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Items: 1 to 50 of 164

1.

Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation.

Hayakawa K, Li YS, Shinton SA, Bandi SR, Formica AM, Brill-Dashoff J, Hardy RR.

Front Immunol. 2019 Mar 15;10:457. doi: 10.3389/fimmu.2019.00457. eCollection 2019.

2.

Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice.

Hayakawa K, Formica AM, Nakao Y, Ichikawa D, Shinton SA, Brill-Dashoff J, Smith MR, Morse HC 3rd, Hardy RR.

J Immunol. 2018 Jul 15;201(2):804-813. doi: 10.4049/jimmunol.1800400. Epub 2018 Jun 13.

3.

NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome.

Hayakawa K, Formica AM, Zhou Y, Ichikawa D, Asano M, Li YS, Shinton SA, Brill-Dashoff J, Núñez G, Hardy RR.

J Exp Med. 2017 Oct 2;214(10):3067-3083. doi: 10.1084/jem.20170497. Epub 2017 Sep 6.

4.

Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes.

Liu X, Li YS, Shinton SA, Rhodes J, Tang L, Feng H, Jette CA, Look AT, Hayakawa K, Hardy RR.

J Immunol. 2017 Sep 1;199(5):1706-1715. doi: 10.4049/jimmunol.1700552. Epub 2017 Jul 24.

5.

Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression.

Hayakawa K, Formica AM, Brill-Dashoff J, Shinton SA, Ichikawa D, Zhou Y, Morse HC 3rd, Hardy RR.

J Exp Med. 2016 Dec 12;213(13):3007-3024. Epub 2016 Nov 29.

6.

Loss of a chromosomal region with synteny to human 13q14 occurs in mouse chronic lymphocytic leukemia that originates from early-generated B-1 B cells.

Hayakawa K, Formica AM, Colombo MJ, Shinton SA, Brill-Dashoff J, Morse Iii HC, Li YS, Hardy RR.

Leukemia. 2016 Jul;30(7):1510-9. doi: 10.1038/leu.2016.61. Epub 2016 Mar 8.

7.

Selection of natural autoreactive B cells.

Hardy RR, Hayakawa K.

Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 92):S80-6. Epub 2015 Oct 12. Review.

PMID:
26457505
8.

Perspectives on fetal derived CD5+ B1 B cells.

Hardy RR, Hayakawa K.

Eur J Immunol. 2015 Nov;45(11):2978-84. doi: 10.1002/eji.201445146. Epub 2015 Sep 23. Review.

9.

Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish.

Seiler C, Gebhart N, Zhang Y, Shinton SA, Li YS, Ross NL, Liu X, Li Q, Bilbee AN, Varshney GK, LaFave MC, Burgess SM, Balciuniene J, Balciunas D, Hardy RR, Kappes DJ, Wiest DL, Rhodes J.

PLoS One. 2015 Jul 10;10(7):e0131908. doi: 10.1371/journal.pone.0131908. eCollection 2015.

10.

A developmental switch between fetal and adult B lymphopoiesis.

Li YS, Zhou Y, Tang L, Shinton SA, Hayakawa K, Hardy RR.

Ann N Y Acad Sci. 2015 Dec;1362:8-15. doi: 10.1111/nyas.12769. Epub 2015 Apr 30. Review.

PMID:
25931205
11.

B cells generated by B-1 development can progress to chronic lymphocytic leukemia.

Hayakawa K, Formica AM, Colombo MJ, Ichikawa D, Shinton SA, Brill-Dashoff J, Hardy RR.

Ann N Y Acad Sci. 2015 Dec;1362:250-5. doi: 10.1111/nyas.12768. Epub 2015 Apr 23. Review.

PMID:
25907284
12.

Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a.

Zhou Y, Li YS, Bandi SR, Tang L, Shinton SA, Hayakawa K, Hardy RR.

J Exp Med. 2015 Apr 6;212(4):569-80. doi: 10.1084/jem.20141510. Epub 2015 Mar 9.

13.

Natural anti-intestinal goblet cell autoantibody production from marginal zone B cells.

Ichikawa D, Asano M, Shinton SA, Brill-Dashoff J, Formica AM, Velcich A, Hardy RR, Hayakawa K.

J Immunol. 2015 Jan 15;194(2):606-14. doi: 10.4049/jimmunol.1402383. Epub 2014 Dec 5.

14.

Leonard Herzenberg (1931-2013): the life of FACS.

Hardy RR, Roederer M.

Immunity. 2013 Dec 12;39(6):989-91. No abstract available.

