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Items: 1 to 50 of 172

1.

A fluorescence-activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques.

Arias-Arias JL, MacPherson DJ, Hill ME, Hardy JA, Mora-Rodríguez R.

J Biol Chem. 2020 Feb 21;295(8):2212-2226. doi: 10.1074/jbc.RA119.011319. Epub 2020 Jan 9.

PMID:
31919100
2.

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies.

Nalls MA, Blauwendraat C, Vallerga CL, Heilbron K, Bandres-Ciga S, Chang D, Tan M, Kia DA, Noyce AJ, Xue A, Bras J, Young E, von Coelln R, Simón-Sánchez J, Schulte C, Sharma M, Krohn L, Pihlstrøm L, Siitonen A, Iwaki H, Leonard H, Faghri F, Gibbs JR, Hernandez DG, Scholz SW, Botia JA, Martinez M, Corvol JC, Lesage S, Jankovic J, Shulman LM, Sutherland M, Tienari P, Majamaa K, Toft M, Andreassen OA, Bangale T, Brice A, Yang J, Gan-Or Z, Gasser T, Heutink P, Shulman JM, Wood NW, Hinds DA, Hardy JA, Morris HR, Gratten J, Visscher PM, Graham RR, Singleton AB; 23andMe Research Team; System Genomics of Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium.

Lancet Neurol. 2019 Dec;18(12):1091-1102. doi: 10.1016/S1474-4422(19)30320-5.

PMID:
31701892
3.

A Nanopore Approach for Analysis of Caspase-7 Activity in Cell Lysates.

Pham B, Eron SJ, Hill ME, Li X, Fahie MA, Hardy JA, Chen M.

Biophys J. 2019 Sep 3;117(5):844-855. doi: 10.1016/j.bpj.2019.07.045. Epub 2019 Aug 2.

PMID:
31427065
4.

Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6.

Okerberg ES, Dagbay KB, Green JL, Soni I, Aban A, Nomanbhoy TK, Savinov SN, Hardy JA, Kozarich JW.

Biochemistry. 2019 Dec 31;58(52):5320-5328. doi: 10.1021/acs.biochem.9b00290. Epub 2019 May 24.

5.

Cysteine Disulfide Traps Reveal Distinct Conformational Ensembles in Dengue Virus NS2B-NS3 Protease.

Hill ME, Yildiz M, Hardy JA.

Biochemistry. 2019 Feb 12;58(6):776-787. doi: 10.1021/acs.biochem.8b00978. Epub 2018 Dec 17.

PMID:
30472839
6.

Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis.

MacPherson DJ, Mills CL, Ondrechen MJ, Hardy JA.

J Biol Chem. 2019 Jan 4;294(1):71-88. doi: 10.1074/jbc.RA118.005914. Epub 2018 Nov 12.

7.

The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target.

Petyuk VA, Chang R, Ramirez-Restrepo M, Beckmann ND, Henrion MYR, Piehowski PD, Zhu K, Wang S, Clarke J, Huentelman MJ, Xie F, Andreev V, Engel A, Guettoche T, Navarro L, De Jager P, Schneider JA, Morris CM, McKeith IG, Perry RH, Lovestone S, Woltjer RL, Beach TG, Sue LI, Serrano GE, Lieberman AP, Albin RL, Ferrer I, Mash DC, Hulette CM, Ervin JF, Reiman EM, Hardy JA, Bennett DA, Schadt E, Smith RD, Myers AJ.

Brain. 2018 Sep 1;141(9):2721-2739. doi: 10.1093/brain/awy215.

8.

Fighting Kinase Drug Resistance with Caspase Activators.

Hardy JA.

Cell Chem Biol. 2018 Aug 16;25(8):927-928. doi: 10.1016/j.chembiol.2018.08.001.

9.

The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins.

Hill ME, Kumar A, Wells JA, Hobman TC, Julien O, Hardy JA.

