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Genetic Characterization and Zoonotic Potential of Highly Pathogenic Avian Influenza Virus A(H5N6/H5N5), Germany, 2017-2018.

Pohlmann A, Hoffmann D, Grund C, Koethe S, Hüssy D, Meier SM, King J, Schinköthe J, Ulrich R, Harder T, Beer M.

Emerg Infect Dis. 2019 Oct;25(10):1973-1976. doi: 10.3201/eid2510.181931.


Variable impact of the hemagglutinin polybasic cleavage site on virulence and pathogenesis of avian influenza H7N7 virus in chickens, turkeys and ducks.

Scheibner D, Ulrich R, Fatola OI, Graaf A, Gischke M, Salaheldin AH, Harder TC, Veits J, Mettenleiter TC, Abdelwhab EM.

Sci Rep. 2019 Aug 9;9(1):11556. doi: 10.1038/s41598-019-47938-3.


Respiratory disease due to mixed viral infections in poultry flocks in Egypt between 2017 and 2018: Upsurge of highly pathogenic avian influenza virus subtype H5N8 since 2018.

Hassan KE, El-Kady MF, El-Sawah AAA, Luttermann C, Parvin R, Shany S, Beer M, Harder T.

Transbound Emerg Dis. 2019 Jul 11. doi: 10.1111/tbed.13281. [Epub ahead of print]


Co-subsistence of avian influenza virus subtypes of low and high pathogenicity in Bangladesh: Challenges for diagnosis, risk assessment and control.

Parvin R, Begum JA, Chowdhury EH, Islam MR, Beer M, Harder T.

Sci Rep. 2019 Jun 5;9(1):8306. doi: 10.1038/s41598-019-44220-4.


Investigation of suspected Newcastle disease (ND) outbreaks in Egypt uncovers a high virus velogenic ND virus burden in small-scale holdings and the presence of multiple pathogens.

Moharam I, Razik AAE, Sultan H, Ghezlan M, Meseko C, Franzke K, Harder T, Beer M, Grund C.

Avian Pathol. 2019 Oct;48(5):406-415. doi: 10.1080/03079457.2019.1612852. Epub 2019 Jul 25.


Mucosal and cutaneous Human Papillomavirus seroprevalence among adults in the prevaccine era in Germany - Results from a nationwide population-based survey.

Loenenbach AD, Poethko-Müller C, Pawlita M, Thamm M, Harder T, Waterboer T, Schröter J, Deleré Y, Wichmann O, Wiese-Posselt M.

Int J Infect Dis. 2019 Jun;83:3-11. doi: 10.1016/j.ijid.2019.03.022. Epub 2019 Mar 20.


[The new standard operating procedure of the German standing committee on vaccination (STIKO): history, structure, and implementation].

Harder T, Koch J, von Kries R, Wichmann O.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Apr;62(4):392-399. doi: 10.1007/s00103-019-02898-x. German.


Fostering Cross-Sector Partnerships: Lessons Learned From a Community Care Team.

Holland DE, Vanderboom CE, Harder TM.

Prof Case Manag. 2019 Mar/Apr;24(2):66-75. doi: 10.1097/NCM.0000000000000310.


Platform for Electrically Pumped Polariton Simulators and Topological Lasers.

Suchomel H, Klembt S, Harder TH, Klaas M, Egorov OA, Winkler K, Emmerling M, Thomale R, Höfling S, Schneider C.

Phys Rev Lett. 2018 Dec 21;121(25):257402. doi: 10.1103/PhysRevLett.121.257402.


A viral race for primacy: co-infection of a natural pair of low and highly pathogenic H7N7 avian influenza viruses in chickens and embryonated chicken eggs.

Graaf A, Ulrich R, Maksimov P, Scheibner D, Koethe S, Abdelwhab EM, Mettenleiter TC, Beer M, Harder T.

Emerg Microbes Infect. 2018 Dec 5;7(1):204. doi: 10.1038/s41426-018-0204-0.


Fungal spores as a source of sodium salt particles in the Amazon basin.

China S, Burrows SM, Wang B, Harder TH, Weis J, Tanarhte M, Rizzo LV, Brito J, Cirino GG, Ma PL, Cliff J, Artaxo P, Gilles MK, Laskin A.

Nat Commun. 2018 Nov 19;9(1):4793. doi: 10.1038/s41467-018-07066-4.


Identification of Novel Gymnodimines and Spirolides from the Marine Dinoflagellate Alexandrium ostenfeldii.

Zurhelle C, Nieva J, Tillmann U, Harder T, Krock B, Tebben J.

