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Can Ciprofloxacin be Used for Precision Treatment of Gonorrhea in Public STD Clinics? Assessment of Ciprofloxacin Susceptibility and an Opportunity for Point-of-Care Testing.

Melendez JH, Hsieh YH, Barnes M, Hardick J, Gilliams EA, Gaydos CA.

Pathogens. 2019 Oct 14;8(4). pii: E189. doi: 10.3390/pathogens8040189.


Self-collected versus clinician-collected samples for HSV-2 and HSV-2/HPV screening in HIV-infected and -uninfected women in the Tapajós region, Amazon, Brazil.

Rodrigues LL, Pilotto JH, Lima LR, Gaydos CA, Hardick J, Morgado MG, Martinelli KG, de Paula VS, Nicol AF.

Int J STD AIDS. 2019 Oct;30(11):1055-1062. doi: 10.1177/0956462419842007. Epub 2019 Aug 27. No abstract available.


Structure Defines Function: Clinically Relevant Mutations in ErbB Kinases.

Niggenaber J, Hardick J, Lategahn J, Rauh D.

J Med Chem. 2019 Aug 28. doi: 10.1021/acs.jmedchem.9b00964. [Epub ahead of print]


Sexually transmitted infections among HIV-infected and HIV-uninfected women in the Tapajós region, Amazon, Brazil: Self-collected vs. clinician-collected samples.

Rodrigues LLS, Hardick J, Nicol AF, Morgado MG, Martinelli KG, de Paula VS, Pilotto JH, Gaydos CA.

PLoS One. 2019 Apr 23;14(4):e0215001. doi: 10.1371/journal.pone.0215001. eCollection 2019.


Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.

Uhlenbrock N, Smith S, Weisner J, Landel I, Lindemann M, Le TA, Hardick J, Gontla R, Scheinpflug R, Czodrowski P, Janning P, Depta L, Quambusch L, Müller MP, Engels B, Rauh D.

Chem Sci. 2019 Feb 13;10(12):3573-3585. doi: 10.1039/c8sc05212c. eCollection 2019 Mar 28.


Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer.

Weisner J, Landel I, Reintjes C, Uhlenbrock N, Trajkovic-Arsic M, Dienstbier N, Hardick J, Ladigan S, Lindemann M, Smith S, Quambusch L, Scheinpflug R, Depta L, Gontla R, Unger A, Müller H, Baumann M, Schultz-Fademrecht C, Günther G, Maghnouj A, Müller MP, Pohl M, Teschendorf C, Wolters H, Viebahn R, Tannapfel A, Uhl W, Hengstler JG, Hahn SA, Siveke JT, Rauh D.

Cancer Res. 2019 May 1;79(9):2367-2378. doi: 10.1158/0008-5472.CAN-18-2861. Epub 2019 Mar 11.


Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors.

Wolle P, Hardick J, Cronin SJF, Engel J, Baumann M, Lategahn J, Penninger JM, Rauh D.

J Med Chem. 2019 Mar 14;62(5):2843-2848. doi: 10.1021/acs.jmedchem.9b00102. Epub 2019 Feb 21.


Antimicrobial Susceptibility of Neisseria gonorrhoeae Isolates in Baltimore, Maryland, 2016: The Importance of Sentinel Surveillance in the Era of Multi-Drug-Resistant Gonorrhea.

Melendez JH, Hardick J, Barnes M, Page KR, Gaydos CA.

Antibiotics (Basel). 2018 Aug 17;7(3). pii: E77. doi: 10.3390/antibiotics7030077.


Molecular screening for Neisseria gonorrhoeae antimicrobial resistance markers in Nigerian men who have sex with men and transgender women.

Hardick J, Crowell TA, Lombardi K, Akintunde A, Odeyemi S, Ivo A, Eluwa G, Njab J, Baral SD, Nowak RG, Quinn TC, Barbian K, Anzick S, Adebajo S, Charurat ME, Ake J, Gaydos CA.

Int J STD AIDS. 2018 Nov;29(13):1273-1281. doi: 10.1177/0956462418780050. Epub 2018 Jul 4.


A paperfluidic platform to detect Neisseria gonorrhoeae in clinical samples.

