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The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde? .

Vara-Ciruelos D, Russell FM, Hardie DG.

Open Biol. 2019 Jul 26;9(7):190099. doi: 10.1098/rsob.190099. Epub 2019 Jul 10.


Reliability of plasma HIV viral load testing beyond 24 hours: Insights gained from a study in a routine diagnostic laboratory.

Hardie D, Korsman S, Ameer S, Vojnov L, Hsiao NY.

PLoS One. 2019 Jul 3;14(7):e0219381. doi: 10.1371/journal.pone.0219381. eCollection 2019.


Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.

Li M, Zhang CS, Zong Y, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC.

Cell Metab. 2019 Jun 10. pii: S1550-4131(19)30258-X. doi: 10.1016/j.cmet.2019.05.018. [Epub ahead of print]


Hepatitis A seroprevalence in Western Cape Province, South Africa: Are we in epidemiological transition?

Enoch A, Hardie DR, Hussey GD, Kagina BM.

S Afr Med J. 2019 Apr 29;109(5):314-318. doi: 10.7196/SAMJ.2019.v109i5.13410.


Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation.

Vara-Ciruelos D, Dandapani M, Russell FM, Grzes KM, Atrih A, Foretz M, Viollet B, Lamont DJ, Cantrell DA, Hardie DG.

Cell Rep. 2019 Apr 16;27(3):690-698.e4. doi: 10.1016/j.celrep.2019.03.067.


Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress.

Zong Y, Zhang CS, Li M, Wang W, Wang Z, Hawley SA, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang C, Ye Z, Lin SY, Piao HL, Hardie DG, Lin SC.

Cell Res. 2019 Jun;29(6):460-473. doi: 10.1038/s41422-019-0163-6. Epub 2019 Apr 4.


Measles Virus Bearing Measles Inclusion Body Encephalitis-Derived Fusion Protein Is Pathogenic after Infection via the Respiratory Route.

Mathieu C, Ferren M, Jurgens E, Dumont C, Rybkina K, Harder O, Stelitano D, Madeddu S, Sanna G, Schwartz D, Biswas S, Hardie D, Hashiguchi T, Moscona A, Horvat B, Niewiesk S, Porotto M.

J Virol. 2019 Apr 3;93(8). pii: e01862-18. doi: 10.1128/JVI.01862-18. Print 2019 Apr 15.


Subacute sclerosing panencephalitis: clinical phenotype, epidemiology, and preventive interventions.

Mekki M, Eley B, Hardie D, Wilmshurst JM.

Dev Med Child Neurol. 2019 Jan 25. doi: 10.1111/dmcn.14166. [Epub ahead of print] Review.


Molecular characterization of an outbreak of enterovirus-associated meningitis in Mossel Bay, South Africa, December 2015-January 2016.

Smuts H, Cronje S, Thomas J, Brink D, Korsman S, Hardie D.

BMC Infect Dis. 2018 Dec 29;18(1):709. doi: 10.1186/s12879-018-3641-4.


Analysis of a Subacute Sclerosing Panencephalitis Genotype B3 Virus from the 2009-2010 South African Measles Epidemic Shows That Hyperfusogenic F Proteins Contribute to Measles Virus Infection in the Brain.

Angius F, Smuts H, Rybkina K, Stelitano D, Eley B, Wilmshurst J, Ferren M, Lalande A, Mathieu C, Moscona A, Horvat B, Hashiguchi T, Porotto M, Hardie D.

J Virol. 2019 Feb 5;93(4). pii: e01700-18. doi: 10.1128/JVI.01700-18. Print 2019 Feb 15.


The LKB1-AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria.

Moral-Sanz J, Lewis SA, MacMillan S, Ross FA, Thomson A, Viollet B, Foretz M, Moran C, Hardie DG, Evans AM.

Sci Signal. 2018 Oct 2;11(550). pii: eaau0296. doi: 10.1126/scisignal.aau0296.


Molecular phenotyping of laboratory mouse strains using 500 multiple reaction monitoring mass spectrometry plasma assays.

Michaud SA, Sinclair NJ, Pětrošová H, Palmer AL, Pistawka AJ, Zhang S, Hardie DB, Mohammed Y, Eshghi A, Richard VR, Sickmann A, Borchers CH.

