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Items: 1 to 50 of 75

1.

MEF-2 isoforms' (A-D) roles in development and tumorigenesis.

Madugula K, Mulherkar R, Khan ZK, Chigbu DI, Patel D, Harhaj EW, Jain P.

Oncotarget. 2019 Apr 12;10(28):2755-2787. doi: 10.18632/oncotarget.26763. eCollection 2019 Apr 12. Review.

2.

Peroxisomes support human herpesvirus 8 latency by stabilizing the viral oncogenic protein vFLIP via the MAVS-TRAF complex.

Choi YB, Choi Y, Harhaj EW.

PLoS Pathog. 2018 May 10;14(5):e1007058. doi: 10.1371/journal.ppat.1007058. eCollection 2018 May.

3.

NF-κB signaling mechanisms in HTLV-1-induced adult T-cell leukemia/lymphoma.

Harhaj EW, Giam CZ.

FEBS J. 2018 Sep;285(18):3324-3336. doi: 10.1111/febs.14492. Epub 2018 May 14. Review.

4.

Regnase-1, a rapid response ribonuclease regulating inflammation and stress responses.

Mao R, Yang R, Chen X, Harhaj EW, Wang X, Fan Y.

Cell Mol Immunol. 2017 May;14(5):412-422. doi: 10.1038/cmi.2016.70. Epub 2017 Feb 13. Review.

5.

TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS.

Choi YB, Shembade N, Parvatiyar K, Balachandran S, Harhaj EW.

Mol Cell Biol. 2016 Dec 19;37(1). pii: e00422-16. doi: 10.1128/MCB.00422-16. Print 2017 Jan 1.

6.

Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity.

Han KJ, Foster D, Harhaj EW, Dzieciatkowska M, Hansen K, Liu CW.

Hum Mol Genet. 2016 Apr 1;25(7):1392-405. doi: 10.1093/hmg/ddw021. Epub 2016 Jan 28.

7.

SHARPINing the knowledge of TCR signal control.

Bowman M, Pan F, Harhaj EW.

Nat Immunol. 2016 Mar;17(3):221-2. doi: 10.1038/ni.3387. No abstract available.

PMID:
26882251
8.

Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon.

Zhou Q, Lavorgna A, Bowman M, Hiscott J, Harhaj EW.

J Biol Chem. 2015 Jun 5;290(23):14729-39. doi: 10.1074/jbc.M114.633065. Epub 2015 Apr 24.

9.

Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB.

Jain P, Lavorgna A, Sehgal M, Gao L, Ginwala R, Sagar D, Harhaj EW, Khan ZK.

Retrovirology. 2015 Feb 27;12:23. doi: 10.1186/s12977-015-0140-1.

10.

Elucidating dynamic protein-protein interactions and ubiquitination in NF-κB signaling pathways.

Shembade N, Harhaj EW.

Methods Mol Biol. 2015;1280:283-95. doi: 10.1007/978-1-4939-2422-6_16.

PMID:
25736755
11.

Oncogenic human T-cell lymphotropic virus type 1 tax suppression of primary innate immune signaling pathways.

Hyun J, Ramos JC, Toomey N, Balachandran S, Lavorgna A, Harhaj E, Barber GN.

J Virol. 2015 May;89(9):4880-93. doi: 10.1128/JVI.02493-14. Epub 2015 Feb 18.

12.
13.

Regulation of HTLV-1 tax stability, cellular trafficking and NF-κB activation by the ubiquitin-proteasome pathway.

Lavorgna A, Harhaj EW.

Viruses. 2014 Oct 23;6(10):3925-43. doi: 10.3390/v6103925. Review.

14.

HTLV-1 tax stabilizes MCL-1 via TRAF6-dependent K63-linked polyubiquitination to promote cell survival and transformation.

Choi YB, Harhaj EW.

PLoS Pathog. 2014 Oct 23;10(10):e1004458. doi: 10.1371/journal.ppat.1004458. eCollection 2014 Oct.

15.

A critical role for IL-17RB signaling in HTLV-1 tax-induced NF-κB activation and T-cell transformation.

