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Items: 1 to 50 of 448

1.

Whi2: a new player in amino acid sensing.

Teng X, Hardwick JM.

Curr Genet. 2019 Jan 30. doi: 10.1007/s00294-018-00929-9. [Epub ahead of print] Review.

PMID:
30701278
2.

Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer.

Cao J, Zhu Z, Wang H, Nichols TC, Lui GYL, Deng S, Rejto PA, VanArsdale T, Hardwick JS, Weinrich SL, Wei P.

Oncogene. 2019 Jan 30. doi: 10.1038/s41388-019-0708-7. [Epub ahead of print]

PMID:
30700828
3.

Targeting intrinsic cell death pathways to control fungal pathogens.

Kulkarni M, Stolp ZD, Hardwick JM.

Biochem Pharmacol. 2019 Jan 17. pii: S0006-2952(19)30018-8. doi: 10.1016/j.bcp.2019.01.012. [Epub ahead of print] Review.

PMID:
30660496
4.

Overview of BCL-2 Family Proteins and Therapeutic Potentials.

Huska JD, Lamb HM, Hardwick JM.

Methods Mol Biol. 2019;1877:1-21. doi: 10.1007/978-1-4939-8861-7_1.

PMID:
30535995
5.

Field Expedient Vasopressors During Aeromedical Evacuation: A Case Series from the Puerto Rico Disaster Response.

Hardwick JM, Murnan SD, Morrison-Ponce DP, Devlin JJ.

Prehosp Disaster Med. 2018 Dec;33(6):668-672. doi: 10.1017/S1049023X18000973. Epub 2018 Nov 9.

PMID:
30409234
6.

TNER: a novel background error suppression method for mutation detection in circulating tumor DNA.

Deng S, Lira M, Huang D, Wang K, Valdez C, Kinong J, Rejto PA, Bienkowska J, Hardwick J, Xie T.

BMC Bioinformatics. 2018 Oct 20;19(1):387. doi: 10.1186/s12859-018-2428-3.

7.

KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect.

Metz KA, Teng X, Coppens I, Lamb HM, Wagner BE, Rosenfeld JA, Chen X, Zhang Y, Kim HJ, Meadow ME, Wang TS, Haberlandt ED, Anderson GW, Leshinsky-Silver E, Bi W, Markello TC, Pratt M, Makhseed N, Garnica A, Danylchuk NR, Burrow TA, Jayakar P, McKnight D, Agadi S, Gbedawo H, Stanley C, Alber M, Prehl I, Peariso K, Ong MT, Mordekar SR, Parker MJ, Crooks D, Agrawal PB, Berry GT, Loddenkemper T, Yang Y, Maegawa GHB, Aouacheria A, Markle JG, Wohlschlegel JA, Hartman AL, Hardwick JM.

Ann Neurol. 2018 Nov;84(5):766-780. doi: 10.1002/ana.25351. Epub 2018 Nov 8.

PMID:
30295347
8.

Quality of life and fear of cancer recurrence in T1 colorectal cancer patients treated with endoscopic or surgical tumor resection.

Dang H, de Vos Tot Nederveen Cappel WH, van der Zwaan SMS, van den Akker-van Marle ME, van Westreenen HL, Backes Y, Moons LMG, Holman FA, Peeters KCMJ, van der Kraan J, Langers AMJ, Lijfering WM, Hardwick JCH, Boonstra JJ.

Gastrointest Endosc. 2019 Mar;89(3):533-544. doi: 10.1016/j.gie.2018.09.026. Epub 2018 Sep 28.

PMID:
30273589
9.

The New Blueprints: Undergraduate Neuroscience Education in the Twenty-First Century.

Wiertelak EP, Hardwick J, Kerchner M, Parfitt K, Ramirez JJ.

J Undergrad Neurosci Educ. 2018 Sep 15;16(3):A244-A251. eCollection 2018 Summer.

10.

Best Practices for Developing, Assessing, and Sustaining Inclusive Curricula: Proceedings of the 2017 Faculty for Undergraduate Neuroscience Workshop.

