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Age at natural menopause and risk of incident cardiovascular disease: a pooled analysis of individual patient data.

Zhu D, Chung HF, Dobson AJ, Pandeya N, Giles GG, Bruinsma F, Brunner EJ, Kuh D, Hardy R, Avis NE, Gold EB, Derby CA, Matthews KA, Cade JE, Greenwood DC, Demakakos P, Brown DE, Sievert LL, Anderson D, Hayashi K, Lee JS, Mizunuma H, Tillin T, Simonsen MK, Adami HO, Weiderpass E, Mishra GD.

Lancet Public Health. 2019 Oct 3. pii: S2468-2667(19)30155-0. doi: 10.1016/S2468-2667(19)30155-0. [Epub ahead of print]


Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study.

Lane CA, Barnes J, Nicholas JM, Sudre CH, Cash DM, Parker TD, Malone IB, Lu K, James SN, Keshavan A, Murray-Smith H, Wong A, Buchanan SM, Keuss SE, Gordon E, Coath W, Barnes A, Dickson J, Modat M, Thomas D, Crutch SJ, Hardy R, Richards M, Fox NC, Schott JM.

Lancet Neurol. 2019 Oct;18(10):942-952. doi: 10.1016/S1474-4422(19)30228-5. Epub 2019 Aug 20.


11β-HSD1 plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy.

Fenton CG, Doig CL, Fareed S, Naylor A, Morrell AP, Addison O, Wehmeyer C, Buckley CD, Cooper MS, Lavery GG, Raza K, Hardy RS.

Arthritis Res Ther. 2019 Aug 16;21(1):188. doi: 10.1186/s13075-019-1972-1.


Prognostic implications of left ventricular strain by speckle-tracking echocardiography in the general population: a meta-analysis.

Al Saikhan L, Park C, Hardy R, Hughes A.

Vasc Health Risk Manag. 2019 Jul 24;15:229-251. doi: 10.2147/VHRM.S206747. eCollection 2019.


Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis.

Fenton CG, Webster JM, Martin CS, Fareed S, Wehmeyer C, Mackie H, Jones R, Seabright AP, Lewis JW, Lai YC, Goodyear CS, Jones SW, Cooper MS, Lavery GG, Langen R, Raza K, Hardy RS.

Arthritis Res Ther. 2019 Aug 1;21(1):182. doi: 10.1186/s13075-019-1962-3.


The relationship between pubertal timing and markers of vascular and cardiac structure and function in men and women aged 60-64 years.

Hardy R, Maddock J, Ghosh AK, Hughes AD, Kuh D.

Sci Rep. 2019 Jul 30;9(1):11037. doi: 10.1038/s41598-019-47164-x.


The effect of mid-life insulin resistance and type 2 diabetes on older-age cognitive state: the explanatory role of early-life advantage.

James SN, Wong A, Tillin T, Hardy R, Chaturvedi N, Richards M.

Diabetologia. 2019 Oct;62(10):1891-1900. doi: 10.1007/s00125-019-4949-3. Epub 2019 Jul 29.


Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019.

