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Items: 1 to 50 of 285

1.

Enhancing Choice and Outcomes for Therapeutic Trials in Chronic Pain: N-of-1 + Imaging (+ i).

Borsook D, Upadhyay J, Hargreaves R, Wager T.

Trends Pharmacol Sci. 2020 Feb;41(2):85-98. doi: 10.1016/j.tips.2019.12.001. Epub 2020 Jan 9. Review.

PMID:
31928747
2.

Losing weight requires less calories.

Hargreaves R.

Vet Rec. 2020 Jan 4;186(1):32. doi: 10.1136/vr.m25. No abstract available.

PMID:
31919259
3.

'We shouldn't classify pet obesity as a disease'.

Hargreaves R.

Vet Rec. 2019 Nov 30;185(21):667. doi: 10.1136/vr.l6737.

PMID:
31780515
4.

Calcitonin Gene-Related Peptide Modulators - The History and Renaissance of a New Migraine Drug Class.

Hargreaves R, Olesen J.

Headache. 2019 Jun;59(6):951-970. doi: 10.1111/head.13510. Epub 2019 Apr 25.

PMID:
31020659
5.

Comparing Anti-Factor Xa and Activated Partial Thromboplastin Levels for Monitoring Unfractionated Heparin.

Wahking RA, Hargreaves RH, Lockwood SM, Haskell SK, Davis KW.

Ann Pharmacother. 2019 Aug;53(8):801-805. doi: 10.1177/1060028019835202. Epub 2019 Feb 27.

PMID:
30813751
6.

Visualizing Kinetically Robust CoIII4L6 Assemblies in Vivo: SPECT Imaging of the Encapsulated [99mTc]TcO4- Anion.

Burke BP, Grantham W, Burke MJ, Nichol GS, Roberts D, Renard I, Hargreaves R, Cawthorne C, Archibald SJ, Lusby PJ.

J Am Chem Soc. 2018 Dec 12;140(49):16877-16881. doi: 10.1021/jacs.8b09582. Epub 2018 Dec 3.

PMID:
30485075
7.

Amyloid beta-positive subjects exhibit longitudinal network-specific reductions in spontaneous brain activity.

Avants BB, Hutchison RM, Mikulskis A, Salinas-Valenzuela C, Hargreaves R, Beaver J, Chiao P; Alzheimer's Disease Neuroimaging Initiative.

Neurobiol Aging. 2019 Feb;74:191-201. doi: 10.1016/j.neurobiolaging.2018.10.002. Epub 2018 Oct 11.

PMID:
30471630
8.

From LBR-101 to Fremanezumab for Migraine.

Bigal ME, Rapoport AM, Silberstein SD, Walter S, Hargreaves RJ, Aycardi E.

CNS Drugs. 2018 Nov;32(11):1025-1037. doi: 10.1007/s40263-018-0579-4. Review.

PMID:
30311143
9.

Brain neurokinin-1 receptor availability in never-medicated patients with major depression - A pilot study.

Nyman M, Eskola O, Kajander J, Jokinen R, Penttinen J, Karjalainen T, Nummenmaa L, Hirvonen J, Burns D, Hargreaves R, Solin O, Hietala J.

J Affect Disord. 2019 Jan 1;242:188-194. doi: 10.1016/j.jad.2018.08.084. Epub 2018 Aug 25.

PMID:
30193189
10.

Could rabies be imported into the UK through rescued street dogs?

Hargreaves R.

Vet Rec. 2017 Nov;181(18):485. doi: 10.1136/vr.j5043. No abstract available.

PMID:
29097573
11.

A critical evaluation of validity and utility of translational imaging in pain and analgesia: Utilizing functional imaging to enhance the process.

Upadhyay J, Geber C, Hargreaves R, Birklein F, Borsook D.

Neurosci Biobehav Rev. 2018 Jan;84:407-423. doi: 10.1016/j.neubiorev.2017.08.004. Epub 2017 Aug 12. Review.

12.

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice.

Hastings NB, Wang X, Song L, Butts BD, Grotz D, Hargreaves R, Fred Hess J, Hong KK, Huang CR, Hyde L, Laverty M, Lee J, Levitan D, Lu SX, Maguire M, Mahadomrongkul V, McEachern EJ, Ouyang X, Rosahl TW, Selnick H, Stanton M, Terracina G, Vocadlo DJ, Wang G, Duffy JL, Parker EM, Zhang L.

