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Items: 1 to 50 of 117

1.

SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors.

Yoshida A, Bu Y, Qie S, Wrangle J, Camp ER, Hazard ES, Hardiman G, de Leeuw R, Knudsen KE, Diehl JA.

Sci Adv. 2019 Sep 18;5(9):eaax6352. doi: 10.1126/sciadv.aax6352. eCollection 2019 Sep.

2.

Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina.

Overbey EG, da Silveira WA, Stanbouly S, Nishiyama NC, Roque-Torres GD, Pecaut MJ, Zawieja DC, Wang C, Willey JS, Delp MD, Hardiman G, Mao XW.

Sci Rep. 2019 Sep 16;9(1):13304. doi: 10.1038/s41598-019-49453-x.

3.

Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients.

Sannino G, Marchetto A, Ranft A, Jabar S, Zacherl C, Alba-Rubio R, Stein S, Wehweck FS, Kiran MM, Hölting TLB, Musa J, Romero-Pérez L, Cidre-Aranaz F, Knott MML, Li J, Jürgens H, Sastre A, Alonso J, Da Silveira W, Hardiman G, Gerke JS, Orth MF, Hartmann W, Kirchner T, Ohmura S, Dirksen U, Grünewald TGP.

EBioMedicine. 2019 Sep;47:156-162. doi: 10.1016/j.ebiom.2019.08.002. Epub 2019 Aug 16.

4.

GAIL: An interactive webserver for inference and dynamic visualization of gene-gene associations based on gene ontology guided mining of biomedical literature.

Couch D, Yu Z, Nam JH, Allen C, Ramos PS, da Silveira WA, Hunt KJ, Hazard ES, Hardiman G, Lawson A, Chung D.

PLoS One. 2019 Jul 1;14(7):e0219195. doi: 10.1371/journal.pone.0219195. eCollection 2019.

5.

Primary cilia defects causing mitral valve prolapse.

Toomer KA, Yu M, Fulmer D, Guo L, Moore KS, Moore R, Drayton KD, Glover J, Peterson N, Ramos-Ortiz S, Drohan A, Catching BJ, Stairley R, Wessels A, Lipschutz JH, Delling FN, Jeunemaitre X, Dina C, Collins RL, Brand H, Talkowski ME, Del Monte F, Mukherjee R, Awgulewitsch A, Body S, Hardiman G, Hazard ES, da Silveira WA, Wang B, Leyne M, Durst R, Markwald RR, Le Scouarnec S, Hagege A, Le Tourneau T, Kohl P, Rog-Zielinska EA, Ellinor PT, Levine RA, Milan DJ, Schott JJ, Bouatia-Naji N, Slaugenhaupt SA, Norris RA.

Sci Transl Med. 2019 May 22;11(493). pii: eaax0290. doi: 10.1126/scitranslmed.aax0290.

PMID:
31118289
6.

A de novo transcriptome assembly approach elucidates the dynamics of ovarian maturation in the swordfish (Xiphias gladius).

Gioacchini G, Marisaldi L, Basili D, Candelma M, Pignalosa P, Aiese Cigliano R, Sanseverino W, Hardiman G, Carnevali O.

Sci Rep. 2019 May 14;9(1):7375. doi: 10.1038/s41598-019-43872-6.

7.

Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells.

Chakraborty P, Chatterjee S, Kesarwani P, Thyagarajan K, Iamsawat S, Dalheim A, Nguyen H, Selvam SP, Nasarre P, Scurti G, Hardiman G, Maulik N, Ball L, Gangaraju V, Rubinstein MP, Klauber-DeMore N, Hill EG, Ogretmen B, Yu XZ, Nishimura MI, Mehrotra S.

J Biol Chem. 2019 Jun 7;294(23):9198-9212. doi: 10.1074/jbc.RA118.006753. Epub 2019 Apr 10.

PMID:
30971427
8.

A high prevalence of biallelic RPE65 mutations in Costa Rican children with Leber congenital amaurosis and early-onset retinal dystrophy.

Glen WB Jr, Peterseim MMW, Badilla R, Znoyko I, Bourg A, Wilson R, Hardiman G, Wolff D, Martinez J.

