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ABC cloning: An efficient, simple, and rapid restriction/ligase-free method.

Qaidi SE, Hardwidge PR.

MethodsX. 2019 Feb 12;6:316-321. doi: 10.1016/j.mex.2019.02.007. eCollection 2019.


High-Throughput Screening for Bacterial Glycosyltransferase Inhibitors.

El Qaidi S, Zhu C, McDonald P, Roy A, Maity PK, Rane D, Perera C, Hardwidge PR.

Front Cell Infect Microbiol. 2018 Dec 18;8:435. doi: 10.3389/fcimb.2018.00435. eCollection 2018.


Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection.

Ren W, Liao Y, Ding X, Jiang Y, Yan J, Xia Y, Tan B, Lin Z, Duan J, Jia X, Yang G, Deng J, Zhu C, Hardwidge PR, Li J, Zhu G, Yin Y.

Mucosal Immunol. 2019 Mar;12(2):531-544. doi: 10.1038/s41385-018-0111-7. Epub 2018 Dec 6.


Hsp90 Interacts with the Bacterial Effector NleH1.

Wu M, Hardwidge PR.

Pathogens. 2018 Nov 13;7(4). pii: E87. doi: 10.3390/pathogens7040087.


Salmonella, E. coli, and Citrobacter Type III Secretion System Effector Proteins that Alter Host Innate Immunity.

El Qaidi S, Wu M, Zhu C, Hardwidge PR.

Adv Exp Med Biol. 2018 Nov 10. doi: 10.1007/5584_2018_289. [Epub ahead of print]


SseL Deubiquitinates RPS3 to Inhibit Its Nuclear Translocation.

Wu M, El Qaidi S, Hardwidge PR.

Pathogens. 2018 Nov 7;7(4). pii: E86. doi: 10.3390/pathogens7040086.


Structural basis for arginine glycosylation of host substrates by bacterial effector proteins.

Park JB, Kim YH, Yoo Y, Kim J, Jun SH, Cho JW, El Qaidi S, Walpole S, Monaco S, García-García AA, Wu M, Hays MP, Hurtado-Guerrero R, Angulo J, Hardwidge PR, Shin JS, Cho HS.

Nat Commun. 2018 Oct 16;9(1):4283. doi: 10.1038/s41467-018-06680-6.


Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens.

Li Z, Quan G, Jiang X, Yang Y, Ding X, Zhang D, Wang X, Hardwidge PR, Ren W, Zhu G.

Front Cell Infect Microbiol. 2018 Sep 14;8:314. doi: 10.3389/fcimb.2018.00314. eCollection 2018. Review.


Isolation and Characterization of N-acyl Homoserine Lactone-Producing Bacteria From Cattle Rumen and Swine Intestines.

Yang Y, Zhou M, Hardwidge PR, Cui H, Zhu G.

Front Cell Infect Microbiol. 2018 May 9;8:155. doi: 10.3389/fcimb.2018.00155. eCollection 2018.


Immunization With Skp Delivered on Outer Membrane Vesicles Protects Mice Against Enterotoxigenic Escherichia coli Challenge.

Hays MP, Houben D, Yang Y, Luirink J, Hardwidge PR.

Front Cell Infect Microbiol. 2018 May 1;8:132. doi: 10.3389/fcimb.2018.00132. eCollection 2018.


Influence of Intestinal Microbiota Transplantation and NleH Expression on Citrobacter rodentium Colonization of Mice.

Wang G, Feuerbacher LA, Hardwidge PR.

Pathogens. 2018 Mar 30;7(2). pii: E35. doi: 10.3390/pathogens7020035.


Binding determinants in the interplay between porcine aminopeptidase N and enterotoxigenic Escherichia coli F4 fimbriae.

Xia P, Quan G, Yang Y, Zhao J, Wang Y, Zhou M, Hardwidge PR, Zhu J, Liu S, Zhu G.

Vet Res. 2018 Feb 26;49(1):23. doi: 10.1186/s13567-018-0519-9.


Complete Genome Sequences of Two Porcine Enterotoxigenic Escherichia coli Strains.

Li Z, Song N, Li W, Hardwidge PR, Bu Z, Liu S.

Genome Announc. 2018 Feb 22;6(8). pii: e00059-18. doi: 10.1128/genomeA.00059-18.


Bacterial LPX motif-harboring virulence factors constitute a species-spanning family of cell-penetrating effectors.