Mar Drugs. 2018 Nov 14;16(11). pii: E446. doi: 10.3390/md16110446.


Endemic situation of multiple avian influenza strains in poultry in Egypt: A continuing nightmare.

Naguib MM, Harder T.

Zoonoses Public Health. 2018 Dec;65(8):908-910. doi: 10.1111/zph.12486. No abstract available.


[The STIKO now recommends the HPV vaccination for boys too].

Klug SJ, van der Sande M, Terhardt M, Zepp F, Röbl-Mathieu M, Meerpohl J, Wiese-Posselt M, Harder T, Wichmann O, Takla A; Ständige Impfkommission (STIKO) und AG HPV der STIKO.

Urologe A. 2018 Nov;57(11):1346-1350. doi: 10.1007/s00120-018-0793-1. German. No abstract available.


Exciton-polariton topological insulator.

Klembt S, Harder TH, Egorov OA, Winkler K, Ge R, Bandres MA, Emmerling M, Worschech L, Liew TCH, Segev M, Schneider C, Höfling S.

Nature. 2018 Oct;562(7728):552-556. doi: 10.1038/s41586-018-0601-5. Epub 2018 Oct 8.


A newly developed tetraplex real-time RT-PCR for simultaneous screening of influenza virus types A, B, C and D.

Henritzi D, Hoffmann B, Wacheck S, Pesch S, Herrler G, Beer M, Harder TC.

Influenza Other Respir Viruses. 2019 Jan;13(1):71-82. doi: 10.1111/irv.12613. Epub 2018 Oct 22.


White-Tailed Sea Eagle (Haliaeetus albicilla) Die-Off Due to Infection with Highly Pathogenic Avian Influenza Virus, Subtype H5N8, in Germany.

Krone O, Globig A, Ulrich R, Harder T, Schinköthe J, Herrmann C, Gerst S, Conraths FJ, Beer M.

Viruses. 2018 Sep 7;10(9). pii: E478. doi: 10.3390/v10090478.


Background paper for the recommendation of HPV vaccination for boys in Germany.

Takla A, Wiese-Posselt M, Harder T, Meerpohl JJ, Röbl-Mathieu M, Terhardt M, van der Sande M, Wichmann O, Zepp F, Klug SJ.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2018 Sep;61(9):1170-1186. doi: 10.1007/s00103-018-2791-2. Review. No abstract available.


A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential.

Grund C, Hoffmann D, Ulrich R, Naguib M, Schinköthe J, Hoffmann B, Harder T, Saenger S, Zscheppang K, Tönnies M, Hippenstiel S, Hocke A, Wolff T, Beer M.

Emerg Microbes Infect. 2018 Jul 19;7(1):132. doi: 10.1038/s41426-018-0130-1.


Efficacy, effectiveness and safety of vaccination against human papillomavirus in males: a systematic review.

Harder T, Wichmann O, Klug SJ, van der Sande MAB, Wiese-Posselt M.

BMC Med. 2018 Jul 18;16(1):110. doi: 10.1186/s12916-018-1098-3. Review.


Subtyping of Swine Influenza Viruses Using a High-Throughput Real-Time PCR Platform.

Goecke NB, Krog JS, Hjulsager CK, Skovgaard K, Harder TC, Breum SØ, Larsen LE.

Front Cell Infect Microbiol. 2018 May 22;8:165. doi: 10.3389/fcimb.2018.00165. eCollection 2018.


From low to high pathogenicity-Characterization of H7N7 avian influenza viruses in two epidemiologically linked outbreaks.

Dietze K, Graaf A, Homeier-Bachmann T, Grund C, Forth L, Pohlmann A, Jeske C, Wintermann M, Beer M, Conraths FJ, Harder T.

Transbound Emerg Dis. 2018 Dec;65(6):1576-1587. doi: 10.1111/tbed.12906. Epub 2018 May 23.


Notes from the Field: Identification of Tourists from Switzerland Exposed to Rabies Virus While Visiting the United States - January 2018.

Pieracci EG, Stanek D, Koch D, Kohl KS, Blanton JD, Harder T, O'Brien M, Leon H, Colarusso P, Baker B, Brown C, Stauffer KE, Petersen BW, Wallace RM.

MMWR Morb Mortal Wkly Rep. 2018 Apr 27;67(16):477-478. doi: 10.15585/mmwr.mm6716a5. No abstract available.


Evidence of exposure of domestic pigs to Highly Pathogenic Avian Influenza H5N1 in Nigeria.

Meseko C, Globig A, Ijomanta J, Joannis T, Nwosuh C, Shamaki D, Harder T, Hoffman D, Pohlmann A, Beer M, Mettenleiter T, Starick E.

