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Items: 1 to 50 of 147

1.

KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders.

Teng X, Aouacheria A, Lionnard L, Metz KA, Soane L, Kamiya A, Hardwick JM.

CNS Neurosci Ther. 2019 Jul;25(7):887-902. doi: 10.1111/cns.13156. Review.

2.

Whi2: a new player in amino acid sensing.

Teng X, Hardwick JM.

Curr Genet. 2019 Jun;65(3):701-709. doi: 10.1007/s00294-018-00929-9. Epub 2019 Jan 30. Review.

PMID:
30701278
3.

Targeting intrinsic cell death pathways to control fungal pathogens.

Kulkarni M, Stolp ZD, Hardwick JM.

Biochem Pharmacol. 2019 Apr;162:71-78. doi: 10.1016/j.bcp.2019.01.012. Epub 2019 Jan 17. Review.

PMID:
30660496
4.

Overview of BCL-2 Family Proteins and Therapeutic Potentials.

Huska JD, Lamb HM, Hardwick JM.

Methods Mol Biol. 2019;1877:1-21. doi: 10.1007/978-1-4939-8861-7_1. Review.

PMID:
30535995
5.

Field Expedient Vasopressors During Aeromedical Evacuation: A Case Series from the Puerto Rico Disaster Response.

Hardwick JM, Murnan SD, Morrison-Ponce DP, Devlin JJ.

Prehosp Disaster Med. 2018 Dec;33(6):668-672. doi: 10.1017/S1049023X18000973. Epub 2018 Nov 9.

PMID:
30409234
6.

KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect.

Metz KA, Teng X, Coppens I, Lamb HM, Wagner BE, Rosenfeld JA, Chen X, Zhang Y, Kim HJ, Meadow ME, Wang TS, Haberlandt ED, Anderson GW, Leshinsky-Silver E, Bi W, Markello TC, Pratt M, Makhseed N, Garnica A, Danylchuk NR, Burrow TA, Jayakar P, McKnight D, Agadi S, Gbedawo H, Stanley C, Alber M, Prehl I, Peariso K, Ong MT, Mordekar SR, Parker MJ, Crooks D, Agrawal PB, Berry GT, Loddenkemper T, Yang Y, Maegawa GHB, Aouacheria A, Markle JG, Wohlschlegel JA, Hartman AL, Hardwick JM.

Ann Neurol. 2018 Nov;84(5):766-780. doi: 10.1002/ana.25351. Epub 2018 Nov 8.

PMID:
30295347
7.

Whi2 signals low leucine availability to halt yeast growth and cell death.

Teng X, Yau E, Sing C, Hardwick JM.

FEMS Yeast Res. 2018 Dec 1;18(8). doi: 10.1093/femsyr/foy095. Review.

PMID:
30165592
8.

Whi2 is a conserved negative regulator of TORC1 in response to low amino acids.

Chen X, Wang G, Zhang Y, Dayhoff-Brannigan M, Diny NL, Zhao M, He G, Sing CN, Metz KA, Stolp ZD, Aouacheria A, Cheng WC, Hardwick JM, Teng X.

PLoS Genet. 2018 Aug 24;14(8):e1007592. doi: 10.1371/journal.pgen.1007592. eCollection 2018 Aug.

9.

Do Fungi Undergo Apoptosis-Like Programmed Cell Death?

Hardwick JM.

MBio. 2018 Jul 31;9(4). pii: e00948-18. doi: 10.1128/mBio.00948-18.

10.

Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death".

Aouacheria A, Cunningham KW, Hardwick JM, Palková Z, Powers T, Severin FF, Váchová L.

Science. 2018 Jun 22;360(6395). pii: eaar6910. doi: 10.1126/science.aar6910.

PMID:
29930109
11.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

12.

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM.

Cell Death Differ. 2018 Mar;25(3):542-572. doi: 10.1038/s41418-017-0020-4. Epub 2017 Dec 11. Review.

13.

Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins.

Aouacheria A, Baghdiguian S, Lamb HM, Huska JD, Pineda FJ, Hardwick JM.

Neurochem Int. 2017 Oct;109:141-161. doi: 10.1016/j.neuint.2017.04.009. Epub 2017 Apr 28. Review.

14.

Controlling caspase activity in life and death.

White K, Arama E, Hardwick JM.

PLoS Genet. 2017 Feb 16;13(2):e1006545. doi: 10.1371/journal.pgen.1006545. eCollection 2017 Feb. No abstract available.

15.

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila.

Tang HL, Tang HM, Fung MC, Hardwick JM.

J Vis Exp. 2016 Nov 27;(117). doi: 10.3791/53992.

16.

Redefining the BH3 Death Domain as a 'Short Linear Motif'.

Aouacheria A, Combet C, Tompa P, Hardwick JM.