15.

A role for IRF4 in the development of CLL.

Shukla V, Ma S, Hardy RR, Joshi SS, Lu R.

Blood. 2013 Oct 17;122(16):2848-55. doi: 10.1182/blood-2013-03-492769. Epub 2013 Aug 7.

16.

The transcriptional landscape of αβ T cell differentiation.

Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C; Immunological Genome Consortium, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Nageswara Rao T, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S.

Nat Immunol. 2013 Jun;14(6):619-32. doi: 10.1038/ni.2590. Epub 2013 May 5.

17.

Identification of transcriptional regulators in the mouse immune system.

Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D; Immunological Genome Project Consortium, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemarte-Pelletier A, Malhotra D, Turley S.

Nat Immunol. 2013 Jun;14(6):633-43. doi: 10.1038/ni.2587. Epub 2013 Apr 28.

18.

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. 1991.

Hardy RR, Carmack CE, Shinton SA, Kemp JD, Hayakawa K.

J Immunol. 2012 Oct 1;189(7):3271-83. No abstract available.

19.

Positive and negative selection of natural autoreactive B cells.

Hardy RR, Hayakawa K.

Adv Exp Med Biol. 2012;750:227-38. doi: 10.1007/978-1-4614-3461-0_17.

PMID:
22903678
20.

Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors.

Cooper CL, Hardy RR, Reth M, Desiderio S.

Blood. 2012 Jun 7;119(23):5438-48. doi: 10.1182/blood-2011-12-397976. Epub 2012 Apr 18.

21.

Transcriptomes of the B and T lineages compared by multiplatform microarray profiling.

Painter MW, Davis S, Hardy RR, Mathis D, Benoist C; Immunological Genome Project Consortium.

J Immunol. 2011 Mar 1;186(5):3047-57. doi: 10.4049/jimmunol.1002695. Epub 2011 Feb 9.

22.

NEDD9 promotes oncogenic signaling in mammary tumor development.

Izumchenko E, Singh MK, Plotnikova OV, Tikhmyanova N, Little JL, Serebriiskii IG, Seo S, Kurokawa M, Egleston BL, Klein-Szanto A, Pugacheva EN, Hardy RR, Wolfson M, Connolly DC, Golemis EA.

Cancer Res. 2009 Sep 15;69(18):7198-206. doi: 10.1158/0008-5472.CAN-09-0795. Epub 2009 Sep 8.

23.

Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma.

Kadariya Y, Yin B, Tang B, Shinton SA, Quinlivan EP, Hua X, Klein-Szanto A, Al-Saleem TI, Bassing CH, Hardy RR, Kruger WD.

Cancer Res. 2009 Jul 15;69(14):5961-9. doi: 10.1158/0008-5472.CAN-09-0145. Epub 2009 Jun 30.

24.

Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.

Amin RH, Cado D, Nolla H, Huang D, Shinton SA, Zhou Y, Hardy RR, Schlissel MS.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):522-7. doi: 10.1073/pnas.0808895106. Epub 2008 Dec 30.

25.

A role for cFLIP in B cell proliferation and stress MAPK regulation.

Zhang H, Rosenberg S, Coffey FJ, He YW, Manser T, Hardy RR, Zhang J.

J Immunol. 2009 Jan 1;182(1):207-15.

26.

Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus.

Giambra V, Volpi S, Emelyanov AV, Pflugh D, Bothwell AL, Norio P, Fan Y, Ju Z, Skoultchi AI, Hardy RR, Frezza D, Birshtein BK.

Mol Cell Biol. 2008 Oct;28(19):6123-33. doi: 10.1128/MCB.00233-08. Epub 2008 Jul 21.

27.

Isolation of Ly-1+/CD5+ B cells by cell sorting.

Hardy RR.

Curr Protoc Immunol. 2003 Aug;Chapter 3:Unit 3.5B. doi: 10.1002/0471142735.im0305bs55.

PMID:
18432908
28.

B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements.

Schram BR, Tze LE, Ramsey LB, Liu J, Najera L, Vegoe AL, Hardy RR, Hippen KL, Farrar MA, Behrens TW.

J Immunol. 2008 Apr 1;180(7):4728-41.

29.

Autoreactive B-1 B cells: constraints on natural autoantibody B cell antigen receptors.

Rowley B, Tang L, Shinton S, Hayakawa K, Hardy RR.

J Autoimmun. 2007 Dec;29(4):236-45. Epub 2007 Sep 21.

30.

