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Items: 1 to 50 of 154

1.

Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs.

Hardy MP, Audemard É, Migneault F, Feghaly A, Brochu S, Gendron P, Boilard É, Major F, Dieudé M, Hébert MJ, Perreault C.

Sci Rep. 2019 May 10;9(1):7203. doi: 10.1038/s41598-019-43591-y.

2.

Optimizing high throughput antibody purification by using continuous chromatography media.

Butcher RE, Martin-Roussety G, Bradford RA, Tester A, Owczarek C, Hardy MP, Chen CG, Sansome G, Fabri LJ, Schmidt PM.

Protein Expr Purif. 2019 Jul;159:75-82. doi: 10.1016/j.pep.2019.03.011. Epub 2019 Mar 25.

PMID:
30917921
3.

PSMB11 Orchestrates the Development of CD4 and CD8 Thymocytes via Regulation of Gene Expression in Cortical Thymic Epithelial Cells.

Apavaloaei A, Brochu S, Dong M, Rouette A, Hardy MP, Villafano G, Murata S, Melichar HJ, Perreault C.

J Immunol. 2019 Feb 1;202(3):966-978. doi: 10.4049/jimmunol.1801288. Epub 2018 Dec 19.

PMID:
30567730
4.

Noncoding regions are the main source of targetable tumor-specific antigens.

Laumont CM, Vincent K, Hesnard L, Audemard É, Bonneil É, Laverdure JP, Gendron P, Courcelles M, Hardy MP, Côté C, Durette C, St-Pierre C, Benhammadi M, Lanoix J, Vobecky S, Haddad E, Lemieux S, Thibault P, Perreault C.

Sci Transl Med. 2018 Dec 5;10(470). pii: eaau5516. doi: 10.1126/scitranslmed.aau5516.

PMID:
30518613
5.

Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins.

Trezise S, Karnowski A, Fedele PL, Mithraprabhu S, Liao Y, D'Costa K, Kueh AJ, Hardy MP, Owczarek CM, Herold MJ, Spencer A, Shi W, Willis SN, Nutt SL, Corcoran LM.

Int J Mol Sci. 2018 Jul 24;19(8). pii: E2161. doi: 10.3390/ijms19082161.

6.

Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.

Schaer CA, Owczarek C, Deuel JW, Schauer S, Baek JH, Yalamanoglu A, Hardy MP, Scotney PD, Schmidt PM, Pelzing M, Soupourmas P, Buehler PW, Schaer DJ.

BMC Biotechnol. 2018 Mar 15;18(1):15. doi: 10.1186/s12896-018-0424-3.

7.

Comparison of the MHC I Immunopeptidome Repertoire of B-Cell Lymphoblasts Using Two Isolation Methods.

Lanoix J, Durette C, Courcelles M, Cossette É, Comtois-Marotte S, Hardy MP, Côté C, Perreault C, Thibault P.

Proteomics. 2018 Jun;18(12):e1700251. doi: 10.1002/pmic.201700251. Epub 2018 Apr 24.

PMID:
29508533
8.

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.

Broughton SE, Hercus TR, Nero TL, Kan WL, Barry EF, Dottore M, Cheung Tung Shing KS, Morton CJ, Dhagat U, Hardy MP, Wilson NJ, Downton MT, Schieber C, Hughes TP, Lopez AF, Parker MW.

Nat Commun. 2018 Jan 26;9(1):386. doi: 10.1038/s41467-017-02633-7.

9.

Immunoproteasomes Control the Homeostasis of Medullary Thymic Epithelial Cells by Alleviating Proteotoxic Stress.

St-Pierre C, Morgand E, Benhammadi M, Rouette A, Hardy MP, Gaboury L, Perreault C.

Cell Rep. 2017 Nov 28;21(9):2558-2570. doi: 10.1016/j.celrep.2017.10.121.

10.