Mol Neurodegener. 2017 May 18;12(1):39. doi: 10.1186/s13024-017-0181-0.

13.

Sentencing for animal cruelty.

Hargreaves R.

Vet Rec. 2017 Mar 11;180(10):256. doi: 10.1136/vr.j1171. No abstract available.

PMID:
28283635
14.

Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys.

Tannenbaum PL, Tye SJ, Stevens J, Gotter AL, Fox SV, Savitz AT, Coleman PJ, Uslaner JM, Kuduk SD, Hargreaves R, Winrow CJ, Renger JJ.

Sleep. 2016 Mar 1;39(3):603-12. doi: 10.5665/sleep.5536.

15.

An expert generalist.

Hargreaves R.

Vet Rec. 2016 Jan 30;178(5):i-ii. doi: 10.1136/vr.i503. No abstract available.

PMID:
26823324
16.

Challenges in developing drugs for primary headaches.

Schytz HW, Hargreaves R, Ashina M.

Prog Neurobiol. 2017 May;152:70-88. doi: 10.1016/j.pneurobio.2015.12.005. Epub 2016 Jan 2. Review.

PMID:
26751129
17.

"The value of Schwartz Rounds should not be underestimated".

Hargreaves R.

Nurs Times. 2015 Apr 1-7;111(14):11. No abstract available.

PMID:
26182583
18.

Test-retest reliability of evoked heat stimulation BOLD fMRI.

Upadhyay J, Lemme J, Anderson J, Bleakman D, Large T, Evelhoch JL, Hargreaves R, Borsook D, Becerra L.

J Neurosci Methods. 2015 Sep 30;253:38-46. doi: 10.1016/j.jneumeth.2015.06.001. Epub 2015 Jun 10.

PMID:
26072245
19.

Optimizing Central Nervous System Drug Development Using Molecular Imaging.

Hargreaves RJ, Hoppin J, Sevigny J, Patel S, Chiao P, Klimas M, Verma A.

Clin Pharmacol Ther. 2015 Jul;98(1):47-60. doi: 10.1002/cpt.132. Epub 2015 May 19. Review.

PMID:
25869938
20.

Functional imaging of olfaction by CBV fMRI in monkeys: insight into the role of olfactory bulb in habituation.

Zhao F, Holahan MA, Houghton AK, Hargreaves R, Evelhoch JL, Winkelmann CT, Williams DS.

Neuroimage. 2015 Feb 1;106:364-72. doi: 10.1016/j.neuroimage.2014.12.001. Epub 2014 Dec 10.

PMID:
25498426
21.

Evidence for orexinergic mechanisms in migraine.

Hoffmann J, Supronsinchai W, Akerman S, Andreou AP, Winrow CJ, Renger J, Hargreaves R, Goadsby PJ.

Neurobiol Dis. 2015 Feb;74:137-43. doi: 10.1016/j.nbd.2014.10.022. Epub 2014 Nov 4.

PMID:
25447225
22.

Addition of an NK1 receptor antagonist to an SSRI did not enhance the antidepressant effects of SSRI monotherapy: results from a randomized clinical trial in patients with major depressive disorder.

Ball WA, Snavely DB, Hargreaves RJ, Szegedi A, Lines C, Reines SA.

Hum Psychopharmacol. 2014 Nov;29(6):568-77. doi: 10.1002/hup.2444. Epub 2014 Oct 20.

PMID:
25330122
23.

Non-invasive bioluminescence imaging of β-cell function in obese-hyperglycemic [ob/ob] mice.

Patel M, Gleason A, O'Malley S, Connolly B, Suresch D, Virostko J, Phillips N, Lin SA, Chen TB, Klimas M, Hargreaves RJ, Sur C, Williams DL Jr, Powers AC, Bednar B.

PLoS One. 2014 Sep 8;9(9):e106693. doi: 10.1371/journal.pone.0106693. eCollection 2014.

24.

Characteristic time courses of cortical and medullary sodium signals measured by noninvasive (23) Na-MRI in rat kidney induced by furosemide.

