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Items: 1 to 50 of 156

1.

Persistent Socioeconomic Inequality in Child Dental Caries in England despite Equal Attendance.

Ravaghi V, Hargreaves DS, Morris AJ.

JDR Clin Trans Res. 2019 Sep 5:2380084419872136. doi: 10.1177/2380084419872136. [Epub ahead of print]

PMID:
31487468
2.

Persistently elevated early warning scores and lactate identifies patients at high risk of mortality in suspected sepsis.

Hargreaves DS, de Carvalho JLJ, Smith L, Picton G, Venn R, Hodgson LE.

Eur J Emerg Med. 2019 Aug 28. doi: 10.1097/MEJ.0000000000000630. [Epub ahead of print]

PMID:
31464702
3.

Tuning the chromatin landscape of embryonic stem cells.

Hargreaves DC.

Stem Cell Investig. 2019 Jul 2;6:16. doi: 10.21037/sci.2019.06.02. eCollection 2019. No abstract available.

4.

Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4.

Gao F, Elliott NJ, Ho J, Sharp A, Shokhirev MN, Hargreaves DC.

Mol Cell. 2019 Sep 5;75(5):891-904.e7. doi: 10.1016/j.molcel.2019.06.024. Epub 2019 Jul 30.

PMID:
31375262
5.

How fair is our service? Evaluating access to specialist paediatric care.

Neale FK, Armstrong EJ, Cohen JM, Segal TY, Hargreaves DS.

Arch Dis Child. 2019 Jul 12. pii: archdischild-2019-317254. doi: 10.1136/archdischild-2019-317254. [Epub ahead of print]

PMID:
31300409
6.

Association of quality of paediatric epilepsy care with mortality and unplanned hospital admissions among children and young people with epilepsy in England: a national longitudinal data linkage study.

Hargreaves DS, Arora S, Viveiro C, Hale DR, Ward JL, Sherlaw-Johnson C, Viner RM, Dunkley C, Cross JH.

Lancet Child Adolesc Health. 2019 Sep;3(9):627-635. doi: 10.1016/S2352-4642(19)30201-9. Epub 2019 Jul 4.

7.

Illness duration, mood and symptom impact in adolescents with chronic fatigue syndrome/myalgic encephalomyelitis?

Neale FK, Christie D, Hargreaves DS, Segal TY.

Arch Dis Child. 2019 Jun 13. pii: archdischild-2018-316720. doi: 10.1136/archdischild-2018-316720. [Epub ahead of print] No abstract available.

PMID:
31196908
8.

Promises and Perils of Group Clinics for Young People Living With Diabetes: A Realist Review.

Papoutsi C, Colligan G, Hagell A, Hargreaves D, Marshall M, Vijayaraghavan S, Greenhalgh T, Finer S.

Diabetes Care. 2019 May;42(5):705-712. doi: 10.2337/dc18-2005.

9.

Turning a crisis into a policy opportunity: lessons learned so far and next steps in the Dutch early years strategy.

Struijs JN, Hargreaves DS.

Lancet Child Adolesc Health. 2019 Feb;3(2):66-68. doi: 10.1016/S2352-4642(18)30384-5. No abstract available.

PMID:
30660207
10.

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.

Tron AE, Belmonte MA, Adam A, Aquila BM, Boise LH, Chiarparin E, Cidado J, Embrey KJ, Gangl E, Gibbons FD, Gregory GP, Hargreaves D, Hendricks JA, Johannes JW, Johnstone RW, Kazmirski SL, Kettle JG, Lamb ML, Matulis SM, Nooka AK, Packer MJ, Peng B, Rawlins PB, Robbins DW, Schuller AG, Su N, Yang W, Ye Q, Zheng X, Secrist JP, Clark EA, Wilson DM, Fawell SE, Hird AW.

Nat Commun. 2018 Dec 17;9(1):5341. doi: 10.1038/s41467-018-07551-w.

11.

A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells.

Gatchalian J, Malik S, Ho J, Lee DS, Kelso TWR, Shokhirev MN, Dixon JR, Hargreaves DC.

Nat Commun. 2018 Dec 3;9(1):5139. doi: 10.1038/s41467-018-07528-9.

12.

Trajectories of change in childhood obesity prevalence across local authorities 2007/08-2015/16: a latent trajectory analysis.

Viner RM, Hargreaves DS.

J Public Health (Oxf). 2018 Nov 22. doi: 10.1093/pubmed/fdy205. [Epub ahead of print]

PMID:
30476176
13.

Computational Design of Epitope-Specific Functional Antibodies.

Nimrod G, Fischman S, Austin M, Herman A, Keyes F, Leiderman O, Hargreaves D, Strajbl M, Breed J, Klompus S, Minton K, Spooner J, Buchanan A, Vaughan TJ, Ofran Y.