An Optimized Hepatitis C Virus E2 Glycoprotein Core Adopts a Functional Homodimer That Efficiently Blocks Virus Entry.

McCaffrey K, Boo I, Owczarek CM, Hardy MP, Perugini MA, Fabri L, Scotney P, Poumbourios P, Drummer HE.

J Virol. 2017 Feb 14;91(5). pii: e01668-16. doi: 10.1128/JVI.01668-16. Print 2017 Mar 1.

11.

The core domain of hepatitis C virus glycoprotein E2 generates potent cross-neutralizing antibodies in guinea pigs.

Vietheer PT, Boo I, Gu J, McCaffrey K, Edwards S, Owczarek C, Hardy MP, Fabri L, Center RJ, Poumbourios P, Drummer HE.

Hepatology. 2017 Apr;65(4):1117-1131. doi: 10.1002/hep.28989. Epub 2017 Feb 14.

12.

A robust robotic high-throughput antibody purification platform.

Schmidt PM, Abdo M, Butcher RE, Yap MY, Scotney PD, Ramunno ML, Martin-Roussety G, Owczarek C, Hardy MP, Chen CG, Fabri LJ.

J Chromatogr A. 2016 Jul 15;1455:9-19. doi: 10.1016/j.chroma.2016.05.076. Epub 2016 May 24.

PMID:
27283099
13.

Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames.

Laumont CM, Daouda T, Laverdure JP, Bonneil É, Caron-Lizotte O, Hardy MP, Granados DP, Durette C, Lemieux S, Thibault P, Perreault C.

Nat Commun. 2016 Jan 5;7:10238. doi: 10.1038/ncomms10238.

14.

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors.

Panousis C, Dhagat U, Edwards KM, Rayzman V, Hardy MP, Braley H, Gauvreau GM, Hercus TR, Smith S, Sehmi R, McMillan L, Dottore M, McClure BJ, Fabri LJ, Vairo G, Lopez AF, Parker MW, Nash AD, Wilson NJ, Wilson MJ, Owczarek CM.

MAbs. 2016;8(3):436-53. doi: 10.1080/19420862.2015.1119352. Epub 2015 Dec 14.

15.

Exogenous administration of protease-resistant, non-matrix-binding IGFBP-2 inhibits tumour growth in a murine model of breast cancer.

Soh CL, McNeil K, Owczarek CM, Hardy MP, Fabri LJ, Pearse M, Delaine CA, Forbes BE.

Br J Cancer. 2015 Dec 1;113(11):1640. doi: 10.1038/bjc.2015.385. No abstract available.

16.

The combination of ISCOMATRIX adjuvant and TLR agonists induces regression of established solid tumors in vivo.

Silva A, Mount A, Krstevska K, Pejoski D, Hardy MP, Owczarek C, Scotney P, Maraskovsky E, Baz Morelli A.

J Immunol. 2015 Mar 1;194(5):2199-207. doi: 10.4049/jimmunol.1402228. Epub 2015 Feb 2.

17.

Unexpected mechanisms of action for a cytokine receptor-blocking antibody.

Hercus TR, Broughton SE, Hardy MP, Nero TL, Wilson NJ, Parker MW, Lopez AF.

Mol Cell Oncol. 2014 Dec 31;1(4):e969129. doi: 10.4161/23288604.2014.969129. eCollection 2014 Oct-Dec.

18.

Review of Azoospermia.

Wosnitzer M, Goldstein M, Hardy MP.

Spermatogenesis. 2014 Mar 31;4:e28218. eCollection 2014. Review.

19.

Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody.

Broughton SE, Hercus TR, Hardy MP, McClure BJ, Nero TL, Dottore M, Huynh H, Braley H, Barry EF, Kan WL, Dhagat U, Scotney P, Hartman D, Busfield SJ, Owczarek CM, Nash AD, Wilson NJ, Parker MW, Lopez AF.