Trends Biochem Sci. 2015 Dec;40(12):736-748. doi: 10.1016/j.tibs.2015.09.007. Epub 2015 Nov 3. Review.

17.

In vivo CaspaseTracker biosensor system for detecting anastasis and non-apoptotic caspase activity.

Tang HL, Tang HM, Fung MC, Hardwick JM.

Sci Rep. 2015 Mar 11;5:9015. doi: 10.1038/srep09015.

18.

Strategies for tracking anastasis, a cell survival phenomenon that reverses apoptosis.

Tang HL, Tang HM, Hardwick JM, Fung MC.

J Vis Exp. 2015 Feb 16;(96). doi: 10.3791/51964.

19.

Cell death in genome evolution.

Teng X, Hardwick JM.

Semin Cell Dev Biol. 2015 Mar;39:3-11. doi: 10.1016/j.semcdb.2015.02.014. Epub 2015 Feb 25. Review.

20.

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G.

Cell Death Differ. 2015 Jan;22(1):58-73. doi: 10.1038/cdd.2014.137. Epub 2014 Sep 19. Review.

21.

Genome evolution in yeast reveals connections between rare mutations in human cancers.

Teng X, Hardwick JM.

Microb Cell. 2014 Jun 2;1(6):206-209. doi: 10.15698/mic2014.06.153.

22.

Genome-wide consequences of deleting any single gene.

Teng X, Dayhoff-Brannigan M, Cheng WC, Gilbert CE, Sing CN, Diny NL, Wheelan SJ, Dunham MJ, Boeke JD, Pineda FJ, Hardwick JM.

Mol Cell. 2013 Nov 21;52(4):485-94. doi: 10.1016/j.molcel.2013.09.026. Epub 2013 Nov 7.

23.

Quantification of genetically controlled cell death in budding yeast.

Teng X, Hardwick JM.

Methods Mol Biol. 2013;1004:161-70. doi: 10.1007/978-1-62703-383-1_12.

24.

Multiple functions of BCL-2 family proteins.

Hardwick JM, Soane L.

Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2). pii: a008722. doi: 10.1101/cshperspect.a008722. Review.

25.

Unlatched BAX pairs for death.

Lamb HM, Hardwick JM.

Cell. 2013 Jan 31;152(3):383-4. doi: 10.1016/j.cell.2013.01.018.

26.

The N-terminal helix of Bcl-xL targets mitochondria.

McNally MA, Soane L, Roelofs BA, Hartman AL, Hardwick JM.

Mitochondrion. 2013 Mar;13(2):119-24. doi: 10.1016/j.mito.2013.01.004. Epub 2013 Jan 16.

27.

Evolution of Bcl-2 homology motifs: homology versus homoplasy.

Aouacheria A, Rech de Laval V, Combet C, Hardwick JM.

Trends Cell Biol. 2013 Mar;23(3):103-11. doi: 10.1016/j.tcb.2012.10.010. Epub 2012 Nov 27.

28.

A new view of the lethal apoptotic pore.

Basañez G, Soane L, Hardwick JM.

PLoS Biol. 2012;10(9):e1001399. doi: 10.1371/journal.pbio.1001399. Epub 2012 Sep 25. Review.

29.

The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice.

Hartman AL, Santos P, Dolce A, Hardwick JM.

PLoS One. 2012;7(9):e45156. doi: 10.1371/journal.pone.0045156. Epub 2012 Sep 12.

30.

Multipolar functions of BCL-2 proteins link energetics to apoptosis.

Hardwick JM, Chen YB, Jonas EA.

Trends Cell Biol. 2012 Jun;22(6):318-28. doi: 10.1016/j.tcb.2012.03.005. Epub 2012 May 5. Review.

31.

N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death.

Ofengeim D, Chen YB, Miyawaki T, Li H, Sacchetti S, Flannery RJ, Alavian KN, Pontarelli F, Roelofs BA, Hickman JA, Hardwick JM, Zukin RS, Jonas EA.

Nat Neurosci. 2012 Feb 26;15(4):574-80. doi: 10.1038/nn.3054.

32.

Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential.

Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM.

J Cell Biol. 2011 Oct 17;195(2):263-76. doi: 10.1083/jcb.201108059. Epub 2011 Oct 10.

33.

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.

Alavian KN, Li H, Collis L, Bonanni L, Zeng L, Sacchetti S, Lazrove E, Nabili P, Flaherty B, Graham M, Chen Y, Messerli SM, Mariggio MA, Rahner C, McNay E, Shore GC, Smith PJ, Hardwick JM, Jonas EA.

Nat Cell Biol. 2011 Sep 18;13(10):1224-33. doi: 10.1038/ncb2330. Erratum in: Nat Cell Biol. 2011 Nov;13(11):1383.

34.

Gene-dependent cell death in yeast.