Liu H, Zhou D, Garcia ML, Kohler MG, Shen X, Williams DS, Klimas MT, Hargreaves RJ, Kaczorowski GJ.

J Magn Reson Imaging. 2015 Jun;41(6):1622-8. doi: 10.1002/jmri.24732. Epub 2014 Aug 28.

PMID:
25168165
25.

Automated one-step radiosynthesis of the CB1 receptor imaging agent [(18) F]MK-9470.

Thomae D, Morley TJ, Hamill T, Carroll VM, Papin C, Twardy NM, Lee HS, Hargreaves R, Baldwin RM, Tamagnan G, Alagille D.

J Labelled Comp Radiopharm. 2014 Aug;57(10):611-4. doi: 10.1002/jlcr.3219. Epub 2014 Aug 25.

PMID:
25156811
26.

Lost but making progress--Where will new analgesic drugs come from?

Borsook D, Hargreaves R, Bountra C, Porreca F.

Sci Transl Med. 2014 Aug 13;6(249):249sr3. doi: 10.1126/scitranslmed.3008320. Review.

27.

International conference on M bovis.

Hargreaves R.

Vet Rec. 2014 Jul 12;175(2):51-2. doi: 10.1136/vr.g4523. No abstract available.

PMID:
25013199
28.

Bovine TB controls.

Hargreaves R.

Vet Rec. 2014 Jun 14;174(24):612-3. doi: 10.1136/vr.g3792. No abstract available.

PMID:
24924970
29.

[(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor.

Bell IM, Gallicchio SN, Stump CA, Bruno JG, Fan H, Gantert LT, Hostetler ED, Kemmerer AL, McWherter M, Moore EL, Mosser SD, Purcell ML, Riffel K, Salvatore CA, Sanabria-Bohórquez S, Staas DD, White RB, Williams M, Zartman CB, Cook JJ, Hargreaves RJ, Kane SA, Graham SL, Selnick HG.

ACS Med Chem Lett. 2013 Jul 18;4(9):863-8. doi: 10.1021/ml400199p. eCollection 2013 Sep 12.

30.

Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.

Liu P, Hamill TG, Chioda M, Chobanian H, Fung S, Guo Y, Chang L, Bakshi R, Hong Q, Dellureficio J, Lin LS, Abbadie C, Alexander J, Jin H, Mandala S, Shiao LL, Li W, Sanabria S, Williams D, Zeng Z, Hajdu R, Jochnowitz N, Rosenbach M, Karanam B, Madeira M, Salituro G, Powell J, Xu L, Terebetski JL, Leone JF, Miller P, Cook J, Holahan M, Joshi A, O'Malley S, Purcell M, Posavec D, Chen TB, Riffel K, Williams M, Hargreaves R, Sullivan KA, Nargund RP, DeVita RJ.

ACS Med Chem Lett. 2013 Apr 20;4(6):509-13. doi: 10.1021/ml4000996. eCollection 2013 Jun 13.

31.

Prestun shocks and mis-stuns during conventional slaughter.

Hargreaves R.

Vet Rec. 2014 May 3;174(18):458. doi: 10.1136/vr.g3017. No abstract available.

PMID:
24795420
32.

Reporting rabies risk.

Hargreaves R.

Vet Rec. 2013 Dec 7;173(22):556-7. doi: 10.1136/vr.f7237. No abstract available.

PMID:
24317617
33.

Badger culling extensions.

Hargreaves R.

Vet Rec. 2013 Nov 23;173(20):505-6. doi: 10.1136/vr.f6964. No abstract available.

PMID:
24272569
34.

(11)C-MK-8278 PET as a tool for pharmacodynamic brain occupancy of histamine 3 receptor inverse agonists.

Van Laere KJ, Sanabria-Bohórquez SM, Mozley DP, Burns DH, Hamill TG, Van Hecken A, De Lepeleire I, Koole M, Bormans G, de Hoon J, Depré M, Cerchio K, Plalcza J, Han L, Renger J, Hargreaves RJ, Iannone R.

J Nucl Med. 2014 Jan;55(1):65-72. doi: 10.2967/jnumed.113.122515. Epub 2013 Nov 21.

35.

Qualification of fMRI as a biomarker for pain in anesthetized rats by comparison with behavioral response in conscious rats.

