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Characterisation of high molecular weight hop proanthocyanidins using Analytical Ultracentrifugation.

Gadon A, Linforth R, Harding SE, Cook D.

Sci Rep. 2019 Sep 2;9(1):12650. doi: 10.1038/s41598-019-49171-4.


Understanding the influence of processing conditions on the extraction of rhamnogalacturonan-I "hairy" pectin from sugar beet pulp.

Mao Y, Lei R, Ryan J, Arrutia Rodriguez F, Rastall B, Chatzifragkou A, Winkworth-Smith C, Harding SE, Ibbett R, Binner E.

Food Chem X. 2019 Jun 30;2:100026. doi: 10.1016/j.fochx.2019.100026.


Submaxillary Mucin: its Effect on Aroma Release from Acidic Drinks and New Insight into the Effect of Aroma Compounds on its Macromolecular Integrity.

Dinu V, Gillis RB, MacCalman T, Lim M, Adams GG, Harding SE, Fisk ID.

Food Biophys. 2019;14(3):278-286. doi: 10.1007/s11483-019-09574-2. Epub 2019 Apr 15.


Mucin immobilization in calcium alginate: A possible mucus mimetic tool for evaluating mucoadhesion and retention of flavour.

Dinu V, Yakubov GE, Lim M, Hurst K, Adams GG, Harding SE, Fisk ID.

Int J Biol Macromol. 2019 Oct 1;138:831-836. doi: 10.1016/j.ijbiomac.2019.07.148. Epub 2019 Jul 25.


Understanding dynamic tissue organization by studying the human body one cell at a time: the human cell atlas (HCA) project.

Noseda M, Harding SE.

Cardiovasc Res. 2018 Oct 1;114(12):e93-e95. doi: 10.1093/cvr/cvy223. No abstract available.


Characterization of acute TLR-7 agonist-induced hemorrhagic myocarditis in mice by multiparametric quantitative cardiac magnetic resonance imaging.

Baxan N, Papanikolaou A, Salles-Crawley I, Lota A, Chowdhury R, Dubois O, Branca J, Hasham MG, Rosenthal N, Prasad SK, Zhao L, Harding SE, Sattler S.

Dis Model Mech. 2019 Aug 16;12(8). pii: dmm040725. doi: 10.1242/dmm.040725.


An enzymatically controlled mucoadhesive system for enhancing flavour during food oral processing.

Dinu V, Gadon A, Hurst K, Lim M, Ayed C, Gillis RB, Adams GG, Harding SE, Fisk ID.

NPJ Sci Food. 2019 Jul 1;3:11. doi: 10.1038/s41538-019-0043-y. eCollection 2019.


Non-chemically modified waxy rice starch stabilised wow emulsions for salt reduction.

Kasprzak M, Wilde P, Hill SE, Harding SE, Ford R, Wolf B.

Food Funct. 2019 Jul 17;10(7):4242-4255. doi: 10.1039/c8fo01938j.


Multi-cellularity in cardiac tissue engineering, how close are we to native heart tissue?

Owen TJ, Harding SE.

J Muscle Res Cell Motil. 2019 Jun;40(2):151-157. doi: 10.1007/s10974-019-09528-8. Epub 2019 Jun 20.


Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro.

Watson SA, Duff J, Bardi I, Zabielska M, Atanur SS, Jabbour RJ, Simon A, Tomas A, Smolenski RT, Harding SE, Perbellini F, Terracciano CM.

Nat Commun. 2019 May 15;10(1):2168. doi: 10.1038/s41467-019-10175-3.


MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.

Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W, Habib J, Narasimham P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, Tan TH, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD.

Cell Stem Cell. 2019 Apr 4;24(4):579-591.e12. doi: 10.1016/j.stem.2019.01.013. Epub 2019 Mar 7.


Ventricular conduction stability test: a method to identify and quantify changes in whole heart activation patterns during physiological stress.

Shun-Shin MJ, Leong KMW, Ng FS, Linton NWF, Whinnett ZI, Koa-Wing M, Qureshi N, Lefroy DC, Harding SE, Lim PB, Peters NS, Francis DP, Varnava AM, Kanagaratnam P.

Europace. 2019 Sep 1;21(9):1422-1431. doi: 10.1093/europace/euz015.


Proteomic Analysis Reveals Temporal Changes in Protein Expression in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes In Vitro.

Hellen N, Pinto Ricardo C, Vauchez K, Whiting G, Wheeler JX, Harding SE.

Stem Cells Dev. 2019 May 1;28(9):565-578. doi: 10.1089/scd.2018.0210. Epub 2019 Mar 20.