Horst AL, Rosenbohm JM, Kolluri N, Hardick J, Gaydos CA, Cabodi M, Klapperich CM, Linnes JC.

Biomed Microdevices. 2018 Apr 11;20(2):35. doi: 10.1007/s10544-018-0280-x.


Clinical and sexual risk correlates of Mycoplasma genitalium in urban pregnant and non-pregnant young women: cross-sectional outcomes using the baseline data from the Women's BioHealth Study.

Trent M, Coleman JS, Hardick J, Perin J, Tabacco L, Huettner S, Ronda J, Felter-Wernsdorfer R, Gaydos CA.

Sex Transm Infect. 2018 Sep;94(6):411-413. doi: 10.1136/sextrans-2017-053367. Epub 2018 Mar 29.


Initial performance evaluation of a spotted array Mobile Analysis Platform (MAP) for the detection of influenza A/B, RSV, and MERS coronavirus.

Hardick J, Metzgar D, Risen L, Myers C, Balansay M, Malcom T, Rothman R, Gaydos C.

Diagn Microbiol Infect Dis. 2018 Jul;91(3):245-247. doi: 10.1016/j.diagmicrobio.2018.02.011. Epub 2018 Feb 17.


Molecular Characterization of Markers Associated With Antimicrobial Resistance in Neisseria gonorrhoeae Identified From Residual Clinical Samples.

Melendez JH, Hardick J, Barnes M, Barnes P, Geddes CD, Gaydos CA.

Sex Transm Dis. 2018 May;45(5):312-315. doi: 10.1097/OLQ.0000000000000755.


Asymptomatic lymphogranuloma venereum among Nigerian men who have sex with men.

Crowell TA, Hardick J, Lombardi K, Parker Z, Kokogho A, Amusu S, Odeyemi S, Ivo A, Baral SD, Nowak RG, Adebajo S, Charurat ME, Ake J, Gaydos CA; TRUST/RV368 Study Group.

Sex Transm Infect. 2018 Dec;94(8):578-581. doi: 10.1136/sextrans-2017-053414. Epub 2018 Jan 29.


Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KIT.

Kaitsiotou H, Keul M, Hardick J, Mühlenberg T, Ketzer J, Ehrt C, Krüll J, Medda F, Koch O, Giordanetto F, Bauer S, Rauh D.

J Med Chem. 2017 Nov 9;60(21):8801-8815. doi: 10.1021/acs.jmedchem.7b00841. Epub 2017 Oct 24.


Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK.

Bührmann M, Wiedemann BM, Müller MP, Hardick J, Ecke M, Rauh D.

PLoS One. 2017 Sep 11;12(9):e0184627. doi: 10.1371/journal.pone.0184627. eCollection 2017.


Covalent Lipid Pocket Ligands Targeting p38α MAPK Mutants.

Bührmann M, Hardick J, Weisner J, Quambusch L, Rauh D.

Angew Chem Int Ed Engl. 2017 Oct 16;56(43):13232-13236. doi: 10.1002/anie.201706345. Epub 2017 Sep 22.


Mobile nucleic acid amplification testing (mobiNAAT) for Chlamydia trachomatis screening in hospital emergency department settings.

Shin DJ, Athamanolap P, Chen L, Hardick J, Lewis M, Hsieh YH, Rothman RE, Gaydos CA, Wang TH.

Sci Rep. 2017 Jul 3;7(1):4495. doi: 10.1038/s41598-017-04781-8.


Lung ultrasound as a diagnostic tool for radiographically-confirmed pneumonia in low resource settings.

Ellington LE, Gilman RH, Chavez MA, Pervaiz F, Marin-Concha J, Compen-Chang P, Riedel S, Rodriguez SJ, Gaydos C, Hardick J, Tielsch JM, Steinhoff M, Benson J, May EA, Figueroa-Quintanilla D, Checkley W; Lung Ultrasound for Pneumonia Assessment (LUPA) Study Investigators.

Respir Med. 2017 Jul;128:57-64. doi: 10.1016/j.rmed.2017.05.007. Epub 2017 May 15.


Microbial Typing by Machine Learned DNA Melt Signatures.

