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Real-Time Image-Guided Ablative Prostate Cancer Radiation Therapy: Results from the TROG 15.01 SPARK Trial.

Keall P, Nguyen DT, O'Brien R, Hewson E, Ball H, Poulsen P, Booth J, Greer P, Hunter P, Wilton L, Bromley R, Kipritidis J, Eade T, Kneebone A, Hruby G, Moodie T, Hayden A, Turner S, Arumugam S, Sidhom M, Hardcastle N, Siva S, Tai KH, Gebski V, Martin J.

Int J Radiat Oncol Biol Phys. 2020 Mar 29. pii: S0360-3016(20)30937-8. doi: 10.1016/j.ijrobp.2020.03.014. [Epub ahead of print]


Lentiviral Vector Induced Modeling of High-Grade Spinal Cord Glioma in Minipigs.

Tora MS, Texakalidis P, Neill S, Wetzel J, Rindler RS, Hardcastle N, Nagarajan PP, Krasnopeyev A, Roach C, James R, Bruce JN, Canoll P, Federici T, Oshinski JN, Boulis NM.

Sci Rep. 2020 Mar 24;10(1):5291. doi: 10.1038/s41598-020-62167-9.


Credentialing of vertebral stereotactic ablative body radiotherapy in a multi-centre trial.

Hardcastle N, Kron T, Cook O, Lehmann J, Mitchell PLR, Siva S.

Phys Med. 2020 Mar 16;72:16-21. doi: 10.1016/j.ejmp.2020.03.004. [Epub ahead of print]


Upright Radiation Therapy-A Historical Reflection and Opportunities for Future Applications.

Rahim S, Korte J, Hardcastle N, Hegarty S, Kron T, Everitt S.

Front Oncol. 2020 Feb 25;10:213. doi: 10.3389/fonc.2020.00213. eCollection 2020. Review.


Extending Aging of Beef Longissimus Lumborum From 21 to 84 Days Postmortem Influences Consumer Eating Quality.

Garmyn A, Hardcastle N, Polkinghorne R, Lucherk L, Miller M.

Foods. 2020 Feb 17;9(2). pii: E208. doi: 10.3390/foods9020208.


Exploring Consumer Palatability of Australian Beef Fajita Meat Enhanced with Phosphate or Sodium Bicarbonate.

Garmyn A, Hardcastle N, Bendele C, Polkinghorne R, Miller M.

Foods. 2020 Feb 11;9(2). pii: E177. doi: 10.3390/foods9020177.


Independent review of 4DCT scans used for SABR treatment planning.

Antony R, Lonski P, Ungureanu E, Hardcastle N, Yeo A, Siva S, Kron T.

J Appl Clin Med Phys. 2020 Mar;21(3):62-67. doi: 10.1002/acm2.12825. Epub 2020 Feb 13.


Frameless Stereotactic Targeting of the Cerebellar Dentate Nucleus in Nonhuman Primates: Translatable Model for the Surgical Delivery of Gene Therapy.

Wetzel JS, Hardcastle N, Tora MS, Federici T, Frey S, Novek J, Arulanandam T, Johnson M, Pielemeier R, Boulis NM.

Stereotact Funct Neurosurg. 2019;97(5-6):293-302. doi: 10.1159/000504858. Epub 2020 Jan 8.


A future of automated image contouring with machine learning in radiation therapy.

Jackson P, Kron T, Hardcastle N.

J Med Radiat Sci. 2019 Dec;66(4):223-225. doi: 10.1002/jmrs.365.


Minimally Invasive Injection to the Phrenic Nerve in a Porcine Hemidiaphragmatic Paralysis Model: A Pilot Study.

Texakalidis P, Tora MS, Canute S, Hardcastle N, Poth K, Donsante A, Federici T, Javidfar J, Boulis NM.

Neurosurgery. 2019 Oct 18. pii: nyz473. doi: 10.1093/neuros/nyz473. [Epub ahead of print]


NaF PET/CT for response assessment of prostate cancer bone metastases treated with single fraction stereotactic ablative body radiotherapy.