Takotsubo Syndrome: Latest Addition to the Expanding Family of Immune-Mediated Diseases?

Sattler S, Couch LS, Harding SE.

JACC Basic Transl Sci. 2018 Dec 31;3(6):779-781. doi: 10.1016/j.jacbts.2018.11.003. eCollection 2018 Dec. No abstract available.


Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits.

Smith JGW, Owen T, Bhagwan JR, Mosqueira D, Scott E, Mannhardt I, Patel A, Barriales-Villa R, Monserrat L, Hansen A, Eschenhagen T, Harding SE, Marston S, Denning C.

Stem Cell Reports. 2018 Nov 13;11(5):1226-1243. doi: 10.1016/j.stemcr.2018.10.006. Epub 2018 Nov 1.


Analytical ultracentrifugation in saliva research: Impact of green tea astringency and its significance on the in-vivo aroma release.

Dinu V, Liu C, Ali J, Ayed C, Gershkovich P, Adams GG, Harding SE, Fisk ID.

Sci Rep. 2018 Sep 6;8(1):13350. doi: 10.1038/s41598-018-31625-w.


The discovery of hydrogen bonds in DNA and a re-evaluation of the 1948 Creeth two-chain model for its structure.

Harding SE, Channell G, Phillips-Jones MK.

Biochem Soc Trans. 2018 Oct 19;46(5):1171-1182. doi: 10.1042/BST20180158. Epub 2018 Sep 6. Review.


A simple cell-alignment protocol for sedimentation velocity analytical ultracentrifugation to complement mechanical and optical alignment procedures.

Channell G, Dinu V, Adams GG, Harding SE.

Eur Biophys J. 2018 Oct;47(7):809-813. doi: 10.1007/s00249-018-1328-9. Epub 2018 Aug 29.


Use of the Extended Fujita method for representing the molecular weight and molecular weight distributions of native and processed oat beta-glucans.

Channell GA, Adams GG, Lu Y, Gillis RB, Dinu V, Grundy MM, Bajka B, Butterworth PJ, Ellis PR, Mackie A, Ballance S, Harding SE.

Sci Rep. 2018 Aug 7;8(1):11809. doi: 10.1038/s41598-018-29997-0.


Production of membrane proteins for characterisation of their pheromone-sensing and antimicrobial resistance functions.

Azam AA, Kinder JM, Khan GN, Alase A, Ma P, Liu Y, Ault JR, Henderson PJF, Chowdhry BZ, Alexander BD, Harding SE, Phillips-Jones MK.

Eur Biophys J. 2018 Oct;47(7):723-737. doi: 10.1007/s00249-018-1325-z. Epub 2018 Jul 31.


Takotsubo Syndrome: Stress or NO Stress?

Couch LS, Harding SE.

JACC Basic Transl Sci. 2018 May 30;3(2):227-229. doi: 10.1016/j.jacbts.2018.03.002. eCollection 2018 Apr. No abstract available.


Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition.

Panahi M, Papanikolaou A, Torabi A, Zhang JG, Khan H, Vazir A, Hasham MG, Cleland JGF, Rosenthal NA, Harding SE, Sattler S.

Cardiovasc Res. 2018 Sep 1;114(11):1445-1461. doi: 10.1093/cvr/cvy145.


Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction.

Kapnisi M, Mansfield C, Marijon C, Guex AG, Perbellini F, Bardi I, Humphrey EJ, Puetzer JL, Mawad D, Koutsogeorgis DC, Stuckey DJ, Terracciano CM, Harding SE, Stevens MM.

Adv Funct Mater. 2018 May 24;28(21):1800618. doi: 10.1002/adfm.201800618.


Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β2AR-cAMP Responsiveness in Murine Hearts.

Wright PT, Bhogal NK, Diakonov I, Pannell LMK, Perera RK, Bork NI, Schobesberger S, Lucarelli C, Faggian G, Alvarez-Laviada A, Zaccolo M, Kamp TJ, Balijepalli RC, Lyon AR, Harding SE, Nikolaev VO, Gorelik J.

Cell Rep. 2018 Apr 10;23(2):459-469. doi: 10.1016/j.celrep.2018.03.053.


Characterisation of insulin analogues therapeutically available to patients.

Adams GG, Meal A, Morgan PS, Alzahrani QE, Zobel H, Lithgo R, Kok MS, Besong DTM, Jiwani SI, Ballance S, Harding SE, Chayen N, Gillis RB.

PLoS One. 2018 Mar 29;13(3):e0195010. doi: 10.1371/journal.pone.0195010. eCollection 2018.


Controlled depolymerisation assessed by analytical ultracentrifugation of low molecular weight chitosan for use in archaeological conservation.

