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Items: 40


Inclusion of enclosed hydration effects in the binding free energy estimation of dopamine D3 receptor complexes.

Pal RK, Gadhiya S, Ramsey S, Cordone P, Wickstrom L, Harding WW, Kurtzman T, Gallicchio E.

PLoS One. 2019 Sep 30;14(9):e0222902. doi: 10.1371/journal.pone.0222902. eCollection 2019.


New Dopamine D3-Selective Receptor Ligands Containing a 6-Methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol Motif.

Gadhiya S, Cordone P, Pal RK, Gallicchio E, Wickstrom L, Kurtzman T, Ramsey S, Harding WW.

ACS Med Chem Lett. 2018 Sep 10;9(10):990-995. doi: 10.1021/acsmedchemlett.8b00229. eCollection 2018 Oct 11.


Structure-activity profiling of alkaloid natural product pharmacophores against a Schistosoma serotonin receptor.

Marchant JS, Harding WW, Chan JD.

Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):550-558. doi: 10.1016/j.ijpddr.2018.09.001. Epub 2018 Sep 28.


Synthesis and evaluation of C9 alkoxy analogues of (-)-stepholidine as dopamine receptor ligands.

Madapa S, Gadhiya S, Kurtzman T, Alberts IL, Ramsey S, Reith M, Harding WW.

Eur J Med Chem. 2017 Jan 5;125:255-268. doi: 10.1016/j.ejmech.2016.09.036. Epub 2016 Sep 14.


New halogenated tris-(phenylalkyl)amines as h5-HT2B receptor ligands.

Kapadia N, Ahmed S, Harding WW.

Bioorg Med Chem Lett. 2016 Jul 15;26(14):3216-3219. doi: 10.1016/j.bmcl.2016.05.079. Epub 2016 May 28.


An alternative synthesis and x-ray crystallographic confirmation of (-)-stepholidine.

Gadhiya SV, Hu C, Harding WW.

Tetrahedron Lett. 2016 May 11;57(19):2090-2092.


Tetrahydroprotoberberine alkaloids with dopamine and σ receptor affinity.

Gadhiya S, Madapa S, Kurtzman T, Alberts IL, Ramsey S, Pillarsetty NK, Kalidindi T, Harding WW.

Bioorg Med Chem. 2016 May 1;24(9):2060-71. doi: 10.1016/j.bmc.2016.03.037. Epub 2016 Mar 21.


Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor.

Ponnala S, Kapadia N, Madapa S, Alberts IL, Harding WW.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5102-6. doi: 10.1016/j.bmcl.2015.10.012. Epub 2015 Oct 9.


C4 phenyl aporphines with selective h5-HT(2B) receptor affinity.

Kapadia N, Harding WW.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3451-4. doi: 10.1016/j.bmcl.2015.07.012. Epub 2015 Jul 11.


Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.

Madapa S, Harding WW.

J Nat Prod. 2015 Apr 24;78(4):722-9. doi: 10.1021/np500893h. Epub 2015 Feb 19.


Aporphinoid antagonists of 5-HT2A receptors: further evaluation of ring A substituents and the size of ring C.

Ponnala S, Kapadia N, Navarro HA, Harding WW.

Chem Biol Drug Des. 2014 Nov;84(5):558-66. doi: 10.1111/cbdd.12345. Epub 2014 Jun 3.


Evaluation of structural effects on 5-HT(2A) receptor antagonism by aporphines: identification of a new aporphine with 5-HT(2A) antagonist activity.

Ponnala S, Gonzales J, Kapadia N, Navarro HA, Harding WW.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1664-7. doi: 10.1016/j.bmcl.2014.02.066. Epub 2014 Mar 4.


A New Route to Azafluoranthene Natural Products via Direct Arylation.

Ponnala S, Harding WW.

European J Org Chem. 2013 Feb 1;3013(6):1107-1115. Epub 2013 Jan 3.


Leonurenones A-C: Labdane diterpenes from Leonotis leonurus.

He F, Lindqvist C, Harding WW.

Phytochemistry. 2012 Nov;83:168-72. doi: 10.1016/j.phytochem.2012.07.014. Epub 2012 Aug 12.


New aporphinoid 5-HT2A and α1A antagonists via structural manipulations of nantenine.

Chaudhary S, Ponnala S, Legendre O, Gonzales JA, Navarro HA, Harding WW.

Bioorg Med Chem. 2011 Oct 1;19(19):5861-8. doi: 10.1016/j.bmc.2011.08.019. Epub 2011 Aug 18.


Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: an SAR study.

Ponnala S, Chaudhary S, González-Sarrias A, Seeram NP, Harding WW.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4462-4. doi: 10.1016/j.bmcl.2011.06.005. Epub 2011 Jun 15.


Synthesis of C-Homoaporphines via Microwave-Assisted Direct Arylation.

Chaudhary S, Harding WW.

Tetrahedron. 2011 Jan 21;67(3):569-575.


Affinity of aporphines for the human 5-HT2A receptor: insights from homology modeling and molecular docking studies.

Pecic S, Makkar P, Chaudhary S, Reddy BV, Navarro HA, Harding WW.

Bioorg Med Chem. 2010 Aug 1;18(15):5562-75. doi: 10.1016/j.bmc.2010.06.043. Epub 2010 Jun 20.


Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations.

