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Items: 15


DNA damage repair defects as a new class of endocrine treatment resistance driver.

Anurag M, Ellis MJ, Haricharan S.

Oncotarget. 2018 Nov 20;9(91):36252-36253. doi: 10.18632/oncotarget.26363. eCollection 2018 Nov 20. No abstract available.


Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer.

Lei JT, Shao J, Zhang J, Iglesia M, Chan DW, Cao J, Anurag M, Singh P, He X, Kosaka Y, Matsunuma R, Crowder R, Hoog J, Phommaly C, Goncalves R, Ramalho S, Peres RMR, Punturi N, Schmidt C, Bartram A, Jou E, Devarakonda V, Holloway KR, Lai WV, Hampton O, Rogers A, Tobias E, Parikh PA, Davies SR, Li S, Ma CX, Suman VJ, Hunt KK, Watson MA, Hoadley KA, Thompson EA, Chen X, Kavuri SM, Creighton CJ, Maher CA, Perou CM, Haricharan S, Ellis MJ.

Cell Rep. 2018 Aug 7;24(6):1434-1444.e7. doi: 10.1016/j.celrep.2018.07.009.


Comprehensive Profiling of DNA Repair Defects in Breast Cancer Identifies a Novel Class of Endocrine Therapy Resistance Drivers.

Anurag M, Punturi N, Hoog J, Bainbridge MN, Ellis MJ, Haricharan S.

Clin Cancer Res. 2018 Oct 1;24(19):4887-4899. doi: 10.1158/1078-0432.CCR-17-3702. Epub 2018 May 23.


Defects in mismatch repair: the Achilles heel of estrogen receptor positive breast cancer with intrinsic endocrine therapy resistance?

Haricharan S, Ellis MJ.

Oncoscience. 2017 Sep 21;4(7-8):77-78. doi: 10.18632/oncoscience.363. eCollection 2017 Jul. No abstract available.


Loss of MutL Disrupts CHK2-Dependent Cell-Cycle Control through CDK4/6 to Promote Intrinsic Endocrine Therapy Resistance in Primary Breast Cancer.

Haricharan S, Punturi N, Singh P, Holloway KR, Anurag M, Schmelz J, Schmidt C, Lei JT, Suman V, Hunt K, Olson JA Jr, Hoog J, Li S, Huang S, Edwards DP, Kavuri SM, Bainbridge MN, Ma CX, Ellis MJ.

Cancer Discov. 2017 Oct;7(10):1168-1183. doi: 10.1158/2159-8290.CD-16-1179. Epub 2017 Aug 11.


Mammary Ductal Environment Is Necessary for Faithful Maintenance of Estrogen Signaling in ER⁺ Breast Cancer.

Haricharan S, Lei J, Ellis M.

Cancer Cell. 2016 Mar 14;29(3):249-250. doi: 10.1016/j.ccell.2016.02.017.


Luminal epithelial cells within the mammary gland can produce basal cells upon oncogenic stress.

Hein SM, Haricharan S, Johnston AN, Toneff MJ, Reddy JP, Dong J, Bu W, Li Y.

Oncogene. 2016 Mar 17;35(11):1461-7. doi: 10.1038/onc.2015.206. Epub 2015 Jun 22.


TLR4 has a TP53-dependent dual role in regulating breast cancer cell growth.

Haricharan S, Brown P.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):E3216-25. doi: 10.1073/pnas.1420811112. Epub 2015 Jun 10.


Somatic mutation load of estrogen receptor-positive breast tumors predicts overall survival: an analysis of genome sequence data.

Haricharan S, Bainbridge MN, Scheet P, Brown PH.

Breast Cancer Res Treat. 2014 Jul;146(1):211-20. doi: 10.1007/s10549-014-2991-x. Epub 2014 May 18.


Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy.

Haricharan S, Dong J, Hein S, Reddy JP, Du Z, Toneff M, Holloway K, Hilsenbeck SG, Huang S, Atkinson R, Woodward W, Jindal S, Borges VF, Gutierrez C, Zhang H, Schedin PJ, Osborne CK, Tweardy DJ, Li Y.

Elife. 2013 Dec 31;2:e00996. doi: 10.7554/eLife.00996.


Contribution of an alveolar cell of origin to the high-grade malignant phenotype of pregnancy-associated breast cancer.

Haricharan S, Hein SM, Dong J, Toneff MJ, Aina OH, Rao PH, Cardiff RD, Li Y.

Oncogene. 2014 Dec 11;33(50):5729-39. doi: 10.1038/onc.2013.521. Epub 2013 Dec 9.


STAT signaling in mammary gland differentiation, cell survival and tumorigenesis.

Haricharan S, Li Y.

Mol Cell Endocrinol. 2014 Jan 25;382(1):560-569. doi: 10.1016/j.mce.2013.03.014. Epub 2013 Mar 28. Review.


Ku must load directly onto the chromosome end in order to mediate its telomeric functions.

Lopez CR, Ribes-Zamora A, Indiviglio SM, Williams CL, Haricharan S, Bertuch AA.

PLoS Genet. 2011 Aug;7(8):e1002233. doi: 10.1371/journal.pgen.1002233. Epub 2011 Aug 11.


Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation.

Reddy JP, Peddibhotla S, Bu W, Zhao J, Haricharan S, Du YC, Podsypanina K, Rosen JM, Donehower LA, Li Y.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3728-33. doi: 10.1073/pnas.0910665107. Epub 2010 Feb 3.


Segregating YKU80 and TLC1 alleles underlying natural variation in telomere properties in wild yeast.

Liti G, Haricharan S, Cubillos FA, Tierney AL, Sharp S, Bertuch AA, Parts L, Bailes E, Louis EJ.

PLoS Genet. 2009 Sep;5(9):e1000659. doi: 10.1371/journal.pgen.1000659. Epub 2009 Sep 18.

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