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Items: 1 to 50 of 96

1.

Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton.

Meiring JCM, Bryce NS, Wang Y, Taft MH, Manstein DJ, Liu Lau S, Stear J, Hardeman EC, Gunning PW.

Curr Biol. 2018 Jul 23;28(14):2331-2337.e5. doi: 10.1016/j.cub.2018.05.053. Epub 2018 Jul 5.

PMID:
29983319
2.

On-target action of anti-tropomyosin drugs regulates glucose metabolism.

Kee AJ, Chagan J, Chan JY, Bryce NS, Lucas CA, Zeng J, Hook J, Treutlein H, Laybutt DR, Stehn JR, Gunning PW, Hardeman EC.

Sci Rep. 2018 Mar 15;8(1):4604. doi: 10.1038/s41598-018-22946-x.

3.

Tropomyosin-directed tuning of myosin motor function: Insights from mutagenesis.

Gunning PW, Hardeman EC.

Cytoskeleton (Hoboken). 2018 Apr;75(4):147-149. doi: 10.1002/cm.21441. Epub 2018 Mar 14. No abstract available.

PMID:
29514407
4.

Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice.

Masedunskas A, Appaduray MA, Lucas CA, Lastra Cagigas M, Heydecker M, Holliday M, Meiring JCM, Hook J, Kee A, White M, Thomas P, Zhang Y, Adelstein RS, Meckel T, Böcking T, Weigert R, Bryce NS, Gunning PW, Hardeman EC.

J Cell Sci. 2018 Mar 19;131(6). pii: jcs212654. doi: 10.1242/jcs.212654.

5.

Fundamental differences.

Gunning PW, Hardeman EC.

Elife. 2018 Feb 1;7. pii: e34477. doi: 10.7554/eLife.34477.

6.

Developmental Profiling of Tropomyosin Expression in Mouse Brain Reveals Tpm4.2 as the Major Post-synaptic Tropomyosin in the Mature Brain.

Suchowerska AK, Fok S, Stefen H, Gunning PW, Hardeman EC, Power J, Fath T.

Front Cell Neurosci. 2017 Dec 22;11:421. doi: 10.3389/fncel.2017.00421. eCollection 2017.

7.

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

Nobis M, Herrmann D, Warren SC, Kadir S, Leung W, Killen M, Magenau A, Stevenson D, Lucas MC, Reischmann N, Vennin C, Conway JRW, Boulghourjian A, Zaratzian A, Law AM, Gallego-Ortega D, Ormandy CJ, Walters SN, Grey ST, Bailey J, Chtanova T, Quinn JMW, Baldock PA, Croucher PI, Schwarz JP, Mrowinska A, Zhang L, Herzog H, Masedunskas A, Hardeman EC, Gunning PW, Del Monte-Nieto G, Harvey RP, Samuel MS, Pajic M, McGhee EJ, Johnsson AE, Sansom OJ, Welch HCE, Morton JP, Strathdee D, Anderson KI, Timpson P.

Cell Rep. 2017 Oct 3;21(1):274-288. doi: 10.1016/j.celrep.2017.09.022.

8.

ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2.

Kee AJ, Bryce NS, Yang L, Polishchuk E, Schevzov G, Weigert R, Polishchuk R, Gunning PW, Hardeman EC.

Cytoskeleton (Hoboken). 2017 Oct;74(10):379-389. doi: 10.1002/cm.21405. Epub 2017 Aug 31.

PMID:
28834398
9.

Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs.

Currier MA, Stehn JR, Swain A, Chen D, Hook J, Eiffe E, Heaton A, Brown D, Nartker BA, Eaves DW, Kloss N, Treutlein H, Zeng J, Alieva IB, Dugina VB, Hardeman EC, Gunning PW, Cripe TP.

Mol Cancer Ther. 2017 Aug;16(8):1555-1565. doi: 10.1158/1535-7163.MCT-16-0873. Epub 2017 May 18.

10.

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.

Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltrán J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT.

J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30.

11.

Tropomyosins.

Gunning PW, Hardeman EC.

Curr Biol. 2017 Jan 9;27(1):R8-R13. doi: 10.1016/j.cub.2016.11.033.

12.

Recruitment Kinetics of Tropomyosin Tpm3.1 to Actin Filament Bundles in the Cytoskeleton Is Independent of Actin Filament Kinetics.

Appaduray MA, Masedunskas A, Bryce NS, Lucas CA, Warren SC, Timpson P, Stear JH, Gunning PW, Hardeman EC.

PLoS One. 2016 Dec 15;11(12):e0168203. doi: 10.1371/journal.pone.0168203. eCollection 2016.

13.

Epidermal YAP2-5SA-ΔC Drives β-Catenin Activation to Promote Keratinocyte Proliferation in Mouse Skin In Vivo.