The protean nature of cells in the B lymphocyte lineage.

Hardy RR, Kincade PW, Dorshkind K.

Immunity. 2007 Jun;26(6):703-14. Review.

31.

Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint.

Anderson SJ, Lauritsen JP, Hartman MG, Foushee AM, Lefebvre JM, Shinton SA, Gerhardt B, Hardy RR, Oravecz T, Wiest DL.

Immunity. 2007 Jun;26(6):759-72. Epub 2007 Jun 7.

32.

Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b.

Kitaura Y, Jang IK, Wang Y, Han YC, Inazu T, Cadera EJ, Schlissel M, Hardy RR, Gu H.

Immunity. 2007 May;26(5):567-78. Epub 2007 May 10.

33.

B-1 B cell development.

Hardy RR.

J Immunol. 2006 Sep 1;177(5):2749-54. Review.

34.

B-1 B cells: development, selection, natural autoantibody and leukemia.

Hardy RR.

Curr Opin Immunol. 2006 Oct;18(5):547-55. Epub 2006 Aug 1. Review.

PMID:
16879952
35.

Lineage specification and plasticity in CD19- early B cell precursors.

Rumfelt LL, Zhou Y, Rowley BM, Shinton SA, Hardy RR.

J Exp Med. 2006 Mar 20;203(3):675-87. Epub 2006 Feb 27.

36.

Evidence of marginal-zone B cell-positive selection in spleen.

Wen L, Brill-Dashoff J, Shinton SA, Asano M, Hardy RR, Hayakawa K.

Immunity. 2005 Sep;23(3):297-308.

37.

Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. 1982.

Butcher EC, Rouse RV, Coffman RL, Nottenburg CN, Hardy RR, Weissman IL.

J Immunol. 2005 Aug 1;175(3):1363-72. No abstract available.

38.

Association of B-1 B cells with follicular dendritic cells in spleen.

Wen L, Shinton SA, Hardy RR, Hayakawa K.

J Immunol. 2005 Jun 1;174(11):6918-26.

39.

Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.

Tze LE, Schram BR, Lam KP, Hogquist KA, Hippen KL, Liu J, Shinton SA, Otipoby KL, Rodine PR, Vegoe AL, Kraus M, Hardy RR, Schlissel MS, Rajewsky K, Behrens TW.

PLoS Biol. 2005 Mar;3(3):e82. Epub 2005 Mar 8.

40.

Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes.

Hardy RR, Hayakawa K.

Springer Semin Immunopathol. 2005 Mar;26(4):363-75. Epub 2004 Dec 21. Review.

PMID:
15611857
41.

Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription.

Maier H, Ostraat R, Gao H, Fields S, Shinton SA, Medina KL, Ikawa T, Murre C, Singh H, Hardy RR, Hagman J.

Nat Immunol. 2004 Oct;5(10):1069-77. Epub 2004 Sep 12.

PMID:
15361869
42.

Characterization of B lymphopoiesis in mouse bone marrow and spleen.

Hardy RR, Shinton SA.

Methods Mol Biol. 2004;271:1-24.

PMID:
15146109
43.

Selection during development of VH11+ B cells: a model for natural autoantibody-producing CD5+ B cells.

Hardy RR, Wei CJ, Hayakawa K.

Immunol Rev. 2004 Feb;197:60-74. Review.

PMID:
14962187
44.

B-cell commitment: deciding on the players.

Hardy RR.

Curr Opin Immunol. 2003 Apr;15(2):158-65. Review.

PMID:
12633665
45.

Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development.

Hayakawa K, Asano M, Shinton SA, Gui M, Wen LJ, Dashoff J, Hardy RR.

J Exp Med. 2003 Jan 6;197(1):87-99.

46.

Development of VH11+ B cells: a model for selection of B cells producing natural autoantibodies.

Hardy RR.

Curr Dir Autoimmun. 2003;6:196-211. Review. No abstract available.

PMID:
12408053
47.

Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression.

Bichi R, Shinton SA, Martin ES, Koval A, Calin GA, Cesari R, Russo G, Hardy RR, Croce CM.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6955-60.

48.

Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation.

Allman D, Lindsley RC, DeMuth W, Rudd K, Shinton SA, Hardy RR.

J Immunol. 2001 Dec 15;167(12):6834-40.

49.

TCR beta chain influences but does not solely control autoreactivity of V alpha 14J281T cells.

Gui M, Li J, Wen LJ, Hardy RR, Hayakawa K.

J Immunol. 2001 Dec 1;167(11):6239-46.

50.

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