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Items: 1 to 50 of 58

1.

Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia.

Yang M, Vesterlund M, Siavelis I, Moura-Castro LH, Castor A, Fioretos T, Jafari R, Lilljebjörn H, Odom DT, Olsson L, Ravi N, Woodward EL, Harewood L, Lehtiö J, Paulsson K.

Nat Commun. 2019 Apr 3;10(1):1519. doi: 10.1038/s41467-019-09469-3.

2.

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy.

Lawrence MG, Obinata D, Sandhu S, Selth LA, Wong SQ, Porter LH, Lister N, Pook D, Pezaro CJ, Goode DL, Rebello RJ, Clark AK, Papargiris M, Van Gramberg J, Hanson AR, Banks P, Wang H, Niranjan B, Keerthikumar S, Hedwards S, Huglo A, Yang R, Henzler C, Li Y, Lopez-Campos F, Castro E, Toivanen R, Azad A, Bolton D, Goad J, Grummet J, Harewood L, Kourambas J, Lawrentschuk N, Moon D, Murphy DG, Sengupta S, Snow R, Thorne H, Mitchell C, Pedersen J, Clouston D, Norden S, Ryan A, Dehm SM, Tilley WD, Pearson RB, Hannan RD, Frydenberg M, Furic L, Taylor RA, Risbridger GP.

Eur Urol. 2018 Nov;74(5):562-572. doi: 10.1016/j.eururo.2018.06.020. Epub 2018 Jul 23.

3.

NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis.

Rodrigues P, Patel SA, Harewood L, Olan I, Vojtasova E, Syafruddin SE, Zaini MN, Richardson EK, Burge J, Warren AY, Stewart GD, Saeb-Parsy K, Samarajiwa SA, Vanharanta S.

Cancer Discov. 2018 Jul;8(7):850-865. doi: 10.1158/2159-8290.CD-17-1211. Epub 2018 Jun 6.

4.

Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours.

Harewood L, Kishore K, Eldridge MD, Wingett S, Pearson D, Schoenfelder S, Collins VP, Fraser P.

Genome Biol. 2017 Jun 27;18(1):125. doi: 10.1186/s13059-017-1253-8.

5.

Multiparametric magnetic resonance imaging for prostate cancer-a comparative study including radical prostatectomy specimens.

Toner L, Papa N, Perera M, Katelaris N, Weerakoon M, Chin K, Harewood L, Bolton DM, Lawrentschuk N.

World J Urol. 2017 Jun;35(6):935-941. doi: 10.1007/s00345-016-1960-x. Epub 2016 Oct 26.

PMID:
27785560
6.

Genetic Analysis of 'PAX6-Negative' Individuals with Aniridia or Gillespie Syndrome.

Ansari M, Rainger J, Hanson IM, Williamson KA, Sharkey F, Harewood L, Sandilands A, Clayton-Smith J, Dollfus H, Bitoun P, Meire F, Fantes J, Franco B, Lorenz B, Taylor DS, Stewart F, Willoughby CE, McEntagart M, Khaw PT, Clericuzio C, Van Maldergem L, Williams D, Newbury-Ecob R, Traboulsi EI, Silva ED, Madlom MM, Goudie DR, Fleck BW, Wieczorek D, Kohlhase J, McTrusty AD, Gardiner C, Yale C, Moore AT, Russell-Eggitt I, Islam L, Lees M, Beales PL, Tuft SJ, Solano JB, Splitt M, Hertz JM, Prescott TE, Shears DJ, Nischal KK, Doco-Fenzy M, Prieur F, Temple IK, Lachlan KL, Damante G, Morrison DA, van Heyningen V, FitzPatrick DR.

PLoS One. 2016 Apr 28;11(4):e0153757. doi: 10.1371/journal.pone.0153757. eCollection 2016.

7.

Reduction in expression of the benign AR transcriptome is a hallmark of localised prostate cancer progression.