Cell Rep. 2018 Nov 20;25(8):2121-2131.e5. doi: 10.1016/j.celrep.2018.10.081.

14.

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.

McCoull W, Cheung T, Anderson E, Barton P, Burgess J, Byth K, Cao Q, Castaldi MP, Chen H, Chiarparin E, Carbajo RJ, Code E, Cowan S, Davey PR, Ferguson AD, Fillery S, Fuller NO, Gao N, Hargreaves D, Howard MR, Hu J, Kawatkar A, Kemmitt PD, Leo E, Molina DM, O'Connell N, Petteruti P, Rasmusson T, Raubo P, Rawlins PB, Ricchiuto P, Robb GR, Schenone M, Waring MJ, Zinda M, Fawell S, Wilson DM.

ACS Chem Biol. 2018 Nov 16;13(11):3131-3141. doi: 10.1021/acschembio.8b00698. Epub 2018 Oct 17.

PMID:
30335946
15.

Racheting Up Repair.

Gatchalian J, Hargreaves DC.

Immunity. 2018 Oct 16;49(4):577-579. doi: 10.1016/j.immuni.2018.09.012.

PMID:
30332621
16.

Impact of preventive primary care on children's unplanned hospital admissions: a population-based birth cohort study of UK children 2000-2013.

Cecil E, Bottle A, Ma R, Hargreaves DS, Wolfe I, Mainous AG 3rd, Saxena S.

BMC Med. 2018 Sep 17;16(1):151. doi: 10.1186/s12916-018-1142-3.

17.

Mental health and well-being trends among children and young people in the UK, 1995-2014: analysis of repeated cross-sectional national health surveys.

Pitchforth J, Fahy K, Ford T, Wolpert M, Viner RM, Hargreaves DS.

Psychol Med. 2019 Jun;49(8):1275-1285. doi: 10.1017/S0033291718001757. Epub 2018 Sep 11.

18.

Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal.

Marian CA, Stoszko M, Wang L, Leighty MW, de Crignis E, Maschinot CA, Gatchalian J, Carter BC, Chowdhury B, Hargreaves DC, Duvall JR, Crabtree GR, Mahmoudi T, Dykhuizen EC.

Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14. doi: 10.1016/j.chembiol.2018.08.004. Epub 2018 Sep 6.

PMID:
30197195
19.

Associations between parental mental health and other family factors and healthcare utilisation among children and young people: a retrospective, cross-sectional study of linked healthcare data.

Dreyer K, Williamson RAP, Hargreaves DS, Rosen R, Deeny SR.

BMJ Paediatr Open. 2018 Jul 30;2(1):e000266. doi: 10.1136/bmjpo-2018-000266. eCollection 2018.

20.
21.

Improving clinical prediction rules in acute kidney injury with the use of biomarkers of cell cycle arrest: a pilot study.

Hodgson LE, Venn RM, Short S, Roderick PJ, Hargreaves D, Selby N, Forni LG.

Biomarkers. 2019 Feb;24(1):23-28. doi: 10.1080/1354750X.2018.1493617. Epub 2018 Dec 9.

PMID:
29943653
22.

Measuring and improving the quality of NHS care for children and young people.

Hargreaves DS, Lemer C, Ewing C, Cornish J, Baker T, Toma K, Saxena S, McCulloch B, McFarlane L, Welch J, Sparrow E, Kossarova L, Lumsden DE, Cheung CRLH.

Arch Dis Child. 2019 Jul;104(7):618-621. doi: 10.1136/archdischild-2017-314564. Epub 2018 May 2. No abstract available.

23.

Children and young people's versus parents' responses in an English national inpatient survey.

Hargreaves DS, Sizmur S, Pitchforth J, Tallett A, Toomey SL, Hopwood B, Schuster MA, Viner RM.

Arch Dis Child. 2018 May;103(5):486-491. doi: 10.1136/archdischild-2017-313801. Epub 2018 Feb 6.

24.

The health benefits of secondary education in adolescents and young adults: An international analysis in 186 low-, middle- and high-income countries from 1990 to 2013.

Viner RM, Hargreaves DS, Ward J, Bonell C, Mokdad AH, Patton G.

SSM Popul Health. 2017 Dec;3:162-171. doi: 10.1016/j.ssmph.2016.12.004.

25.

Correction to "Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors".

Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW.

ACS Med Chem Lett. 2017 Oct 18;8(11):1204. doi: 10.1021/acsmedchemlett.7b00397. eCollection 2017 Nov 9.

26.

A forward view for child health: integrating across the system to improve health and reduce hospital attendances for children and young people.

Viner RM, Hargreaves DS.