Sci Rep. 2018 Apr 12;8(1):5900. doi: 10.1038/s41598-018-24371-6.


Routine screening for colonization by Gram-negative bacteria in neonates at intensive care units for the prediction of sepsis: systematic review and meta-analysis.

Seidel J, Haller S, Eckmanns T, Harder T.

J Hosp Infect. 2018 Aug;99(4):367-380. doi: 10.1016/j.jhin.2018.03.017. Epub 2018 Mar 22. Review.


Highly Pathogenic Avian Influenza H5N8 Clade in Germany in 2016/2017.

Globig A, Staubach C, Sauter-Louis C, Dietze K, Homeier-Bachmann T, Probst C, Gethmann J, Depner KR, Grund C, Harder TC, Starick E, Pohlmann A, Höper D, Beer M, Mettenleiter TC, Conraths FJ.

Front Vet Sci. 2018 Jan 24;4:240. doi: 10.3389/fvets.2017.00240. eCollection 2017.


Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans.

Tareq FS, Hasan CM, Rahman MM, Hanafi MMM, Colombi Ciacchi L, Michaelis M, Harder T, Tebben J, Islam MT, Spiteller P.

J Nat Prod. 2018 Feb 23;81(2):400-404. doi: 10.1021/acs.jnatprod.7b00525. Epub 2018 Jan 30.


Molecular subtyping of European swine influenza viruses and scaling to high-throughput analysis.

Bonin E, Quéguiner S, Woudstra C, Gorin S, Barbier N, Harder TC, Fach P, Hervé S, Simon G.

Virol J. 2018 Jan 10;15(1):7. doi: 10.1186/s12985-018-0920-z.


Swarm incursions of reassortants of highly pathogenic avian influenza virus strains H5N8 and H5N5, clade, Germany, winter 2016/17.

Pohlmann A, Starick E, Grund C, Höper D, Strebelow G, Globig A, Staubach C, Conraths FJ, Mettenleiter TC, Harder T, Beer M.

Sci Rep. 2018 Jan 8;8(1):15. doi: 10.1038/s41598-017-16936-8.


Human resources estimates for antibiotic stewardship teams: evidence-based approaches for recommendations are needed.

Harder T, Eckmanns T, Schmidt N, Kern WV, Sin MA.

Clin Microbiol Infect. 2018 May;24(5):554-556. doi: 10.1016/j.cmi.2017.12.020. Epub 2018 Jan 6. No abstract available.


Multiple introductions of reassorted highly pathogenic avian influenza viruses (H5N8) clade causing outbreaks in wild birds and poultry in Egypt.

Yehia N, Naguib MM, Li R, Hagag N, El-Husseiny M, Mosaad Z, Nour A, Rabea N, Hasan WM, Hassan MK, Harder T, Arafa AA.

Infect Genet Evol. 2018 Mar;58:56-65. doi: 10.1016/j.meegid.2017.12.011. Epub 2017 Dec 14.


PRECEPT: an evidence assessment framework for infectious disease epidemiology, prevention and control.

Harder T, Takla A, Eckmanns T, Ellis S, Forland F, James R, Meerpohl JJ, Morgan A, Rehfuess E, Schünemann H, Zuiderent-Jerak T, de Carvalho Gomes H, Wichmann O.

Euro Surveill. 2017 Oct;22(40). doi: 10.2807/1560-7917.ES.2017.22.40.16-00620.


Natural Reassortants of Potentially Zoonotic Avian Influenza Viruses H5N1 and H9N2 from Egypt Display Distinct Pathogenic Phenotypes in Experimentally Infected Chickens and Ferrets.

Naguib MM, Ulrich R, Kasbohm E, Eng CLP, Hoffmann D, Grund C, Beer M, Harder TC.

J Virol. 2017 Nov 14;91(23). pii: e01300-17. doi: 10.1128/JVI.01300-17. Print 2017 Dec 1.


Insights into genetic diversity and biological propensities of potentially zoonotic avian influenza H9N2 viruses circulating in Egypt.

Naguib MM, Arafa AS, Parvin R, Beer M, Vahlenkamp T, Harder TC.

Virology. 2017 Nov;511:165-174. doi: 10.1016/j.virol.2017.08.028. Epub 2017 Aug 29.


Heterologous post-infection immunity against Egyptian avian influenza virus (AIV) H9N2 modulates the course of subsequent infection by highly pathogenic AIV H5N1, but vaccination immunity does not.

Naguib MM, Grund C, Arafa AS, Abdelwhab EM, Beer M, Harder TC.

