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The Fluoroquinolone Finafloxacin Protects BALB/c Mice Against an Intranasal Infection With Francisella tularensis Strain SchuS4.

Barnes KB, Hamblin KA, Richards MI, Laws TR, Vente A, Atkins HS, Harding SV.

Front Microbiol. 2019 May 1;10:904. doi: 10.3389/fmicb.2019.00904. eCollection 2019.


Disulfiram, an alcohol dependence therapy, can inhibit the in vitro growth of Francisella tularensis.

Hamblin KA, Flick-Smith H, Barnes KB, Pereira-Leal JB, Surkont J, Hampson R, Atkins HS, Harding SV.

Int J Antimicrob Agents. 2019 Jul;54(1):85-88. doi: 10.1016/j.ijantimicag.2019.04.002. Epub 2019 Apr 25.


Positioning the Value of Dietary Carbohydrate, Carbohydrate Quality, Glycemic Index, and GI Labelling to the Canadian Consumer for Improving Dietary Patterns.

Marinangeli CPF, Castellano J, Torrance P, Lewis J, Gall Casey C, Tanuta J, Curran J, Harding SV, Jenkins DJA, Sievenpiper JL.

Nutrients. 2019 Feb 22;11(2). pii: E457. doi: 10.3390/nu11020457.


Betaine or folate can equally furnish remethylation to methionine and increase transmethylation in methionine-restricted neonates.

Robinson JL, McBreairty LE, Randell EW, Harding SV, Bartlett RK, Brunton JA, Bertolo RF.

J Nutr Biochem. 2018 Sep;59:129-135. doi: 10.1016/j.jnutbio.2018.06.001. Epub 2018 Jun 11.


Sleep extension is a feasible lifestyle intervention in free-living adults who are habitually short sleepers: a potential strategy for decreasing intake of free sugars? A randomized controlled pilot study.

Al Khatib HK, Hall WL, Creedon A, Ooi E, Masri T, McGowan L, Harding SV, Darzi J, Pot GK.

Am J Clin Nutr. 2018 Jan 1;107(1):43-53. doi: 10.1093/ajcn/nqx030. Erratum in: Am J Clin Nutr. 2018 Apr 1;107(4):676.


Barley β-glucan reduces blood cholesterol levels via interrupting bile acid metabolism.

Wang Y, Harding SV, Thandapilly SJ, Tosh SM, Jones PJH, Ames NP.

Br J Nutr. 2017 Nov;118(10):822-829. doi: 10.1017/S0007114517002835. Epub 2017 Nov 8.


Demonstrating the Protective Efficacy of the Novel Fluoroquinolone Finafloxacin against an Inhalational Exposure to Burkholderia pseudomallei.

Barnes KB, Hamblin KA, Richards MI, Laws TR, Vente A, Atkins HS, Harding SV.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00082-17. doi: 10.1128/AAC.00082-17. Print 2017 Jul.


Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague.

Hamblin KA, Armstrong SJ, Barnes KB, Davies C, Laws T, Blanchard JD, Harding SV, Atkins HS.

Front Microbiol. 2017 Feb 6;8:91. doi: 10.3389/fmicb.2017.00091. eCollection 2017.


Protein Synthesis in Mucin-Producing Tissues Is Conserved When Dietary Threonine Is Limiting in Piglets.

Munasinghe LL, Robinson JL, Harding SV, Brunton JA, Bertolo RF.

J Nutr. 2017 Feb;147(2):202-210. doi: 10.3945/jn.116.236786. Epub 2017 Jan 4.


The effects of partial sleep deprivation on energy balance: a systematic review and meta-analysis.

Al Khatib HK, Harding SV, Darzi J, Pot GK.

Eur J Clin Nutr. 2017 May;71(5):614-624. doi: 10.1038/ejcn.2016.201. Epub 2016 Nov 2. Review.


Colitis, independent of macronutrient intake, compromises bone structure and strength in growing piglets.

Vassilyadi P, Harding SV, Hazell TJ, Weiler HA, Wykes LJ.

Pediatr Res. 2016 Nov;80(5):753-758. doi: 10.1038/pr.2016.135. Epub 2016 Jun 28.


A Bioluminescent Francisella tularensis SCHU S4 Strain Enables Noninvasive Tracking of Bacterial Dissemination and the Evaluation of Antibiotics in an Inhalational Mouse Model of Tularemia.