Ophthalmic Genet. 2019 Apr;40(2):110-117. doi: 10.1080/13816810.2019.1582069. Epub 2019 Mar 14.

PMID:
30870047
9.

A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies COL22A1 as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast Transition.

Watanabe T, Baker Frost DA, Mlakar L, Heywood J, da Silveira WA, Hardiman G, Feghali-Bostwick C.

Genes (Basel). 2019 Jan 22;10(2). pii: E75. doi: 10.3390/genes10020075.

10.

Molecular Profiling of RNA Tumors Using High-Throughput RNA Sequencing: From Raw Data to Systems Level Analyses.

da Silveira WA, Hazard ES, Chung D, Hardiman G.

Methods Mol Biol. 2019;1908:185-204. doi: 10.1007/978-1-4939-9004-7_13.

PMID:
30649729
11.

Molecular Profiling of RNA Tumors Using High-Throughput RNA Sequencing: Overview of Library Preparation Methods.

Courtney SM, da Silveira WA, Hazard ES, Hardiman G.

Methods Mol Biol. 2019;1908:169-184. doi: 10.1007/978-1-4939-9004-7_12.

PMID:
30649728
12.

Pipeline for Integrated Microarray Expression Normalization Tool Kit (PIMENTo) for Tumor Microarray Profiling Experiments.

Nash T, Huff M, Glen WB Jr, Hardiman G.

Methods Mol Biol. 2019;1908:153-168. doi: 10.1007/978-1-4939-9004-7_11.

PMID:
30649727
13.

Systems analysis of the liver transcriptome in adult male zebrafish exposed to the non-ionic surfactant nonylphenol.

Huff M, da Silveira W, Starr Hazard E, Courtney SM, Renaud L, Hardiman G.

Gen Comp Endocrinol. 2019 Jan 15;271:1-14. doi: 10.1016/j.ygcen.2018.10.016. Epub 2018 Oct 25.

PMID:
30563618
14.

Transcriptomic analysis of short-term 17α-ethynylestradiol exposure in two Californian sentinel fish species sardine (Sardinops sagax) and mackerel (Scomber japonicus).

Renaud L, Agarwal N, Richards DJ, Falcinelli S, Hazard ES, Carnevali O, Hyde J, Hardiman G.

Environ Pollut. 2019 Jan;244:926-937. doi: 10.1016/j.envpol.2018.10.058. Epub 2018 Oct 20.

PMID:
30469287
15.

A Novel CLCN5 Mutation Associated With Focal Segmental Glomerulosclerosis and Podocyte Injury.

Solanki AK, Arif E, Morinelli T, Wilson RC, Hardiman G, Deng P, Arthur JM, Velez JC, Nihalani D, Janech MG, Budisavljevic MN.

Kidney Int Rep. 2018 Jun 18;3(6):1443-1453. doi: 10.1016/j.ekir.2018.06.003. eCollection 2018 Nov.

16.

Interplay Between MicroRNAs and Targeted Genes in Cellular Homeostasis of Adult Zebrafish (Danio rerio).

Renaud L, da Silveira WA, Glen WB Jr, Hazard ES; and, Hardiman G.

Curr Genomics. 2018 Nov;19(7):615-629. doi: 10.2174/1389202919666180503124522.

17.

De Novo Hepatic Transcriptome Assembly and Systems Level Analysis of Three Species of Dietary Fish, Sardinops sagax, Scomber japonicus, and Pleuronichthys verticalis.

Richards DJ, Renaud L, Agarwal N, Starr Hazard E, Hyde J, Hardiman G.

Genes (Basel). 2018 Oct 25;9(11). pii: E521. doi: 10.3390/genes9110521.

18.

An Analytic Approach Using Candidate Gene Selection and Logic Forest to Identify Gene by Environment Interactions (G × E) for Systemic Lupus Erythematosus in African Americans.

Wolf BJ, Ramos PS, Hyer JM, Ramakrishnan V, Gilkeson GS, Hardiman G, Nietert PJ, Kamen DL.

Genes (Basel). 2018 Oct 15;9(10). pii: E496. doi: 10.3390/genes9100496.