Hardcastle N, Hofman MS, Lee CY, Callahan J, Selbie L, Foroudi F, Shaw M, Chander S, Lim A, Chesson B, Murphy DG, Kron T, Siva S.

Radiat Oncol. 2019 Sep 5;14(1):164. doi: 10.1186/s13014-019-1359-0.


Functional restoration of elbow flexion in nonobstetric brachial plexus injuries: A meta-analysis of nerve transfers versus grafts.

Texakalidis P, Hardcastle N, Tora MS, Boulis NM.

Microsurgery. 2020 Feb;40(2):261-267. doi: 10.1002/micr.30510. Epub 2019 Sep 4. Review.


The accuracy and precision of the KIM motion monitoring system used in the multi-institutional TROG 15.01 Stereotactic Prostate Ablative Radiotherapy with KIM (SPARK) trial.

Hewson EA, Nguyen DT, O'Brien R, Kim JH, Montanaro T, Moodie T, Greer PB, Hardcastle N, Eade T, Kneebone A, Hruby G, Hayden AJ, Turner S, Siva S, Tai KH, Hunter P, Sams J, Poulsen PR, Booth JT, Martin J, Keall PJ.

Med Phys. 2019 Nov;46(11):4725-4737. doi: 10.1002/mp.13784. Epub 2019 Sep 20.


Systematic endobronchial ultrasound-guided transbronchial needle aspiration improves radiotherapy planning in non-small cell lung cancer.

Cole AJ, Hardcastle N, Turgeon GA, Thomas R, Irving LB, Jennings BR, Ball D, Kron T, Steinfort DP, Siva S.

ERJ Open Res. 2019 Jul 15;5(3). pii: 00004-2019. doi: 10.1183/23120541.00004-2019. eCollection 2019 Jul.


Clinical impact of removing respiratory motion during liver SABR.

Gargett M, Haddad C, Kneebone A, Booth JT, Hardcastle N.

Radiat Oncol. 2019 Jun 3;14(1):93. doi: 10.1186/s13014-019-1300-6.


Both four-dimensional computed tomography and four-dimensional cone beam computed tomography under-predict lung target motion during radiotherapy.

Steiner E, Shieh CC, Caillet V, Booth J, O'Brien R, Briggs A, Hardcastle N, Jayamanne D, Szymura K, Eade T, Keall P.

Radiother Oncol. 2019 Jun;135:65-73. doi: 10.1016/j.radonc.2019.02.019. Epub 2019 Mar 14.


Recovery of shoulder abduction in traumatic brachial plexus palsy: a systematic review and meta-analysis of nerve transfer versus nerve graft.

Hardcastle N, Texakalidis P, Nagarajan P, Tora MS, Boulis NM.

Neurosurg Rev. 2019 Apr 17. doi: 10.1007/s10143-019-01100-9. [Epub ahead of print] Review.


Elbow flexion in neonatal brachial plexus palsy: a meta-analysis of graft versus transfer.

Tora MS, Hardcastle N, Texakalidis P, Wetzel J, Chern JJ.

Childs Nerv Syst. 2019 Jun;35(6):929-935. doi: 10.1007/s00381-019-04133-z. Epub 2019 Mar 28. Review.


The VAMPIRE challenge: A multi-institutional validation study of CT ventilation imaging.

Kipritidis J, Tahir BA, Cazoulat G, Hofman MS, Siva S, Callahan J, Hardcastle N, Yamamoto T, Christensen GE, Reinhardt JM, Kadoya N, Patton TJ, Gerard SE, Duarte I, Archibald-Heeren B, Byrne M, Sims R, Ramsay S, Booth JT, Eslick E, Hegi-Johnson F, Woodruff HC, Ireland RH, Wild JM, Cai J, Bayouth JE, Brock K, Keall PJ.

Med Phys. 2019 Mar;46(3):1198-1217. doi: 10.1002/mp.13346. Epub 2019 Feb 1.


TROG 15.03 phase II clinical trial of Focal Ablative STereotactic Radiosurgery for Cancers of the Kidney - FASTRACK II.

