Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 327


AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner.

Seabright AP, Fine NHF, Barlow JP, Lord SO, Musa I, Gray A, Bryant JA, Banzhaf M, Lavery GG, Hardie DG, Hodson DJ, Philp A, Lai YC.

FASEB J. 2020 Mar 22. doi: 10.1096/fj.201903051R. [Epub ahead of print]


AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control.

González A, Hall MN, Lin SC, Hardie DG.

Cell Metab. 2020 Mar 3;31(3):472-492. doi: 10.1016/j.cmet.2020.01.015. Review.


Glucose Starvation Blocks Translation at Multiple Levels.

Zhang CS, Hardie DG, Lin SC.

Cell Metab. 2020 Feb 4;31(2):217-218. doi: 10.1016/j.cmet.2020.01.005.


Mechanism of Activation of AMPK by Cordycepin.

Hawley SA, Ross FA, Russell FM, Atrih A, Lamont DJ, Hardie DG.

Cell Chem Biol. 2020 Feb 20;27(2):214-222.e4. doi: 10.1016/j.chembiol.2020.01.004. Epub 2020 Jan 27.


The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde? .

Vara-Ciruelos D, Russell FM, Hardie DG.

Open Biol. 2019 Jul 26;9(7):190099. doi: 10.1098/rsob.190099. Epub 2019 Jul 10.


Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.

Li M, Zhang CS, Zong Y, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC.

Cell Metab. 2019 Sep 3;30(3):508-524.e12. doi: 10.1016/j.cmet.2019.05.018. Epub 2019 Jun 13.


Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation.

Vara-Ciruelos D, Dandapani M, Russell FM, Grzes KM, Atrih A, Foretz M, Viollet B, Lamont DJ, Cantrell DA, Hardie DG.

Cell Rep. 2019 Apr 16;27(3):690-698.e4. doi: 10.1016/j.celrep.2019.03.067.


Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress.

Zong Y, Zhang CS, Li M, Wang W, Wang Z, Hawley SA, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang C, Ye Z, Lin SY, Piao HL, Hardie DG, Lin SC.

Cell Res. 2019 Jun;29(6):460-473. doi: 10.1038/s41422-019-0163-6. Epub 2019 Apr 4.


The LKB1-AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria.

Moral-Sanz J, Lewis SA, MacMillan S, Ross FA, Thomson A, Viollet B, Foretz M, Moran C, Hardie DG, Evans AM.

Sci Signal. 2018 Oct 2;11(550). pii: eaau0296. doi: 10.1126/scisignal.aau0296.


Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity.

Thomas EC, Hook SC, Gray A, Chadt A, Carling D, Al-Hasani H, Heesom KJ, Hardie DG, Tavaré JM.

Biochem J. 2018 Sep 25;475(18):2969-2983. doi: 10.1042/BCJ20180475.


Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK.

Fyffe FA, Hawley SA, Gray A, Hardie DG.

Methods Mol Biol. 2018;1732:69-86. doi: 10.1007/978-1-4939-7598-3_5.


Keeping the home fires burning: AMP-activated protein kinase.

Hardie DG.

J R Soc Interface. 2018 Jan;15(138). pii: 20170774. doi: 10.1098/rsif.2017.0774. Review.


AMPK: Sensing Glucose as well as Cellular Energy Status.

Lin SC, Hardie DG.

Cell Metab. 2018 Feb 6;27(2):299-313. doi: 10.1016/j.cmet.2017.10.009. Epub 2017 Nov 16. Review.


Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival.

Vara-Ciruelos D, Dandapani M, Gray A, Egbani EO, Evans AM, Hardie DG.

Mol Cancer Res. 2018 Feb;16(2):345-357. doi: 10.1158/1541-7786.MCR-17-0323. Epub 2017 Nov 13.


CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.

Lopez-Mejia IC, Lagarrigue S, Giralt A, Martinez-Carreres L, Zanou N, Denechaud PD, Castillo-Armengol J, Chavey C, Orpinell M, Delacuisine B, Nasrallah A, Collodet C, Zhang L, Viollet B, Hardie DG, Fajas L.

Mol Cell. 2017 Oct 19;68(2):336-349.e6. doi: 10.1016/j.molcel.2017.09.034.


AMP-activated protein kinase - not just an energy sensor.

Hardie DG, Lin SC.

F1000Res. 2017 Sep 22;6:1724. doi: 10.12688/f1000research.11960.1. eCollection 2017. Review.


The mechanisms of action of metformin.

Rena G, Hardie DG, Pearson ER.

