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The Bub1-TPR Domain Interacts Directly with Mad3 to Generate Robust Spindle Checkpoint Arrest.

Leontiou I, London N, May KM, Ma Y, Grzesiak L, Medina-Pritchard B, Amin P, Jeyaprakash AA, Biggins S, Hardwick KG.

Curr Biol. 2019 Jul 22;29(14):2407-2414.e7. doi: 10.1016/j.cub.2019.06.011. Epub 2019 Jun 27.


Regulated reconstitution of spindle checkpoint arrest and silencing through chemically induced dimerisation in vivo.

Amin P, Soper Ní Chafraidh S, Leontiou I, Hardwick KG.

J Cell Sci. 2018 Oct 4;132(4). pii: jcs219766. doi: 10.1242/jcs.219766.


Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest.

May KM, Paldi F, Hardwick KG.

Curr Biol. 2017 Apr 24;27(8):1221-1228. doi: 10.1016/j.cub.2017.03.013. Epub 2017 Mar 30.


Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast.

Meadows JC, Lancaster TC, Buttrick GJ, Sochaj AM, Messin LJ, Del Mar Mora-Santos M, Hardwick KG, Millar JBA.

Cell Rep. 2017 Feb 7;18(6):1422-1433. doi: 10.1016/j.celrep.2017.01.032.


Generation of a Spindle Checkpoint Arrest from Synthetic Signaling Assemblies.

Yuan I, Leontiou I, Amin P, May KM, Soper Ní Chafraidh S, Zlámalová E, Hardwick KG.

Curr Biol. 2017 Jan 9;27(1):137-143. doi: 10.1016/j.cub.2016.11.014. Epub 2016 Dec 22.


Correction: Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.

Zich J, May K, Paraskevopoulos K, Sen O, Syred HM, van der Sar S, Patel H, Moresco JJ, Sarkeshik A, Yates JR 3rd, Rappsilber J, Hardwick KG.

PLoS Genet. 2016 Apr 21;12(4):e1006009. doi: 10.1371/journal.pgen.1006009. eCollection 2016 Apr. No abstract available.


Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.

Zich J, May K, Paraskevopoulos K, Sen O, Syred HM, van der Sar S, Patel H, Moresco JJ, Sarkeshik A, Yates JR 3rd, Rappsilber J, Hardwick KG.

PLoS Genet. 2016 Feb 16;12(2):e1005834. doi: 10.1371/journal.pgen.1005834. eCollection 2016 Feb. Erratum in: PLoS Genet. 2016 Apr;12(4):e1006009.


The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast.

Folco HD, Campbell CS, May KM, Espinoza CA, Oegema K, Hardwick KG, Grewal SIS, Desai A.

Curr Biol. 2015 Feb 2;25(3):348-356. doi: 10.1016/j.cub.2014.11.060. Epub 2015 Jan 22.


Dss1 is a 26S proteasome ubiquitin receptor.

Paraskevopoulos K, Kriegenburg F, Tatham MH, Rösner HI, Medina B, Larsen IB, Brandstrup R, Hardwick KG, Hay RT, Kragelund BB, Hartmann-Petersen R, Gordon C.

Mol Cell. 2014 Nov 6;56(3):453-61. doi: 10.1016/j.molcel.2014.09.008. Epub 2014 Oct 9.


Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function.

Kim HS, Mukhopadhyay R, Rothbart SB, Silva AC, Vanoosthuyse V, Radovani E, Kislinger T, Roguev A, Ryan CJ, Xu J, Jahari H, Hardwick KG, Greenblatt JF, Krogan NJ, Fillingham JS, Strahl BD, Bouhassira EE, Edelmann W, Keogh MC.

Cell Rep. 2014 Mar 13;6(5):892-905. doi: 10.1016/j.celrep.2014.01.029. Epub 2014 Feb 22.


Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1.

Patel H, Zich J, Serrels B, Rickman C, Hardwick KG, Frame MC, Brunton VG.

Nat Commun. 2013;4:2056. doi: 10.1038/ncomms3056.


Phosphodependent recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 kinase maintains the spindle checkpoint.