Siva S, Chesson B, Bressel M, Pryor D, Higgs B, Reynolds HM, Hardcastle N, Montgomery R, Vanneste B, Khoo V, Ruben J, Lau E, Hofman MS, De Abreu Lourenco R, Sridharan S, Brook NR, Martin J, Lawrentschuk N, Kron T, Foroudi F.

BMC Cancer. 2018 Oct 23;18(1):1030. doi: 10.1186/s12885-018-4916-2.


An augmented correlation framework for the estimation of tumour translational and rotational motion during external beam radiotherapy treatments using intermittent monoscopic x-ray imaging and an external respiratory signal.

Nguyen DT, Booth JT, Caillet V, Hardcastle N, Briggs A, Haddad C, Eade T, O'Brien R, Keall PJ.

Phys Med Biol. 2018 Oct 9;63(20):205003. doi: 10.1088/1361-6560/aadf2c.


Comparison of radiobiological parameters for 90Y radionuclide therapy (RNT) and external beam radiotherapy (EBRT) in vitro.

Gholami YH, Willowson KP, Forwood NJ, Harvie R, Hardcastle N, Bromley R, Ryu H, Yuen S, Howell VM, Kuncic Z, Bailey DL.

EJNMMI Phys. 2018 Sep 3;5(1):18. doi: 10.1186/s40658-018-0217-8.


Functional lung imaging in radiation therapy for lung cancer: A systematic review and meta-analysis.

Bucknell NW, Hardcastle N, Bressel M, Hofman MS, Kron T, Ball D, Siva S.

Radiother Oncol. 2018 Nov;129(2):196-208. doi: 10.1016/j.radonc.2018.07.014. Epub 2018 Aug 3.


Deep Learning Renal Segmentation for Fully Automated Radiation Dose Estimation in Unsealed Source Therapy.

Jackson P, Hardcastle N, Dawe N, Kron T, Hofman MS, Hicks RJ.

Front Oncol. 2018 Jun 14;8:215. doi: 10.3389/fonc.2018.00215. eCollection 2018.


Future forum, Hobart, October 29, 2017: examining the role of medical physics in cancer research.

Ebert MA, Hardcastle N, Kron T.

Australas Phys Eng Sci Med. 2018 Sep;41(3):571-579. doi: 10.1007/s13246-018-0659-2. Epub 2018 Jun 25.


4-Dimensional Cone Beam Computed Tomography-Measured Target Motion Underrepresents Actual Motion.

Steiner E, Shieh CC, Caillet V, Booth J, Hardcastle N, Briggs A, Jayamanne D, Haddad C, Eade T, Keall P.

Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):932-940. doi: 10.1016/j.ijrobp.2018.04.056. Epub 2018 Apr 27.


A novel high-resolution 2D silicon array detector for small field dosimetry with FFF photon beams.

Biasi G, Petasecca M, Guatelli S, Hardcastle N, Carolan M, Perevertaylo V, Kron T, Rosenfeld AB.

Phys Med. 2018 Jan;45:117-126. doi: 10.1016/j.ejmp.2017.12.010. Epub 2017 Dec 20.


Credentialing of radiotherapy centres in Australasia for TROG 09.02 (Chisel), a Phase III clinical trial on stereotactic ablative body radiotherapy of early stage lung cancer.

Kron T, Chesson B, Hardcastle N, Crain M, Clements N, Burns M, Ball D.

Br J Radiol. 2018 May;91(1085):20170737. doi: 10.1259/bjr.20170737. Epub 2018 Mar 6.


AAV gene delivery to the spinal cord: serotypes, methods, candidate diseases, and clinical trials.

Hardcastle N, Boulis NM, Federici T.

Expert Opin Biol Ther. 2018 Mar;18(3):293-307. doi: 10.1080/14712598.2018.1416089. Epub 2017 Dec 18. Review.


Experience with an abdominal compression band for radiotherapy of upper abdominal tumours.

Van Gelder R, Wong S, Le A, Podreka A, Briggs A, Haddad C, Hardcastle N.

J Med Radiat Sci. 2018 Mar;65(1):48-54. doi: 10.1002/jmrs.254. Epub 2017 Dec 5.


Experimental verification of dose enhancement effects in a lung phantom from inline magnetic fields.