Calin-Jageman RJ, Calin-Jageman IE, Acosta VM, Hardwick J, Johnson BR, Wiertelak E.

J Undergrad Neurosci Educ. 2018 Sep 15;16(3):A42-A43. eCollection 2018 Summer. No abstract available.

11.

Whi2 signals low leucine availability to halt yeast growth and cell death.

Teng X, Yau E, Sing C, Hardwick JM.

FEMS Yeast Res. 2018 Dec 1;18(8). doi: 10.1093/femsyr/foy095.

PMID:
30165592
12.

Whi2 is a conserved negative regulator of TORC1 in response to low amino acids.

Chen X, Wang G, Zhang Y, Dayhoff-Brannigan M, Diny NL, Zhao M, He G, Sing CN, Metz KA, Stolp ZD, Aouacheria A, Cheng WC, Hardwick JM, Teng X.

PLoS Genet. 2018 Aug 24;14(8):e1007592. doi: 10.1371/journal.pgen.1007592. eCollection 2018 Aug.

13.

Do Fungi Undergo Apoptosis-Like Programmed Cell Death?

Hardwick JM.

MBio. 2018 Jul 31;9(4). pii: e00948-18. doi: 10.1128/mBio.00948-18.

14.

Successful closure of a chronic vesicorectal fistula after radical prostatectomy with an over-the-scope clip.

Langers AMJ, Bevers RFM, Boonstra JJ, Hardwick JCH.

Endoscopy. 2018 Sep;50(9):E272-E273. doi: 10.1055/a-0641-4865. Epub 2018 Jul 3. No abstract available.

PMID:
29969802
15.

Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis.

Paauwe M, Schoonderwoerd MJA, Helderman RFCP, Harryvan TJ, Groenewoud A, van Pelt GW, Bor R, Hemmer DM, Versteeg HH, Snaar-Jagalska BE, Theuer CP, Hardwick JCH, Sier CFM, Ten Dijke P, Hawinkels LJAC.

Clin Cancer Res. 2018 Dec 15;24(24):6331-6344. doi: 10.1158/1078-0432.CCR-18-0329. Epub 2018 Jun 26.

PMID:
29945992
16.

Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death".

Aouacheria A, Cunningham KW, Hardwick JM, Palková Z, Powers T, Severin FF, Váchová L.

Science. 2018 Jun 22;360(6395). pii: eaar6910. doi: 10.1126/science.aar6910.

PMID:
29930109
17.

Decreased Nursing Staffing Adversely Affects Emergency Department Throughput Metrics.

Ramsey Z, Palter JS, Hardwick J, Moskoff J, Christian EL, Bailitz J.

West J Emerg Med. 2018 May;19(3):496-500. doi: 10.5811/westjem.2018.1.36327. Epub 2018 Apr 5.

18.

Tracers for Fluorescence-Guided Surgery: How Elongation of the Polymethine Chain in Cyanine Dyes Alters the Pharmacokinetics of a Dual-Modality c[RGDyK] Tracer.

Buckle T, van Willigen DM, Spa SJ, Hensbergen AW, van der Wal S, de Korne CM, Welling MM, van der Poel HG, Hardwick JCH, van Leeuwen FWB.

J Nucl Med. 2018 Jun;59(6):986-992. doi: 10.2967/jnumed.117.205575. Epub 2018 Feb 15.

PMID:
29449447
19.

Increased ethanol-inducible cytochrome P450-2E1 and cytochrome P450 isoforms in exosomes of alcohol-exposed rodents and patients with alcoholism through oxidative and endoplasmic reticulum stress.

Cho YE, Mezey E, Hardwick JP, Salem N Jr, Clemens DL, Song BJ.

Hepatol Commun. 2017 Jul 13;1(7):675-690. doi: 10.1002/hep4.1066. eCollection 2017 Sep.

20.

Hairy and enhancer of split 6 prevents hepatic lipid accumulation through inhibition of Pparg2 expression.

Park JE, Lee M, Kim SC, Zhang Y, Hardwick JP, Lee YK.

Hepatol Commun. 2017 Nov 8;1(10):1085-1098. doi: 10.1002/hep4.1120. eCollection 2017 Dec.