Wakefield JMK, Gillis RB, Adams GG, McQueen CMA, Harding SE.

Eur Biophys J. 2018 Oct;47(7):769-775. doi: 10.1007/s00249-018-1290-6. Epub 2018 Mar 17.


Interaction studies of a protein and carbohydrate system using an integrated approach: a case study of the miniagrin-heparin system.

Patel TR, Besong TMD, Meier M, McEleney K, Harding SE, Winzor DJ, Stetefeld J.

Eur Biophys J. 2018 Oct;47(7):751-759. doi: 10.1007/s00249-018-1291-5. Epub 2018 Mar 12.


Antimicrobial resistance (AMR) nanomachines-mechanisms for fluoroquinolone and glycopeptide recognition, efflux and/or deactivation.

Phillips-Jones MK, Harding SE.

Biophys Rev. 2018 Apr;10(2):347-362. doi: 10.1007/s12551-018-0404-9. Epub 2018 Mar 10. Review.


The adaptive immune response to cardiac injury-the true roadblock to effective regenerative therapies?

Sattler S, Fairchild P, Watt FM, Rosenthal N, Harding SE.

NPJ Regen Med. 2017 Jun 19;2:19. doi: 10.1038/s41536-017-0022-3. eCollection 2017. Review.


Estrogen deficiency compromised the β2AR-Gs/Gi coupling: implications for arrhythmia and cardiac injury.

Hou H, Zhao Z, Machuki JO, Zhang L, Zhang Y, Fu L, Wu J, Liu Y, Harding SE, Sun H.

Pflugers Arch. 2018 Mar;470(3):559-570. doi: 10.1007/s00424-017-2098-4. Epub 2018 Jan 2.


Calcium channel blockers for primary and secondary Raynaud's phenomenon.

Rirash F, Tingey PC, Harding SE, Maxwell LJ, Tanjong Ghogomu E, Wells GA, Tugwell P, Pope J.

Cochrane Database Syst Rev. 2017 Dec 13;12:CD000467. doi: 10.1002/14651858.CD000467.pub2. Review.


Repolarization abnormalities unmasked with exercise in sudden cardiac death survivors with structurally normal hearts.

Leong KMW, Ng FS, Roney C, Cantwell C, Shun-Shin MJ, Linton NWF, Whinnett ZI, Lefroy DC, Davies DW, Harding SE, Lim PB, Francis D, Peters NS, Varnava AM, Kanagaratnam P.

J Cardiovasc Electrophysiol. 2018 Jan;29(1):115-126. doi: 10.1111/jce.13375. Epub 2017 Dec 7.


ST-Elevation Magnitude Correlates With Right Ventricular Outflow Tract Conduction Delay in Type I Brugada ECG.

Leong KMW, Ng FS, Yao C, Roney C, Taraborrelli P, Linton NWF, Whinnett ZI, Lefroy DC, Davies DW, Boon Lim P, Harding SE, Peters NS, Kanagaratnam P, Varnava AM.

Circ Arrhythm Electrophysiol. 2017 Oct;10(10). pii: e005107. doi: 10.1161/CIRCEP.117.005107.


Hierarchical statistical techniques are necessary to draw reliable conclusions from analysis of isolated cardiomyocyte studies.

Sikkel MB, Francis DP, Howard J, Gordon F, Rowlands C, Peters NS, Lyon AR, Harding SE, MacLeod KT.

Cardiovasc Res. 2017 Dec 1;113(14):1743-1752. doi: 10.1093/cvr/cvx151.


Investigation of cardiac fibroblasts using myocardial slices.

Perbellini F, Watson SA, Scigliano M, Alayoubi S, Tkach S, Bardi I, Quaife N, Kane C, Dufton NP, Simon A, Sikkel MB, Faggian G, Randi AM, Gorelik J, Harding SE, Terracciano CM.

Cardiovasc Res. 2018 Jan 1;114(1):77-89. doi: 10.1093/cvr/cvx152.


Molecular pathways of oestrogen receptors and β-adrenergic receptors in cardiac cells: Recognition of their similarities, interactions and therapeutic value.

Machuki JO, Zhang HY, Harding SE, Sun H.

Acta Physiol (Oxf). 2018 Feb;222(2). doi: 10.1111/apha.12978. Epub 2017 Oct 30. Review.


Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Encapsulating Bioactive Hydrogels Improve Rat Heart Function Post Myocardial Infarction.

Chow A, Stuckey DJ, Kidher E, Rocco M, Jabbour RJ, Mansfield CA, Darzi A, Harding SE, Stevens MM, Athanasiou T.