Lavorgna A, Matsuoka M, Harhaj EW.

PLoS Pathog. 2014 Oct 23;10(10):e1004418. doi: 10.1371/journal.ppat.1004418. eCollection 2014 Oct.

16.
17.
18.

RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling.

Charoenthongtrakul S, Gao L, Parvatiyar K, Lee D, Harhaj EW.

PLoS One. 2013;8(1):e53717. doi: 10.1371/journal.pone.0053717. Epub 2013 Jan 7.

19.

The NLRP4-DTX4 axis: a key suppressor of TBK1 and innate antiviral signaling.

Charoenthongtrakul S, Gao L, Harhaj EW.

Cell Mol Immunol. 2012 Nov;9(6):431-3. doi: 10.1038/cmi.2012.49. Epub 2012 Oct 15. No abstract available.

20.

Regulation of NF-κB by deubiquitinases.

Harhaj EW, Dixit VM.

Immunol Rev. 2012 Mar;246(1):107-24. doi: 10.1111/j.1600-065X.2012.01100.x. Review.

21.

Regulation of NF-κB signaling by the A20 deubiquitinase.

Shembade N, Harhaj EW.

Cell Mol Immunol. 2012 Mar;9(2):123-30. doi: 10.1038/cmi.2011.59. Epub 2012 Feb 20. Review.

22.

EBV LMP1: New and shared pathways to NF-κB activation.

Lavorgna A, Harhaj EW.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2188-9. doi: 10.1073/pnas.1121357109. Epub 2012 Feb 2. No abstract available.

23.

An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation.

Lavorgna A, Harhaj EW.

J Virol. 2012 Mar;86(6):3357-69. doi: 10.1128/JVI.06456-11. Epub 2012 Jan 18. Erratum in: J Virol. 2012 May;86(9):5409.

24.
25.

IKKi: a novel regulator of Act1, IL-17 signaling and pulmonary inflammation.

Shembade N, Harhaj EW.

Cell Mol Immunol. 2011 Nov;8(6):447-9. doi: 10.1038/cmi.2011.44. Epub 2011 Sep 19. No abstract available.

26.

ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.

Gao L, Coope H, Grant S, Ma A, Ley SC, Harhaj EW.

J Biol Chem. 2011 Oct 21;286(42):36592-602. doi: 10.1074/jbc.M111.283762. Epub 2011 Sep 1.

27.

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.

Shembade N, Pujari R, Harhaj NS, Abbott DW, Harhaj EW.

Nat Immunol. 2011 Jul 17;12(9):834-43. doi: 10.1038/ni.2066.

28.

Human T cell leukemia virus type 1 Tax inhibits innate antiviral signaling via NF-kappaB-dependent induction of SOCS1.

Charoenthongtrakul S, Zhou Q, Shembade N, Harhaj NS, Harhaj EW.

J Virol. 2011 Jul;85(14):6955-62. doi: 10.1128/JVI.00007-11. Epub 2011 May 18.

29.

Deubiquitinases in the regulation of NF-κB signaling.

Harhaj EW, Dixit VM.

Cell Res. 2011 Jan;21(1):22-39. doi: 10.1038/cr.2010.166. Epub 2010 Nov 30. Review.

30.

Regulation of inflammatory and antiviral signaling by A20.

Parvatiyar K, Harhaj EW.

Microbes Infect. 2011 Mar;13(3):209-15. doi: 10.1016/j.micinf.2010.11.003. Epub 2010 Nov 25. Review.

31.

A20 inhibition of NFκB and inflammation: targeting E2:E3 ubiquitin enzyme complexes.

Shembade N, Harhaj E.

Cell Cycle. 2010 Jul 1;9(13):2481-2. No abstract available.

32.

Cell signaling. Anchors away for ubiquitin chains.

Parvatiyar K, Harhaj EW.

Science. 2010 Jun 4;328(5983):1244-5. doi: 10.1126/science.1192296. No abstract available.

33.

TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases.

Parvatiyar K, Barber GN, Harhaj EW.