Andini N, Wang B, Athamanolap P, Hardick J, Masek BJ, Thair S, Hu A, Avornu G, Peterson S, Cogill S, Rothman RE, Carroll KC, Gaydos CA, Wang JT, Batzoglou S, Yang S.

Sci Rep. 2017 Feb 6;7:42097. doi: 10.1038/srep42097.


Performance of self-collected penile-meatal swabs compared to clinician-collected urethral swabs for the detection of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium by nucleic acid amplification assays.

Dize L, Barnes P Jr, Barnes M, Hsieh YH, Marsiglia V, Duncan D, Hardick J, Gaydos CA.

Diagn Microbiol Infect Dis. 2016 Oct;86(2):131-5. doi: 10.1016/j.diagmicrobio.2016.07.018. Epub 2016 Jul 25.


Low-Cost 3D Printers Enable High-Quality and Automated Sample Preparation and Molecular Detection.

Chan K, Coen M, Hardick J, Gaydos CA, Wong KY, Smith C, Wilson SA, Vayugundla SP, Wong S.

PLoS One. 2016 Jun 30;11(6):e0158502. doi: 10.1371/journal.pone.0158502. eCollection 2016.


Microwave-accelerated method for ultra-rapid extraction of Neisseria gonorrhoeae DNA for downstream detection.

Melendez JH, Santaus TM, Brinsley G, Kiang D, Mali B, Hardick J, Gaydos CA, Geddes CD.

Anal Biochem. 2016 Oct 1;510:33-40. doi: 10.1016/j.ab.2016.06.017. Epub 2016 Jun 17.


A Rapid and Low-Cost PCR Thermal Cycler for Infectious Disease Diagnostics.

Chan K, Wong PY, Yu P, Hardick J, Wong KY, Wilson SA, Wu T, Hui Z, Gaydos C, Wong SS.

PLoS One. 2016 Feb 12;11(2):e0149150. doi: 10.1371/journal.pone.0149150. eCollection 2016.


Sequencing ebola and marburg viruses genomes using microarrays.

Hardick J, Woelfel R, Gardner W, Ibrahim S.

J Med Virol. 2016 Aug;88(8):1303-8. doi: 10.1002/jmv.24487. Epub 2016 Feb 8.


Nested Machine Learning Facilitates Increased Sequence Content for Large-Scale Automated High Resolution Melt Genotyping.

Fraley SI, Athamanolap P, Masek BJ, Hardick J, Carroll KC, Hsieh YH, Rothman RE, Gaydos CA, Wang TH, Yang S.

Sci Rep. 2016 Jan 18;6:19218. doi: 10.1038/srep19218.


Universal digital high-resolution melt: a novel approach to broad-based profiling of heterogeneous biological samples.

Fraley SI, Hardick J, Masek BJ, Athamanolap P, Rothman RE, Gaydos CA, Carroll KC, Wakefield T, Wang TH, Yang S.

Nucleic Acids Res. 2016 Jan 8;44(1):508. doi: 10.1093/nar/gkv1083. Epub 2015 Oct 17. No abstract available.


Prospective comparison of RT-PCR/ESI-MS to Prodesse ProFlu Plus and Cepheid GenXpert for the detection of Influenza A and B viruses.

Hardick J, Dugas A, Goheen J, Rothman R, Gaydos C.

J Virol Methods. 2015 Mar;214:43-5. doi: 10.1016/j.jviromet.2015.01.002. Epub 2015 Feb 11.


Evaluation of the Xpert Flu rapid PCR assay in high-risk emergency department patients.

Dugas AF, Valsamakis A, Gaydos CA, Forman M, Hardick J, Kidambi P, Amin S, Gupta A, Rothman RE.

J Clin Microbiol. 2014 Dec;52(12):4353-5. doi: 10.1128/JCM.02343-14. Epub 2014 Sep 24.


A rabbit model of non-typhoidal Salmonella bacteremia.

Panda A, Tatarov I, Masek BJ, Hardick J, Crusan A, Wakefield T, Carroll K, Yang S, Hsieh YH, Lipsky MM, McLeod CG, Levine MM, Rothman RE, Gaydos CA, DeTolla LJ.