Norkowski S, Körner B, Greune L, Stolle AS, Lubos ML, Hardwidge PR, Schmidt MA, Rüter C.

Cell Mol Life Sci. 2018 Jun;75(12):2273-2289. doi: 10.1007/s00018-017-2733-4. Epub 2017 Dec 28.


NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity.

El Qaidi S, Chen K, Halim A, Siukstaite L, Rueter C, Hurtado-Guerrero R, Clausen H, Hardwidge PR.

J Biol Chem. 2017 Jul 7;292(27):11423-11430. doi: 10.1074/jbc.M117.790675. Epub 2017 May 18.


Enterotoxigenic Escherichia coli Flagellin Inhibits TNF-Induced NF-κB Activation in Intestinal Epithelial Cells.

Wang G, Geisbrecht BV, Rueter C, Hardwidge PR.

Pathogens. 2017 May 17;6(2). pii: E18. doi: 10.3390/pathogens6020018.


Intestinal Microbiota-Derived GABA Mediates Interleukin-17 Expression during Enterotoxigenic Escherichia coli Infection.

Ren W, Yin J, Xiao H, Chen S, Liu G, Tan B, Li N, Peng Y, Li T, Zeng B, Li W, Wei H, Yin Z, Wu G, Hardwidge PR, Yin Y.

Front Immunol. 2017 Jan 16;7:685. doi: 10.3389/fimmu.2016.00685. eCollection 2016.


Bacterium-Derived Cell-Penetrating Peptides Deliver Gentamicin To Kill Intracellular Pathogens.

Gomarasca M, F C Martins T, Greune L, Hardwidge PR, Schmidt MA, Rüter C.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02545-16. doi: 10.1128/AAC.02545-16. Print 2017 Apr.


Immunization with the MipA, Skp, or ETEC_2479 Antigens Confers Protection against Enterotoxigenic E. coli Strains Expressing Different Colonization Factors in a Mouse Pulmonary Challenge Model.

Hays MP, Kumar A, Martinez-Becerra FJ, Hardwidge PR.

Front Cell Infect Microbiol. 2016 Dec 12;6:181. doi: 10.3389/fcimb.2016.00181. eCollection 2016.


High and low-virulent bovine Pasteurella multocida capsular type A isolates exhibit different virulence gene expression patterns in vitro and in vivo.

Li N, Long Q, Du H, Zhang J, Pan T, Wu C, Lei G, Peng Y, Hardwidge PR.

Vet Microbiol. 2016 Nov 30;196:44-49. doi: 10.1016/j.vetmic.2016.10.017. Epub 2016 Oct 12.


Cell membrane-anchored MUC4 promotes tumorigenicity in epithelial carcinomas.

Xia P, Choi AH, Deng Z, Yang Y, Zhao J, Wang Y, Hardwidge PR, Zhu G.

Oncotarget. 2017 Feb 21;8(8):14147-14157. doi: 10.18632/oncotarget.13122. Review.


Vaccinating with conserved Escherichia coli antigens does not alter the mouse intestinal microbiome.

Hays MP, Ericsson AC, Yang Y, Hardwidge PR.

BMC Res Notes. 2016 Aug 11;9(1):401. doi: 10.1186/s13104-016-2208-y.


Citrobacter rodentium NleB Protein Inhibits Tumor Necrosis Factor (TNF) Receptor-associated Factor 3 (TRAF3) Ubiquitination to Reduce Host Type I Interferon Production.

Gao X, Pham TH, Feuerbacher LA, Chen K, Hays MP, Singh G, Rueter C, Hurtado-Guerrero R, Hardwidge PR.

J Biol Chem. 2016 Aug 26;291(35):18232-8. doi: 10.1074/jbc.M116.738278. Epub 2016 Jul 7.


Construction and sequencing of an infectious clone of the goose embryo-adapted Muscovy duck parvovirus vaccine strain FZ91-30.

Wang J, Huang Y, Zhou M, Hardwidge PR, Zhu G.

Virol J. 2016 Jun 21;13:104. doi: 10.1186/s12985-016-0564-9.


Porcine aminopeptidase N binds to F4+ enterotoxigenic Escherichia coli fimbriae.

Xia P, Wang Y, Zhu C, Zou Y, Yang Y, Liu W, Hardwidge PR, Zhu G.