Shepperd LA, Meadows JC, Sochaj AM, Lancaster TC, Zou J, Buttrick GJ, Rappsilber J, Hardwick KG, Millar JB.

Curr Biol. 2012 May 22;22(10):891-9. doi: 10.1016/j.cub.2012.03.051. Epub 2012 Apr 19.


Kinase activity of fission yeast Mph1 is required for Mad2 and Mad3 to stably bind the anaphase promoting complex.

Zich J, Sochaj AM, Syred HM, Milne L, Cook AG, Ohkura H, Rappsilber J, Hardwick KG.

Curr Biol. 2012 Feb 21;22(4):296-301. doi: 10.1016/j.cub.2011.12.049. Epub 2012 Jan 25.


Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B.

Buttrick GJ, Meadows JC, Lancaster TC, Vanoosthuyse V, Shepperd LA, Hoe KL, Kim DU, Park HO, Hardwick KG, Millar JB.

Mol Biol Cell. 2011 Dec;22(23):4486-502. doi: 10.1091/mbc.E11-07-0608. Epub 2011 Sep 30.


Spindle checkpoint silencing requires association of PP1 to both Spc7 and kinesin-8 motors.

Meadows JC, Shepperd LA, Vanoosthuyse V, Lancaster TC, Sochaj AM, Buttrick GJ, Hardwick KG, Millar JB.

Dev Cell. 2011 Jun 14;20(6):739-50. doi: 10.1016/j.devcel.2011.05.008.


Spindle checkpoint silencing: ensuring rapid and concerted anaphase onset.

Hardwick KG, Shah JV.

F1000 Biol Rep. 2010 Jul 22;2:55. doi: 10.3410/B2-55.


Overcoming inhibition in the spindle checkpoint.

Vanoosthuyse V, Hardwick KG.

Genes Dev. 2009 Dec 15;23(24):2799-805. doi: 10.1101/gad.1882109. Review.


An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe.

Kim HS, Vanoosthuyse V, Fillingham J, Roguev A, Watt S, Kislinger T, Treyer A, Carpenter LR, Bennett CS, Emili A, Greenblatt JF, Hardwick KG, Krogan NJ, Bähler J, Keogh MC.

Nat Struct Mol Biol. 2009 Dec;16(12):1286-93. doi: 10.1038/nsmb.1688. Epub 2009 Nov 15.


Bub3p facilitates spindle checkpoint silencing in fission yeast.

Vanoosthuyse V, Meadows JC, van der Sar SJ, Millar JB, Hardwick KG.

Mol Biol Cell. 2009 Dec;20(24):5096-105. doi: 10.1091/mbc.E09-09-0762.


Getting down to the phosphorylated 'nuts and bolts' of spindle checkpoint signalling.

Zich J, Hardwick KG.

Trends Biochem Sci. 2010 Jan;35(1):18-27. doi: 10.1016/j.tibs.2009.09.002. Epub 2009 Oct 15. Review.


A novel protein phosphatase 1-dependent spindle checkpoint silencing mechanism.

Vanoosthuyse V, Hardwick KG.

Curr Biol. 2009 Jul 28;19(14):1176-81. doi: 10.1016/j.cub.2009.05.060. Epub 2009 Jul 9.


The spindle checkpoint: assays for the analysis of spindle checkpoint arrest and recovery.

Fernius J, Hardwick KG.

Methods Mol Biol. 2009;545:243-58. doi: 10.1007/978-1-60327-993-2_15.


The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).

Sczaniecka M, Feoktistova A, May KM, Chen JS, Blyth J, Gould KL, Hardwick KG.

J Biol Chem. 2008 Aug 22;283(34):23039-47. doi: 10.1074/jbc.M803594200. Epub 2008 Jun 13.


The spindle checkpoint: how do cells delay anaphase onset?

Sczaniecka MM, Hardwick KG.

SEB Exp Biol Ser. 2008;59:243-56. Review.


Bub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis.

Fernius J, Hardwick KG.

PLoS Genet. 2007 Nov;3(11):e213. Epub 2007 Oct 15.


Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint".

Taylor SS, Hardwick KG, Sawin KE, Biggins S, Piatti S, Khodjakov A, Rieder CL, Salmon ED, Musacchio A.

Science. 2007 May 18;316(5827):982; author reply 982.


Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores.

King EM, Rachidi N, Morrice N, Hardwick KG, Stark MJ.

Genes Dev. 2007 May 15;21(10):1163-8.


Novel sfi1 alleles uncover additional functions for Sfi1p in bipolar spindle assembly and function.

Anderson VE, Prudden J, Prochnik S, Giddings TH Jr, Hardwick KG.

Mol Biol Cell. 2007 Jun;18(6):2047-56. Epub 2007 Mar 28.


Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis.

Vanoosthuyse V, Prykhozhij S, Hardwick KG.

Mol Biol Cell. 2007 May;18(5):1657-69. Epub 2007 Feb 14.


The spindle checkpoint.

May KM, Hardwick KG.

J Cell Sci. 2006 Oct 15;119(Pt 20):4139-42. Review. No abstract available.


Control of Shugoshin function during fission-yeast meiosis.

Vaur S, Cubizolles F, Plane G, Genier S, Rabitsch PK, Gregan J, Nasmyth K, Vanoosthuyse V, Hardwick KG, Javerzat JP.

Curr Biol. 2005 Dec 20;15(24):2263-70.


Bub1 and the multilayered inhibition of Cdc20-APC/C in mitosis.

Vanoosthuyse V, Hardwick KG.

Trends Cell Biol. 2005 May;15(5):231-3. Review.


Checkpoint signalling: Mad2 conformers and signal propagation.

Hardwick KG.

Curr Biol. 2005 Feb 22;15(4):R122-4. Review.


The complexity of Bub1 regulation--phosphorylation, phosphorylation, phosphorylation.

Vanoosthuyse V, Hardwick KG.

Cell Cycle. 2003 Mar-Apr;2(2):118-9. No abstract available.


Analysis of Bub3 spindle checkpoint function in Xenopus egg extracts.

Campbell L, Hardwick KG.

J Cell Sci. 2003 Feb 15;116(Pt 4):617-28.


The spindle checkpoint: structural insights into dynamic signalling.

Musacchio A, Hardwick KG.

Nat Rev Mol Cell Biol. 2002 Oct;3(10):731-41. Review.


Distinct chromosome segregation roles for spindle checkpoint proteins.

Warren CD, Brady DM, Johnston RC, Hanna JS, Hardwick KG, Spencer FA.

Mol Biol Cell. 2002 Sep;13(9):3029-41.


The awesome power of multiple model systems: interpreting the complex nature of spindle checkpoint signaling.

Millband DN, Campbell L, Hardwick KG.

Trends Cell Biol. 2002 May;12(5):205-9. Review.


Cdc28 activates exit from mitosis in budding yeast.

Rudner AD, Hardwick KG, Murray AW.

J Cell Biol. 2000 Jun 26;149(7):1361-76.


MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p.

Hardwick KG, Johnston RC, Smith DL, Murray AW.

J Cell Biol. 2000 Mar 6;148(5):871-82.


The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins.

Chen RH, Brady DM, Smith D, Murray AW, Hardwick KG.

Mol Biol Cell. 1999 Aug;10(8):2607-18.


Lesions in many different spindle components activate the spindle checkpoint in the budding yeast Saccharomyces cerevisiae.

Hardwick KG, Li R, Mistrot C, Chen RH, Dann P, Rudner A, Murray AW.

Genetics. 1999 Jun;152(2):509-18.


Budding yeast Cdc20: a target of the spindle checkpoint.

Hwang LH, Lau LF, Smith DL, Mistrot CA, Hardwick KG, Hwang ES, Amon A, Murray AW.

Science. 1998 Feb 13;279(5353):1041-4. Erratum in: Science 1998 May 29;280(5368):1331.


The spindle checkpoint.

Hardwick KG.

Trends Genet. 1998 Jan;14(1):1-4. Review. No abstract available.


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