Comp Immunol Microbiol Infect Dis. 2014 Sep;37(4):211-20. doi: 10.1016/j.cimid.2014.05.004. Epub 2014 Jul 3.


A case-control study evaluating RT-PCR/ESI-MS technology compared to direct fluorescent antibody and xTAG RVP PCR.

Hardick J, Sadiq S, Perelstein E, Peterson S, Rothman R, Gaydos CA.

Diagn Microbiol Infect Dis. 2014 Jun;79(2):187-9. doi: 10.1016/j.diagmicrobio.2014.02.009. Epub 2014 Feb 24.


Point of care diagnostics for sexually transmitted infections: perspectives and advances.

Gaydos C, Hardick J.

Expert Rev Anti Infect Ther. 2014 Jun;12(6):657-72. doi: 10.1586/14787210.2014.880651. Epub 2014 Feb 3. Review.


Is there evidence for resistance of ocular Chlamydia trachomatis to azithromycin after mass treatment for trachoma control?

West SK, Moncada J, Munoz B, Mkocha H, Storey P, Hardick J, Gaydos CA, Quinn TC, Schachter J.

J Infect Dis. 2014 Jul 1;210(1):65-71. Epub 2014 Jan 19.


Sensitive detection and serovar differentiation of typhoidal and nontyphoidal Salmonella enterica species using 16S rRNA Gene PCR coupled with high-resolution melt analysis.

Masek BJ, Hardick J, Won H, Yang S, Hsieh YH, Rothman RE, Gaydos CA.

J Mol Diagn. 2014 Mar;16(2):261-6. doi: 10.1016/j.jmoldx.2013.10.011. Epub 2013 Dec 21.


Universal digital high-resolution melt: a novel approach to broad-based profiling of heterogeneous biological samples.

Fraley SI, Hardick J, Masek BJ, Athamanolap P, Rothman RE, Gaydos CA, Carroll KC, Wakefield T, Wang TH, Yang S.

Nucleic Acids Res. 2013 Oct;41(18):e175. doi: 10.1093/nar/gkt684. Epub 2013 Aug 9. Erratum in: Nucleic Acids Res. 2016 Jan 8;44(1):508. Jo Masek, Billie [Corrected to Masek, Billie J].


Reverse transcription-PCR-electrospray ionization mass spectrometry for rapid detection of biothreat and common respiratory pathogens.

Jeng K, Hardick J, Rothman R, Yang S, Won H, Peterson S, Hsieh YH, Masek BJ, Carroll KC, Gaydos CA.

J Clin Microbiol. 2013 Oct;51(10):3300-7. doi: 10.1128/JCM.01443-13. Epub 2013 Jul 31.


Evaluation of the Pan Influenza detection kit utilizing the PLEX-ID and influenza samples from the 2011 respiratory season.

A Murillo L, Hardick J, Jeng K, Gaydos CA.

J Virol Methods. 2013 Oct;193(1):173-6. doi: 10.1016/j.jviromet.2013.06.006. Epub 2013 Jun 10.


A new rapid molecular point-of-care assay for Trichomonas vaginalis: preliminary performance data.

Pearce DM, Styles DN, Hardick JP, Gaydos CA.

Sex Transm Infect. 2013 Sep;89(6):495-7. doi: 10.1136/sextrans-2012-051000. Epub 2013 Apr 20.


Harnessing genomic approaches for infectious disease diagnosis in emergency medicine: getting closer to prime time.

Rothman RE, Yang S, Hardick J, Gaydos CA.

Ann Emerg Med. 2012 Nov;60(5):621-3. doi: 10.1016/j.annemergmed.2012.07.109. Epub 2012 Aug 22. No abstract available.


Chlamydia trachomatis strains show specific clustering for men who have sex with men compared to heterosexual populations in Sweden, the Netherlands, and the United States.

Christerson L, Bom RJ, Bruisten SM, Yass R, Hardick J, Bratt G, Gaydos CA, Morré SA, Herrmann B.

J Clin Microbiol. 2012 Nov;50(11):3548-55. doi: 10.1128/JCM.01713-12. Epub 2012 Aug 22.


Comparative analysis of two broad-range PCR assays for pathogen detection in positive-blood-culture bottles: PCR-high-resolution melting analysis versus PCR-mass spectrometry.