Stuchbery R, Macintyre G, Cmero M, Harewood LM, Peters JS, Costello AJ, Hovens CM, Corcoran NM.

Oncotarget. 2016 May 24;7(21):31384-92. doi: 10.18632/oncotarget.8915.

8.

Does perineural invasion in a radical prostatectomy specimen predict biochemical recurrence in men with prostate cancer?

Reeves F, Hovens CM, Harewood L, Battye S, Peters JS, Costello AJ, Corcoran NM.

Can Urol Assoc J. 2015 May-Jun;9(5-6):E252-5. doi: 10.5489/cuaj.2619.

9.

A Potential Contributory Role for Ciliary Dysfunction in the 16p11.2 600 kb BP4-BP5 Pathology.

Migliavacca E, Golzio C, Männik K, Blumenthal I, Oh EC, Harewood L, Kosmicki JA, Loviglio MN, Giannuzzi G, Hippolyte L, Maillard AM, Alfaiz AA; 16p11.2 European Consortium, van Haelst MM, Andrieux J, Gusella JF, Daly MJ, Beckmann JS, Jacquemont S, Talkowski ME, Katsanis N, Reymond A.

Am J Hum Genet. 2015 May 7;96(5):784-96. doi: 10.1016/j.ajhg.2015.04.002. Epub 2015 Apr 30.

10.

The impact of chromosomal rearrangements on regulation of gene expression.

Harewood L, Fraser P.

Hum Mol Genet. 2014 Sep 15;23(R1):R76-82. doi: 10.1093/hmg/ddu278. Epub 2014 Jun 6. Review.

PMID:
24907073
11.

Structural variation-associated expression changes are paralleled by chromatin architecture modifications.

Gheldof N, Witwicki RM, Migliavacca E, Leleu M, Didelot G, Harewood L, Rougemont J, Reymond A.

PLoS One. 2013 Nov 12;8(11):e79973. doi: 10.1371/journal.pone.0079973. eCollection 2013.

12.

Presence or absence of a positive pathological margin outperforms any other margin-associated variable in predicting clinically relevant biochemical recurrence in Gleason 7 prostate cancer.

Huang JG, Pedersen J, Hong MK, Harewood LM, Peters J, Costello AJ, Hovens CM, Corcoran NM.

BJU Int. 2013 May;111(6):921-7. doi: 10.1111/j.1464-410X.2012.11665.x. Epub 2013 Jan 25.

13.

Re-evaluating the biological significance of seminal vesicle invasion (SVI) in locally advanced prostate cancer.

Sapre N, Pedersen J, Hong MK, Harewood L, Peters J, Costello AJ, Hovens CM, Corcoran NM.

BJU Int. 2012 Dec;110 Suppl 4:58-63. doi: 10.1111/j.1464-410X.2012.11477.x.

14.

A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders.

Zufferey F, Sherr EH, Beckmann ND, Hanson E, Maillard AM, Hippolyte L, Macé A, Ferrari C, Kutalik Z, Andrieux J, Aylward E, Barker M, Bernier R, Bouquillon S, Conus P, Delobel B, Faucett WA, Goin-Kochel RP, Grant E, Harewood L, Hunter JV, Lebon S, Ledbetter DH, Martin CL, Männik K, Martinet D, Mukherjee P, Ramocki MB, Spence SJ, Steinman KJ, Tjernagel J, Spiro JE, Reymond A, Beckmann JS, Chung WK, Jacquemont S; Simons VIP Consortium; 16p11.2 European Consortium.

J Med Genet. 2012 Oct;49(10):660-8. doi: 10.1136/jmedgenet-2012-101203. Erratum in: J Med Genet. 2014 Jul;51(7):478.

15.

Utility of RhoC and ZAG protein expression as biomarkers for prediction of PSA failure following radical prostatectomy for high grade prostate cancer.

Mills J, Oliver A, Sherwin JC, Frydenberg M, Peters JS, Costello A, Harewood L, Love C, Redgrave N, van Golen KL, Bailey M, Pedersen J.