ACS Chem Biol. 2018 Sep 21;13(9):2398-2405. doi: 10.1021/acschembio.8b00508. Epub 2018 Aug 14.

PMID:
30080377
10.

Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.

Tubeleviciute-Aydin A, Zhou L, Sharma G, Soni IV, Savinov SN, Hardy JA, LeBlanc AC.

Sci Rep. 2018 Mar 13;8(1):4428. doi: 10.1038/s41598-018-22283-z.

11.

Caspase-9 CARD : core domain interactions require a properly formed active site.

Huber KL, Serrano BP, Hardy JA.

Biochem J. 2018 Mar 29;475(6):1177-1196. doi: 10.1042/BCJ20170913.

12.

Multiple Mechanisms of Zinc-Mediated Inhibition for the Apoptotic Caspases-3, -6, -7, and -8.

Eron SJ, MacPherson DJ, Dagbay KB, Hardy JA.

ACS Chem Biol. 2018 May 18;13(5):1279-1290. doi: 10.1021/acschembio.8b00064. Epub 2018 Apr 11.

13.

Phosphorylation by protein kinase A disassembles the caspase-9 core.

Serrano BP, Hardy JA.

Cell Death Differ. 2018 Jun;25(6):1025-1039. doi: 10.1038/s41418-017-0052-9. Epub 2018 Jan 19.

14.

Lipogels for Encapsulation of Hydrophilic Proteins and Hydrophobic Small Molecules.

Homyak CC, Fernandez A, Touve MA, Zhao B, Anson F, Hardy JA, Vachet RW, Gianneschi NC, Ross JL, Thayumanavan S.

Biomacromolecules. 2018 Jan 8;19(1):132-140. doi: 10.1021/acs.biomac.7b01300. Epub 2017 Dec 15.

15.

Active site-adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9.

Serrano BP, Szydlo HS, Alfandari D, Hardy JA.

J Biol Chem. 2017 Dec 29;292(52):21352-21365. doi: 10.1074/jbc.M117.811976. Epub 2017 Oct 24.

16.

Utilizing Inverse Emulsion Polymerization To Generate Responsive Nanogels for Cytosolic Protein Delivery.

Raghupathi K, Eron SJ, Anson F, Hardy JA, Thayumanavan S.

Mol Pharm. 2017 Dec 4;14(12):4515-4524. doi: 10.1021/acs.molpharmaceut.7b00643. Epub 2017 Nov 2.

17.

Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.

Dagbay KB, Hardy JA.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7977-E7986. doi: 10.1073/pnas.1704640114. Epub 2017 Sep 1.

18.

Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency.

Dagbay KB, Hill ME, Barrett E, Hardy JA.

Biochemistry. 2017 Aug 29;56(34):4568-4577. doi: 10.1021/acs.biochem.7b00357. Epub 2017 Aug 16.

19.

NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases.

Blauwendraat C, Faghri F, Pihlstrom L, Geiger JT, Elbaz A, Lesage S, Corvol JC, May P, Nicolas A, Abramzon Y, Murphy NA, Gibbs JR, Ryten M, Ferrari R, Bras J, Guerreiro R, Williams J, Sims R, Lubbe S, Hernandez DG, Mok KY, Robak L, Campbell RH, Rogaeva E, Traynor BJ, Chia R, Chung SJ; International Parkinson's Disease Genomics Consortium (IPDGC), COURAGE-PD Consortium, Hardy JA, Brice A, Wood NW, Houlden H, Shulman JM, Morris HR, Gasser T, Krüger R, Heutink P, Sharma M, Simón-Sánchez J, Nalls MA, Singleton AB, Scholz SW.

Neurobiol Aging. 2017 Sep;57:247.e9-247.e13. doi: 10.1016/j.neurobiolaging.2017.05.009. Epub 2017 May 17.

20.

The Birth of the Modern Era of Parkinson's Disease Genetics.

Singleton AB, Hardy JA, Gasser T.