Commun Biol. 2018 Jun 27;1:78. doi: 10.1038/s42003-018-0087-6. eCollection 2018.


Congenital rubella syndrome surveillance in South Africa using a sentinel site approach: a cross-sectional study.

Motaze NV, Manamela J, Smit S, Rabie H, Harper K, duPlessis N, Reubenson G, Coetzee M, Ballot D, Moore D, Nuttall J, Linley L, Tooke L, Kriel J, Hallbauer U, Sutton C, Moodley P, Hardie D, Mazanderani AH, Goosen F, Kyaw T, Leroux D, Hussain A, Singh R, Kelly C, Ducasse G, Muller M, Blaauw M, Hamese M, Leeuw T, Mekgoe O, Rakgole P, Dungwa N, Maphosa T, Sanyane K, Preiser W, Cohen C, Suchard M.

Clin Infect Dis. 2018 Sep 8. doi: 10.1093/cid/ciy758. [Epub ahead of print]


Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity.

Thomas EC, Hook SC, Gray A, Chadt A, Carling D, Al-Hasani H, Heesom KJ, Hardie DG, Tavaré JM.

Biochem J. 2018 Sep 25;475(18):2969-2983. doi: 10.1042/BCJ20180475.


Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis.

Huang HY, Rivas-Caicedo A, Renevey F, Cannelle H, Peranzoni E, Scarpellino L, Hardie DL, Pommier A, Schaeuble K, Favre S, Vogt TK, Arenzana-Seisdedos F, Schneider P, Buckley CD, Donnadieu E, Luther SA.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6826-E6835. doi: 10.1073/pnas.1712628115. Epub 2018 Jul 2.


Fulminant hepatitis B virus (HBV) infection in an infant following mother-to-child transmission of an e-minus HBV mutant: Time to relook at HBV prophylaxis in South African infants.

Ogunbusi O, Smuts H, Eley B, Korsman S, De Lacy R, Hardie DR.

S Afr Med J. 2018 Apr 25;108(5):389-392. doi: 10.7196/SAMJ.2018.v108i5.13017.


Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK.

Fyffe FA, Hawley SA, Gray A, Hardie DG.

Methods Mol Biol. 2018;1732:69-86. doi: 10.1007/978-1-4939-7598-3_5.


Keeping the home fires burning: AMP-activated protein kinase.

Hardie DG.

J R Soc Interface. 2018 Jan;15(138). pii: 20170774. doi: 10.1098/rsif.2017.0774. Review.


Proteomic Profiling of Leishmania donovani Promastigote Subcellular Organelles.

Jardim A, Hardie DB, Boitz J, Borchers CH.

J Proteome Res. 2018 Mar 2;17(3):1194-1215. doi: 10.1021/acs.jproteome.7b00817. Epub 2018 Feb 5.


Extreme call amplitude from near-field acoustic wave coupling in the stridulating water insect Micronecta scholtzi (Micronectinae).

Reid A, Hardie DJW, Mackie D, Jackson JC, Windmill JFC.

J R Soc Interface. 2018 Jan;15(138). pii: 20170768. doi: 10.1098/rsif.2017.0768.


AMPK: Sensing Glucose as well as Cellular Energy Status.

Lin SC, Hardie DG.

Cell Metab. 2018 Feb 6;27(2):299-313. doi: 10.1016/j.cmet.2017.10.009. Epub 2017 Nov 16. Review.


Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival.

Vara-Ciruelos D, Dandapani M, Gray A, Egbani EO, Evans AM, Hardie DG.

Mol Cancer Res. 2018 Feb;16(2):345-357. doi: 10.1158/1541-7786.MCR-17-0323. Epub 2017 Nov 13.


CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.

Lopez-Mejia IC, Lagarrigue S, Giralt A, Martinez-Carreres L, Zanou N, Denechaud PD, Castillo-Armengol J, Chavey C, Orpinell M, Delacuisine B, Nasrallah A, Collodet C, Zhang L, Viollet B, Hardie DG, Fajas L.

Mol Cell. 2017 Oct 19;68(2):336-349.e6. doi: 10.1016/j.molcel.2017.09.034.


AMP-activated protein kinase - not just an energy sensor.

Hardie DG, Lin SC.

F1000Res. 2017 Sep 22;6:1724. doi: 10.12688/f1000research.11960.1. eCollection 2017. Review.