Pecic S, McAnuff MA, Harding WW.

J Enzyme Inhib Med Chem. 2011 Feb;26(1):46-55. doi: 10.3109/14756361003671078. Epub 2010 Jun 28.


Microwave-Assisted Direct Biaryl Coupling: First Application to the Synthesis of Aporphines.

Chaudhary S, Pecic S, Legendre O, Harding WW.

Tetrahedron Lett. 2009 May 20;50(20):2437-2439.


Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.

Legendre O, Pecic S, Chaudhary S, Zimmerman SM, Fantegrossi WE, Harding WW.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. doi: 10.1016/j.bmcl.2009.11.053. Epub 2009 Nov 20.


(+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners.

Chaudhary S, Pecic S, Legendre O, Navarro HA, Harding WW.

Bioorg Med Chem Lett. 2009 May 1;19(9):2530-2. doi: 10.1016/j.bmcl.2009.03.048. Epub 2009 Mar 16.


Herkinorin analogues with differential beta-arrestin-2 interactions.

Tidgewell K, Groer CE, Harding WW, Lozama A, Schmidt M, Marquam A, Hiemstra J, Partilla JS, Dersch CM, Rothman RB, Bohn LM, Prisinzano TE.

J Med Chem. 2008 Apr 24;51(8):2421-31. doi: 10.1021/jm701162g. Epub 2008 Apr 2.


New Drimane Sesquiterpenoids from Tidestromia oblongifolia.

Chaudhary S, Thomas V, Todaro L, Legendre O, Pecic S, Harding WW.

Nat Prod Commun. 2008;3(11):1747-1750.


Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues.

Simpson DS, Katavic PL, Lozama A, Harding WW, Parrish D, Deschamps JR, Dersch CM, Partilla JS, Rothman RB, Navarro H, Prisinzano TE.

J Med Chem. 2007 Jul 26;50(15):3596-603. Epub 2007 Jun 20.


An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization.

Groer CE, Tidgewell K, Moyer RA, Harding WW, Rothman RB, Prisinzano TE, Bohn LM.

Mol Pharmacol. 2007 Feb;71(2):549-57. Epub 2006 Nov 7.


Enantioselective synthesis of (2R,3R)- and (2S,3S)-2- [(3-chlorophenyl)-(2-methoxyphenoxy)methyl]morpholine.

Harding WW, Hodge M, Wang Z, Woolverton WL, Parrish D, Deschamps JR, Prisinzano TE.

Tetrahedron Asymmetry. 2005 Jul 4;16(13):2249-2256.


Synthesis of salvinorin A analogues as opioid receptor probes.

Tidgewell K, Harding WW, Lozama A, Cobb H, Shah K, Kannan P, Dersch CM, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE.

J Nat Prod. 2006 Jun;69(6):914-8.


Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring.

Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Dersch CM, Rothman RB, Prisinzano TE.

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3170-4. Epub 2006 Apr 18.


Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A.

Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Gilmour B, Navarro H, Rothman RB, Prisinzano TE.

J Nat Prod. 2006 Jan;69(1):107-12.


Kappa opioids as potential treatments for stimulant dependence.

Prisinzano TE, Tidgewell K, Harding WW.

AAPS J. 2005 Oct 19;7(3):E592-9. Review.


Pharmacokinetics of the plant-derived kappa-opioid hallucinogen salvinorin A in nonhuman primates.

Schmidt MD, Schmidt MS, Butelman ER, Harding WW, Tidgewell K, Murry DJ, Kreek MJ, Prisinzano TE.

Synapse. 2005 Dec 1;58(3):208-10.


Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands.

Harding WW, Tidgewell K, Byrd N, Cobb H, Dersch CM, Butelman ER, Rothman RB, Prisinzano TE.

J Med Chem. 2005 Jul 28;48(15):4765-71.


Hypoglycemic effects of steroidal sapogenins isolated from Jamaican bitter yam, Dioscorea polygonoides.

McAnuff MA, Harding WW, Omoruyi FO, Jacobs H, Morrison EY, Asemota HN.

Food Chem Toxicol. 2005 Nov;43(11):1667-72.


Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum.

Harding WW, Tidgewell K, Schmidt M, Shah K, Dersch CM, Snyder J, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE.

Org Lett. 2005 Jul 7;7(14):3017-20.


A facile method for the preparation of deuterium labeled salvinorin A: synthesis of [2,2,2-2H3]-salvinorin A.

Tidgewell K, Harding WW, Schmidt M, Holden KG, Murry DJ, Prisinzano TE.

Bioorg Med Chem Lett. 2004 Oct 18;14(20):5099-102.


Cycloartanes, protolimonoids, a pregnane and a new ergostane from Trichilia reticulata.

Harding WW, Jacobs H, Lewis PA, McLean S, Reynolds WF.

Nat Prod Lett. 2001;15(4):253-60.


New diterpenes from Jatropha divaricata.

Denton RW, Harding WW, Anderson CI, Jacobs H, McLean S, Reynolds WF.

J Nat Prod. 2001 Jun;64(6):829-31.


Alvaradoins A-D. Anthracenone C arabinosides from alvaradoa jamaicensis

Harding WW, Henry GE, Lewis PA, Jacobs H, McLean S, Reynolds WF.

J Nat Prod. 1999 Jan;62(1):98-101.


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