Stem Cell Reports. 2017 Nov 14;9(5):1415-1422. doi: 10.1016/j.stemcr.2017.09.003. Epub 2017 Oct 5.


Full hydrodynamic reversibility of the weak dimerization of vancomycin and elucidation of its interaction with VanS monomers at clinical concentration.

Phillips-Jones MK, Lithgo R, Dinu V, Gillis RB, Harding JE, Adams GG, Harding SE.

Sci Rep. 2017 Oct 5;7(1):12697. doi: 10.1038/s41598-017-12620-z.


Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells.

Martinez VG, Ontoria-Oviedo I, Ricardo CP, Harding SE, Sacedon R, Varas A, Zapata A, Sepulveda P, Vicente A.

Stem Cell Res Ther. 2017 Sep 29;8(1):208. doi: 10.1186/s13287-017-0659-2.


Glargine and degludec: Solution behaviour of higher dose synthetic insulins.

Adams GG, Alzahrani Q, Jiwani SI, Meal A, Morgan PS, Coffey F, Kok S, Rowe AJ, Harding SE, Chayen N, Gillis RB.

Sci Rep. 2017 Aug 4;7(1):7287. doi: 10.1038/s41598-017-06642-w.


The Effectiveness of Lifestyle Adaptation for the Prevention of Prediabetes in Adults: A Systematic Review.

Kerrison G, Gillis RB, Jiwani SI, Alzahrani Q, Kok S, Harding SE, Shaw I, Adams GG.

J Diabetes Res. 2017;2017:8493145. doi: 10.1155/2017/8493145. Epub 2017 Apr 16. Review.


Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis.

Yang C, Xu Y, Yu M, Lee D, Alharti S, Hellen N, Ahmad Shaik N, Banaganapalli B, Sheikh Ali Mohamoud H, Elango R, Przyborski S, Tenin G, Williams S, O'Sullivan J, Al-Radi OO, Atta J, Harding SE, Keavney B, Lako M, Armstrong L.

Hum Mol Genet. 2017 Aug 15;26(16):3031-3045. doi: 10.1093/hmg/ddx140.


Foreword to 'Quantitative and analytical relations in biochemistry'-a special issue in honour of Donald J. Winzor's 80th birthday.

Hall D, Harding SE.

Biophys Rev. 2016 Dec;8(4):269-277. doi: 10.1007/s12551-016-0227-5. Epub 2016 Nov 4. Review.


T-tubule remodelling disturbs localized β2-adrenergic signalling in rat ventricular myocytes during the progression of heart failure.

Schobesberger S, Wright P, Tokar S, Bhargava A, Mansfield C, Glukhov AV, Poulet C, Buzuk A, Monszpart A, Sikkel M, Harding SE, Nikolaev VO, Lyon AR, Gorelik J.

Cardiovasc Res. 2017 Jun 1;113(7):770-782. doi: 10.1093/cvr/cvx074.


Erratum: High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes: [J. Biophotonics 9, No. 3, 311-323 (2016)].

Sikkel MB, Kumar S, Maioli V, Rowlands C, Gordon F, Harding SE, Lyon AR, MacLeod KT, Dunsby C.

J Biophotonics. 2017 May;10(5):744-745. doi: 10.1002/jbio.201700062. Epub 2017 May 3.


In situ polymerisation of isoeugenol as a green consolidation method for waterlogged archaeological wood.

McHale E, Steindal CC, Kutzke H, Benneche T, Harding SE.

Sci Rep. 2017 Apr 27;7:46481. doi: 10.1038/srep46481.


Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin.

Phillips-Jones MK, Channell G, Kelsall CJ, Hughes CS, Ashcroft AE, Patching SG, Dinu V, Gillis RB, Adams GG, Harding SE.

Sci Rep. 2017 Apr 11;7:46180. doi: 10.1038/srep46180.


Quantifying the Release of Biomarkers of Myocardial Necrosis from Cardiac Myocytes and Intact Myocardium.

Marjot J, Kaier TE, Martin ED, Reji SS, Copeland O, Iqbal M, Goodson B, Hamren S, Harding SE, Marber MS.

Clin Chem. 2017 May;63(5):990-996. doi: 10.1373/clinchem.2016.264648. Epub 2017 Apr 4.


Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease.

Hasham MG, Baxan N, Stuckey DJ, Branca J, Perkins B, Dent O, Duffy T, Hameed TS, Stella SE, Bellahcene M, Schneider MD, Harding SE, Rosenthal N, Sattler S.

Dis Model Mech. 2017 Mar 1;10(3):259-270. doi: 10.1242/dmm.027409.

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