Perceptions and development needs of assistant practitioners supporting individuals with dementia.

Hardie D, Smith J.

Br J Nurs. 2017 Sep 7;26(16):918-923. doi: 10.12968/bjon.2017.26.16.918.


Stromal cell markers are differentially expressed in the synovial tissue of patients with early arthritis.

Choi IY, Karpus ON, Turner JD, Hardie D, Marshall JL, de Hair MJH, Maijer KI, Tak PP, Raza K, Hamann J, Buckley CD, Gerlag DM, Filer A.

PLoS One. 2017 Aug 9;12(8):e0182751. doi: 10.1371/journal.pone.0182751. eCollection 2017.


The mechanisms of action of metformin.

Rena G, Hardie DG, Pearson ER.

Diabetologia. 2017 Sep;60(9):1577-1585. doi: 10.1007/s00125-017-4342-z. Epub 2017 Aug 3. Review.


Targeting an energy sensor to treat diabetes.

Hardie DG.

Science. 2017 Aug 4;357(6350):455-456. doi: 10.1126/science.aao1913. No abstract available.


Contamination with HIV antibody may be responsible for false positive results in specimens tested on automated platforms running HIV 4th generation assays in a region of high HIV prevalence.

Hardie DR, Korsman SN, Hsiao NY, Morobadi MD, Vawda S, Goedhals D.

PLoS One. 2017 Jul 31;12(7):e0182167. doi: 10.1371/journal.pone.0182167. eCollection 2017.


Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.

Zhang CS, Hawley SA, Zong Y, Li M, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, Piao HL, Hardie DG, Lin SC.

Nature. 2017 Aug 3;548(7665):112-116. doi: 10.1038/nature23275. Epub 2017 Jul 19.


Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib.

Ross FA, Hawley SA, Auciello FR, Gowans GJ, Atrih A, Lamont DJ, Hardie DG.

Cell Chem Biol. 2017 Jul 20;24(7):813-824.e4. doi: 10.1016/j.chembiol.2017.05.021. Epub 2017 Jun 15.


A novel, de novo mutation in the PRKAG2 gene: infantile-onset phenotype and the signaling pathway involved.

Xu Y, Gray A, Hardie DG, Uzun A, Shaw S, Padbury J, Phornphutkul C, Tseng YT.

Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H283-H292. doi: 10.1152/ajpheart.00813.2016. Epub 2017 May 26.


AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.

Salt IP, Hardie DG.

Circ Res. 2017 May 26;120(11):1825-1841. doi: 10.1161/CIRCRESAHA.117.309633. Review.


Multiplexed MRM-Based Protein Quantitation Using Two Different Stable Isotope-Labeled Peptide Isotopologues for Calibration.

LeBlanc A, Michaud SA, Percy AJ, Hardie DB, Yang J, Sinclair NJ, Proudfoot JI, Pistawka A, Smith DS, Borchers CH.

J Proteome Res. 2017 Jul 7;16(7):2527-2536. doi: 10.1021/acs.jproteome.7b00094. Epub 2017 Jun 2.


Human pegivirus-1 in the CSF of patients with HIV-associated neurocognitive disorder (HAND) may be derived from blood in highly viraemic patients.

Hardie D, Smuts H.

J Clin Virol. 2017 Jun;91:58-61. doi: 10.1016/j.jcv.2017.04.007. Epub 2017 Apr 6.


Zero-tolerance biosecurity protects high-conservation-value island nature reserve.

Scott JK, McKirdy SJ, van der Merwe J, Green R, Burbidge AA, Pickles G, Hardie DC, Morris K, Kendrick PG, Thomas ML, Horton KL, O'Connor SM, Downs J, Stoklosa R, Lagdon R, Marks B, Nairn M, Mengersen K.

Sci Rep. 2017 Apr 10;7(1):772. doi: 10.1038/s41598-017-00450-y.


Diagnostic accuracy of two multiplex real-time polymerase chain reaction assays for the diagnosis of meningitis in children in a resource-limited setting.

Khumalo J, Nicol M, Hardie D, Muloiwa R, Mteshana P, Bamford C.

PLoS One. 2017 Mar 27;12(3):e0173948. doi: 10.1371/journal.pone.0173948. eCollection 2017.


