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Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development.

El Shahawy M, Reibring CG, Hallberg K, Neben CL, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A.

Int J Mol Sci. 2019 May 8;20(9). pii: E2275. doi: 10.3390/ijms20092275.


TMEM16A calcium-activated chloride currents in supporting cells of the mouse olfactory epithelium.

Henriques T, Agostinelli E, Hernandez-Clavijo A, Maurya DK, Rock JR, Harfe BD, Menini A, Pifferi S.

J Gen Physiol. 2019 Jul 1;151(7):954-966. doi: 10.1085/jgp.201812310. Epub 2019 May 2.


Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus.

Peck SH, McKee KK, Tobias JW, Malhotra NR, Harfe BD, Smith LJ.

Sci Rep. 2017 Sep 5;7(1):10504. doi: 10.1038/s41598-017-10692-5.


Developmental mechanisms of intervertebral disc and vertebral column formation.

Lawson LY, Harfe BD.

Wiley Interdiscip Rev Dev Biol. 2017 Nov;6(6). doi: 10.1002/wdev.283. Epub 2017 Jul 18. Review.


Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid.

El Shahawy M, Reibring CG, Neben CL, Hallberg K, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A.

PLoS Genet. 2017 Jul 17;13(7):e1006914. doi: 10.1371/journal.pgen.1006914. eCollection 2017 Jul.


SHH Protein Variance in the Limb Bud Is Constrained by Feedback Regulation and Correlates with Altered Digit Patterning.

Zhang R, Lee C, Lawson LY, Svete LJ, McIntyre LM, Harfe BD.

G3 (Bethesda). 2017 Mar 10;7(3):851-858. doi: 10.1534/g3.116.033019.


BMPs are direct triggers of interdigital programmed cell death.

Kaltcheva MM, Anderson MJ, Harfe BD, Lewandoski M.

Dev Biol. 2016 Mar 15;411(2):266-276. doi: 10.1016/j.ydbio.2015.12.016. Epub 2016 Jan 27.


Notochord to Nucleus Pulposus Transition.

Lawson L, Harfe BD.

Curr Osteoporos Rep. 2015 Oct;13(5):336-41. doi: 10.1007/s11914-015-0284-x. Review.


Development of the Olfactory Epithelium and Nasal Glands in TMEM16A-/- and TMEM16A+/+ Mice.

Maurya DK, Henriques T, Marini M, Pedemonte N, Galietta LJ, Rock JR, Harfe BD, Menini A.

PLoS One. 2015 Jun 11;10(6):e0129171. doi: 10.1371/journal.pone.0129171. eCollection 2015.


Musculoskeletal integration at the wrist underlies the modular development of limb tendons.

Huang AH, Riordan TJ, Pryce B, Weibel JL, Watson SS, Long F, Lefebvre V, Harfe BD, Stadler HS, Akiyama H, Tufa SF, Keene DR, Schweitzer R.

Development. 2015 Jul 15;142(14):2431-41. doi: 10.1242/dev.122374. Epub 2015 Jun 10.


Ano1, a Ca2+-activated Cl- channel, coordinates contractility in mouse intestine by Ca2+ transient coordination between interstitial cells of Cajal.

Singh RD, Gibbons SJ, Saravanaperumal SA, Du P, Hennig GW, Eisenman ST, Mazzone A, Hayashi Y, Cao C, Stoltz GJ, Ordog T, Rock JR, Harfe BD, Szurszewski JH, Farrugia G.

J Physiol. 2014 Sep 15;592(18):4051-68. doi: 10.1113/jphysiol.2014.277152. Epub 2014 Jul 25.


Dynamics of BMP signaling in limb bud mesenchyme and polydactyly.

Norrie JL, Lewandowski JP, Bouldin CM, Amarnath S, Li Q, Vokes MS, Ehrlich LIR, Harfe BD, Vokes SA.

Dev Biol. 2014 Sep 15;393(2):270-281. doi: 10.1016/j.ydbio.2014.07.003. Epub 2014 Jul 14.


Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish.

deCarvalho TN, Subedi A, Rock J, Harfe BD, Thisse C, Thisse B, Halpern ME, Hong E.

Genesis. 2014 Jun;52(6):636-55. doi: 10.1002/dvg.22785. Epub 2014 May 8.


An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool.

Anderegg A, Lin HP, Chen JA, Caronia-Brown G, Cherepanova N, Yun B, Joksimovic M, Rock J, Harfe BD, Johnson R, Awatramani R.

PLoS Genet. 2013;9(12):e1003973. doi: 10.1371/journal.pgen.1003973. Epub 2013 Dec 12.


Phylogenetic, expression, and functional analyses of anoctamin homologs in Caenorhabditis elegans.

Wang Y, Alam T, Hill-Harfe K, Lopez AJ, Leung CK, Iribarne D, Bruggeman B, Miyamoto MM, Harfe BD, Choe KP.

Am J Physiol Regul Integr Comp Physiol. 2013 Dec;305(11):R1376-89. doi: 10.1152/ajpregu.00303.2012. Epub 2013 Sep 18. Retraction in: Am J Physiol Regul Integr Comp Physiol. 2015 Dec 1;309(11):R1461.


Needle puncture injury causes acute and long-term mechanical deficiency in a mouse model of intervertebral disc degeneration.

Martin JT, Gorth DJ, Beattie EE, Harfe BD, Smith LJ, Elliott DM.

J Orthop Res. 2013 Aug;31(8):1276-82. doi: 10.1002/jor.22355. Epub 2013 Apr 1.


Foxa1 and Foxa2 are required for formation of the intervertebral discs.

Maier JA, Lo Y, Harfe BD.

PLoS One. 2013;8(1):e55528. doi: 10.1371/journal.pone.0055528. Epub 2013 Jan 31.


The transmembrane protein 16A Ca(2+)-activated Cl- channel in airway smooth muscle contributes to airway hyperresponsiveness.

Zhang CH, Li Y, Zhao W, Lifshitz LM, Li H, Harfe BD, Zhu MS, ZhuGe R.

Am J Respir Crit Care Med. 2013 Feb 15;187(4):374-81. doi: 10.1164/rccm.201207-1303OC. Epub 2012 Dec 13.


Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation.

Hu JK, McGlinn E, Harfe BD, Kardon G, Tabin CJ.

Genes Dev. 2012 Sep 15;26(18):2088-102. doi: 10.1101/gad.187385.112.


Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP.

Repetto E, Briata P, Kuziner N, Harfe BD, McManus MT, Gherzi R, Rosenfeld MG, Trabucchi M.

PLoS Genet. 2012;8(7):e1002823. doi: 10.1371/journal.pgen.1002823. Epub 2012 Jul 26. Erratum in: PLoS Genet. 2012 Sep;8(9). doi:10.1371/annotation/c93e4b67-d237-48fb-aec7-0db398407bb4.


Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs.

Choi KS, Lee C, Harfe BD.

Mech Dev. 2012 Sep-Dec;129(9-12):255-62. doi: 10.1016/j.mod.2012.07.003. Epub 2012 Jul 25.


Bmp2, Bmp4 and Bmp7 are co-required in the mouse AER for normal digit patterning but not limb outgrowth.

Choi KS, Lee C, Maatouk DM, Harfe BD.

PLoS One. 2012;7(5):e37826. doi: 10.1371/journal.pone.0037826. Epub 2012 May 25.


The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons.

Cho H, Yang YD, Lee J, Lee B, Kim T, Jang Y, Back SK, Na HS, Harfe BD, Wang F, Raouf R, Wood JN, Oh U.

Nat Neurosci. 2012 May 27;15(7):1015-21. doi: 10.1038/nn.3111.


TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression.

Duvvuri U, Shiwarski DJ, Xiao D, Bertrand C, Huang X, Edinger RS, Rock JR, Harfe BD, Henson BJ, Kunzelmann K, Schreiber R, Seethala RS, Egloff AM, Chen X, Lui VW, Grandis JR, Gollin SM.