19.

miRmapper: A Tool for Interpretation of miRNA⁻mRNA Interaction Networks.

da Silveira WA, Renaud L, Simpson J, Glen WB Jr, Hazard ES, Chung D, Hardiman G.

Genes (Basel). 2018 Sep 14;9(9). pii: E458. doi: 10.3390/genes9090458.

20.

Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome.

Lal C, Hardiman G, Kumbhare S, Strange C.

Sleep Breath. 2019 Mar;23(1):251-257. doi: 10.1007/s11325-018-1693-8. Epub 2018 Jul 2.

PMID:
29968150
21.

MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer.

de Leeuw R, McNair C, Schiewer MJ, Neupane NP, Brand LJ, Augello MA, Li Z, Cheng LC, Yoshida A, Courtney SM, Hazard ES, Hardiman G, Hussain MH, Diehl JA, Drake JM, Kelly WK, Knudsen KE.

Clin Cancer Res. 2018 Sep 1;24(17):4201-4214. doi: 10.1158/1078-0432.CCR-18-0410. Epub 2018 May 8.

22.

Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP).

Huff M, da Silveira WA, Carnevali O, Renaud L, Hardiman G.

Sci Rep. 2018 Feb 1;8(1):2118. doi: 10.1038/s41598-018-20266-8.

23.

Effects of age on growth in Atlantic bluefin tuna (Thunnus thynnus).

Api M, Bonfanti E, Lombardo F, Pignalosa P, Hardiman G, Carnevali O.

Gen Comp Endocrinol. 2018 Sep 1;265:64-70. doi: 10.1016/j.ygcen.2018.01.010. Epub 2018 Jan 12.

PMID:
29339181
24.

Semi-supervised identification of cancer subgroups using survival outcomes and overlapping grouping information.

Wei W, Sun Z, da Silveira WA, Yu Z, Lawson A, Hardiman G, Kelemen LE, Chung D.

Stat Methods Med Res. 2019 Jul;28(7):2137-2149. doi: 10.1177/0962280217752980. Epub 2018 Jan 16.

PMID:
29336210
25.

ShinyGPA: An interactive visualization toolkit for investigating pleiotropic architecture using GWAS datasets.

Kortemeier E, Ramos PS, Hunt KJ, Kim HJ, Hardiman G, Chung D.

PLoS One. 2018 Jan 8;13(1):e0190949. doi: 10.1371/journal.pone.0190949. eCollection 2018.

26.

CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.

Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt MW, Dhar P, Selvam SP, Fu J, Zhang J, Nguyen H, Kang I, Toth K, Al-Homrani M, Husain M, Beeson G, Ball L, Helke K, Husain S, Garrett-Mayer E, Hardiman G, Mehrotra M, Nishimura MI, Beeson CC, Bupp MG, Wu J, Ogretmen B, Paulos CM, Rathmell J, Yu XZ, Mehrotra S.

Cell Metab. 2018 Jan 9;27(1):85-100.e8. doi: 10.1016/j.cmet.2017.10.006. Epub 2017 Nov 9.

27.

SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability.

Kota V, Sommer G, Hazard ES, Hardiman G, Twiss JL, Heise T.

Mol Cell Biol. 2017 Dec 29;38(2). pii: e00129-17. doi: 10.1128/MCB.00129-17. Print 2018 Jan 15.

28.

The Plasticizer Bisphenol A Perturbs the Hepatic Epigenome: A Systems Level Analysis of the miRNome.

Renaud L, Silveira WAD, Hazard ES, Simpson J, Falcinelli S, Chung D, Carnevali O, Hardiman G.

Genes (Basel). 2017 Oct 13;8(10). pii: E269. doi: 10.3390/genes8100269.

29.

A CCR2+ myeloid cell niche required for pancreatic β cell growth.

Mussar K, Pardike S, Hohl TM, Hardiman G, Cirulli V, Crisa L.

JCI Insight. 2017 Aug 3;2(15). pii: 93834. doi: 10.1172/jci.insight.93834. eCollection 2017 Aug 3.

30.

Larval Red Drum (Sciaenops ocellatus) Sublethal Exposure to Weathered Deepwater Horizon Crude Oil: Developmental and Transcriptomic Consequences.

Xu EG, Khursigara AJ, Magnuson J, Hazard ES, Hardiman G, Esbaugh AJ, Roberts AP, Schlenk D.