21.

Epigenetic Modifications of Cytosine: Biophysical Properties, Regulation, and Function in Mammalian DNA.

Hardwick JS, Lane AN, Brown T.

Bioessays. 2018 Mar;40(3). doi: 10.1002/bies.201700199. Epub 2018 Jan 25. Review.

PMID:
29369386
22.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

23.

Patterns of Metastatic Spread and Mechanisms of Resistance to Crizotinib in ROS1-Positive Non-Small-Cell Lung Cancer.

Gainor JF, Tseng D, Yoda S, Dagogo-Jack I, Friboulet L, Lin JJ, Hubbeling HG, Dardaei L, Farago AF, Schultz KR, Ferris LA, Piotrowska Z, Hardwick J, Huang D, Mino-Kenudson M, Iafrate AJ, Hata AN, Yeap BY, Shaw AT.

JCO Precis Oncol. 2017;2017. doi: 10.1200/PO.17.00063. Epub 2017 Aug 16.

24.

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM.

Cell Death Differ. 2018 Mar;25(3):542-572. doi: 10.1038/s41418-017-0020-4. Epub 2017 Dec 11. Review.

PMID:
29229998
25.

Src family kinase inhibitors blunt PACAP-induced PAC1 receptor endocytosis, phosphorylation of ERK, and the increase in cardiac neuron excitability.

Tompkins JD, Clason TA, Buttolph TR, Girard BM, Linden AK, Hardwick JC, Merriam LA, May V, Parsons RL.

Am J Physiol Cell Physiol. 2018 Feb 1;314(2):C233-C241. doi: 10.1152/ajpcell.00223.2017. Epub 2017 Nov 15.

26.

Effect of chronic low body temperature on feeding and gut passage in a plethodontid salamander.

Marvin GA, Bryan R, Hardwick J.

J Therm Biol. 2017 Oct;69:319-324. doi: 10.1016/j.jtherbio.2017.09.003. Epub 2017 Sep 18.

PMID:
29037400
27.

Safety of endoscopic mucosal resection (EMR) of large non-pedunculated colorectal adenomas in the elderly.

Bronsgeest K, Huisman JF, Langers A, Boonstra JJ, Schenk BE, de Vos Tot Nederveen Cappel WH, Vasen HFA, Hardwick JCH.

Int J Colorectal Dis. 2017 Dec;32(12):1711-1717. doi: 10.1007/s00384-017-2892-7. Epub 2017 Sep 8.

28.

Creating space for relationships.

Maataoui SL, Hardwick JS, Lundquist TS.

Psychol Serv. 2017 Aug;14(3):347-351. doi: 10.1037/ser0000179.

PMID:
28805419
29.

Stoichiometry and Dispersity of DNA Nanostructures Using Photobleaching Pair-Correlation Analysis.

Hariri AA, Hamblin GD, Hardwick JS, Godin R, Desjardins JF, Wiseman PW, Sleiman HF, Cosa G.

Bioconjug Chem. 2017 Sep 20;28(9):2340-2349. doi: 10.1021/acs.bioconjchem.7b00369. Epub 2017 Aug 22.

PMID:
28777539
30.

Multispectral fluorescence guided surgery; a feasibility study in a phantom using a clinical-grade laparoscopic camera system.

van Willigen DM, van den Berg NS, Buckle T, KleinJan GH, Hardwick JC, van der Poel HG, van Leeuwen FW.

Am J Nucl Med Mol Imaging. 2017 Jul 15;7(3):138-147. eCollection 2017.

31.

Randomised controlled trial of transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND Study).

Barendse RM, Musters GD, de Graaf EJR, van den Broek FJC, Consten ECJ, Doornebosch PG, Hardwick JC, de Hingh IHJT, Hoff C, Jansen JM, van Milligen de Wit AWM, van der Schelling GP, Schoon EJ, Schwartz MP, Weusten BLAM, Dijkgraaf MG, Fockens P, Bemelman WA, Dekker E; TREND Study group.