Hall CA, Flick-Smith HC, Harding SV, Atkins HS, Titball RW.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7206-7215. Print 2016 Dec.


Dietary Resistant Starch Supplementation Increases High-Density Lipoprotein Particle Number in Pigs Fed a Western Diet.

Rideout TC, Harding SV, Raslawsky A, Rempel CB.

J Diet Suppl. 2017 May 4;14(3):334-345. Epub 2016 Sep 21.


Dietary Methyl Donors Contribute to Whole-Body Protein Turnover and Protein Synthesis in Skeletal Muscle and the Jejunum in Neonatal Piglets.

Robinson JL, Harding SV, Brunton JA, Bertolo RF.

J Nutr. 2016 Oct;146(10):2007-2012. Epub 2016 Aug 31.


Dietary methyl donors affect in vivo methionine partitioning between transmethylation and protein synthesis in the neonatal piglet.

Robinson JL, Bartlett RK, Harding SV, Randell EW, Brunton JA, Bertolo RF.

Amino Acids. 2016 Dec;48(12):2821-2830. Epub 2016 Aug 25.


Health claims using the term 'sustained energy' are trending but glycaemic response data are being used to support: is this misleading without context?

Marinangeli CP, Harding SV.

J Hum Nutr Diet. 2016 Aug;29(4):401-4. doi: 10.1111/jhn.12359. Epub 2016 Mar 29.


High-Molecular-Weight β-Glucan Decreases Serum Cholesterol Differentially Based on the CYP7A1 rs3808607 Polymorphism in Mildly Hypercholesterolemic Adults.

Wang Y, Harding SV, Eck P, Thandapilly SJ, Gamel TH, Abdel-Aal el-SM, Crow GH, Tosh SM, Jones PJ, Ames NP.

J Nutr. 2016 Apr;146(4):720-7. doi: 10.3945/jn.115.223206. Epub 2016 Mar 2.


Betaine is as effective as folate at re-synthesizing methionine for protein synthesis during moderate methionine deficiency in piglets.

McBreairty LE, Robinson JL, Harding SV, Randell EW, Brunton JA, Bertolo RF.

Eur J Nutr. 2016 Dec;55(8):2423-2430. Epub 2015 Sep 29.


Experimental colitis and malnutrition differentially affect the metabolism of glutathione and related sulfhydryl metabolites in different tissues.

Vassilyadi P, Harding SV, Nitschmann E, Wykes LJ.

Eur J Nutr. 2016 Jun;55(4):1769-76. doi: 10.1007/s00394-015-0995-x. Epub 2015 Jul 25.


Effects of Plant Sterol and Stanol Consumption on Blood Pressure and Endothelial Function.

Yue SY, Rideout TC, Harding SV.

J AOAC Int. 2015 May-Jun;98(3):729-34. doi: 10.5740/jaoacint.SGEYue. Epub 2015 May 4. Review.


Triglyceride-Lowering Response to Plant Sterol and Stanol Consumption.

Rideout TC, Marinangeli CP, Harding SV.

J AOAC Int. 2015 May-Jun;98(3):707-15. doi: 10.5740/jaoacint.SGERideout. Epub 2015 May 4. Review.


Desaturation index versus isotopically measured de novo lipogenesis as an indicator of acute systemic lipogenesis.

Harding SV, Bateman KP, Kennedy BP, Rideout TC, Jones PJ.

BMC Res Notes. 2015 Feb 23;8:49. doi: 10.1186/s13104-015-1016-0.


Complementary Cholesterol-Lowering Response of a Phytosterol/α-Lipoic Acid Combination in Obese Zucker Rats.

Rideout TC, Carrier B, Wen S, Raslawsky A, Browne RW, Harding SV.

J Diet Suppl. 2016;13(3):283-99. doi: 10.3109/19390211.2015.1008616. Epub 2015 Feb 9.


The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis.

AbuAli G, Chaisaklert W, Stelloo E, Pazarentzos E, Hwang MS, Qize D, Harding SV, Al-Rubaish A, Alzahrani AJ, Al-Ali A, Sanders TA, Aboagye EO, Grimm S.

Oncogene. 2015 Mar 26;34(13):1718-28. doi: 10.1038/onc.2014.93. Epub 2014 Apr 28.


Liposome encapsulation of ciprofloxacin improves protection against highly virulent Francisella tularensis strain Schu S4.

Hamblin KA, Armstrong SJ, Barnes KB, Davies C, Wong JP, Blanchard JD, Harding SV, Simpson AJ, Atkins HS.