Environ Sci Technol. 2017 Sep 5;51(17):10162-10172. doi: 10.1021/acs.est.7b02037. Epub 2017 Aug 18.

PMID:
28768411
31.

Developmental transcriptomic analyses for mechanistic insights into critical pathways involved in embryogenesis of pelagic mahi-mahi (Coryphaena hippurus).

Xu EG, Mager EM, Grosell M, Stieglitz JD, Hazard ES, Hardiman G, Schlenk D.

PLoS One. 2017 Jul 10;12(7):e0180454. doi: 10.1371/journal.pone.0180454. eCollection 2017.

32.

Environmental perfluorooctane sulfonate exposure drives T cell activation in bottlenose dolphins.

Soloff AC, Wolf BJ, White ND, Muir D, Courtney S, Hardiman G, Bossart GD, Fair PA.

J Appl Toxicol. 2017 Sep;37(9):1108-1116. doi: 10.1002/jat.3465. Epub 2017 Apr 19.

33.

Novel transcriptome assembly and comparative toxicity pathway analysis in mahi-mahi (Coryphaena hippurus) embryos and larvae exposed to Deepwater Horizon oil.

Xu EG, Mager EM, Grosell M, Hazard ES, Hardiman G, Schlenk D.

Sci Rep. 2017 Mar 15;7:44546. doi: 10.1038/srep44546.

34.

Genomics pipelines and data integration: challenges and opportunities in the research setting.

Davis-Turak J, Courtney SM, Hazard ES, Glen WB Jr, da Silveira WA, Wesselman T, Harbin LP, Wolf BJ, Chung D, Hardiman G.

Expert Rev Mol Diagn. 2017 Mar;17(3):225-237. doi: 10.1080/14737159.2017.1282822. Epub 2017 Jan 25. Review.

35.

Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma.

Janakiraman H, House RP, Talwar S, Courtney SM, Hazard ES, Hardiman G, Mehrotra S, Howe PH, Gangaraju V, Palanisamy V.

Oncogene. 2017 Jun 1;36(22):3137-3148. doi: 10.1038/onc.2016.451. Epub 2016 Dec 12.

36.

GPA-MDS: A Visualization Approach to Investigate Genetic Architecture among Phenotypes Using GWAS Results.

Wei W, Ramos PS, Hunt KJ, Wolf BJ, Hardiman G, Chung D.

Int J Genomics. 2016;2016:6589843. Epub 2016 Oct 27.

37.

Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine.

Zollars E, Courtney SM, Wolf BJ, Allaire N, Ranger A, Hardiman G, Petri M.

Int J Genomics. 2016;2016:7862962. doi: 10.1155/2016/7862962. Epub 2016 Aug 30.

38.

Systems analysis of the prostate transcriptome in African-American men compared with European-American men.

Hardiman G, Savage SJ, Hazard ES, Wilson RC, Courtney SM, Smith MT, Hollis BW, Halbert CH, Gattoni-Celli S.

Pharmacogenomics. 2016 Jul;17(10):1129-1143. Epub 2016 Jun 30.

39.

Time- and Oil-Dependent Transcriptomic and Physiological Responses to Deepwater Horizon Oil in Mahi-Mahi (Coryphaena hippurus) Embryos and Larvae.

Xu EG, Mager EM, Grosell M, Pasparakis C, Schlenker LS, Stieglitz JD, Benetti D, Hazard ES, Courtney SM, Diamante G, Freitas J, Hardiman G, Schlenk D.

Environ Sci Technol. 2016 Jul 19;50(14):7842-51. doi: 10.1021/acs.est.6b02205. Epub 2016 Jul 8.

PMID:
27348429
40.

Amplification of WHSC1L1 regulates expression and estrogen-independent activation of ERα in SUM-44 breast cancer cells and is associated with ERα over-expression in breast cancer.

Irish JC, Mills JN, Turner-Ivey B, Wilson RC, Guest ST, Rutkovsky A, Dombkowski A, Kappler CS, Hardiman G, Ethier SP.

Mol Oncol. 2016 Jun;10(6):850-65. doi: 10.1016/j.molonc.2016.02.003. Epub 2016 Feb 27.