Cancer Res. 2012 Jul 1;72(13):3270-81. doi: 10.1158/0008-5472.CAN-12-0475-T. Epub 2012 May 7.


Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons.

Huang WC, Xiao S, Huang F, Harfe BD, Jan YN, Jan LY.

Neuron. 2012 Apr 12;74(1):179-92. doi: 10.1016/j.neuron.2012.01.033.


Avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: implications for evolution of the vertebrate disc.

Bruggeman BJ, Maier JA, Mohiuddin YS, Powers R, Lo Y, Guimarães-Camboa N, Evans SM, Harfe BD.

Dev Dyn. 2012 Apr;241(4):675-83. doi: 10.1002/dvdy.23750. Epub 2012 Feb 21.


Electrical slow waves in the mouse oviduct are dependent upon a calcium activated chloride conductance encoded by Tmem16a.

Dixon RE, Hennig GW, Baker SA, Britton FC, Harfe BD, Rock JR, Sanders KM, Ward SM.

Biol Reprod. 2012 Jan 19;86(1):1-7. doi: 10.1095/biolreprod.111.095554. Print 2012 Jan.


Ano1 as a regulator of proliferation.

Stanich JE, Gibbons SJ, Eisenman ST, Bardsley MR, Rock JR, Harfe BD, Ordog T, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2011 Dec;301(6):G1044-51. doi: 10.1152/ajpgi.00196.2011. Epub 2011 Sep 22.


Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs.

Choi KS, Harfe BD.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9484-9. doi: 10.1073/pnas.1007566108. Epub 2011 May 23.


Keeping up with the zone of polarizing activity: New roles for an old signaling center.

Harfe BD.

Dev Dyn. 2011 May;240(5):915-9. doi: 10.1002/dvdy.22597. Epub 2011 Feb 28. Review.


Nuclei pulposi formation from the embryonic notochord occurs normally in GDF-5-deficient mice.

Maier JA, Harfe BD.

Spine (Phila Pa 1976). 2011 Nov 15;36(24):E1555-61. doi: 10.1097/BRS.0b013e318210eec4.


The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning.

Zhang Z, O'Rourke JR, McManus MT, Lewandoski M, Harfe BD, Sun X.

Dev Biol. 2011 Mar 15;351(2):254-65. doi: 10.1016/j.ydbio.2011.01.005. Epub 2011 Jan 20.


Degeneration and regeneration of the intervertebral disc: lessons from development.

Smith LJ, Nerurkar NL, Choi KS, Harfe BD, Elliott DM.

Dis Model Mech. 2011 Jan;4(1):31-41. doi: 10.1242/dmm.006403. Epub 2010 Dec 1. Review.


The sonic hedgehog pathway in chordoid tumours.

Cates JM, Itani DM, Coffin CM, Harfe BD.

Histopathology. 2010 Jun;56(7):978-9. doi: 10.1111/j.1365-2559.2010.03572.x. Epub 2010 May 22. No abstract available.


Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning.

Bouldin CM, Gritli-Linde A, Ahn S, Harfe BD.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5489-94. doi: 10.1073/pnas.0912818107. Epub 2010 Mar 8.


Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells.

Romanenko VG, Catalán MA, Brown DA, Putzier I, Hartzell HC, Marmorstein AD, Gonzalez-Begne M, Rock JR, Harfe BD, Melvin JE.

J Biol Chem. 2010 Apr 23;285(17):12990-3001. doi: 10.1074/jbc.M109.068544. Epub 2010 Feb 22.


The microRNA-processing enzyme dicer maintains juxtaglomerular cells.

Sequeira-Lopez ML, Weatherford ET, Borges GR, Monteagudo MC, Pentz ES, Harfe BD, Carretero O, Sigmund CD, Gomez RA.

J Am Soc Nephrol. 2010 Mar;21(3):460-7. doi: 10.1681/ASN.2009090964. Epub 2010 Jan 7.


Studies on expression and function of the TMEM16A calcium-activated chloride channel.

Huang F, Rock JR, Harfe BD, Cheng T, Huang X, Jan YN, Jan LY.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21413-8. doi: 10.1073/pnas.0911935106. Epub 2009 Nov 24.