Pathology. 2012 Oct;44(6):513-8.

PMID:
22935975
16.

Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling.

Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP.

Cell. 2012 Jun 8;149(6):1207-20. doi: 10.1016/j.cell.2012.03.048.

17.

Human epithelial basal cells are cells of origin of prostate cancer, independent of CD133 status.

Taylor RA, Toivanen R, Frydenberg M, Pedersen J, Harewood L; Australian Prostate Cancer Bioresource, Collins AT, Maitland NJ, Risbridger GP.

Stem Cells. 2012 Jun;30(6):1087-96. doi: 10.1002/stem.1094. Erratum in: Stem Cells. 2012 Aug;30(8):1786.

18.

2q34-qter duplication and 4q34.2-qter deletion in a patient with developmental delay.

Rashidi-Nezhad A, Parvaneh N, Farzanfar F, Azimi C, Harewood L, Akrami SM, Reymond A.

Eur J Med Genet. 2012 Mar;55(3):203-10. doi: 10.1016/j.ejmg.2012.01.012. Epub 2012 Feb 4.

PMID:
22370062
19.

Positive surgical margins are a risk factor for significant biochemical recurrence only in intermediate-risk disease.

Corcoran NM, Hovens CM, Metcalfe C, Hong MK, Pedersen J, Casey RG, Peters J, Harewood L, Goldenberg SL, Costello AJ, Gleave ME.

BJU Int. 2012 Sep;110(6):821-7. doi: 10.1111/j.1464-410X.2011.10868.x. Epub 2012 Jan 18.

20.

Structural variation and its effect on expression.

Harewood L, Chaignat E, Reymond A.

Methods Mol Biol. 2012;838:173-86. doi: 10.1007/978-1-61779-507-7_8.

PMID:
22228012
21.

The ability of prostate-specific antigen (PSA) density to predict an upgrade in Gleason score between initial prostate biopsy and prostatectomy diminishes with increasing tumour grade due to reduced PSA secretion per unit tumour volume.

Corcoran NM, Casey RG, Hong MK, Pedersen J, Connolly S, Peters J, Harewood L, Gleave ME, Costello AJ, Hovens CM, Goldenberg SL.

BJU Int. 2012 Jul;110(1):36-42. doi: 10.1111/j.1464-410X.2011.10681.x. Epub 2011 Nov 15.

22.

Underestimation of Gleason score at prostate biopsy reflects sampling error in lower volume tumours.

Corcoran NM, Hovens CM, Hong MK, Pedersen J, Casey RG, Connolly S, Peters J, Harewood L, Gleave ME, Goldenberg SL, Costello AJ.

BJU Int. 2012 Mar;109(5):660-4. doi: 10.1111/j.1464-410X.2011.10543.x. Epub 2011 Sep 2.

23.

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.