Zhao F, Williams M, Bowlby M, Houghton A, Hargreaves R, Evelhoch J, Williams DS.

Neuroimage. 2014 Jan 1;84:724-32. doi: 10.1016/j.neuroimage.2013.09.036. Epub 2013 Sep 21.

PMID:
24064074
36.

Translational PET imaging research.

Hargreaves RJ, Rabiner EA.

Neurobiol Dis. 2014 Jan;61:32-8. doi: 10.1016/j.nbd.2013.08.017. Epub 2013 Sep 17. Review.

PMID:
24055214
37.

Why does sleep stop migraine?

Bigal ME, Hargreaves RJ.

Curr Pain Headache Rep. 2013 Oct;17(10):369. doi: 10.1007/s11916-013-0369-0. Erratum in: Curr Pain Headache Rep. 2014 Jan;18(1):390.

PMID:
24037443
38.

In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232.

Hostetler ED, Joshi AD, Sanabria-Bohórquez S, Fan H, Zeng Z, Purcell M, Gantert L, Riffel K, Williams M, O'Malley S, Miller P, Selnick HG, Gallicchio SN, Bell IM, Salvatore CA, Kane SA, Li CC, Hargreaves RJ, de Groot T, Bormans G, Van Hecken A, Derdelinckx I, de Hoon J, Reynders T, Declercq R, De Lepeleire I, Kennedy WP, Blanchard R, Marcantonio EE, Sur C, Cook JJ, Van Laere K, Evelhoch JL.

J Pharmacol Exp Ther. 2013 Nov;347(2):478-86. doi: 10.1124/jpet.113.206458. Epub 2013 Aug 23.

PMID:
23975906
39.

2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways.

Kassick AJ, Jiang J, Bunda J, Wilson D, Bao J, Lu H, Lin P, Ball RG, Doss GA, Tong X, Tsao KL, Wang H, Chicchi G, Karanam B, Tschirret-Guth R, Samuel K, Hora DF, Kumar S, Madeira M, Eng W, Hargreaves R, Purcell M, Gantert L, Cook J, DeVita RJ, Mills SG.

J Med Chem. 2013 Jul 25;56(14):5940-8. doi: 10.1021/jm400751p. Epub 2013 Jul 9.

PMID:
23808489
40.

Effect of odanacatib on bone turnover markers, bone density and geometry of the spine and hip of ovariectomized monkeys: a head-to-head comparison with alendronate.

Williams DS, McCracken PJ, Purcell M, Pickarski M, Mathers PD, Savitz AT, Szumiloski J, Jayakar RY, Somayajula S, Krause S, Brown K, Winkelmann CT, Scott BB, Cook L, Motzel SL, Hargreaves R, Evelhoch JL, Cabal A, Dardzinski BJ, Hangartner TN, Duong LT.

Bone. 2013 Oct;56(2):489-96. doi: 10.1016/j.bone.2013.06.008. Epub 2013 Jun 24.

PMID:
23806798
41.

High-resolution peripheral quantitative computed tomography and finite element analysis of bone strength at the distal radius in ovariectomized adult rhesus monkey demonstrate efficacy of odanacatib and differentiation from alendronate.

Cabal A, Jayakar RY, Sardesai S, Phillips EA, Szumiloski J, Posavec DJ, Mathers PD, Savitz AT, Scott BB, Winkelmann CT, Motzel S, Cook L, Hargreaves R, Evelhoch JL, Dardzinski BJ, Hangartner TN, McCracken PJ, Duong LT, Williams DS.

Bone. 2013 Oct;56(2):497-505. doi: 10.1016/j.bone.2013.06.011. Epub 2013 Jun 20.

PMID:
23791777
42.

Quantitative electroencephalography within sleep/wake states differentiates GABAA modulators eszopiclone and zolpidem from dual orexin receptor antagonists in rats.

Fox SV, Gotter AL, Tye SJ, Garson SL, Savitz AT, Uslaner JM, Brunner JI, Tannenbaum PL, McDonald TP, Hodgson R, Yao L, Bowlby MR, Kuduk SD, Coleman PJ, Hargreaves R, Winrow CJ, Renger JJ.

Neuropsychopharmacology. 2013 Nov;38(12):2401-8. doi: 10.1038/npp.2013.139. Epub 2013 May 31.