Multiphasic and tissue-specific roles of sonic hedgehog in cloacal septation and external genitalia development.

Seifert AW, Bouldin CM, Choi KS, Harfe BD, Cohn MJ.

Development. 2009 Dec;136(23):3949-57. doi: 10.1242/dev.042291.


Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles.

Hwang SJ, Blair PJ, Britton FC, O'Driscoll KE, Hennig G, Bayguinov YR, Rock JR, Harfe BD, Sanders KM, Ward SM.

J Physiol. 2009 Oct 15;587(Pt 20):4887-904. doi: 10.1113/jphysiol.2009.176198. Epub 2009 Aug 17.


Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport.

Ousingsawat J, Martins JR, Schreiber R, Rock JR, Harfe BD, Kunzelmann K.

J Biol Chem. 2009 Oct 16;284(42):28698-703. doi: 10.1074/jbc.M109.012120. Epub 2009 Aug 13.


TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A.

Almaça J, Tian Y, Aldehni F, Ousingsawat J, Kongsuphol P, Rock JR, Harfe BD, Schreiber R, Kunzelmann K.

J Biol Chem. 2009 Oct 16;284(42):28571-8. doi: 10.1074/jbc.M109.010074. Epub 2009 Aug 4.


Aberrant FGF signaling, independent of ectopic hedgehog signaling, initiates preaxial polydactyly in Dorking chickens.

Bouldin CM, Harfe BD.

Dev Biol. 2009 Oct 1;334(1):133-41. doi: 10.1016/j.ydbio.2009.07.009. Epub 2009 Jul 17.


LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages.

Ruggiero T, Trabucchi M, De Santa F, Zupo S, Harfe BD, McManus MT, Rosenfeld MG, Briata P, Gherzi R.

FASEB J. 2009 Sep;23(9):2898-908. doi: 10.1096/fj.09-131342. Epub 2009 May 7.


Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice.

Soukup GA, Fritzsch B, Pierce ML, Weston MD, Jahan I, McManus MT, Harfe BD.

Dev Biol. 2009 Apr 15;328(2):328-41. doi: 10.1016/j.ydbio.2009.01.037. Epub 2009 Feb 4.


Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways.

Rock JR, O'Neal WK, Gabriel SE, Randell SH, Harfe BD, Boucher RC, Grubb BR.

J Biol Chem. 2009 May 29;284(22):14875-80. doi: 10.1074/jbc.C109.000869. Epub 2009 Apr 10.


In the limb AER Bmp2 and Bmp4 are required for dorsal-ventral patterning and interdigital cell death but not limb outgrowth.

Maatouk DM, Choi KS, Bouldin CM, Harfe BD.

Dev Biol. 2009 Mar 15;327(2):516-23. doi: 10.1016/j.ydbio.2009.01.004. Epub 2009 Jan 13.


Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract.

Pastorelli LM, Wells S, Fray M, Smith A, Hough T, Harfe BD, McManus MT, Smith L, Woolf AS, Cheeseman M, Greenfield A.

Mamm Genome. 2009 Mar;20(3):140-51. doi: 10.1007/s00335-008-9169-y. Epub 2009 Jan 24.


Sertoli cell Dicer is essential for spermatogenesis in mice.

Papaioannou MD, Pitetti JL, Ro S, Park C, Aubry F, Schaad O, Vejnar CE, Kühne F, Descombes P, Zdobnov EM, McManus MT, Guillou F, Harfe BD, Yan W, Jégou B, Nef S.

Dev Biol. 2009 Feb 1;326(1):250-9. doi: 10.1016/j.ydbio.2008.11.011. Epub 2008 Nov 28.


Expression patterns of the Tmem16 gene family during cephalic development in the mouse.

Gritli-Linde A, Vaziri Sani F, Rock JR, Hallberg K, Iribarne D, Harfe BD, Linde A.

Gene Expr Patterns. 2009 Mar;9(3):178-91. doi: 10.1016/j.gep.2008.11.002. Epub 2008 Nov 25.


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