41.

Insulin receptor substrate 1 is a substrate of the Pim protein kinases.

Song JH, Padi SK, Luevano LA, Minden MD, DeAngelo DJ, Hardiman G, Ball LE, Warfel NA, Kraft AS.

Oncotarget. 2016 Apr 12;7(15):20152-65. doi: 10.18632/oncotarget.7918.

42.

Acute stress enhances the expression of neuroprotection- and neurogenesis-associated genes in the hippocampus of a mouse restraint model.

Sannino G, Pasqualini L, Ricciardelli E, Montilla P, Soverchia L, Ruggeri B, Falcinelli S, Renzi A, Ludka C, Kirchner T, Grünewald TG, Ciccocioppo R, Ubaldi M, Hardiman G.

Oncotarget. 2016 Feb 23;7(8):8455-65. doi: 10.18632/oncotarget.7225.

43.

Differential Gene Expression in Liver, Gill, and Olfactory Rosettes of Coho Salmon (Oncorhynchus kisutch) After Acclimation to Salinity.

Maryoung LA, Lavado R, Bammler TK, Gallagher EP, Stapleton PL, Beyer RP, Farin FM, Hardiman G, Schlenk D.

Mar Biotechnol (NY). 2015 Dec;17(6):703-17. doi: 10.1007/s10126-015-9649-5. Epub 2015 Aug 11.

44.

Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.

Kwon HY, Bajaj J, Ito T, Blevins A, Konuma T, Weeks J, Lytle NK, Koechlein CS, Rizzieri D, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T.

Cell Stem Cell. 2015 Aug 6;17(2):152-164. doi: 10.1016/j.stem.2015.06.006. Epub 2015 Jul 23.

45.

A post-developmental genetic screen for zebrafish models of inherited liver disease.

Kim SH, Wu SY, Baek JI, Choi SY, Su Y, Flynn CR, Gamse JT, Ess KC, Hardiman G, Lipschutz JH, Abumrad NN, Rockey DC.

PLoS One. 2015 May 7;10(5):e0125980. doi: 10.1371/journal.pone.0125980. eCollection 2015.

46.

Biomarkers of hippocampal gene expression in a mouse restraint chronic stress model.

Ubaldi M, Ricciardelli E, Pasqualini L, Sannino G, Soverchia L, Ruggeri B, Falcinelli S, Renzi A, Ludka C, Ciccocioppo R, Hardiman G.

Pharmacogenomics. 2015;16(5):471-82. doi: 10.2217/pgs.15.3.

PMID:
25916519
47.

A gp130-Src-YAP module links inflammation to epithelial regeneration.

Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M.

Nature. 2015 Mar 5;519(7541):57-62. doi: 10.1038/nature14228. Epub 2015 Feb 25.

48.

The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-κB signaling, and inflammatory gene expression in human aortic valve cells.

Patel V, Carrion K, Hollands A, Hinton A, Gallegos T, Dyo J, Sasik R, Leire E, Hardiman G, Mohamed SA, Nigam S, King CC, Nizet V, Nigam V.

FASEB J. 2015 May;29(5):1859-68. doi: 10.1096/fj.14-257808. Epub 2015 Jan 28.

49.

Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-β signaling.

Banerjee I, Carrion K, Serrano R, Dyo J, Sasik R, Lund S, Willems E, Aceves S, Meili R, Mercola M, Chen J, Zambon A, Hardiman G, Doherty TA, Lange S, del Álamo JC, Nigam V.

J Mol Cell Cardiol. 2015 Feb;79:133-44. doi: 10.1016/j.yjmcc.2014.11.003. Epub 2014 Nov 13.

50.

A developmental hepatotoxicity study of dietary bisphenol A in Sparus aurata juveniles.

Maradonna F, Nozzi V, Dalla Valle L, Traversi I, Gioacchini G, Benato F, Colletti E, Gallo P, Di Marco Pisciottano I, Mita DG, Hardiman G, Mandich A, Carnevali O.

Comp Biochem Physiol C Toxicol Pharmacol. 2014 Nov;166:1-13. doi: 10.1016/j.cbpc.2014.06.004. Epub 2014 Jun 27.

PMID:
24981242

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