Antimicrob Agents Chemother. 2014 Jun;58(6):3053-9. doi: 10.1128/AAC.02555-13. Epub 2014 Mar 17.


Phytosterols protect against diet-induced hypertriglyceridemia in Syrian golden hamsters.

Rideout TC, Ramprasath V, Griffin JD, Browne RW, Harding SV, Jones PJ.

Lipids Health Dis. 2014 Jan 6;13:5. doi: 10.1186/1476-511X-13-5.


Consumption of wheat bran modified by autoclaving reduces fat mass in hamsters.

Harding SV, Sapirstein HD, Rideout TC, Marinangeli CP, Dona AK, Jones PJ.

Eur J Nutr. 2014 Apr;53(3):793-802. doi: 10.1007/s00394-013-0583-x. Epub 2013 Oct 8.


Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glanders.

Barnes KB, Steward J, Thwaite JE, Lever MS, Davies CH, Armstrong SJ, Laws TR, Roughley N, Harding SV, Atkins TP, Simpson AJ, Atkins HS.

Int J Antimicrob Agents. 2013 Jun;41(6):552-7. doi: 10.1016/j.ijantimicag.2013.02.007. Epub 2013 Mar 19.


Assessment of antimicrobial peptide LL-37 as a post-exposure therapy to protect against respiratory tularemia in mice.

Flick-Smith HC, Fox MA, Hamblin KA, Richards MI, Jenner DC, Laws TR, Phelps AL, Taylor C, Harding SV, Ulaeto DO, Atkins HS.

Peptides. 2013 May;43:96-101. doi: 10.1016/j.peptides.2013.02.024. Epub 2013 Mar 14.


Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition.

Gillingham LG, Harding SV, Rideout TC, Yurkova N, Cunnane SC, Eck PK, Jones PJ.

Am J Clin Nutr. 2013 Jan;97(1):195-207. doi: 10.3945/ajcn.112.043117. Epub 2012 Dec 5.


Evidence for using alpha-lipoic acid in reducing lipoprotein and inflammatory related atherosclerotic risk.

Harding SV, Rideout TC, Jones PJ.

J Diet Suppl. 2012 Jun;9(2):116-27. doi: 10.3109/19390211.2012.683136. Review.


Metabolic and genetic factors modulating subject specific LDL-C responses to plant sterol therapy.

Rideout TC, Harding SV, Mackay DS.

Can J Physiol Pharmacol. 2012 May;90(5):509-14. doi: 10.1139/y2012-060. Epub 2012 Apr 17. Review.


Characterization of the Burkholderia pseudomallei K96243 capsular polysaccharide I coding region.

Cuccui J, Milne TS, Harmer N, George AJ, Harding SV, Dean RE, Scott AE, Sarkar-Tyson M, Wren BW, Titball RW, Prior JL.

Infect Immun. 2012 Mar;80(3):1209-21. doi: 10.1128/IAI.05805-11. Epub 2012 Jan 17.


A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.

Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, Marshall LE, Mobbs GW, Mohamed R, Nathan S, Ngugi SA, Ong C, Ooi WF, Partridge LJ, Phillips HL, Raih MF, Ruzheinikov S, Sarkar-Tyson M, Sedelnikova SE, Smither SJ, Tan P, Titball RW, Wilson SA, Rice DW.

Science. 2011 Nov 11;334(6057):821-4. doi: 10.1126/science.1211915.


Whole and fractionated yellow pea flours modulate insulin, glucose, oxygen consumption, and the caecal microbiome in Golden Syrian hamsters.

Marinangeli CP, Krause D, Harding SV, Rideout TC, Zhu F, Jones PJ.

Appl Physiol Nutr Metab. 2011 Dec;36(6):811-20. doi: 10.1139/h11-101. Epub 2011 Oct 25.


A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulence.

Norville IH, Harmer NJ, Harding SV, Fischer G, Keith KE, Brown KA, Sarkar-Tyson M, Titball RW.

Infect Immun. 2011 Nov;79(11):4299-307. doi: 10.1128/IAI.00134-11. Epub 2011 Aug 22.


Development of reagents and assays for the detection of pathogenic Burkholderia species.

Qazi O, Rani M, Gnanam AJ, Cullen TW, Stead CM, Kensing H, McCaul K, Ngugi S, Prior JL, Lipka A, Nagy JM, Gregory CW, Judy BM, Harding SV, Titball RW, Sidhu SS, Trent MS, Kitto GB, Torres A, Estes DM, Iverson B, Georgiou G, Brown KA.