43.

Parallel buprenorphine phMRI responses in conscious rodents and healthy human subjects.

Becerra L, Upadhyay J, Chang PC, Bishop J, Anderson J, Baumgartner R, Schwarz AJ, Coimbra A, Wallin D, Nutile L, George E, Maier G, Sunkaraneni S, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Borsook D.

J Pharmacol Exp Ther. 2013 Apr;345(1):41-51. doi: 10.1124/jpet.112.201145. Epub 2013 Jan 31.

PMID:
23370795
44.

Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.

Parmentier-Batteur S, Hutson PH, Menzel K, Uslaner JM, Mattson BA, O'Brien JA, Magliaro BC, Forest T, Stump CA, Tynebor RM, Anthony NJ, Tucker TJ, Zhang XF, Gomez R, Huszar SL, Lambeng N, Fauré H, Le Poul E, Poli S, Rosahl TW, Rocher JP, Hargreaves R, Williams TM.

Neuropharmacology. 2014 Jul;82:161-73. doi: 10.1016/j.neuropharm.2012.12.003. Epub 2013 Jan 2.

PMID:
23291536
45.

Evaluation of [¹⁸F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human.

Hostetler ED, Sanabria-Bohórquez S, Eng W, Joshi AD, Patel S, Gibson RE, O'Malley S, Krause SM, Ryan C, Riffel K, Bi S, Okamoto O, Kawamoto H, Ozaki S, Ohta H, de Groot T, Bormans G, Depré M, de Hoon J, De Lepeleire I, Reynders T, Cook JJ, Burns HD, Egan M, Cho W, van Laere K, Hargreaves RJ.

Neuroimage. 2013 Mar;68:1-10. doi: 10.1016/j.neuroimage.2012.11.053. Epub 2012 Dec 11.

PMID:
23238431
46.

"It Ain't Over 'til It's Over" (a) -The Search for Treatments and Cures for Alzheimer's Disease.

Hargreaves RJ.

ACS Med Chem Lett. 2012 Oct 29;3(11):862-6. doi: 10.1021/ml300359g. eCollection 2012 Nov 8.

47.

Orexin receptors as therapeutic drug targets.

Gotter AL, Roecker AJ, Hargreaves R, Coleman PJ, Winrow CJ, Renger JJ.

Prog Brain Res. 2012;198:163-88. doi: 10.1016/B978-0-444-59489-1.00010-0. Review.

PMID:
22813974
48.

Equivalent dynamic human brain NK1-receptor occupancy following single-dose i.v. fosaprepitant vs. oral aprepitant as assessed by PET imaging.

Van Laere K, De Hoon J, Bormans G, Koole M, Derdelinckx I, De Lepeleire I, Declercq R, Sanabria Bohorquez SM, Hamill T, Mozley PD, Tatosian D, Xie W, Liu Y, Liu F, Zappacosta P, Mahon C, Butterfield KL, Rosen LB, Murphy MG, Hargreaves RJ, Wagner JA, Shadle CR.

Clin Pharmacol Ther. 2012 Aug;92(2):243-50. doi: 10.1038/clpt.2012.62. Epub 2012 Jun 27.

PMID:
22739139
49.

Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain.

Borsook D, Upadhyay J, Klimas M, Schwarz AJ, Coimbra A, Baumgartner R, George E, Potter WZ, Large T, Bleakman D, Evelhoch J, Iyengar S, Becerra L, Hargreaves RJ.

Drug Discov Today. 2012 Sep;17(17-18):964-73. doi: 10.1016/j.drudis.2012.05.004. Epub 2012 May 10. Review.

PMID:
22579743
50.

Evaluation of high-resolution peripheral quantitative computed tomography, finite element analysis and biomechanical testing in a pre-clinical model of osteoporosis: a study with odanacatib treatment in the ovariectomized adult rhesus monkey.

Jayakar RY, Cabal A, Szumiloski J, Sardesai S, Phillips EA, Laib A, Scott BB, Pickarski M, Duong LT, Winkelmann CT, McCracken PJ, Hargreaves R, Hangartner TN, Williams DS.

Bone. 2012 Jun;50(6):1379-88. doi: 10.1016/j.bone.2012.03.017. Epub 2012 Mar 24.

PMID:
22469953

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