J Parkinsons Dis. 2017;7(s1):S87-S93. doi: 10.3233/JPD-179009. Review. No abstract available.

21.

Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.

Dagbay KB, Bolik-Coulon N, Savinov SN, Hardy JA.

J Biol Chem. 2017 Mar 24;292(12):4885-4897. doi: 10.1074/jbc.M116.773499. Epub 2017 Feb 2.

22.

A blood-based gene expression and signaling pathway analysis to differentiate between high and low grade gliomas.

Ponnampalam SN, Kamaluddin NR, Zakaria Z, Matheneswaran V, Ganesan D, Haspani MS, Ryten M, Hardy JA.

Oncol Rep. 2017 Jan;37(1):10-22. doi: 10.3892/or.2016.5285. Epub 2016 Nov 29.

23.

Effective visual design and communication practices for research posters: Exemplars based on the theory and practice of multimedia learning and rhetoric.

Pedwell RK, Hardy JA, Rowland SL.

Biochem Mol Biol Educ. 2017 May;45(3):249-261. doi: 10.1002/bmb.21034. Epub 2016 Dec 7.

24.

Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms.

Eron SJ, Raghupathi K, Hardy JA.

Structure. 2017 Jan 3;25(1):27-39. doi: 10.1016/j.str.2016.11.001. Epub 2016 Nov 23.

25.

A genome-wide association study in multiple system atrophy.

Sailer A, Scholz SW, Nalls MA, Schulte C, Federoff M, Price TR, Lees A, Ross OA, Dickson DW, Mok K, Mencacci NE, Schottlaender L, Chelban V, Ling H, O'Sullivan SS, Wood NW, Traynor BJ, Ferrucci L, Federoff HJ, Mhyre TR, Morris HR, Deuschl G, Quinn N, Widner H, Albanese A, Infante J, Bhatia KP, Poewe W, Oertel W, Höglinger GU, Wüllner U, Goldwurm S, Pellecchia MT, Ferreira J, Tolosa E, Bloem BR, Rascol O, Meissner WG, Hardy JA, Revesz T, Holton JL, Gasser T, Wenning GK, Singleton AB, Houlden H; European Multiple System Atrophy Study Group and the UK Multiple System Atrophy Study Group.

Neurology. 2016 Oct 11;87(15):1591-1598. Epub 2016 Sep 14.

26.

Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies.

Geiger JT, Ding J, Crain B, Pletnikova O, Letson C, Dawson TM, Rosenthal LS, Pantelyat A, Gibbs JR, Albert MS, Hernandez DG, Hillis AE, Stone DJ, Singleton AB; North American Brain Expression Consortium, Hardy JA, Troncoso JC, Scholz SW.

Neurobiol Dis. 2016 Oct;94:55-62. doi: 10.1016/j.nbd.2016.06.004. Epub 2016 Jun 14.

27.

Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.

Hill ME, MacPherson DJ, Wu P, Julien O, Wells JA, Hardy JA.

ACS Chem Biol. 2016 Jun 17;11(6):1603-12. doi: 10.1021/acschembio.5b00971. Epub 2016 Mar 31.

28.

Reactive Self-Assembly of Polymers and Proteins to Reversibly Silence a Killer Protein.

Ventura J, Eron SJ, González-Toro DC, Raghupathi K, Wang F, Hardy JA, Thayumanavan S.

Biomacromolecules. 2015 Oct 12;16(10):3161-71. doi: 10.1021/acs.biomac.5b00779. Epub 2015 Sep 10.

29.

CHCHD2 and Parkinson's disease.

Jansen IE, Bras JM, Lesage S, Schulte C, Gibbs JR, Nalls MA, Brice A, Wood NW, Morris H, Hardy JA, Singleton AB, Gasser T, Heutink P, Sharma M; IPDGC.

Lancet Neurol. 2015 Jul;14(7):678-9. doi: 10.1016/S1474-4422(15)00094-0. No abstract available.

PMID:
26067110
30.