Faraday Discuss. 2011;149:23-36; discussion 63-77.


The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei.

Burtnick MN, Brett PJ, Harding SV, Ngugi SA, Ribot WJ, Chantratita N, Scorpio A, Milne TS, Dean RE, Fritz DL, Peacock SJ, Prior JL, Atkins TP, Deshazer D.

Infect Immun. 2011 Apr;79(4):1512-25. doi: 10.1128/IAI.01218-10. Epub 2011 Feb 7.


CD4+ T-cell immunity to the Burkholderia pseudomallei ABC transporter LolC in melioidosis.

Chu KK, Tippayawat P, Walker NJ, Harding SV, Atkins HS, Maillere B, Bancroft GJ, Lertmemongkolchai G, Altmann DM.

Eur J Immunol. 2011 Jan;41(1):107-15. doi: 10.1002/eji.201040881. Epub 2010 Dec 3.


Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis.

Ngugi SA, Ventura VV, Qazi O, Harding SV, Kitto GB, Estes DM, Dell A, Titball RW, Atkins TP, Brown KA, Hitchen PG, Prior JL.

Vaccine. 2010 Nov 3;28(47):7551-5. doi: 10.1016/j.vaccine.2010.08.058. Epub 2010 Sep 15.


Hepatic nuclear sterol regulatory binding element protein 2 abundance is decreased and that of ABCG5 increased in male hamsters fed plant sterols.

Harding SV, Rideout TC, Jones PJ.

J Nutr. 2010 Jul;140(7):1249-54. doi: 10.3945/jn.109.120311. Epub 2010 May 26.


High basal fractional cholesterol synthesis is associated with nonresponse of plasma LDL cholesterol to plant sterol therapy.

Rideout TC, Harding SV, Mackay D, Abumweis SS, Jones PJ.

Am J Clin Nutr. 2010 Jul;92(1):41-6. doi: 10.3945/ajcn.2009.29073. Epub 2010 May 5.


Diacylglycerol oil reduces body fat but does not alter energy or lipid metabolism in overweight, hypertriglyceridemic women.

Yuan Q, Ramprasath VR, Harding SV, Rideout TC, Chan YM, Jones PJ.

J Nutr. 2010 Jun;140(6):1122-6. doi: 10.3945/jn.110.121665. Epub 2010 Apr 21.


Combination drug-diet therapies for dyslipidemia.

Rideout TC, Harding SV, Marinangeli CP, Jones PJ.

Transl Res. 2010 May;155(5):220-7. doi: 10.1016/j.trsl.2009.12.005. Epub 2010 Jan 19. Review.


Consumption of plant sterols reduces plasma and hepatic triglycerides and modulates the expression of lipid regulatory genes and de novo lipogenesis in C57BL/6J mice.

Rideout TC, Harding SV, Jones PJ.

Mol Nutr Food Res. 2010 May;54 Suppl 1:S7-13. doi: 10.1002/mnfr.201000027.


Altering dietary lysine:arginine ratio has little effect on cardiovascular risk factors and vascular reactivity in moderately hypercholesterolemic adults.

Vega-López S, Matthan NR, Ausman LM, Harding SV, Rideout TC, Ai M, Otokozawa S, Freed A, Kuvin JT, Jones PJ, Schaefer EJ, Lichtenstein AH.

Atherosclerosis. 2010 Jun;210(2):555-62. doi: 10.1016/j.atherosclerosis.2009.12.002. Epub 2009 Dec 5.


Maintaining adequate nutrition, not probiotic administration, prevents growth stunting and maintains skeletal muscle protein synthesis rates in a piglet model of colitis.

Harding SV, Adegoke OA, Fraser KG, Marliss EB, Chevalier S, Kimball SR, Jefferson LS, Wykes LJ.

Pediatr Res. 2010 Mar;67(3):268-73. doi: 10.1203/PDR.0b013e3181cb8e49.


Red algal cellular biomass lowers circulating cholesterol concentrations in Syrian golden hamsters consuming hypercholesterolaemic diets.

Harding SV, Zhao HL, Marinangeli CP, Day AG, Dillon HF, Jain D, Jones PJ.

Br J Nutr. 2009 Sep;102(6):842-7. doi: 10.1017/S0007114509380046. Epub 2009 Jun 16.


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