Donaldson K, Buchanich JM, Grigson PS, Deneke E, Donaldson K, Vrana KE, Sacks DB, Kuehn GJ, Cardamone D, Pesce A, Smiley S, Nickley J, Krock K, Thomas R, Wilkerson ML, Farag HA, Challa SR, Tice AM, Wolk DM, Prichard J, Grant ML, Regmi S, Kerbacher B, Quinton LE, Farag HA, Tice AM, Wolk DM, Olson J, Haynes A, Yu E, McCully KS, Assi J, Wong M, Zarrin-Khameh N, Nifong TP, Hawker CD, Carlton GT, Rivera JM, Foulis PR, Zuraw A, Morlote D, Peker D, Reddy V, Harada S, Crutchfield C, Zander D, Barbhuiya MA, Pederson EC, Straub ML, Scott SC, Neibauer TL, Salter WF, Creer MH, Zhu Y, Bornhorst JA, Theobald JP, Algeciras-Schimnich A, Cao L, Knox J, Hardy R, Texas HJ, McGuire MF, Hunter RL, Brown RE, Hicks J, Hicks J, Cai Z, Brown RE, Ali Y, Cheng KC, Katz SR, Ding Y, Vanselow DJ, Yakovlev MA, Lin AY, Clark DP, Vargas P, Xin X, Copper JE, Canfield VA, Ang KC, Wang Y, Xiao X, De Carlo F, van Rossum DB, La Rivière PJ, Newell J, Hossler C, Roche M, Warrick J, Phaeton R, Kesterson J, Donaldson K, Myers C, Barrios R, Mintz P, Robyak K, Hamilton C, McGhee P, Pederson C, Straub M, Scott S, Neibauer T, Salter W, Creer M, Zhu Y, Hamilton C, Robyak K, McGhee P, Pederson C, Straub M, Scott S, Neibauer T, Salter W, Creer M, Zhu Y, Singh N, Morlote D, Vnencak-Jones C, Yemelyanova A, Harada S, Shah M, Moghadamtousi SZ, Lan C, Duose D, Hu P, Esquenazi Y, Luthra R, Ballester LY, Koenig AN, Liu CG, Zhang J, Kalia A, Al-Habib A, Van Arsdall M, Dhingra S, Patel K, Tatevian N.

Ann Clin Lab Sci. 2019 May;49(3):403-416. No abstract available.


Correction to: Socioeconomic inequalities in childhood-to-adulthood BMI tracking in three British birth cohorts.

Norris T, Bann D, Hardy R, Johnson W.

Int J Obes (Lond). 2019 Aug;43(8):1656. doi: 10.1038/s41366-019-0403-3.


Structural connectivity and risk for anhedonia after trauma: A prospective study and replication.

Fani N, Michopoulos V, van Rooij SJH, Clendinen C, Hardy RA, Jovanovic T, Rothbaum BO, Ressler KJ, Stevens JS.

J Psychiatr Res. 2019 Sep;116:34-41. doi: 10.1016/j.jpsychires.2019.05.009. Epub 2019 May 14.


Socioeconomic inequalities in childhood-to-adulthood BMI tracking in three British birth cohorts.

Norris T, Bann D, Hardy R, Johnson W.

Int J Obes (Lond). 2019 Jun 5. doi: 10.1038/s41366-019-0387-z. [Epub ahead of print] Erratum in: Int J Obes (Lond). 2019 Aug;43(8):1656.


Number of children and body composition in later life among men and women: Results from a British birth cohort study.

Bridger Staatz C, Hardy R.

PLoS One. 2019 May 29;14(5):e0209529. doi: 10.1371/journal.pone.0209529. eCollection 2019.


State Laws and Nonprofit Hospital Community Benefit Spending.

Johnson EK, Hardy R, Santos T, Leider JP, Lindrooth RC, Tung GJ.

J Public Health Manag Pract. 2019 Jul/Aug;25(4):E9-E17. doi: 10.1097/PHH.0000000000000885.


Attentional control abnormalities in posttraumatic stress disorder: Functional, behavioral, and structural correlates.

Fani N, King TZ, Clendinen C, Hardy RA, Surapaneni S, Blair JR, White SF, Powers A, Ely TD, Jovanovic T, Ressler KJ, Bradley B.

J Affect Disord. 2019 Jun 15;253:343-351. doi: 10.1016/j.jad.2019.04.098. Epub 2019 Apr 30.


Developmental factors associated with decline in grip strength from midlife to old age: a British birth cohort study.

Kuh D, Hardy R, Blodgett JM, Cooper R.

BMJ Open. 2019 May 9;9(5):e025755. doi: 10.1136/bmjopen-2018-025755.


Explaining differential vulnerability to climate change: A social science review.

Thomas K, Hardy RD, Lazrus H, Mendez M, Orlove B, Rivera-Collazo I, Roberts JT, Rockman M, Warner BP, Winthrop R.

Wiley Interdiscip Rev Clim Change. 2019 Mar-Apr;10(2):e565. doi: 10.1002/wcc.565. Epub 2018 Dec 7. Review.


Associations of medical conditions, lifestyle and unintentional weight loss in early old age: The 1946 British Birth Cohort.

Cao Y, Hardy R, Wulaningsih W.