Cell Rep. 2014 Jul 24;8(2):410-9. doi: 10.1016/j.celrep.2014.06.038. Epub 2014 Jul 17.

20.

Immunoproteasomes shape the transcriptome and regulate the function of dendritic cells.

de Verteuil DA, Rouette A, Hardy MP, Lavallée S, Trofimov A, Gaucher É, Perreault C.

J Immunol. 2014 Aug 1;193(3):1121-32. doi: 10.4049/jimmunol.1400871. Epub 2014 Jun 23.

21.

Exogenous administration of protease-resistant, non-matrix-binding IGFBP-2 inhibits tumour growth in a murine model of breast cancer.

Soh CL, McNeil K, Owczarek CM, Hardy MP, Fabri LJ, Pearse M, Delaine CA, Forbes BE.

Br J Cancer. 2014 Jun 10;110(12):2855-64. doi: 10.1038/bjc.2014.232. Epub 2014 May 22. Erratum in: Br J Cancer. 2015 Dec 1;113(11):1640.

22.

Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides.

Granados DP, Sriranganadane D, Daouda T, Zieger A, Laumont CM, Caron-Lizotte O, Boucher G, Hardy MP, Gendron P, Côté C, Lemieux S, Thibault P, Perreault C.

Nat Commun. 2014 Apr 9;5:3600. doi: 10.1038/ncomms4600.

23.

Identification of potent antagonist antibodies against mouse IL-13Rα1 using novel bioassays.

Edwards KM, Huynh H, Prasad R, McDonald A, Hardy MP, Scotney P, Owczarek CM, Busfield SJ, Panousis C, Wilson NJ.

J Immunol Methods. 2014 May;407:48-57. doi: 10.1016/j.jim.2014.03.019. Epub 2014 Apr 3.

PMID:
24704819
24.

Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock.

Samarajiwa SA, Mangan NE, Hardy MP, Najdovska M, Dubach D, Braniff SJ, Owczarek CM, Hertzog PJ.

J Immunol. 2014 May 1;192(9):4425-35. doi: 10.4049/jimmunol.1302388. Epub 2014 Apr 2.

25.

Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.

Broughton SE, Hercus TR, Nero TL, Dhagat U, Owczarek CM, Hardy MP, Fabri LJ, Scotney PD, Nash AD, Wilson NJ, Lopez AF, Parker MW.

Acta Crystallogr F Struct Biol Commun. 2014 Mar;70(Pt 3):358-61. doi: 10.1107/S2053230X14002593. Epub 2014 Feb 19.

26.

A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk.

Larsson M, Rayzman V, Nolte MW, Nickel KF, Björkqvist J, Jämsä A, Hardy MP, Fries M, Schmidbauer S, Hedenqvist P, Broomé M, Pragst I, Dickneite G, Wilson MJ, Nash AD, Panousis C, Renné T.

Sci Transl Med. 2014 Feb 5;6(222):222ra17. doi: 10.1126/scitranslmed.3006804.

27.

Rejection of leukemic cells requires antigen-specific T cells with high functional avidity.

Vincent K, Hardy MP, Trofimov A, Laumont CM, Sriranganadane D, Hadj-Mimoune S, Salem Fourati I, Soudeyns H, Thibault P, Perreault C.

Biol Blood Marrow Transplant. 2014 Jan;20(1):37-45. doi: 10.1016/j.bbmt.2013.10.020. Epub 2013 Oct 23.

28.

Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats.

Spanevello MD, Tajouri SI, Mirciov C, Kurniawan N, Pearse MJ, Fabri LJ, Owczarek CM, Hardy MP, Bradford RA, Ramunno ML, Turnley AM, Ruitenberg MJ, Boyd AW, Bartlett PF.

J Neurotrauma. 2013 Jun 15;30(12):1023-34. doi: 10.1089/neu.2012.2729.

29.

The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells.