Gut. 2018 May;67(5):837-846. doi: 10.1136/gutjnl-2016-313101. Epub 2017 Jun 28.

PMID:
28659349
32.

Recruitment of endosomal signaling mediates the forskolin modulation of guinea pig cardiac neuron excitability.

Hardwick JC, Clason TA, Tompkins JD, Girard BM, Baran CN, Merriam LA, May V, Parsons RL.

Am J Physiol Cell Physiol. 2017 Aug 1;313(2):C219-C227. doi: 10.1152/ajpcell.00094.2017. Epub 2017 Jun 7.

33.

Statin Use After Diagnosis of Colon Cancer and Patient Survival.

Voorneveld PW, Reimers MS, Bastiaannet E, Jacobs RJ, van Eijk R, Zanders MMJ, Herings RMC, van Herk-Sukel MPP, Kodach LL, van Wezel T, Kuppen PJK, Morreau H, van de Velde CJH, Hardwick JCH, Liefers GJ.

Gastroenterology. 2017 Aug;153(2):470-479.e4. doi: 10.1053/j.gastro.2017.05.011. Epub 2017 May 13.

PMID:
28512021
34.

5-Formylcytosine does not change the global structure of DNA.

Hardwick JS, Ptchelkine D, El-Sagheer AH, Tear I, Singleton D, Phillips SEV, Lane AN, Brown T.

Nat Struct Mol Biol. 2017 Jun;24(6):544-552. doi: 10.1038/nsmb.3411. Epub 2017 May 15.

35.

Putting the Wnt up colon cancer.

Hawinkels LJ, Hardwick JC.

Gut. 2017 Jun;66(6):983-984. doi: 10.1136/gutjnl-2016-312584. Epub 2016 Nov 10. No abstract available.

PMID:
28501817
36.

Extracolonic cancer risk in Dutch patients with APC (adenomatous polyposis coli)-associated polyposis.

Ghorbanoghli Z, Bastiaansen BA, Langers AM, Nagengast FM, Poley JW, Hardwick JC, Koornstra JJ, Sanduleanu S, de Vos Tot Nederveen Cappel WH, Witteman BJ, Morreau H, Dekker E, Vasen HF.

J Med Genet. 2018 Jan;55(1):11-14. doi: 10.1136/jmedgenet-2017-104545. Epub 2017 May 10.

PMID:
28490611
37.

Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins.

Aouacheria A, Baghdiguian S, Lamb HM, Huska JD, Pineda FJ, Hardwick JM.

Neurochem Int. 2017 Oct;109:141-161. doi: 10.1016/j.neuint.2017.04.009. Epub 2017 Apr 28. Review.

38.

An aggressive form of transthyretin amyloidosis.

Dasgupta NR, Wang AK, Hardwick J, Benson MD.

Amyloid. 2017 Mar;24(sup1):95-96. doi: 10.1080/13506129.2017.1284057. No abstract available.

PMID:
28434309
39.

Controlling caspase activity in life and death.

White K, Arama E, Hardwick JM.

PLoS Genet. 2017 Feb 16;13(2):e1006545. doi: 10.1371/journal.pgen.1006545. eCollection 2017 Feb. No abstract available.

40.

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila.

Tang HL, Tang HM, Fung MC, Hardwick JM.

J Vis Exp. 2016 Nov 27;(117). doi: 10.3791/53992.

41.

Liver test abnormalities predict complicated disease behaviour in patients with newly diagnosed Crohn's disease.

Barendregt J, de Jong M, Haans JJ, van Hoek B, Hardwick J, Veenendaal R, van der Meulen A, Srivastava N, Stuyt R, Maljaars J.

Int J Colorectal Dis. 2017 Apr;32(4):459-467. doi: 10.1007/s00384-016-2706-3. Epub 2016 Nov 29.

42.

Colonoscopy in Lynch syndrome: the need for a new quality score.

Boonstra JJ, de Vos Tot Nederveen Cappel WH, Langers AM, van der Sluis H, Hardwick JH, Vasen HF.

Fam Cancer. 2017 Apr;16(2):239-241. doi: 10.1007/s10689-016-9950-0. No abstract available.