Jacquemont S, Reymond A, Zufferey F, Harewood L, Walters RG, Kutalik Z, Martinet D, Shen Y, Valsesia A, Beckmann ND, Thorleifsson G, Belfiore M, Bouquillon S, Campion D, de Leeuw N, de Vries BB, Esko T, Fernandez BA, Fernández-Aranda F, Fernández-Real JM, Gratacòs M, Guilmatre A, Hoyer J, Jarvelin MR, Kooy RF, Kurg A, Le Caignec C, Männik K, Platt OS, Sanlaville D, Van Haelst MM, Villatoro Gomez S, Walha F, Wu BL, Yu Y, Aboura A, Addor MC, Alembik Y, Antonarakis SE, Arveiler B, Barth M, Bednarek N, Béna F, Bergmann S, Beri M, Bernardini L, Blaumeiser B, Bonneau D, Bottani A, Boute O, Brunner HG, Cailley D, Callier P, Chiesa J, Chrast J, Coin L, Coutton C, Cuisset JM, Cuvellier JC, David A, de Freminville B, Delobel B, Delrue MA, Demeer B, Descamps D, Didelot G, Dieterich K, Disciglio V, Doco-Fenzy M, Drunat S, Duban-Bedu B, Dubourg C, El-Sayed Moustafa JS, Elliott P, Faas BH, Faivre L, Faudet A, Fellmann F, Ferrarini A, Fisher R, Flori E, Forer L, Gaillard D, Gerard M, Gieger C, Gimelli S, Gimelli G, Grabe HJ, Guichet A, Guillin O, Hartikainen AL, Heron D, Hippolyte L, Holder M, Homuth G, Isidor B, Jaillard S, Jaros Z, Jiménez-Murcia S, Helas GJ, Jonveaux P, Kaksonen S, Keren B, Kloss-Brandstätter A, Knoers NV, Koolen DA, Kroisel PM, Kronenberg F, Labalme A, Landais E, Lapi E, Layet V, Legallic S, Leheup B, Leube B, Lewis S, Lucas J, MacDermot KD, Magnusson P, Marshall C, Mathieu-Dramard M, McCarthy MI, Meitinger T, Mencarelli MA, Merla G, Moerman A, Mooser V, Morice-Picard F, Mucciolo M, Nauck M, Ndiaye NC, Nordgren A, Pasquier L, Petit F, Pfundt R, Plessis G, Rajcan-Separovic E, Ramelli GP, Rauch A, Ravazzolo R, Reis A, Renieri A, Richart C, Ried JS, Rieubland C, Roberts W, Roetzer KM, Rooryck C, Rossi M, Saemundsen E, Satre V, Schurmann C, Sigurdsson E, Stavropoulos DJ, Stefansson H, Tengström C, Thorsteinsdóttir U, Tinahones FJ, Touraine R, Vallée L, van Binsbergen E, Van der Aa N, Vincent-Delorme C, Visvikis-Siest S, Vollenweider P, Völzke H, Vulto-van Silfhout AT, Waeber G, Wallgren-Pettersson C, Witwicki RM, Zwolinksi S, Andrieux J, Estivill X, Gusella JF, Gustafsson O, Metspalu A, Scherer SW, Stefansson K, Blakemore AI, Beckmann JS, Froguel P.

Nature. 2011 Aug 31;478(7367):97-102. doi: 10.1038/nature10406.

24.

Upgrade in Gleason score between prostate biopsies and pathology following radical prostatectomy significantly impacts upon the risk of biochemical recurrence.

Corcoran NM, Hong MK, Casey RG, Hurtado-Coll A, Peters J, Harewood L, Goldenberg SL, Hovens CM, Costello AJ, Gleave ME.

BJU Int. 2011 Oct;108(8 Pt 2):E202-10. doi: 10.1111/j.1464-410X.2011.10119.x. Epub 2011 Mar 28.

25.

Prostate tumour volume is an independent predictor of early biochemical recurrence in a high risk radical prostatectomy subgroup.

Hong MK, Namdarian B, Corcoran NM, Pedersen J, Murphy DG, Peters JS, Harewood L, Sapre N, Rzetelski-West K, Costello AJ, Hovens CM.

Pathology. 2011 Feb;43(2):138-42. doi: 10.1097/PAT.0b013e3283420155.

PMID:
21233675
26.

Esrrg functions in early branch generation of the ureteric bud and is essential for normal development of the renal papilla.

Berry R, Harewood L, Pei L, Fisher M, Brownstein D, Ross A, Alaynick WA, Moss J, Hastie ND, Hohenstein P, Davies JA, Evans RM, FitzPatrick DR.

Hum Mol Genet. 2011 Mar 1;20(5):917-26. doi: 10.1093/hmg/ddq530. Epub 2010 Dec 6.

27.

Bilateral renal agenesis/hypoplasia/dysplasia (BRAHD): postmortem analysis of 45 cases with breakpoint mapping of two de novo translocations.