First effects of rising amyloid-β in transgenic mouse brain: synaptic transmission and gene expression.

Cummings DM, Liu W, Portelius E, Bayram S, Yasvoina M, Ho SH, Smits H, Ali SS, Steinberg R, Pegasiou CM, James OT, Matarin M, Richardson JC, Zetterberg H, Blennow K, Hardy JA, Salih DA, Edwards FA.

Brain. 2015 Jul;138(Pt 7):1992-2004. doi: 10.1093/brain/awv127. Epub 2015 May 16.

31.

Co-delivery of protein and small molecule therapeutics using nanoparticle-stabilized nanocapsules.

Kim CS, Mout R, Zhao Y, Yeh YC, Tang R, Jeong Y, Duncan B, Hardy JA, Rotello VM.

Bioconjug Chem. 2015 May 20;26(5):950-4. doi: 10.1021/acs.bioconjchem.5b00146. Epub 2015 Apr 30.

32.

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.

Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R; International Parkinson's Disease Genomics Consortium (IPDGC); Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI); 23andMe; GenePD; NeuroGenetics Research Consortium (NGRC); Hussman Institute of Human Genomics (HIHG); Ashkenazi Jewish Dataset Investigator; Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE); North American Brain Expression Consortium (NABEC); United Kingdom Brain Expression Consortium (UKBEC); Greek Parkinson's Disease Consortium; Alzheimer Genetic Analysis Group, Ikram MA, Ioannidis JP, Hadjigeorgiou GM, Bis JC, Martinez M, Perlmutter JS, Goate A, Marder K, Fiske B, Sutherland M, Xiromerisiou G, Myers RH, Clark LN, Stefansson K, Hardy JA, Heutink P, Chen H, Wood NW, Houlden H, Payami H, Brice A, Scott WK, Gasser T, Bertram L, Eriksson N, Foroud T, Singleton AB.

Nat Genet. 2014 Sep;46(9):989-93. doi: 10.1038/ng.3043. Epub 2014 Jul 27.

33.

A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.

Dagbay K, Eron SJ, Serrano BP, Velázquez-Delgado EM, Zhao Y, Lin D, Vaidya S, Hardy JA.

Methods Enzymol. 2014;544:215-49. doi: 10.1016/B978-0-12-417158-9.00009-1.

34.

Allosteric inhibition of the NS2B-NS3 protease from dengue virus.

Yildiz M, Ghosh S, Bell JA, Sherman W, Hardy JA.

ACS Chem Biol. 2013 Dec 20;8(12):2744-52. doi: 10.1021/cb400612h. Epub 2013 Oct 28.

35.

Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules.

Tang R, Kim CS, Solfiell DJ, Rana S, Mout R, Velázquez-Delgado EM, Chompoosor A, Jeong Y, Yan B, Zhu ZJ, Kim C, Hardy JA, Rotello VM.

ACS Nano. 2013 Aug 27;7(8):6667-6673. doi: 10.1021/nn402753y. Epub 2013 Jul 8.

36.

A tunable, modular approach to fluorescent protease-activated reporters.

Wu P, Nicholls SB, Hardy JA.

Biophys J. 2013 Apr 2;104(7):1605-14. doi: 10.1016/j.bpj.2013.01.058.

37.

Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface.

Huber KL, Ghosh S, Hardy JA.

Biopolymers. 2012;98(5):451-65. doi: 10.1002/bip.22080.

38.

Structural basis of fluorescence quenching in caspase activatable-GFP.

Nicholls SB, Hardy JA.

Protein Sci. 2013 Mar;22(3):247-57. doi: 10.1002/pro.2188. Epub 2013 Jan 10.

39.

Identification of protease exosite-interacting peptides that enhance substrate cleavage kinetics.

Jabaiah AM, Getz JA, Witkowski WA, Hardy JA, Daugherty PS.

Biol Chem. 2012 Sep;393(9):933-41. doi: 10.1515/hsz-2012-0162.