Akladios B, Mendoza-Reinoso V, Samuel MS, Hardeman EC, Khosrotehrani K, Key B, Beverdam A.

J Invest Dermatol. 2017 Mar;137(3):716-726. doi: 10.1016/j.jid.2016.10.029. Epub 2016 Nov 2.

14.

RNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome.

Corley SM, Canales CP, Carmona-Mora P, Mendoza-Reinosa V, Beverdam A, Hardeman EC, Wilkins MR, Palmer SJ.

BMC Genomics. 2016 Jun 13;17:450. doi: 10.1186/s12864-016-2801-4.

15.

Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge.

Brayford S, Bryce NS, Schevzov G, Haynes EM, Bear JE, Hardeman EC, Gunning PW.

Curr Biol. 2016 May 23;26(10):1312-8. doi: 10.1016/j.cub.2016.03.028. Epub 2016 Apr 21.

16.

Treatment with ActRIIB-mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy.

Tinklenberg J, Meng H, Yang L, Liu F, Hoffmann RG, Dasgupta M, Allen KP, Beggs AH, Hardeman EC, Pearsall RS, Fitts RH, Lawlor MW.

Am J Pathol. 2016 Jun;186(6):1568-81. doi: 10.1016/j.ajpath.2016.02.008. Epub 2016 Apr 18.

17.

Modulating myosin restores muscle function in a mouse model of nemaline myopathy.

Lindqvist J, Levy Y, Pati-Alam A, Hardeman EC, Gregorevic P, Ochala J.

Ann Neurol. 2016 May;79(5):717-725. doi: 10.1002/ana.24619. Epub 2016 Mar 22.

18.

A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics.

Bonello TT, Janco M, Hook J, Byun A, Appaduray M, Dedova I, Hitchcock-DeGregori S, Hardeman EC, Stehn JR, Böcking T, Gunning PW.

Sci Rep. 2016 Jan 25;6:19816. doi: 10.1038/srep19816.

19.

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue.

Erami Z, Herrmann D, Warren SC, Nobis M, McGhee EJ, Lucas MC, Leung W, Reischmann N, Mrowinska A, Schwarz JP, Kadir S, Conway JRW, Vennin C, Karim SA, Campbell AD, Gallego-Ortega D, Magenau A, Murphy KJ, Ridgway RA, Law AM, Walters SN, Grey ST, Croucher DR, Zhang L, Herzog H, Hardeman EC, Gunning PW, Ormandy CJ, Evans TRJ, Strathdee D, Sansom OJ, Morton JP, Anderson KI, Timpson P.

Cell Rep. 2016 Jan 5;14(1):152-167. doi: 10.1016/j.celrep.2015.12.020. Epub 2015 Dec 24.

20.

An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake.

Kee AJ, Yang L, Lucas CA, Greenberg MJ, Martel N, Leong GM, Hughes WE, Cooney GJ, James DE, Ostap EM, Han W, Gunning PW, Hardeman EC.

Traffic. 2016 Jan;17(1):80-1. doi: 10.1111/tra.12342. No abstract available.

21.

The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation.

Carmona-Mora P, Widagdo J, Tomasetig F, Canales CP, Cha Y, Lee W, Alshawaf A, Dottori M, Whan RM, Hardeman EC, Palmer SJ.

Hum Genet. 2015 Oct;134(10):1099-115. doi: 10.1007/s00439-015-1591-0. Epub 2015 Aug 15.

PMID:
26275350
22.

Tropomyosin - master regulator of actin filament function in the cytoskeleton.

Gunning PW, Hardeman EC, Lappalainen P, Mulvihill DP.

J Cell Sci. 2015 Aug 15;128(16):2965-74. doi: 10.1242/jcs.172502. Epub 2015 Aug 3. Review.

23.

Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton.

Jalilian I, Heu C, Cheng H, Freittag H, Desouza M, Stehn JR, Bryce NS, Whan RM, Hardeman EC, Fath T, Schevzov G, Gunning PW.

PLoS One. 2015 May 15;10(5):e0126214. doi: 10.1371/journal.pone.0126214. eCollection 2015.

24.

Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments.

Schevzov G, Kee AJ, Wang B, Sequeira VB, Hook J, Coombes JD, Lucas CA, Stehn JR, Musgrove EA, Cretu A, Assoian R, Fath T, Hanoch T, Seger R, Pleines I, Kile BT, Hardeman EC, Gunning PW.

Mol Biol Cell. 2015 Jul 1;26(13):2475-90. doi: 10.1091/mbc.E14-10-1453. Epub 2015 May 13.

25.

An actin filament population defined by the tropomyosin Tpm3.1 regulates glucose uptake.