Arch Dis Child. 2018 Feb;103(2):117-118. doi: 10.1136/archdischild-2017-314032. Epub 2017 Nov 4. No abstract available.

PMID:
29102963
27.

The impact of out-of-hospital models of care on paediatric emergency department presentations.

Viner RM, Blackburn F, White F, Mannie R, Parr T, Nelson S, Lemer C, Riddell A, Watson M, Cleugh F, Heys M, Hargreaves DS.

Arch Dis Child. 2018 Feb;103(2):128-136. doi: 10.1136/archdischild-2017-313307. Epub 2017 Oct 26.

PMID:
29074734
28.

Midcarpal Instability: The Role of Wrist Arthroscopy.

Higgin RPC, Hargreaves DG.

Hand Clin. 2017 Nov;33(4):717-726. doi: 10.1016/j.hcl.2017.06.003. Review.

PMID:
28991583
29.

Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers.

Kelso TWR, Porter DK, Amaral ML, Shokhirev MN, Benner C, Hargreaves DC.

Elife. 2017 Oct 2;6. pii: e30506. doi: 10.7554/eLife.30506.

30.

Adolescence and Later Life Disease Burden: Quantifying the Contribution of Adolescent Tobacco Initiation From Longitudinal Cohorts.

Viner RM, Hargreaves DS, Motta JVDS, Horta B, Mokdad AH, Patton G.

J Adolesc Health. 2017 Aug;61(2):171-178. doi: 10.1016/j.jadohealth.2017.02.011.

PMID:
28734324
31.

Correction to Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.

McCoull W, Abrams RD, Anderson E, Blades K, Barton P, Box M, Burgess J, Byth K, Cao Q, Chuaqui C, Carbajo RJ, Cheung T, Code E, Ferguson AD, Fillery S, Fuller NO, Gangl E, Gao N, Grist M, Hargreaves D, Howard MR, Hu J, Kemmitt PD, Nelson JE, O'Connell N, Prince DB, Raubo P, Rawlins PB, Robb GR, Shi J, Waring MJ, Whittaker D, Wylot M, Zhu X.

J Med Chem. 2017 Jul 27;60(14):6459. doi: 10.1021/acs.jmedchem.7b00962. Epub 2017 Jul 17. No abstract available.

PMID:
28714680
32.

Group clinics for young adults with diabetes in an ethnically diverse, socioeconomically deprived setting (TOGETHER study): protocol for a realist review, co-design and mixed methods, participatory evaluation of a new care model.

Papoutsi C, Hargreaves D, Colligan G, Hagell A, Patel A, Campbell-Richards D, Viner RM, Vijayaraghavan S, Marshall M, Greenhalgh T, Finer S.

BMJ Open. 2017 Jun 21;7(6):e017363. doi: 10.1136/bmjopen-2017-017363.

33.

Predictors of emergency department attendance following NHS 111 calls for children and young people: analysis of linked data.

Robinson C, Wolters A, Steventon A, Hargreaves D, Pope R, Maconochie I.

Clin Med (Lond). 2017 Jun;17(Suppl 3):s13. doi: 10.7861/clinmedicine.17-3-s13. No abstract available.

34.

Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.

McCoull W, Abrams RD, Anderson E, Blades K, Barton P, Box M, Burgess J, Byth K, Cao Q, Chuaqui C, Carbajo RJ, Cheung T, Code E, Ferguson AD, Fillery S, Fuller NO, Gangl E, Gao N, Grist M, Hargreaves D, Howard MR, Hu J, Kemmitt PD, Nelson JE, O'Connell N, Prince DB, Raubo P, Rawlins PB, Robb GR, Shi J, Waring MJ, Whittaker D, Wylot M, Zhu X.

J Med Chem. 2017 May 25;60(10):4386-4402. doi: 10.1021/acs.jmedchem.7b00359. Epub 2017 May 9. Erratum in: J Med Chem. 2017 Jul 27;60(14):6459.

PMID:
28485934
35.

TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin.

Miller EL, Hargreaves DC, Kadoch C, Chang CY, Calarco JP, Hodges C, Buenrostro JD, Cui K, Greenleaf WJ, Zhao K, Crabtree GR.

Nat Struct Mol Biol. 2017 Apr;24(4):344-352. doi: 10.1038/nsmb.3384. Epub 2017 Feb 27.

36.

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.

Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW.

ACS Med Chem Lett. 2016 Dec 27;8(2):239-244. doi: 10.1021/acsmedchemlett.6b00464. eCollection 2017 Feb 9. Erratum in: ACS Med Chem Lett. 2017 Oct 18;8(11):1204.

37.

Improving health-care quality in resource-poor settings.

Nambiar B, Hargreaves DS, Morroni C, Heys M, Crowe S, Pagel C, Fitzgerald F, Pinheiro SF, Devakumar D, Mann S, Lakhanpaul M, Marshall M, Colbourn T.