PMID:
27830406
43.

Comprehensive Characterization of Oncogenic Drivers in Asian Lung Adenocarcinoma.

Li S, Choi YL, Gong Z, Liu X, Lira M, Kan Z, Oh E, Wang J, Ting JC, Ye X, Reinhart C, Liu X, Pei Y, Zhou W, Chen R, Fu S, Jin G, Jiang A, Fernandez J, Hardwick J, Kang MW, I H, Zheng H, Kim J, Mao M.

J Thorac Oncol. 2016 Dec;11(12):2129-2140. doi: 10.1016/j.jtho.2016.08.142. Epub 2016 Sep 9. Erratum in: J Thorac Oncol. 2017 Feb;12 (2):408.

44.

Activation of MEK/ERK signaling contributes to the PACAP-induced increase in guinea pig cardiac neuron excitability.

Tompkins JD, Clason TA, Hardwick JC, Girard BM, Merriam LA, May V, Parsons RL.

Am J Physiol Cell Physiol. 2016 Oct 1;311(4):C643-C651. doi: 10.1152/ajpcell.00164.2016. Epub 2016 Aug 3.

45.

Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: results ofa pilot study.

van Erp SJ, Leicher LW, Hennink SD, Ghorbanoghli Z, Breg SA, Morreau H, Nielsen M, Hardwick JC, Roukema JA, Langers AM, de Vos Tot Nederveen Cappel WH, Vasen HF.

Scand J Gastroenterol. 2016 Oct;51(10):1227-32. doi: 10.1080/00365521.2016.1193219. Epub 2016 Jun 16.

46.

Endoscopic mucosal resection (EMR) versus endoscopic submucosal dissection (ESD) for resection of large distal non-pedunculated colorectal adenomas (MATILDA-trial): rationale and design of a multicenter randomized clinical trial.

Backes Y, Moons LM, van Bergeijk JD, Berk L, Ter Borg F, Ter Borg PC, Elias SG, Geesing JM, Groen JN, Hadithi M, Hardwick JC, Kerkhof M, Mangen MJ, Straathof JW, Schröder R, Schwartz MP, Spanier BW, de Vos Tot Nederveen Cappel WH, Wolfhagen FH, Koch AD.

BMC Gastroenterol. 2016 May 26;16(1):56. doi: 10.1186/s12876-016-0468-6.

47.

Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage.

Guarini G, Kiyooka T, Ohanyan V, Pung YF, Marzilli M, Chen YR, Chen CL, Kang PT, Hardwick JP, Kolz CL, Yin L, Wilson GL, Shokolenko I, Dobson JG Jr, Fenton R, Chilian WM.

Basic Res Cardiol. 2016 May;111(3):29. doi: 10.1007/s00395-016-0547-4. Epub 2016 Apr 4.

48.

Endoglin targeting inhibits tumor angiogenesis and metastatic spread in breast cancer.

Paauwe M, Heijkants RC, Oudt CH, van Pelt GW, Cui C, Theuer CP, Hardwick JC, Sier CF, Hawinkels LJ.

Oncogene. 2016 Aug 4;35(31):4069-79. doi: 10.1038/onc.2015.509. Epub 2016 Jan 25.

PMID:
26804178
49.

An accessible pharmacodynamic transcriptional biomarker for notch target engagement.

Tanis KQ, Podtelezhnikov AA, Blackman SC, Hing J, Railkar RA, Lunceford J, Klappenbach JA, Wei B, Harman A, Camargo LM, Shah S, Finney EM, Hardwick JS, Loboda A, Watters J, Bergstrom DA, Demuth T, Herman GA, Strack PR, Iannone R.

Clin Pharmacol Ther. 2016 Apr;99(4):370-80. doi: 10.1002/cpt.335. Epub 2016 Feb 17.

PMID:
26765077
50.

Geriatricians in perioperative medicine: developing subspecialty training.

Braude P, Partridge JS, Hardwick J, Shipway DJ, Dhesi JK.

Br J Anaesth. 2016 Jan;116(1):4-6. doi: 10.1093/bja/aev403. No abstract available.

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