Diabetologia. 2017 Sep;60(9):1577-1585. doi: 10.1007/s00125-017-4342-z. Epub 2017 Aug 3. Review.


Targeting an energy sensor to treat diabetes.

Hardie DG.

Science. 2017 Aug 4;357(6350):455-456. doi: 10.1126/science.aao1913. No abstract available.


Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.

Zhang CS, Hawley SA, Zong Y, Li M, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, Piao HL, Hardie DG, Lin SC.

Nature. 2017 Aug 3;548(7665):112-116. doi: 10.1038/nature23275. Epub 2017 Jul 19.


Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib.

Ross FA, Hawley SA, Auciello FR, Gowans GJ, Atrih A, Lamont DJ, Hardie DG.

Cell Chem Biol. 2017 Jul 20;24(7):813-824.e4. doi: 10.1016/j.chembiol.2017.05.021. Epub 2017 Jun 15.


A novel, de novo mutation in the PRKAG2 gene: infantile-onset phenotype and the signaling pathway involved.

Xu Y, Gray A, Hardie DG, Uzun A, Shaw S, Padbury J, Phornphutkul C, Tseng YT.

Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H283-H292. doi: 10.1152/ajpheart.00813.2016. Epub 2017 May 26.


AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.

Salt IP, Hardie DG.

Circ Res. 2017 May 26;120(11):1825-1841. doi: 10.1161/CIRCRESAHA.117.309633. Review.


An Oncogenic Role for the Ubiquitin Ligase UBE2O by Targeting AMPK-α2 for Degradation.

Hardie DG.

Cancer Cell. 2017 Feb 13;31(2):163-165. doi: 10.1016/j.ccell.2017.01.010.


The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.

Hawley SA, Ford RJ, Smith BK, Gowans GJ, Mancini SJ, Pitt RD, Day EA, Salt IP, Steinberg GR, Hardie DG.

Diabetes. 2016 Sep;65(9):2784-94. doi: 10.2337/db16-0058. Epub 2016 Jul 5.


AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2.

Fogarty S, Ross FA, Vara Ciruelos D, Gray A, Gowans GJ, Hardie DG.

Mol Cancer Res. 2016 Aug;14(8):683-95. doi: 10.1158/1541-7786.MCR-15-0479. Epub 2016 May 2.


AMP-activated protein kinase inhibits Kv 1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation.

Moral-Sanz J, Mahmoud AD, Ross FA, Eldstrom J, Fedida D, Hardie DG, Evans AM.

J Physiol. 2016 Sep 1;594(17):4901-15. doi: 10.1113/JP272032. Epub 2016 Jun 30.


AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours.

Ross FA, MacKintosh C, Hardie DG.

FEBS J. 2016 Aug;283(16):2987-3001. doi: 10.1111/febs.13698. Epub 2016 Mar 24. Review.


AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs.

Hardie DG, Schaffer BE, Brunet A.

Trends Cell Biol. 2016 Mar;26(3):190-201. doi: 10.1016/j.tcb.2015.10.013. Epub 2015 Nov 23. Review.


Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms.

Ross FA, Jensen TE, Hardie DG.

Biochem J. 2016 Jan 15;473(2):189-99. doi: 10.1042/BJ20150910. Epub 2015 Nov 5.


Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade.

Yung MM, Ross FA, Hardie DG, Leung TH, Zhan J, Ngan HY, Chan DW.

Integr Cancer Ther. 2016 Sep;15(3):376-89. doi: 10.1177/1534735415611747. Epub 2015 Oct 19.


Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?

Hardie DG.

Clin Cancer Res. 2015 Sep 1;21(17):3836-40. doi: 10.1158/1078-0432.CCR-14-3300. Epub 2015 Jul 7. Review.


AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle.

Schneider H, Schubert KM, Blodow S, Kreutz CP, Erdogmus S, Wiedenmann M, Qiu J, Fey T, Ruth P, Lubomirov LT, Pfitzer G, Mederos Y Schnitzler M, Hardie DG, Gudermann T, Pohl U.

Hypertension. 2015 Jul;66(1):108-16. doi: 10.1161/HYPERTENSIONAHA.115.05514. Epub 2015 Jun 1.


PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain.

Jensen TE, Ross FA, Kleinert M, Sylow L, Knudsen JR, Gowans GJ, Hardie DG, Richter EA.

Biochem J. 2015 May 1;467(3):461-72. doi: 10.1042/BJ20141142.


AMPK--sensing energy while talking to other signaling pathways.

Hardie DG.