Harewood L, Liu M, Keeling J, Howatson A, Whiteford M, Branney P, Evans M, Fantes J, Fitzpatrick DR.

PLoS One. 2010 Aug 25;5(8):e12375. doi: 10.1371/journal.pone.0012375.

28.

The effect of translocation-induced nuclear reorganization on gene expression.

Harewood L, Schütz F, Boyle S, Perry P, Delorenzi M, Bickmore WA, Reymond A.

Genome Res. 2010 May;20(5):554-64. doi: 10.1101/gr.103622.109. Epub 2010 Mar 8.

29.

'Crommelin-type' symmetrical tetramelic reduction deformity: a new case and breakpoint mapping of a reported case with de-novo t(2;12)(p25.1;q23.3).

Harewood L, Keeling JW, Fantes JA, Opitz JM, FitzPatrick DR.

Clin Dysmorphol. 2010 Jan;19(1):5-13. doi: 10.1097/MCD.0b013e328331ddbe.

PMID:
19996735
30.

FISH mapping of de novo apparently balanced chromosome rearrangements identifies characteristics associated with phenotypic abnormality.

Fantes JA, Boland E, Ramsay J, Donnai D, Splitt M, Goodship JA, Stewart H, Whiteford M, Gautier P, Harewood L, Holloway S, Sharkey F, Maher E, van Heyningen V, Clayton-Smith J, Fitzpatrick DR, Black GC.

Am J Hum Genet. 2008 Apr;82(4):916-26. doi: 10.1016/j.ajhg.2008.02.007. Epub 2008 Mar 27. Erratum in: Am J Hum Genet. 2008 Apr;82(4):1019.

31.

Side effects of genome structural changes.

Reymond A, Henrichsen CN, Harewood L, Merla G.

Curr Opin Genet Dev. 2007 Oct;17(5):381-6. Epub 2007 Oct 24. Review.

PMID:
17913489
32.

A diminutive chromosome 21 centromere in acute lymphoblastic leukemia.

Roberts KA, Martineau M, Broadfield ZJ, Gibson BE, Harewood L, Stewart J, Harrison CJ.

Cancer Genet Cytogenet. 2006 May;167(1):78-81.

PMID:
16682292
33.

A balanced reciprocal translocation in a case of hypomelanosis of Ito with confirmation of mosaicism using buccal cell interphase FISH.

Keng WT, Harewood L, Grace E, Paxton C, Lam WW, Fitzpatrick DR.

Am J Med Genet A. 2006 May 15;140(10):1111-3. No abstract available.

PMID:
16596668
34.

Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study.

Harrison CJ, Moorman AV, Barber KE, Broadfield ZJ, Cheung KL, Harris RL, Jalali GR, Robinson HM, Strefford JC, Stewart A, Wright S, Griffiths M, Ross FM, Harewood L, Martineau M.

Br J Haematol. 2005 May;129(4):520-30.

PMID:
15877734
35.

Amplification of the ABL gene in T-cell acute lymphoblastic leukemia.

Barber KE, Martineau M, Harewood L, Stewart M, Cameron E, Strefford JC, Rutherford S, Allen TD, Broadfield ZJ, Cheung KL, Harris RL, Jalali GR, Moorman AV, Robinson HM, Harrison CJ.

Leukemia. 2004 Jun;18(6):1153-6. No abstract available.

PMID:
15057249
36.

Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome.

Robinson HM, Broadfield ZJ, Cheung KL, Harewood L, Harris RL, Jalali GR, Martineau M, Moorman AV, Taylor KE, Richards S, Mitchell C, Harrison CJ.

Leukemia. 2003 Nov;17(11):2249-50. No abstract available.

PMID:
14523475
37.

Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases.

Harewood L, Robinson H, Harris R, Al-Obaidi MJ, Jalali GR, Martineau M, Moorman AV, Sumption N, Richards S, Mitchell C, Harrison CJ.

Leukemia. 2003 Mar;17(3):547-53. Review.