Kee AJ, Yang L, Lucas CA, Greenberg MJ, Martel N, Leong GM, Hughes WE, Cooney GJ, James DE, Ostap EM, Han W, Gunning PW, Hardeman EC.

Traffic. 2015 Jul;16(7):691-711. doi: 10.1111/tra.12282. Epub 2015 Apr 29. Erratum in: Traffic. 2016 Jan;17(1):80-1.

26.

Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens.

Caldwell BJ, Lucas C, Kee AJ, Gaus K, Gunning PW, Hardeman EC, Yap AS, Gomez GA.

Cytoskeleton (Hoboken). 2014 Dec;71(12):663-76. doi: 10.1002/cm.21202. Epub 2015 Jan 31.

PMID:
25545457
27.

Alterations at the cross-bridge level are associated with a paradoxical gain of muscle function in vivo in a mouse model of nemaline myopathy.

Gineste C, Ottenheijm C, Le Fur Y, Banzet S, Pecchi E, Vilmen C, Cozzone PJ, Koulmann N, Hardeman EC, Bendahan D, Gondin J.

PLoS One. 2014 Sep 30;9(9):e109066. doi: 10.1371/journal.pone.0109066. eCollection 2014.

28.

Sexually dimorphic myofilament function in a mouse model of nemaline myopathy.

Lindqvist J, Hardeman EC, Ochala J.

Arch Biochem Biophys. 2014 Dec 15;564:37-42. doi: 10.1016/j.abb.2014.09.011. Epub 2014 Sep 24.

PMID:
25261348
29.

The role of GTF2IRD1 in the auditory pathology of Williams-Beuren Syndrome.

Canales CP, Wong AC, Gunning PW, Housley GD, Hardeman EC, Palmer SJ.

Eur J Hum Genet. 2015 Jun;23(6):774-80. doi: 10.1038/ejhg.2014.188. Epub 2014 Sep 24.

30.

Lighting up microtubule cytoskeleton dynamics in skeletal muscle.

Masedunskas A, Appaduray M, Gunning PW, Hardeman EC.

Intravital. 2014 May 30;3(1):e29293. doi: 10.4161/intv.29293. eCollection 2014.

31.

Properties of regenerated mouse extensor digitorum longus muscle following notexin injury.

Head SI, Houweling PJ, Chan S, Chen G, Hardeman EC.

Exp Physiol. 2014 Apr;99(4):664-74. doi: 10.1113/expphysiol.2013.077289. Epub 2014 Jan 10.

32.

A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells.

Stehn JR, Haass NK, Bonello T, Desouza M, Kottyan G, Treutlein H, Zeng J, Nascimento PR, Sequeira VB, Butler TL, Allanson M, Fath T, Hill TA, McCluskey A, Schevzov G, Palmer SJ, Hardeman EC, Winlaw D, Reeve VE, Dixon I, Weninger W, Cripe TP, Gunning PW.

Cancer Res. 2013 Aug 15;73(16):5169-82. doi: 10.1158/0008-5472.CAN-12-4501. Erratum in: Cancer Res. 2013 Oct 1;73(19):6094.

33.

Aged skeletal muscle retains the ability to fully regenerate functional architecture.

Lee AS, Anderson JE, Joya JE, Head SI, Pather N, Kee AJ, Gunning PW, Hardeman EC.

Bioarchitecture. 2013 Mar-Apr;3(2):25-37. doi: 10.4161/bioa.24966. Epub 2013 Jul 1.

34.

Cardiac α-actin over-expression therapy in dominant ACTA1 disease.

Ravenscroft G, McNamara E, Griffiths LM, Papadimitriou JM, Hardeman EC, Bakker AJ, Davies KE, Laing NG, Nowak KJ.

Hum Mol Genet. 2013 Oct 1;22(19):3987-97. doi: 10.1093/hmg/ddt252. Epub 2013 Jun 4.

PMID:
23736297
35.

Distinct underlying mechanisms of limb and respiratory muscle fiber weaknesses in nemaline myopathy.

Lindqvist J, Cheng AJ, Renaud G, Hardeman EC, Ochala J.

J Neuropathol Exp Neurol. 2013 Jun;72(6):472-81. doi: 10.1097/NEN.0b013e318293b1cc.

PMID:
23656990
36.

Combined MRI and ³¹P-MRS investigations of the ACTA1(H40Y) mouse model of nemaline myopathy show impaired muscle function and altered energy metabolism.

Gineste C, Le Fur Y, Vilmen C, Le Troter A, Pecchi E, Cozzone PJ, Hardeman EC, Bendahan D, Gondin J.

PLoS One. 2013 Apr 16;8(4):e61517. doi: 10.1371/journal.pone.0061517. Print 2013.