Delisle JS, Giroux M, Boucher G, Landry JR, Hardy MP, Lemieux S, Jones RG, Wilhelm BT, Perreault C.

Genes Immun. 2013 Mar;14(2):115-26. doi: 10.1038/gene.2012.63. Epub 2013 Jan 17. Erratum in: Genes Immun. 2013 Mar;14(2):132.

PMID:
23328844
30.

Parting messages from current and former editors of the Journal of Andrology.

Bartke A, Orgebin-Crist MC, Desjardins C, Lewis R, Tindall D, Hamilton DW, Pryor JL, Schlegel PN, Hardy MP, Burnett AL, Darney SP, Sandlow J.

J Androl. 2012 Nov-Dec;33(6):1068-74. doi: 10.2164/jandrol.112.017475. Epub 2012 Aug 9.

PMID:
22879531
31.

Circadian variation of the response of T cells to antigen.

Fortier EE, Rooney J, Dardente H, Hardy MP, Labrecque N, Cermakian N.

J Immunol. 2011 Dec 15;187(12):6291-300. doi: 10.4049/jimmunol.1004030. Epub 2011 Nov 9.

32.

The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation.

Caron E, Vincent K, Fortier MH, Laverdure JP, Bramoullé A, Hardy MP, Voisin G, Roux PP, Lemieux S, Thibault P, Perreault C.

Mol Syst Biol. 2011 Sep 27;7:533. doi: 10.1038/msb.2011.68.

33.

Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes.

Rafei M, Hardy MP, Williams P, Vanegas JR, Forner KA, Dulude G, Labrecque N, Galipeau J, Perreault C.

J Immunol. 2011 Sep 15;187(6):3133-44. doi: 10.4049/jimmunol.1101097. Epub 2011 Aug 15.

34.

Role of 11β-OH-C(19) and C(21) steroids in the coupling of 11β-HSD1 and 17β-HSD3 in regulation of testosterone biosynthesis in rat Leydig cells.

Latif SA, Shen M, Ge RS, Sottas CM, Hardy MP, Morris DJ.

Steroids. 2011 Jun;76(7):682-9. doi: 10.1016/j.steroids.2011.03.007. Epub 2011 Apr 2.

PMID:
21440566
35.

Normoxic expression of hypoxia-inducible factor 1 in rat Leydig cells in vivo and in vitro.

Palladino MA, Pirlamarla PR, McNamara J, Sottas CM, Korah N, Hardy MP, Hales DB, Hermo L.

J Androl. 2011 May-Jun;32(3):307-23. doi: 10.2164/jandrol.110.011494. Epub 2010 Oct 21.

PMID:
20966422
36.

Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I molecules.

de Verteuil D, Muratore-Schroeder TL, Granados DP, Fortier MH, Hardy MP, Bramoullé A, Caron E, Vincent K, Mader S, Lemieux S, Thibault P, Perreault C.

Mol Cell Proteomics. 2010 Sep;9(9):2034-47. doi: 10.1074/mcp.M900566-MCP200. Epub 2010 May 19.

37.

Kit ligand cytoplasmic domain is essential for basolateral sorting in vivo and has roles in spermatogenesis and hematopoiesis.

Deshpande S, Agosti V, Manova K, Moore MA, Hardy MP, Besmer P.

Dev Biol. 2010 Jan 15;337(2):199-210. doi: 10.1016/j.ydbio.2009.10.022. Epub 2009 Oct 27.

38.

The role of the Leydig cell in spermatogenic function.

Ge R, Chen G, Hardy MP.

Adv Exp Med Biol. 2008;636:255-69. doi: 10.1007/978-0-387-09597-4_14. Review. No abstract available.

PMID:
19856172
39.

Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1.

Bilodeau M, MacRae T, Gaboury L, Laverdure JP, Hardy MP, Mayotte N, Paradis V, Harton S, Perreault C, Sauvageau G.