An Oncogenic Role for the Ubiquitin Ligase UBE2O by Targeting AMPK-α2 for Degradation.

Hardie DG.

Cancer Cell. 2017 Feb 13;31(2):163-165. doi: 10.1016/j.ccell.2017.01.010.


Metabolomic profiling of prostate cancer by matrix assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry imaging using Matrix Coating Assisted by an Electric Field (MCAEF).

Wang X, Han J, Hardie DB, Yang J, Pan J, Borchers CH.

Biochim Biophys Acta Proteins Proteom. 2017 Jul;1865(7):755-767. doi: 10.1016/j.bbapap.2016.12.012. Epub 2016 Dec 23.


Characterization and Diagnostic Application of Trypanosoma cruzi Trypomastigote Excreted-Secreted Antigens Shed in Extracellular Vesicles Released from Infected Mammalian Cells.

Bautista-López NL, Ndao M, Camargo FV, Nara T, Annoura T, Hardie DB, Borchers CH, Jardim A.

J Clin Microbiol. 2017 Mar;55(3):744-758. doi: 10.1128/JCM.01649-16. Epub 2016 Dec 14.


Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage.

Croft AP, Naylor AJ, Marshall JL, Hardie DL, Zimmermann B, Turner J, Desanti G, Adams H, Yemm AI, Müller-Ladner U, Dayer JM, Neumann E, Filer A, Buckley CD.

Arthritis Res Ther. 2016 Nov 18;18(1):270.


Multiplexed panel of precisely quantified salivary proteins for biomarker assessment.

Percy AJ, Hardie DB, Jardim A, Yang J, Elliott MH, Zhang S, Mohammed Y, Borchers CH.

Proteomics. 2017 Mar;17(6). doi: 10.1002/pmic.201600230. Epub 2016 Oct 19.


Multiplexed MRM-based assays for the quantitation of proteins in mouse plasma and heart tissue.

Percy AJ, Michaud SA, Jardim A, Sinclair NJ, Zhang S, Mohammed Y, Palmer AL, Hardie DB, Yang J, LeBlanc AM, Borchers CH.

Proteomics. 2017 Apr;17(7). doi: 10.1002/pmic.201600097. Epub 2016 Nov 18.


The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.

Hawley SA, Ford RJ, Smith BK, Gowans GJ, Mancini SJ, Pitt RD, Day EA, Salt IP, Steinberg GR, Hardie DG.

Diabetes. 2016 Sep;65(9):2784-94. doi: 10.2337/db16-0058. Epub 2016 Jul 5.


AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2.

Fogarty S, Ross FA, Vara Ciruelos D, Gray A, Gowans GJ, Hardie DG.

Mol Cancer Res. 2016 Aug;14(8):683-95. doi: 10.1158/1541-7786.MCR-15-0479. Epub 2016 May 2.


AMP-activated protein kinase inhibits Kv 1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation.

Moral-Sanz J, Mahmoud AD, Ross FA, Eldstrom J, Fedida D, Hardie DG, Evans AM.

J Physiol. 2016 Sep 1;594(17):4901-15. doi: 10.1113/JP272032. Epub 2016 Jun 30.


Insights from the pollination drop proteome and the ovule transcriptome of Cephalotaxus at the time of pollination drop production.

Pirone-Davies C, Prior N, von Aderkas P, Smith D, Hardie D, Friedman WE, Mathews S.

Ann Bot. 2016 May;117(6):973-84. doi: 10.1093/aob/mcw026. Epub 2016 Apr 4.


AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours.

Ross FA, MacKintosh C, Hardie DG.

FEBS J. 2016 Aug;283(16):2987-3001. doi: 10.1111/febs.13698. Epub 2016 Mar 24. Review.


The use of matrix coating assisted by an electric field (MCAEF) to enhance mass spectrometric imaging of human prostate cancer biomarkers.

Wang X, Han J, Hardie DB, Yang J, Borchers CH.

J Mass Spectrom. 2016 Jan;51(1):86-95. doi: 10.1002/jms.3728.


AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs.

Hardie DG, Schaffer BE, Brunet A.

Trends Cell Biol. 2016 Mar;26(3):190-201. doi: 10.1016/j.tcb.2015.10.013. Epub 2015 Nov 23. Review.

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