Cell Metab. 2014 Dec 2;20(6):939-52. doi: 10.1016/j.cmet.2014.09.013. Epub 2014 Oct 30. Review.


Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α.

Rog-Zielinska EA, Craig MA, Manning JR, Richardson RV, Gowans GJ, Dunbar DR, Gharbi K, Kenyon CJ, Holmes MC, Hardie DG, Smith GL, Chapman KE.

Cell Death Differ. 2015 Jul;22(7):1106-16. doi: 10.1038/cdd.2014.181. Epub 2014 Oct 31.


Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation.

Pirkmajer S, Kulkarni SS, Tom RZ, Ross FA, Hawley SA, Hardie DG, Zierath JR, Chibalin AV.

Diabetes. 2015 Feb;64(2):360-9. doi: 10.2337/db14-0508. Epub 2014 Oct 22.


AMPK: positive and negative regulation, and its role in whole-body energy homeostasis.

Hardie DG.

Curr Opin Cell Biol. 2015 Apr;33:1-7. doi: 10.1016/ Epub 2014 Sep 26. Review.


Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP.

Auciello FR, Ross FA, Ikematsu N, Hardie DG.

FEBS Lett. 2014 Sep 17;588(18):3361-6. doi: 10.1016/j.febslet.2014.07.025. Epub 2014 Jul 30.


Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK.

Hunter RW, Foretz M, Bultot L, Fullerton MD, Deak M, Ross FA, Hawley SA, Shpiro N, Viollet B, Barron D, Kemp BE, Steinberg GR, Hardie DG, Sakamoto K.

Chem Biol. 2014 Jul 17;21(7):866-79. doi: 10.1016/j.chembiol.2014.05.014.


A new protein kinase cascade.

Hardie DG.

Nat Rev Mol Cell Biol. 2014 Apr;15(4):223. doi: 10.1038/nrm3771. Epub 2014 Mar 12. No abstract available.


AMPK: regulating energy balance at the cellular and whole body levels.

Hardie DG, Ashford ML.

Physiology (Bethesda). 2014 Mar;29(2):99-107. doi: 10.1152/physiol.00050.2013. Review.


Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells.

Hawley SA, Ross FA, Gowans GJ, Tibarewal P, Leslie NR, Hardie DG.

Biochem J. 2014 Apr 15;459(2):275-87. doi: 10.1042/BJ20131344.


AMPK: a cellular energy sensor primarily regulated by AMP.

Gowans GJ, Hardie DG.

Biochem Soc Trans. 2014 Feb;42(1):71-5. doi: 10.1042/BST20130244.


Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle.

Hadad SM, Hardie DG, Appleyard V, Thompson AM.

Clin Transl Oncol. 2014 Aug;16(8):746-52. doi: 10.1007/s12094-013-1144-8. Epub 2013 Dec 12.


Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, Chen ZP, O'Neill HM, Ford RJ, Palanivel R, O'Brien M, Hardie DG, Macaulay SL, Schertzer JD, Dyck JR, van Denderen BJ, Kemp BE, Steinberg GR.

Nat Med. 2013 Dec;19(12):1649-54. doi: 10.1038/nm.3372. Epub 2013 Nov 3.


Glycogen content regulates peroxisome proliferator activated receptor-∂ (PPAR-∂) activity in rat skeletal muscle.

Philp A, MacKenzie MG, Belew MY, Towler MC, Corstorphine A, Papalamprou A, Hardie DG, Baar K.

PLoS One. 2013 Oct 17;8(10):e77200. doi: 10.1371/journal.pone.0077200. eCollection 2013.


AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation.

Gowans GJ, Hawley SA, Ross FA, Hardie DG.

Cell Metab. 2013 Oct 1;18(4):556-66. doi: 10.1016/j.cmet.2013.08.019.


AMPK: mediating the metabolic effects of salicylate-based drugs?

Steinberg GR, Dandapani M, Hardie DG.

Trends Endocrinol Metab. 2013 Oct;24(10):481-7. doi: 10.1016/j.tem.2013.06.002. Epub 2013 Jul 19.


AMPK: a target for drugs and natural products with effects on both diabetes and cancer.

Hardie DG.

Diabetes. 2013 Jul;62(7):2164-72. doi: 10.2337/db13-0368. Review.


LKB1 and AMPK and the cancer-metabolism link - ten years after.

Hardie DG, Alessi DR.

BMC Biol. 2013 Apr 15;11:36. doi: 10.1186/1741-7007-11-36. Review.

Supplemental Content

Loading ...
Support Center