Vet Res. 2016 Feb 9;47:24. doi: 10.1186/s13567-016-0313-5.


d-lactic acid production from renewable lignocellulosic biomass via genetically modified Lactobacillus plantarum.

Zhang Y, Kumar A, Hardwidge PR, Tanaka T, Kondo A, Vadlani PV.

Biotechnol Prog. 2016 Mar;32(2):271-8. doi: 10.1002/btpr.2212. Epub 2016 Jan 8.


Enhanced D-lactic acid production from renewable resources using engineered Lactobacillus plantarum.

Zhang Y, Vadlani PV, Kumar A, Hardwidge PR, Govind R, Tanaka T, Kondo A.

Appl Microbiol Biotechnol. 2016 Jan;100(1):279-88. doi: 10.1007/s00253-015-7016-0. Epub 2015 Oct 3.


More than a locomotive organelle: flagella in Escherichia coli.

Zhou M, Yang Y, Chen P, Hu H, Hardwidge PR, Zhu G.

Appl Microbiol Biotechnol. 2015 Nov;99(21):8883-90. doi: 10.1007/s00253-015-6946-x. Epub 2015 Sep 8. Review.


Protective Enterotoxigenic Escherichia coli Antigens in a Murine Intranasal Challenge Model.

Kumar A, Hays M, Lim F, Foster LJ, Zhou M, Zhu G, Miesner T, Hardwidge PR.

PLoS Negl Trop Dis. 2015 Aug 5;9(8):e0003924. doi: 10.1371/journal.pntd.0003924. eCollection 2015.


Membrane cholesterol plays an important role in enteropathogen adhesion and the activation of innate immunity via flagellin-TLR5 signaling.

Zhou M, Duan Q, Li Y, Yang Y, Hardwidge PR, Zhu G.

Arch Microbiol. 2015 Aug;197(6):797-803. doi: 10.1007/s00203-015-1115-2. Epub 2015 May 3.


Contribution of Crk adaptor proteins to host cell and bacteria interactions.

Martinez-Quiles N, Feuerbacher LA, Benito-León M, Hardwidge PR.

Biomed Res Int. 2014;2014:372901. doi: 10.1155/2014/372901. Epub 2014 Nov 25. Review.


Mouse intestinal innate immune responses altered by enterotoxigenic Escherichia coli (ETEC) infection.

Ren W, Yin J, Duan J, Liu G, Zhu X, Chen S, Li T, Wang S, Tang Y, Hardwidge PR.

Microbes Infect. 2014 Nov;16(11):954-61. doi: 10.1016/j.micinf.2014.09.005. Epub 2014 Oct 1.


Draft Genome Sequence of Enterotoxigenic Escherichia coli Strain W25K.

Ren W, Liu G, Yin J, Chen S, Li T, Kong X, Peng Y, Yin Y, Hardwidge PR.

Genome Announc. 2014 Jun 26;2(3). pii: e00593-14. doi: 10.1128/genomeA.00593-14.


Methionine deficiency reduces autophagy and accelerates death in intestinal epithelial cells infected with enterotoxigenic Escherichia coli.

Tang Y, Tan B, Xiong X, Li F, Ren W, Kong X, Qiu W, Hardwidge PR, Yin Y.

Amino Acids. 2015 Oct;47(10):2199-204. doi: 10.1007/s00726-014-1781-4. Epub 2014 Jun 26.


Quorum-sensing gene luxS regulates flagella expression and Shiga-like toxin production in F18ab Escherichia coli.

Yang Y, Zhou M, Hou H, Zhu J, Yao F, Zhang X, Zhu X, Hardwidge PR, Zhu G.

Can J Microbiol. 2014 Jun;60(6):355-61. doi: 10.1139/cjm-2014-0178. Epub 2014 Apr 17.


Enterotoxigenic Escherichia coli infection induces intestinal epithelial cell autophagy.

Tang Y, Li F, Tan B, Liu G, Kong X, Hardwidge PR, Yin Y.

Vet Microbiol. 2014 Jun 25;171(1-2):160-4. doi: 10.1016/j.vetmic.2014.03.025. Epub 2014 Mar 30.


Streptococcus suis type 2 SSU0587 protein is a beta-galactosidase that contributes to bacterial adhesion but not to virulence in mice.

Tang Y, Zhang X, Yin Y, Hardwidge PR, Fang W.

J Vet Med Sci. 2014 Jul;76(7):1055-9. Epub 2014 Mar 27.