Teng X, Cheng WC, Qi B, Yu TX, Ramachandran K, Boersma MD, Hattier T, Lehmann PV, Pineda FJ, Hardwick JM.

Cell Death Dis. 2011 Aug 4;2:e188. doi: 10.1038/cddis.2011.72.

35.

Flying to a halt: Drosophila Aven arrests the cell cycle.

Roelofs BA, Hardwick JM.

Cell Cycle. 2011 May 1;10(9):1350-51. Epub 2011 May 1. No abstract available.

36.

Mitochondrial involvement in cell death of non-mammalian eukaryotes.

Abdelwahid E, Rolland S, Teng X, Conradt B, Hardwick JM, White K.

Biochim Biophys Acta. 2011 Apr;1813(4):597-607. doi: 10.1016/j.bbamcr.2010.10.008. Epub 2010 Oct 13. Review.

37.

Seizure tests distinguish intermittent fasting from the ketogenic diet.

Hartman AL, Zheng X, Bergbower E, Kennedy M, Hardwick JM.

Epilepsia. 2010 Aug;51(8):1395-402. doi: 10.1111/j.1528-1167.2010.02577.x. Epub 2010 Apr 30.

38.

The apoptosome at high resolution.

Teng X, Hardwick JM.

Cell. 2010 Apr 30;141(3):402-4. doi: 10.1016/j.cell.2010.04.015.

39.

SnapShot: BCL-2 proteins.

Hardwick JM, Youle RJ.

Cell. 2009 Jul 23;138(2):404, 404.e1. doi: 10.1016/j.cell.2009.07.003. No abstract available.

40.

Reliable method for detection of programmed cell death in yeast.

Teng X, Hardwick JM.

Methods Mol Biol. 2009;559:335-42. doi: 10.1007/978-1-60327-017-5_23.

41.

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G.

Cell Death Differ. 2009 Aug;16(8):1093-107. doi: 10.1038/cdd.2009.44. Epub 2009 Apr 17. Review.

42.

Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons.

Berman SB, Chen YB, Qi B, McCaffery JM, Rucker EB 3rd, Goebbels S, Nave KA, Arnold BA, Jonas EA, Pineda FJ, Hardwick JM.

J Cell Biol. 2009 Mar 9;184(5):707-19. doi: 10.1083/jcb.200809060. Epub 2009 Mar 2.

43.

Bcl-2 turns deadly.

Qi B, Hardwick JM.

Nat Chem Biol. 2008 Dec;4(12):722-3. doi: 10.1038/nchembio1208-722. No abstract available.

44.

Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects.

Cheng WC, Teng X, Park HK, Tucker CM, Dunham MJ, Hardwick JM.

Cell Death Differ. 2008 Dec;15(12):1838-46. doi: 10.1038/cdd.2008.117. Epub 2008 Aug 29.

45.

Aven-dependent activation of ATM following DNA damage.

Guo JY, Yamada A, Kajino T, Wu JQ, Tang W, Freel CD, Feng J, Chau BN, Wang MZ, Margolis SS, Yoo HY, Wang XF, Dunphy WG, Irusta PM, Hardwick JM, Kornbluth S.

Curr Biol. 2008 Jul 8;18(13):933-42. doi: 10.1016/j.cub.2008.05.045. Epub 2008 Jun 19.

46.

Unravelling the bcl-2 apoptosis code with a simple model system.

Basañez G, Hardwick JM.

PLoS Biol. 2008 Jun 17;6(6):e154. doi: 10.1371/journal.pbio.0060154. No abstract available.

47.

Mitochondrial death pathways in yeast and mammalian cells.

Cheng WC, Leach KM, Hardwick JM.

Biochim Biophys Acta. 2008 Jul;1783(7):1272-9. doi: 10.1016/j.bbamcr.2008.04.012. Epub 2008 May 2. Review.

48.

Mitochondrial fission and fusion dynamics: the long and short of it.

Berman SB, Pineda FJ, Hardwick JM.

Cell Death Differ. 2008 Jul;15(7):1147-52. doi: 10.1038/cdd.2008.57. Epub 2008 Apr 25. Review.

49.

Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons.

Li H, Chen Y, Jones AF, Sanger RH, Collis LP, Flannery R, McNay EC, Yu T, Schwarzenbacher R, Bossy B, Bossy-Wetzel E, Bennett MV, Pypaert M, Hickman JA, Smith PJ, Hardwick JM, Jonas EA.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2169-74. doi: 10.1073/pnas.0711647105. Epub 2008 Feb 4.

50.

Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels.

Siskind LJ, Feinstein L, Yu T, Davis JS, Jones D, Choi J, Zuckerman JE, Tan W, Hill RB, Hardwick JM, Colombini M.

J Biol Chem. 2008 Mar 14;283(11):6622-30. doi: 10.1074/jbc.M706115200. Epub 2008 Jan 2.

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