PLoS One. 2019 Apr 9;14(4):e0211952. doi: 10.1371/journal.pone.0211952. eCollection 2019.


Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation.

Hayakawa K, Li YS, Shinton SA, Bandi SR, Formica AM, Brill-Dashoff J, Hardy RR.

Front Immunol. 2019 Mar 15;10:457. doi: 10.3389/fimmu.2019.00457. eCollection 2019.


Metabolomic correlates of central adiposity and earlier-life body mass index.

Wulaningsih W, Proitsi P, Wong A, Kuh D, Hardy R.

J Lipid Res. 2019 Jun;60(6):1136-1143. doi: 10.1194/jlr.P085944. Epub 2019 Mar 18.


Dysregulation of the hypothalamic pituitary adrenal (HPA) axis and cognitive capability at older ages: individual participant meta-analysis of five cohorts.

Gardner M, Lightman S, Kuh D, Comijs H, Deeg D, Gallacher J, Geoffroy MC, Kivimaki M, Kumari M, Power C, Hardy R, Richards M, Ben-Shlomo Y.

Sci Rep. 2019 Mar 14;9(1):4555. doi: 10.1038/s41598-019-40566-x.


Data Resource Profile: Cohort and Longitudinal Studies Enhancement Resources (CLOSER).

O'Neill D, Benzeval M, Boyd A, Calderwood L, Cooper C, Corti L, Dennison E, Fitzsimons E, Goodman A, Hardy R, Inskip H, Molloy L, Sacker A, Sudlow A, Sullivan A, Park A.

Int J Epidemiol. 2019 Jun 1;48(3):675-676i. doi: 10.1093/ije/dyz004. No abstract available.


Premenopausal cardiovascular disease and age at natural menopause: a pooled analysis of over 170,000 women.

Zhu D, Chung HF, Pandeya N, Dobson AJ, Hardy R, Kuh D, Brunner EJ, Bruinsma F, Giles GG, Demakakos P, Lee JS, Mizunuma H, Hayashi K, Adami HO, Weiderpass E, Mishra GD.

Eur J Epidemiol. 2019 Mar;34(3):235-246. doi: 10.1007/s10654-019-00490-w. Epub 2019 Feb 5.


Systemic Inflammation and Cardio-Renal Organ Damage Biomarkers in Middle Age Are Associated With Physical Capability Up to 9 Years Later.

Kuh D, Cooper R, Sattar N, Welsh P, Hardy R, Ben-Shlomo Y.

Circulation. 2019 Apr 23;139(17):1988-1999. doi: 10.1161/CIRCULATIONAHA.118.037332.


Informal caregiving experiences in posttraumatic stress disorder: A content analysis of an online community.

Ferrell EL, Russin SE, Hardy RM.

J Community Psychol. 2019 May;47(4):757-771. doi: 10.1002/jcop.22151. Epub 2018 Dec 27.


Childhood cognition and age-related change in standing balance performance from mid to later life: findings from a British birth cohort.

Blodgett JM, Kuh D, Hardy R, Davis DHJ, Cooper R.

J Gerontol A Biol Sci Med Sci. 2018 Dec 8. doi: 10.1093/gerona/gly275. [Epub ahead of print]


Childhood adversity and DNA methylation in two population-based cohorts.

Houtepen LC, Hardy R, Maddock J, Kuh D, Anderson EL, Relton CL, Suderman MJ, Howe LD.

Transl Psychiatry. 2018 Dec 3;8(1):266. doi: 10.1038/s41398-018-0307-3.


GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O'Donnell CJ.

Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5.


Age at Onset of Walking in Infancy Is Associated With Hip Shape in Early Old Age.

Ireland A, Saunders FR, Muthuri SG, Pavlova AV, Hardy RJ, Martin KR, Barr RJ, Adams JE, Kuh D, Aspden RM, Gregory JS, Cooper R.

J Bone Miner Res. 2019 Mar;34(3):455-463. doi: 10.1002/jbmr.3627. Epub 2019 Jan 15.


Relationships between intensity, duration, cumulative dose, and timing of smoking with age at menopause: A pooled analysis of individual data from 17 observational studies.