PLoS One. 2009 Oct 19;4(10):e7500. doi: 10.1371/journal.pone.0007500.

40.

Normal responses to restraint stress in mice lacking the gene for neuronal nitric oxide synthase.

Weissman BA, Sottas CM, Holmes M, Zhou P, Iadecola C, Hardy DO, Ge RS, Hardy MP.

J Androl. 2009 Sep-Oct;30(5):614-20. doi: 10.2164/jandrol.108.007443. Epub 2009 Mar 19.

41.

ER stress affects processing of MHC class I-associated peptides.

Granados DP, Tanguay PL, Hardy MP, Caron E, de Verteuil D, Meloche S, Perreault C.

BMC Immunol. 2009 Feb 16;10:10. doi: 10.1186/1471-2172-10-10.

42.

In utero and lactational exposures to diethylhexyl-phthalate affect two populations of Leydig cells in male Long-Evans rats.

Lin H, Lian QQ, Hu GX, Jin Y, Zhang Y, Hardy DO, Chen GR, Lu ZQ, Sottas CM, Hardy MP, Ge RS.

Biol Reprod. 2009 May;80(5):882-8. doi: 10.1095/biolreprod.108.072975. Epub 2009 Jan 14.

43.

Activins regulate 17beta-hydroxysteroid dehydrogenase type I transcription in murine gonadotrope cells.

Bak B, Carpio L, Kipp JL, Lamba P, Wang Y, Ge RS, Hardy MP, Mayo KE, Bernard DJ.

J Endocrinol. 2009 Apr;201(1):89-104. doi: 10.1677/JOE-08-0460. Epub 2009 Jan 9.

PMID:
19136618
44.

Memory T-lymphocyte survival does not require T-cell receptor expression.

Leignadier J, Hardy MP, Cloutier M, Rooney J, Labrecque N.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20440-5. doi: 10.1073/pnas.0806289106. Epub 2008 Dec 12.

45.

Characterization of a novel gain of function glucocorticoid receptor knock-in mouse.

Zhang J, Ge R, Matte-Martone C, Goodwin J, Shlomchik WD, Mamula MJ, Kooshkabadi A, Hardy MP, Geller D.

J Biol Chem. 2009 Mar 6;284(10):6249-59. doi: 10.1074/jbc.M807997200. Epub 2008 Nov 18.

46.

Modulation of 11beta-hydroxysteroid dehydrogenase expression by bombesin: a possible mechanism for glucocorticoid resistance in androgen independent prostate cancer.

Lee JG, Ge R, Hardy DO, Leong K, Nanus DM, Hardy MP, Shen R.

Horm Metab Res. 2008 Nov;40(11):772-8. doi: 10.1055/s-2008-1080897. Epub 2008 Aug 22.

PMID:
18726827
47.

Androgen-forming stem Leydig cells: identification, function and therapeutic potential.

Zhang Y, Ge R, Hardy MP.

Dis Markers. 2008;24(4-5):277-86. Review.

48.

Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero.

Lin H, Ge RS, Chen GR, Hu GX, Dong L, Lian QQ, Hardy DO, Sottas CM, Li XK, Hardy MP.

Proc Natl Acad Sci U S A. 2008 May 20;105(20):7218-22. doi: 10.1073/pnas.0709260105. Epub 2008 May 9.

49.

Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes.

Field SF, Nejentsev S, Walker NM, Howson JM, Godfrey LM, Jolley JD, Hardy MP, Todd JA.

Diabetes. 2008 Jun;57(6):1753-6. doi: 10.2337/db07-1402. Epub 2008 Mar 10.

50.

The MHC class I peptide repertoire is molded by the transcriptome.

Fortier MH, Caron E, Hardy MP, Voisin G, Lemieux S, Perreault C, Thibault P.

J Exp Med. 2008 Mar 17;205(3):595-610. doi: 10.1084/jem.20071985. Epub 2008 Feb 25.

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