37.

Tropomyosin regulates cell migration during skin wound healing.

Lees JG, Ching YW, Adams DH, Bach CT, Samuel MS, Kee AJ, Hardeman EC, Gunning P, Cowin AJ, O'Neill GM.

J Invest Dermatol. 2013 May;133(5):1330-9. doi: 10.1038/jid.2012.489. Epub 2013 Jan 10.

38.

SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation.

Widagdo J, Taylor KM, Gunning PW, Hardeman EC, Palmer SJ.

PLoS One. 2012;7(11):e49283. doi: 10.1371/journal.pone.0049283. Epub 2012 Nov 8.

39.

GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.

Palmer SJ, Taylor KM, Santucci N, Widagdo J, Chan YK, Yeo JL, Adams M, Gunning PW, Hardeman EC.

J Cell Sci. 2012 Nov 1;125(Pt 21):5040-50. doi: 10.1242/jcs.102798. Epub 2012 Aug 16.

40.

Mutation of Gtf2ird1 from the Williams-Beuren syndrome critical region results in facial dysplasia, motor dysfunction, and altered vocalisations.

Howard ML, Palmer SJ, Taylor KM, Arthurson GJ, Spitzer MW, Du X, Pang TY, Renoir T, Hardeman EC, Hannan AJ.

Neurobiol Dis. 2012 Mar;45(3):913-22. doi: 10.1016/j.nbd.2011.12.010. Epub 2011 Dec 11.

PMID:
22198572
41.

Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy.

Nguyen MA, Joya JE, Kee AJ, Domazetovska A, Yang N, Hook JW, Lemckert FA, Kettle E, Valova VA, Robinson PJ, North KN, Gunning PW, Mitchell CA, Hardeman EC.

Brain. 2011 Dec;134(Pt 12):3516-29. doi: 10.1093/brain/awr274. Epub 2011 Nov 8.

PMID:
22067542
42.

The Ski proto-oncogene regulates body composition and suppresses lipogenesis.

Leong GM, Kee AJ, Millard SM, Martel N, Eriksson N, Turner N, Cooney GJ, Hardeman EC, Muscat GE.

Int J Obes (Lond). 2010 Mar;34(3):524-36. doi: 10.1038/ijo.2009.265. Epub 2009 Dec 22.

PMID:
20029376
43.

Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism.

Palmer SJ, Santucci N, Widagdo J, Bontempo SJ, Taylor KM, Tay ES, Hook J, Lemckert F, Gunning PW, Hardeman EC.

J Biol Chem. 2010 Feb 12;285(7):4715-24. doi: 10.1074/jbc.M109.086660. Epub 2009 Dec 9.

44.

Diverse roles of the actin cytoskeleton in striated muscle.

Kee AJ, Gunning PW, Hardeman EC.

J Muscle Res Cell Motil. 2009;30(5-6):187-97. doi: 10.1007/s10974-009-9193-x. Epub 2009 Dec 8. Review.

PMID:
19997772
45.

A cytoskeletal tropomyosin can compromise the structural integrity of skeletal muscle.

Kee AJ, Gunning PW, Hardeman EC.

Cell Motil Cytoskeleton. 2009 Sep;66(9):710-20. doi: 10.1002/cm.20400.

PMID:
19530183
46.

Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle.

Lee AS, Kahatapitiya P, Kramer B, Joya JE, Hook J, Liu R, Schevzov G, Alexander IE, McCowage G, Montarras D, Gunning PW, Hardeman EC.

Stem Cells. 2009 May;27(5):1098-108. doi: 10.1002/stem.28.

47.

Tropomyosins in skeletal muscle diseases.

Kee AJ, Hardeman EC.

Adv Exp Med Biol. 2008;644:143-57. Review.

PMID:
19209820
48.

Mouse models for thin filament disease.

Nguyen MA, Hardeman EC.

Adv Exp Med Biol. 2008;642:66-77. Review.

PMID:
19181094
49.

Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy.

Cowling BS, McGrath MJ, Nguyen MA, Cottle DL, Kee AJ, Brown S, Schessl J, Zou Y, Joya J, Bönnemann CG, Hardeman EC, Mitchell CA.

J Cell Biol. 2008 Dec 15;183(6):1033-48. doi: 10.1083/jcb.200804077.

50.

Cytoskeletal tropomyosin Tm5NM1 is required for normal excitation-contraction coupling in skeletal muscle.

Vlahovich N, Kee AJ, Van der Poel C, Kettle E, Hernandez-Deviez D, Lucas C, Lynch GS, Parton RG, Gunning PW, Hardeman EC.

Mol Biol Cell. 2009 Jan;20(1):400-9. doi: 10.1091/mbc.E08-06-0616. Epub 2008 Nov 12.

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