophila.

Pfleger CM, Harvey KF, Yan H, Hariharan IK.

Fly (Austin). 2007 Mar-Apr;1(2):95-105.

PMID:
18820468
28.

FOXO-regulated transcription restricts overgrowth of Tsc mutant organs.

Harvey KF, Mattila J, Sofer A, Bennett FC, Ramsey MR, Ellisen LW, Puig O, Hariharan IK.

J Cell Biol. 2008 Feb 25;180(4):691-6. doi: 10.1083/jcb.200710100.

29.

Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/ras signaling pathway.

Tseng AS, Tapon N, Kanda H, Cigizoglu S, Edelmann L, Pellock B, White K, Hariharan IK.

Curr Biol. 2007 Apr 17;17(8):728-33. Epub 2007 Mar 29.

30.

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling.

Pellock BJ, Buff E, White K, Hariharan IK.

Dev Biol. 2007 Apr 1;304(1):102-15. Epub 2006 Dec 15.

31.

Growth regulation: a beginning for the hippo pathway.

Hariharan IK.

Curr Biol. 2006 Dec 19;16(24):R1037-9.

32.

Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.

Walker JA, Tchoudakova AV, McKenney PT, Brill S, Wu D, Cowley GS, Hariharan IK, Bernards A.

Genes Dev. 2006 Dec 1;20(23):3311-23. Epub 2006 Nov 17.

33.

Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila.

Hariharan IK, Bilder D.

Annu Rev Genet. 2006;40:335-61. Review.

PMID:
16872256
34.

The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death.

Mills K, Daish T, Harvey KF, Pfleger CM, Hariharan IK, Kumar S.

J Cell Biol. 2006 Mar 13;172(6):809-15.

35.
36.
37.

Melting fat away in flies.

Reis T, Hariharan IK.

Cell Metab. 2005 Aug;2(2):82-4.

38.

Infrequent mutations of Archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer.

Kwak EL, Moberg KH, Wahrer DC, Quinn JE, Gilmore PM, Graham CA, Hariharan IK, Harkin DP, Haber DA, Bell DW.

Gynecol Oncol. 2005 Jul;98(1):124-8.

PMID:
15913747
39.

Ras and Rap: are former enemies now friends?

Hariharan IK.

Dev Cell. 2005 Mar;8(3):303-4.

40.

The Drosophila F box protein archipelago regulates dMyc protein levels in vivo.

Moberg KH, Mukherjee A, Veraksa A, Artavanis-Tsakonas S, Hariharan IK.

Curr Biol. 2004 Jun 8;14(11):965-74.

41.

Big things from a little RNA.

Moberg KH, Hariharan IK.

Trends Cell Biol. 2003 Sep;13(9):455-7. Review.

PMID:
12946623
42.
43.

Yeast, flies, worms, and fish in the study of human disease.

Hariharan IK, Haber DA.

N Engl J Med. 2003 Jun 12;348(24):2457-63. Review. No abstract available.

PMID:
12802034
45.

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.

Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber D, Hariharan IK.

Cell. 2002 Aug 23;110(4):467-78.

46.

Regulation of growth and cell proliferation during eye development.

Neufeld TP, Hariharan IK.

Results Probl Cell Differ. 2002;37:107-33. Review. No abstract available.

PMID:
25707072
47.

The coupling of cell growth to the cell cycle.

Tapon N, Moberg KH, Hariharan IK.

Curr Opin Cell Biol. 2001 Dec;13(6):731-7. Review.

PMID:
11698190
48.

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines.

Moberg KH, Bell DW, Wahrer DC, Haber DA, Hariharan IK.

Nature. 2001 Sep 20;413(6853):311-6.

PMID:
11565033
49.

Of flies and men--studying human disease in Drosophila.

Bernards A, Hariharan IK.

Curr Opin Genet Dev. 2001 Jun;11(3):274-8. Review.

PMID:
11377963
50.

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

Tapon N, Ito N, Dickson BJ, Treisman JE, Hariharan IK.

Cell. 2001 May 4;105(3):345-55.

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