Oborn BM, Gargett MA, Causer TJ, Alnaghy SJ, Hardcastle N, Metcalfe PE, Keall PJ.

Radiother Oncol. 2017 Dec;125(3):433-438. doi: 10.1016/j.radonc.2017.09.012. Epub 2017 Oct 3.


MLC tracking for lung SABR reduces planning target volumes and dose to organs at risk.

Caillet V, Keall PJ, Colvill E, Hardcastle N, O'Brien R, Szymura K, Booth JT.

Radiother Oncol. 2017 Jul;124(1):18-24. doi: 10.1016/j.radonc.2017.06.016. Epub 2017 Jun 24.


A Bayesian approach for three-dimensional markerless tumor tracking using kV imaging during lung radiotherapy.

Shieh CC, Caillet V, Dunbar M, Keall PJ, Booth JT, Hardcastle N, Haddad C, Eade T, Feain I.

Phys Med Biol. 2017 Apr 21;62(8):3065-3080. doi: 10.1088/1361-6560/aa6393. Epub 2017 Mar 21.


Serotonin and arginine-vasopressin mediate sex differences in the regulation of dominance and aggression by the social brain.

Terranova JI, Song Z, Larkin TE 2nd, Hardcastle N, Norvelle A, Riaz A, Albers HE.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13233-13238. Epub 2016 Nov 2.


The first patient treatment of electromagnetic-guided real time adaptive radiotherapy using MLC tracking for lung SABR.

Booth JT, Caillet V, Hardcastle N, O'Brien R, Szymura K, Crasta C, Harris B, Haddad C, Eade T, Keall PJ.

Radiother Oncol. 2016 Oct;121(1):19-25. doi: 10.1016/j.radonc.2016.08.025. Epub 2016 Sep 17.


On the use of a convolution-superposition algorithm for plan checking in lung stereotactic body radiation therapy.

Hardcastle N, Oborn BM, Haworth A.

J Appl Clin Med Phys. 2016 Sep 8;17(5):99-110. doi: 10.1120/jacmp.v17i5.6186.


Australia and New Zealand Faculty of Radiation Oncology Lung Interest Cooperative: 2015 consensus guidelines for the use of advanced technologies in the radiation therapy treatment of locally advanced non-small cell lung cancer.

Dwyer PM, Lao L, Ruben JD, Yap ML, Siva S, Hegi-Johnson F, Hardcastle N, Barber J, Lehman M, Ball D, Vinod SK.

J Med Imaging Radiat Oncol. 2016 Oct;60(5):686-692. doi: 10.1111/1754-9485.12501. Epub 2016 Jul 28. No abstract available.


A Multidisciplinary Evaluation of a Web-based eLearning Training Programme for SAFRON II (TROG 13.01): a Multicentre Randomised Study of Stereotactic Radiotherapy for Lung Metastases.

Pham D, Hardcastle N, Foroudi F, Kron T, Bressel M, Hilder B, Chesson B, Oates R, Montgomery R, Ball D, Siva S.

Clin Oncol (R Coll Radiol). 2016 Sep;28(9):e101-8. doi: 10.1016/j.clon.2016.03.005. Epub 2016 Apr 23.


A randomised phase II trial of Stereotactic Ablative Fractionated radiotherapy versus Radiosurgery for Oligometastatic Neoplasia to the lung (TROG 13.01 SAFRON II).

Siva S, Kron T, Bressel M, Haas M, Mai T, Vinod S, Sasso G, Wong W, Le H, Eade T, Hardcastle N, Chesson B, Pham D, Høyer M, Montgomery R, Ball D.

BMC Cancer. 2016 Mar 4;16:183. doi: 10.1186/s12885-016-2227-z.


Dose enhancement in radiotherapy of small lung tumors using inline magnetic fields: A Monte Carlo based planning study.

Oborn BM, Ge Y, Hardcastle N, Metcalfe PE, Keall PJ.

Med Phys. 2016 Jan;43(1):368. doi: 10.1118/1.4938580.


Image guidance and stabilization for stereotactic ablative body radiation therapy (SABR) treatment of primary kidney cancer.