J Biol Chem. 2010 May 14;285(20):14999-5009. doi: 10.1074/jbc.M110.109819. Epub 2010 Mar 19.

34.

Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes.

Shembade N, Ma A, Harhaj EW.

Science. 2010 Feb 26;327(5969):1135-9. doi: 10.1126/science.1182364.

35.

Role of the proteasome in the downregulation of transcription factors NFkappaB and C/EBP in macrophages from tumor hosts.

Perry G, Iragavarapu-Charyulu V, Harhaj EW, Torroella-Kouri M.

Oncol Rep. 2010 Mar;23(3):875-81.

PMID:
20127032
36.

Role of post-translational modifications of HTLV-1 Tax in NF-κB activation.

Shembade N, Harhaj EW.

World J Biol Chem. 2010 Jan 26;1(1):13-20. doi: 10.4331/wjbc.v1.i1.13.

37.

ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.

Tao M, Scacheri PC, Marinis JM, Harhaj EW, Matesic LE, Abbott DW.

Curr Biol. 2009 Aug 11;19(15):1255-63. doi: 10.1016/j.cub.2009.06.038. Epub 2009 Jul 9.

38.

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.

Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW.

EMBO J. 2009 Mar 4;28(5):513-22. doi: 10.1038/emboj.2008.285. Epub 2009 Jan 8.

39.

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20.

Shembade N, Harhaj NS, Parvatiyar K, Copeland NG, Jenkins NA, Matesic LE, Harhaj EW.

Nat Immunol. 2008 Mar;9(3):254-62. doi: 10.1038/ni1563. Epub 2008 Feb 3.

PMID:
18246070
40.

The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.

Shembade N, Harhaj NS, Yamamoto M, Akira S, Harhaj EW.

J Virol. 2007 Dec;81(24):13735-42. Epub 2007 Oct 17.

41.

Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.

Shembade N, Harhaj NS, Liebl DJ, Harhaj EW.

EMBO J. 2007 Sep 5;26(17):3910-22. Epub 2007 Aug 16.

42.

Deregulated expression of CD40 ligand in HTLV-I infection: distinct mechanisms of downregulation in HTLV-I-transformed cell lines and ATL patients.

Harhaj NS, Janic B, Ramos JC, Harrington WJ Jr, Harhaj EW.

Virology. 2007 May 25;362(1):99-108. Epub 2007 Jan 26.

43.
44.

IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma.

Ramos JC, Ruiz P Jr, Ratner L, Reis IM, Brites C, Pedroso C, Byrne GE Jr, Toomey NL, Andela V, Harhaj EW, Lossos IS, Harrington WJ Jr.

Blood. 2007 Apr 1;109(7):3060-8.

45.

Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse.

Kamanaka M, Kim ST, Wan YY, Sutterwala FS, Lara-Tejero M, Galán JE, Harhaj E, Flavell RA.

Immunity. 2006 Dec;25(6):941-52. Epub 2006 Nov 30.

46.

Regulation of human T-cell leukemia virus type 1 gene expression by Sp1 and Sp3 interaction with TRE-1 repeat III.

Yao J, Grant C, Harhaj E, Nonnemacher M, Alefantis T, Martin J, Jain P, Wigdahl B.

DNA Cell Biol. 2006 May;25(5):262-76.

PMID:
16716116
47.

Mechanisms of persistent NF-kappaB activation by HTLV-I tax.

Harhaj EW, Harhaj NS.

IUBMB Life. 2005 Feb;57(2):83-91. Review.

48.

Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway.

Harhaj EW, Harhaj NS, Grant C, Mostoller K, Alefantis T, Sun SC, Wigdahl B.

Virology. 2005 Mar 1;333(1):145-58.

49.

Secretion of the human T cell leukemia virus type I transactivator protein tax.

Alefantis T, Mostoller K, Jain P, Harhaj E, Grant C, Wigdahl B.

J Biol Chem. 2005 Apr 29;280(17):17353-62. Epub 2005 Jan 19.

50.

Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.

Liao G, Zhang M, Harhaj EW, Sun SC.

J Biol Chem. 2004 Jun 18;279(25):26243-50. Epub 2004 Apr 14.

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