Zhu D, Chung HF, Pandeya N, Dobson AJ, Cade JE, Greenwood DC, Crawford SL, Avis NE, Gold EB, Mitchell ES, Woods NF, Anderson D, Brown DE, Sievert LL, Brunner EJ, Kuh D, Hardy R, Hayashi K, Lee JS, Mizunuma H, Giles GG, Bruinsma F, Tillin T, Simonsen MK, Adami HO, Weiderpass E, Canonico M, Ancelin ML, Demakakos P, Mishra GD.

PLoS Med. 2018 Nov 27;15(11):e1002704. doi: 10.1371/journal.pmed.1002704. eCollection 2018 Nov.


Early-life adversity, later-life mental health, and resilience resources: a longitudinal population-based birth cohort analysis.

Cosco TD, Hardy R, Howe LD, Richards M.

Int Psychogeriatr. 2018 Nov 23:1-10. doi: 10.1017/S1041610218001795. [Epub ahead of print]


Associations between back pain across adulthood and spine shape in early old age in a British birth cohort.

Muthuri SG, Pavlova AV, Saunders FR, Hardy RJ, Gregory JS, Barr RJ, Martin KR, Adams JE, Kuh D, Aspden RM, Cooper R.

Sci Rep. 2018 Nov 5;8(1):16309. doi: 10.1038/s41598-018-34628-9.


Physical Activity, Sedentary Time, and Cardiovascular Disease Biomarkers at Age 60 to 64 Years.

Elhakeem A, Cooper R, Whincup P, Brage S, Kuh D, Hardy R.

J Am Heart Assoc. 2018 Aug 21;7(16):e007459. doi: 10.1161/JAHA.117.007459. Erratum in: J Am Heart Assoc. 2018 Oct 16;7(20):e004284.


A Sharing Meanings Approach for Interdisciplinary Hazards Research.

Hardy RD.

Risk Anal. 2018 Oct 10. doi: 10.1111/risa.13216. [Epub ahead of print]


Glucocorticoid activation by 11β-hydroxysteroid dehydrogenase enzymes in relation to inflammation and glycaemic control in chronic kidney disease: A cross-sectional study.

Sagmeister MS, Taylor AE, Fenton A, Wall NA, Chanouzas D, Nightingale PG, Ferro CJ, Arlt W, Cockwell P, Hardy RS, Harper L.

Clin Endocrinol (Oxf). 2019 Jan;90(1):241-249. doi: 10.1111/cen.13889. Epub 2018 Nov 15.


Lifetime cognition and late midlife blood metabolites: findings from a British birth cohort.

Proitsi P, Kuh D, Wong A, Maddock J, Bendayan R, Wulaningsih W, Hardy R, Richards M.

Transl Psychiatry. 2018 Sep 26;8(1):203. doi: 10.1038/s41398-018-0253-0.


Evaluating the success of public participation in integrated catchment management.

Rollason E, Bracken LJ, Hardy RJ, Large ARG.

J Environ Manage. 2018 Dec 15;228:267-278. doi: 10.1016/j.jenvman.2018.09.024. Epub 2018 Sep 15.


Parental age and offspring leukocyte telomere length and attrition in midlife: Evidence from the 1946 British birth cohort.

Wulaningsih W, Hardy R, Wong A, Kuh D.

Exp Gerontol. 2018 Oct 2;112:92-96. doi: 10.1016/j.exger.2018.09.008. Epub 2018 Sep 15.


Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis.

Skaaby T, Kilpeläinen TO, Taylor AE, Mahendran Y, Wong A, Ahluwalia TS, Paternoster L, Trompet S, Stott DJ, Flexeder C, Zhou A, Brusselle G, Sajjad A, Lahousse L, Tiemeier H, Have CT, Thuesen BH, Kårhus LL, Møllehave LT, Leth-Møller KB, Shabanzadeh DM, Gonzalez-Quintela A, Power C, Hyppönen E, Kuh D, Hardy R, Meitinger T, Jukema JW, Völker U, Nauck M, Völzke H, Friedrich N, Bonten TN, Noordam R, Mook-Kanamori DO, Tolstrup JS, Taube C, Peters A, Grallert H, Strauch K, Schulz H, Grarup N, Hansen T, Pedersen O, Burgess S, Munafò MR, Linneberg A.