Jeng K, Gaydos CA, Blyn LB, Yang S, Won H, Matthews H, Toleno D, Hsieh YH, Carroll KC, Hardick J, Masek B, Kecojevic A, Sampath R, Peterson S, Rothman RE.

J Clin Microbiol. 2012 Oct;50(10):3287-92. doi: 10.1128/JCM.00677-12. Epub 2012 Aug 1.


A broad range assay for rapid detection and etiologic characterization of bacterial meningitis: performance testing in samples from sub-Sahara.

Won H, Yang S, Gaydos C, Hardick J, Ramachandran P, Hsieh YH, Kecojevic A, Njanpop-Lafourcade BM, Mueller JE, Tameklo TA, Badziklou K, Gessner BD, Rothman RE.

Diagn Microbiol Infect Dis. 2012 Sep;74(1):22-7. doi: 10.1016/j.diagmicrobio.2012.05.015. Epub 2012 Jul 17.


Monitoring seasonal influenza A evolution: rapid 2009 pandemic H1N1 surveillance with an reverse transcription-polymerase chain reaction/electro-spray ionization mass spectrometry assay.

Jeng K, Massire C, Zembower TR, Deyde VM, Gubareva LV, Hsieh YH, Rothman RE, Sampath R, Penugonda S, Metzgar D, Blyn LB, Hardick J, Gaydos CA.

J Clin Virol. 2012 Aug;54(4):332-6. doi: 10.1016/j.jcv.2012.05.002. Epub 2012 Jun 4.


Identification of bacterial pathogens in ascitic fluids from patients with suspected spontaneous bacterial peritonitis by use of broad-range PCR (16S PCR) coupled with high-resolution melt analysis.

Hardick J, Won H, Jeng K, Hsieh YH, Gaydos CA, Rothman RE, Yang S.

J Clin Microbiol. 2012 Jul;50(7):2428-32. doi: 10.1128/JCM.00345-12. Epub 2012 May 9.


Application of a 16S rRNA PCR-high-resolution melt analysis assay for rapid detection of Salmonella Bacteremia.

Jeng K, Yang S, Won H, Gaydos CA, Hsieh YH, Kecojevic A, Carroll KC, Hardick J, Rothman RE.

J Clin Microbiol. 2012 Mar;50(3):1122-4. doi: 10.1128/JCM.05121-11. Epub 2012 Jan 11.


Detection of Crimean-Congo hemorrhagic fever, Hanta, and sandfly fever viruses by real-time RT-PCR.

Ibrahim SM, Aitichou M, Hardick J, Blow J, O'Guinn ML, Schmaljohn C.

Methods Mol Biol. 2011;665:357-68. doi: 10.1007/978-1-60761-817-1_19.


Gene expression profiling of monkeypox virus-infected cells reveals novel interfaces for host-virus interactions.

Alkhalil A, Hammamieh R, Hardick J, Ichou MA, Jett M, Ibrahim S.

Virol J. 2010 Jul 28;7:173. doi: 10.1186/1743-422X-7-173.


Mycoplasma genitalium as a contributor to the multiple etiologies of cervicitis in women attending sexually transmitted disease clinics.

Gaydos C, Maldeis NE, Hardick A, Hardick J, Quinn TC.

Sex Transm Dis. 2009 Oct;36(10):598-606. doi: 10.1097/OLQ.0b013e3181b01948.


Testing and validation of high density resequencing microarray for broad range biothreat agents detection.

Leski TA, Lin B, Malanoski AP, Wang Z, Long NC, Meador CE, Barrows B, Ibrahim S, Hardick JP, Aitichou M, Schnur JM, Tibbetts C, Stenger DA.

PLoS One. 2009 Aug 11;4(8):e6569. doi: 10.1371/journal.pone.0006569.


Mycoplasma genitalium compared to chlamydia, gonorrhoea and trichomonas as an aetiological agent of urethritis in men attending STD clinics.

Gaydos C, Maldeis NE, Hardick A, Hardick J, Quinn TC.

Sex Transm Infect. 2009 Oct;85(6):438-40. doi: 10.1136/sti.2008.035477. Epub 2009 Apr 20.

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