Bull World Health Organ. 2017 Jan 1;95(1):76-78. doi: 10.2471/BLT.16.170803. Epub 2016 Nov 30. No abstract available.

38.

Experience of Primary Care Services Among Early Adolescents in England and Association With Health Outcomes.

Yassaee AA, Hargreaves DS, Chester K, Lamb S, Hagell A, Brooks FM.

J Adolesc Health. 2017 Apr;60(4):388-394. doi: 10.1016/j.jadohealth.2016.09.022. Epub 2016 Dec 1.

PMID:
27914972
39.

Determination of Urinary Neopterin/Creatinine Ratio to Distinguish Active Tuberculosis from Latent Mycobacterium tuberculosis Infection.

Eisenhut M, Hargreaves DS, Scott A, Housley D, Walters A, Mulla R.

J Biomark. 2016;2016:5643853. doi: 10.1155/2016/5643853. Epub 2016 Jun 28.

40.

Fifteen-minute consultation: public health for paediatricians-adolescent public health.

Hargreaves DS, Williams B, Straw F, Gregorowski A, Yassaee A, Devakumar D.

Arch Dis Child Educ Pract Ed. 2016 Oct;101(5):258-63. doi: 10.1136/archdischild-2015-309890. Epub 2016 Jul 4.

PMID:
27378521
41.

Integrated care for childhood epilepsy: ongoing challenges and lessons for other long-term conditions.

Bali A, Hargreaves DS, Cowman J, Lakhanpaul M, Dunkley C, Power M, Cross JH.

Arch Dis Child. 2016 Nov;101(11):1057-1062. doi: 10.1136/archdischild-2015-309794. Epub 2016 May 24. Review.

PMID:
27221818
42.

US Children And Adolescents Had Fewer Annual Doctor And Dentist Contacts Than Their Dutch Counterparts, 2010-12.

Hargreaves DS, Struijs JN, Schuster MA.

Health Aff (Millwood). 2015 Dec;34(12):2113-20. doi: 10.1377/hlthaff.2015.0709.

PMID:
26643632
43.

Midcarpal instability.

Hargreaves DG.

J Hand Surg Eur Vol. 2016 Jan;41(1):86-93. doi: 10.1177/1753193415617756. Epub 2015 Nov 22. Review.

PMID:
26598109
44.

Analysis of crystallization data in the Protein Data Bank.

Kirkwood J, Hargreaves D, O'Keefe S, Wilson J.

Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1228-34. doi: 10.1107/S2053230X15014892. Epub 2015 Sep 23.

45.

Slowed Diffusion and Excluded Volume Both Contribute to the Effects of Macromolecular Crowding on Alcohol Dehydrogenase Steady-State Kinetics.

Schneider SH, Lockwood SP, Hargreaves DI, Slade DJ, LoConte MA, Logan BE, McLaughlin EE, Conroy MJ, Slade KM.

Biochemistry. 2015 Sep 29;54(38):5898-906. doi: 10.1021/acs.biochem.5b00533. Epub 2015 Sep 16.

PMID:
26333028
46.

Unmet Health Care Need in US Adolescents and Adult Health Outcomes.

Hargreaves DS, Elliott MN, Viner RM, Richmond TK, Schuster MA.

Pediatrics. 2015 Sep;136(3):513-20. doi: 10.1542/peds.2015-0237. Epub 2015 Aug 17.

47.

Comparison of Health Care Experience and Access Between Young and Older Adults in 11 High-Income Countries.

Hargreaves DS, Greaves F, Levay C, Mitchell I, Koch U, Esch T, Denny S, Frich JC, Struijs J, Sheikh A.

J Adolesc Health. 2015 Oct;57(4):413-20. doi: 10.1016/j.jadohealth.2015.05.015. Epub 2015 Jul 21.

48.

The voices of children and young people in health: where are we now?

Weil LG, Lemer C, Webb E, Hargreaves DS.

Arch Dis Child. 2015 Oct;100(10):915-7. doi: 10.1136/archdischild-2014-307492. Epub 2015 Jun 4. Review. No abstract available.

PMID:
26044136
49.

Using isoelectric point to determine the pH for initial protein crystallization trials.

Kirkwood J, Hargreaves D, O'Keefe S, Wilson J.

Bioinformatics. 2015 May 1;31(9):1444-51. doi: 10.1093/bioinformatics/btv011. Epub 2015 Jan 7.

50.

Learning to listen: delivering patient-centered care for adolescents.

Hargreaves DS.

J Adolesc Health. 2014 Oct;55(4):463-4. doi: 10.1016/j.jadohealth.2014.07.013. No abstract available.

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