Addiction. 2019 Feb;114(2):216-225. doi: 10.1111/add.14438. Epub 2018 Oct 30.


Unravelling how glucocorticoids work in rheumatoid arthritis.

Hardy R, Cooper MS.

Nat Rev Rheumatol. 2018 Oct;14(10):566-567. doi: 10.1038/s41584-018-0079-4. No abstract available.


Lifetime affective problems and later-life cognitive state: Over 50 years of follow-up in a British birth cohort study.

James SN, Davis D, O'Hare C, Sharma N, John A, Gaysina D, Hardy R, Kuh D, Richards M.

J Affect Disord. 2018 Dec 1;241:348-355. doi: 10.1016/j.jad.2018.07.078. Epub 2018 Jul 30.


Cognitive and neural facets of dissociation in a traumatized population.

Fani N, King TZ, Powers A, Hardy RA, Siegle GJ, Blair RJ, Surapaneni S, van Rooij S, Ressler KJ, Jovanovic T, Bradley B.

Emotion. 2019 Aug;19(5):863-875. doi: 10.1037/emo0000466. Epub 2018 Aug 20.


Urban-Rural Differences in Service Utilization and Costs of Care for Racial-Ethnic Groups Hospitalized With Poststroke Aphasia.

Hardy RY, Lindrooth RC, Peach RK, Ellis C.

Arch Phys Med Rehabil. 2019 Feb;100(2):254-260. doi: 10.1016/j.apmr.2018.06.033. Epub 2018 Aug 10.


Associations between body size, nutrition and socioeconomic position in early life and the epigenome: A systematic review.

Maddock J, Wulaningsih W, Fernandez JC, Ploubidis GB, Goodman A, Bell J, Kuh D, Hardy R.

PLoS One. 2018 Aug 10;13(8):e0201672. doi: 10.1371/journal.pone.0201672. eCollection 2018.


Childhood Exposures, Asthma, Smoking, Interactions, and the Catch-Up Hypothesis.

Allinson JP, Hardy R, Donaldson GC, Wedzicha JA.

Ann Am Thorac Soc. 2018 Oct;15(10):1241-1242. doi: 10.1513/AnnalsATS.201807-444LE. No abstract available.


A dietary pattern derived using B-vitamins and its relationship with vascular markers over the life course.

Maddock J, Ambrosini GL, Griffin JL, West JA, Wong A, Hardy R, Ray S.

Clin Nutr. 2019 Jun;38(3):1464-1473. doi: 10.1016/j.clnu.2018.06.969. Epub 2018 Jun 28.


Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption.

Sanders FWB, Acharjee A, Walker C, Marney L, Roberts LD, Imamura F, Jenkins B, Case J, Ray S, Virtue S, Vidal-Puig A, Kuh D, Hardy R, Allison M, Forouhi N, Murray AJ, Wareham N, Vacca M, Koulman A, Griffin JL.

Genome Biol. 2018 Jun 20;19(1):79. doi: 10.1186/s13059-018-1439-8.


A Bayesian approach to investigate life course hypotheses involving continuous exposures.

Madathil S, Joseph L, Hardy R, Rousseau MC, Nicolau B.

Int J Epidemiol. 2018 Oct 1;47(5):1623-1635. doi: 10.1093/ije/dyy107.


Glucocorticoids and Bone: Consequences of Endogenous and Exogenous Excess and Replacement Therapy.

Hardy RS, Zhou H, Seibel MJ, Cooper MS.

Endocr Rev. 2018 Oct 1;39(5):519-548. doi: 10.1210/er.2018-00097. Review.


Body mass index and waist circumference in early adulthood are associated with thoracolumbar spine shape at age 60-64: The Medical Research Council National Survey of Health and Development.

Pavlova AV, Muthuri SG, Cooper R, Saunders FR, Gregory JS, Barr RJ, Martin KR, Adams JE, Kuh D, Hardy RJ, Aspden RM.

PLoS One. 2018 Jun 14;13(6):e0197570. doi: 10.1371/journal.pone.0197570. eCollection 2018.

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