PMID:
12646943
38.

Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis.

Harrison CJ, Mazzullo H, Ross FM, Cheung KL, Gerrard G, Harewood L, Mehta A, Lachmann HJ, Hawkins PN, Orchard KH.

Br J Haematol. 2002 May;117(2):427-35.

PMID:
11972529
39.

ETV6/AML1 fusion by FISH in adult acute lymphoblastic leukemia.

Jabber Al-Obaidi MS, Martineau M, Bennett CF, Franklin IM, Goldstone AH, Harewood L, Jalali GR, Prentice HG, Richards SM, Roberts K, Harrison CJ; Medical Research Council Adult Leukaemia Working Party.

Leukemia. 2002 Apr;16(4):669-74.

40.

A case-control study of the androgen receptor gene CAG repeat polymorphism in Australian prostate carcinoma subjects.

Beilin J, Harewood L, Frydenberg M, Mameghan H, Martyres RF, Farish SJ, Yue C, Deam DR, Byron KA, Zajac JD.

Cancer. 2001 Aug 15;92(4):941-9.

PMID:
11550169
41.

Three further cases of t(8;14)(q11.2;q32) in acute lymphoblastic leukemia.

Byatt SA, Cheung KL, Lillington DM, Mazzullo H, Martineau M, Bennett C, Roberts K, Harewood L, Sumption N, Humphreys M, Burrett J, Harrison CJ.

Leukemia. 2001 Aug;15(8):1304-5. No abstract available.

42.

MR imaging of renal masses interpreted on CT to be suspicious.

Tello R, Davison BD, O'Malley M, Fenlon H, Thomson KR, Witte DJ, Harewood L.

AJR Am J Roentgenol. 2000 Apr;174(4):1017-22.

PMID:
10749242
43.

Vitamin D-receptor genotypes as independent genetic predictors of decreased bone mineral density in primary biliary cirrhosis.

Springer JE, Cole DE, Rubin LA, Cauch-Dudek K, Harewood L, Evrovski J, Peltekova VD, Heathcote EJ.

Gastroenterology. 2000 Jan;118(1):145-51.

PMID:
10611163
44.

Percutaneous management of caliceal diverticular calculi: technique and outcome.

Donnellan SM, Harewood LM, Webb DR.

J Endourol. 1999 Mar;13(2):83-8.

PMID:
10213100
45.

Transitional cell carcinoma growing along an indwelling nephrostomy tube track.

Sengupta S, Harewood L.

Br J Urol. 1998 Oct;82(4):591. No abstract available.

PMID:
9806197
46.

Retroperitoneal and pelvic extraperitoneal laparoscopy: an international perspective.

Gill IS, Clayman RV, Albala DM, Aso Y, Chiu AW, Das S, Donovan JF, Fuchs GJ, Gaur DD, Go H, Gomella LG, Grune MT, Harewood LM, Janetschek G, Knapp PM, McDougall EM, Nakada SY, Preminger GM, Puppo P, Rassweiler JJ, Royce PL, Thomas R, Urban DA, Winfield HN.

Urology. 1998 Oct;52(4):566-71.

PMID:
9763072
47.

Antiretrovirals during pregnancy in HIV-1-positive women in New York City.

Fischer C, Rosenwald V, Harewood L, Blum C.

Lancet. 1998 Apr 4;351(9108):1029-30. No abstract available.

PMID:
9546512
48.

Extraperitoneal laparoscopic caliceal diverticulectomy.

Harewood LM, Agarwal D, Lindsay S, Vaughan MG, Cleeve LK, Webb DR.

J Endourol. 1996 Oct;10(5):425-30.

PMID:
8905488
49.

A study of the efficacy and safety of transurethral needle ablation (TUNA) treatment for benign prostatic hyperplasia.

Millard RJ, Harewood LM, Tamaddon K.

Neurourol Urodyn. 1996;15(6):619-28; discussion 628-9.

PMID:
8916114
50.

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