J Gen Virol. 2017 Jun;98(6):1169-1173. doi: 10.1099/jgv.0.000767. Epub 2017 Jun 8.


Predicted vs observed effectiveness of outer membrane vesicle (OMV) vaccines against meningococcal serogroup B disease: Systematic review.

Harder T, Koch J, Wichmann O, Hellenbrand W.

J Infect. 2017 Aug;75(2):81-94. doi: 10.1016/j.jinf.2017.05.001. Epub 2017 May 6. Review.


Risk of Intussusception After Rotavirus Vaccination.

Koch J, Harder T, von Kries R, Wichmann O.

Dtsch Arztebl Int. 2017 Apr 14;114(15):255-262. doi: 10.3238/arztebl.2017.0255.


New real time and conventional RT-PCRs for updated molecular diagnosis of infectious bronchitis virus infection (IBV) in chickens in Egypt associated with frequent co-infections with avian influenza and Newcastle Disease viruses.

Naguib MM, El-Kady MF, Lüschow D, Hassan KE, Arafa AS, El-Zanaty A, Hassan MK, Hafez HM, Grund C, Harder TC.

J Virol Methods. 2017 Jul;245:19-27. doi: 10.1016/j.jviromet.2017.02.018. Epub 2017 Mar 21.


Isolation and genetic characterization of a novel H5N1 virus from a vaccinated meat-turkeys flock in Egypt.

Salaheldin AH, Veits J, Abd El-Hamid HS, Harder TC, Devrishov D, Mettenleiter TC, Hafez HM, Abdelwhab EM.

Virol J. 2017 Mar 9;14(1):48. doi: 10.1186/s12985-017-0697-5.


Novel real-time PCR-based patho- and phylotyping of potentially zoonotic avian influenza A subtype H5 viruses at risk of incursion into Europe in 2017.

Naguib MM, Graaf A, Fortin A, Luttermann C, Wernery U, Amarin N, Hussein HA, Sultan H, Al Adhadh B, Hassan MK, Beer M, Monne I, Harder TC.

Euro Surveill. 2017 Jan 5;22(1). pii: 30435. doi: 10.2807/1560-7917.ES.2017.22.1.30435. No abstract available.


Effectiveness of the 23-Valent Pneumococcal Polysaccharide Vaccine (PPV23) against Pneumococcal Disease in the Elderly: Systematic Review and Meta-Analysis.

Falkenhorst G, Remschmidt C, Harder T, Hummers-Pradier E, Wichmann O, Bogdan C.

PLoS One. 2017 Jan 6;12(1):e0169368. doi: 10.1371/journal.pone.0169368. eCollection 2017. Review.


Outbreaks among Wild Birds and Domestic Poultry Caused by Reassorted Influenza A(H5N8) Clade Viruses, Germany, 2016.

Pohlmann A, Starick E, Harder T, Grund C, Höper D, Globig A, Staubach C, Dietze K, Strebelow G, Ulrich RG, Schinköthe J, Teifke JP, Conraths FJ, Mettenleiter TC, Beer M.

Emerg Infect Dis. 2017 Apr;23(4):633-636. doi: 10.3201/eid2304.161949. Epub 2017 Apr 15.


Highly pathogenic avian influenza A(H5N8) outbreaks: protection and management of exposed people in Europe, 2014/15 and 2016.

Adlhoch C, Brown IH, Angelova SG, Bálint Á, Bouwstra R, Buda S, Castrucci MR, Dabrera G, Dán Á, Grund C, Harder T, van der Hoek W, Krisztalovics K, Parry-Ford F, Popescu R, Wallensten A, Zdravkova A, Zohari S, Tsolova S, Penttinen P.

Euro Surveill. 2016 Dec 8;21(49). pii: 30419. doi: 10.2807/1560-7917.ES.2016.21.49.30419.


Progressive glycosylation of the haemagglutinin of avian influenza H5N1 modulates virus replication, virulence and chicken-to-chicken transmission without significant impact on antigenic drift.

Abdelwhab EM, Veits J, Tauscher K, Ziller M, Grund C, Hassan MK, Shaheen M, Harder TC, Teifke J, Stech J, Mettenleiter TC.

J Gen Virol. 2016 Dec;97(12):3193-3204. doi: 10.1099/jgv.0.000648. Epub 2016 Oct 28.


Effectiveness, immunogenicity and safety of 23-valent pneumococcal polysaccharide vaccine revaccinations in the elderly: a systematic review.

Remschmidt C, Harder T, Wichmann O, Bogdan C, Falkenhorst G.

BMC Infect Dis. 2016 Nov 25;16(1):711. Review.

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