Escherichia coli type III secretion system 2: a new kind of T3SS?

Zhou M, Guo Z, Duan Q, Hardwidge PR, Zhu G.

Vet Res. 2014 Mar 19;45:32. doi: 10.1186/1297-9716-45-32. Review.


Influence of NleH effector expression, host genetics, and inflammation on Citrobacter rodentium colonization of mice.

Feuerbacher LA, Hardwidge PR.

Microbes Infect. 2014 May;16(5):429-33. doi: 10.1016/j.micinf.2014.02.003. Epub 2014 Mar 5.


'Drugs from bugs': bacterial effector proteins as promising biological (immune-) therapeutics.

Rüter C, Hardwidge PR.

FEMS Microbiol Lett. 2014 Feb;351(2):126-32. doi: 10.1111/1574-6968.12333. Epub 2013 Dec 11. Review.


Flagellin and F4 fimbriae have opposite effects on biofilm formation and quorum sensing in F4ac+ enterotoxigenic Escherichia coli.

Zhou M, Guo Z, Yang Y, Duan Q, Zhang Q, Yao F, Zhu J, Zhang X, Hardwidge PR, Zhu G.

Vet Microbiol. 2014 Jan 10;168(1):148-53. doi: 10.1016/j.vetmic.2013.10.014. Epub 2013 Oct 26.


The RNA chaperone Hfq regulates expression of fimbrial-related genes and virulence of Salmonella enterica serovar Enteritidis.

Meng X, Meng X, Zhu C, Wang H, Wang J, Nie J, Hardwidge PR, Zhu G.

FEMS Microbiol Lett. 2013 Sep;346(2):90-6. doi: 10.1111/1574-6968.12206. Epub 2013 Jul 15.


Contribution of flagellin subunit FliC to piglet epithelial cells invasion by F18ab E. coli.

Duan Q, Zhou M, Liang H, Zhu X, Guo Z, Li Y, Hardwidge PR, Zhu G.

Vet Microbiol. 2013 Sep 27;166(1-2):220-4. doi: 10.1016/j.vetmic.2013.04.030. Epub 2013 May 22.


F18ab Escherichia coli flagella expression is regulated by acyl-homoserine lactone and contributes to bacterial virulence.

Yang Y, Yao F, Zhou M, Zhu J, Zhang X, Bao W, Wu S, Hardwidge PR, Zhu G.

Vet Microbiol. 2013 Aug 30;165(3-4):378-83. doi: 10.1016/j.vetmic.2013.04.020. Epub 2013 Apr 30.


Both flagella and F4 fimbriae from F4ac+ enterotoxigenic Escherichia coli contribute to attachment to IPEC-J2 cells in vitro.

Zhou M, Duan Q, Zhu X, Guo Z, Li Y, Hardwidge PR, Zhu G.

Vet Res. 2013 May 13;44:30. doi: 10.1186/1297-9716-44-30.


The enterohemorrhagic Escherichia coli effector protein NleF binds mammalian Tmp21.

Olsen RL, Echtenkamp F, Cheranova D, Deng W, Finlay BB, Hardwidge PR.

Vet Microbiol. 2013 May 31;164(1-2):164-70. doi: 10.1016/j.vetmic.2013.01.028. Epub 2013 Feb 4.


NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-κB activation.

Gao X, Wang X, Pham TH, Feuerbacher LA, Lubos ML, Huang M, Olsen R, Mushegian A, Slawson C, Hardwidge PR.

Cell Host Microbe. 2013 Jan 16;13(1):87-99. doi: 10.1016/j.chom.2012.11.010. Epub 2013 Jan 16. Erratum in: Cell Host Microbe. 2013 Mar 13;13(3):371-2.


Enterotoxigenic Escherichia coli prevents host NF-κB activation by targeting IκBα polyubiquitination.

Wang X, Hardwidge PR.

Infect Immun. 2012 Dec;80(12):4417-25. doi: 10.1128/IAI.00809-12. Epub 2012 Oct 1.


Heat-labile enterotoxin-induced activation of NF-κB and MAPK pathways in intestinal epithelial cells impacts enterotoxigenic Escherichia coli (ETEC) adherence.

Wang X, Gao X, Hardwidge PR.

Cell Microbiol. 2012 Aug;14(8):1231-41. doi: 10.1111/j.1462-5822.2012.01793.x. Epub 2012 Apr 16.

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