40.

Genome wide assessment of young onset Parkinson's disease from Finland.

Hernandez DG, Nalls MA, Ylikotila P, Keller M, Hardy JA, Majamaa K, Singleton AB.

PLoS One. 2012;7(7):e41859. doi: 10.1371/journal.pone.0041859. Epub 2012 Jul 24.

41.

Zinc-mediated allosteric inhibition of caspase-6.

Velázquez-Delgado EM, Hardy JA.

J Biol Chem. 2012 Oct 19;287(43):36000-11. doi: 10.1074/jbc.M112.397752. Epub 2012 Aug 13. Erratum in: J Biol Chem. 2013 Apr 19;288(16):11508.

42.

Mechanism of zinc-mediated inhibition of caspase-9.

Huber KL, Hardy JA.

Protein Sci. 2012 Jul;21(7):1056-65. doi: 10.1002/pro.2090. Epub 2012 May 24.

43.

Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.

Velázquez-Delgado EM, Hardy JA.

Structure. 2012 Apr 4;20(4):742-51. doi: 10.1016/j.str.2012.02.003. Epub 2012 Apr 3.

44.

Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.

Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T, Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA, Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB, Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP; 23andMe Genetic Epidemiology of Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium; Parkinson's Disease GWAS Consortium; Wellcome Trust Case Control Consortium 2), Young P, Tanzi RE, Khoury MJ, Zipp F, Lehrach H, Ioannidis JP, Bertram L.

PLoS Genet. 2012;8(3):e1002548. doi: 10.1371/journal.pgen.1002548. Epub 2012 Mar 15.

45.

Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice.

Matsuki T, Zaka M, Guerreiro R, van der Brug MP, Cooper JA, Cookson MR, Hardy JA, Howell BW.

PLoS One. 2012;7(2):e31152. doi: 10.1371/journal.pone.0031152. Epub 2012 Feb 15.

46.

A coding variant in CR1 interacts with APOE-ε4 to influence cognitive decline.

Keenan BT, Shulman JM, Chibnik LB, Raj T, Tran D, Sabuncu MR; Alzheimer's Disease Neuroimaging Initiative, Allen AN, Corneveaux JJ, Hardy JA, Huentelman MJ, Lemere CA, Myers AJ, Nicholson-Weller A, Reiman EM, Evans DA, Bennett DA, De Jager PL.

Hum Mol Genet. 2012 May 15;21(10):2377-88. doi: 10.1093/hmg/dds054. Epub 2012 Feb 17.

47.

Modeling nonaqueous proton wires built from helical peptides: biased proton transfer driven by helical dipoles.

López GE, Colón-Díaz I, Cruz A, Ghosh S, Nicholls SB, Viswanathan U, Hardy JA, Auerbach SM.

J Phys Chem A. 2012 Feb 2;116(4):1283-8. doi: 10.1021/jp210208m. Epub 2012 Jan 20.

PMID:
22188565
48.

A designed redox-controlled caspase.

Witkowski WA, Hardy JA.

Protein Sci. 2011 Aug;20(8):1421-31. doi: 10.1002/pro.673.

49.

Mechanism of a genetically encoded dark-to-bright reporter for caspase activity.

Nicholls SB, Chu J, Abbruzzese G, Tremblay KD, Hardy JA.

J Biol Chem. 2011 Jul 15;286(28):24977-86. doi: 10.1074/jbc.M111.221648. Epub 2011 May 10.

50.

CR1 is associated with amyloid plaque burden and age-related cognitive decline.

Chibnik LB, Shulman JM, Leurgans SE, Schneider JA, Wilson RS, Tran D, Aubin C, Buchman AS, Heward CB, Myers AJ, Hardy JA, Huentelman MJ, Corneveaux JJ, Reiman EM, Evans DA, Bennett DA, De Jager PL.

Ann Neurol. 2011 Mar;69(3):560-9. doi: 10.1002/ana.22277. Epub 2011 Mar 9.

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