Pham D, Kron T, Bressel M, Foroudi F, Hardcastle N, Schneider M, Soteriou S, Innes J, Siva S.

Pract Radiat Oncol. 2015 Nov-Dec;5(6):e597-605. doi: 10.1016/j.prro.2015.08.002. Epub 2015 Aug 20.


Accuracy and Utility of Deformable Image Registration in (68)Ga 4D PET/CT Assessment of Pulmonary Perfusion Changes During and After Lung Radiation Therapy.

Hardcastle N, Hofman MS, Hicks RJ, Callahan J, Kron T, MacManus MP, Ball DL, Jackson P, Siva S.

Int J Radiat Oncol Biol Phys. 2015 Sep 1;93(1):196-204. doi: 10.1016/j.ijrobp.2015.05.011. Epub 2015 May 14.


Ventilation/Perfusion Positron Emission Tomography--Based Assessment of Radiation Injury to Lung.

Siva S, Hardcastle N, Kron T, Bressel M, Callahan J, MacManus MP, Shaw M, Plumridge N, Hicks RJ, Steinfort D, Ball DL, Hofman MS.

Int J Radiat Oncol Biol Phys. 2015 Oct 1;93(2):408-17. doi: 10.1016/j.ijrobp.2015.06.005. Epub 2015 Jun 9.


Dosimetric Consequences of 3D Versus 4D PET/CT for Target Delineation of Lung Stereotactic Radiotherapy.

Siva S, Chesson B, Callahan JW, Hardcastle N, Crawford L, Antippa P, Wright G, MacManus MP, Hicks RJ, Kron T, Ball DL.

J Thorac Oncol. 2015 Jul;10(7):1112-5. doi: 10.1097/JTO.0000000000000555.


High-resolution pulmonary ventilation and perfusion PET/CT allows for functionally adapted intensity modulated radiotherapy in lung cancer.

Siva S, Thomas R, Callahan J, Hardcastle N, Pham D, Kron T, Hicks RJ, MacManus MP, Ball DL, Hofman MS.

Radiother Oncol. 2015 May;115(2):157-62. doi: 10.1016/j.radonc.2015.04.013. Epub 2015 Apr 29.


Calculating integral dose using data exported from a commercial record and verify system.

Fox C, Hardcastle N, Lim A, Khor R.

Australas Phys Eng Sci Med. 2015 Jun;38(2):283-8. doi: 10.1007/s13246-015-0341-x. Epub 2015 Apr 14.


Ga-68 MAA Perfusion 4D-PET/CT Scanning Allows for Functional Lung Avoidance Using Conformal Radiation Therapy Planning.

Siva S, Devereux T, Ball DL, MacManus MP, Hardcastle N, Kron T, Bressel M, Foroudi F, Plumridge N, Steinfort D, Shaw M, Callahan J, Hicks RJ, Hofman MS.

Technol Cancer Res Treat. 2016 Feb;15(1):114-21. doi: 10.1177/1533034614565534. Epub 2015 Jan 9.


Predictors of respiratory-induced lung tumour motion measured on four-dimensional computed tomography.

Tan KV, Thomas R, Hardcastle N, Pham D, Kron T, Foroudi F, Ball D, Te Marvelde L, Bressel M, Siva S.

Clin Oncol (R Coll Radiol). 2015 Apr;27(4):197-204. doi: 10.1016/j.clon.2014.12.001. Epub 2014 Dec 27.


Cutaneous leishmaniasis acquired during a brief visit to Cyprus.

de Silva TI, Debroy Kidambi A, Green ST, Mahadeva U, Mcgregor AC, Levy M, Hardcastle N.

J Infect. 2015 Mar;70(3):314-6. doi: 10.1016/j.jinf.2014.11.001. Epub 2014 Nov 15. No abstract available.


Short communication: timeline of radiation-induced kidney function loss after stereotactic ablative body radiotherapy of renal cell carcinoma as evaluated by serial (99m)Tc-DMSA SPECT/CT.

Jackson P, Foroudi F, Pham D, Hofman MS, Hardcastle N, Callahan J, Kron T, Siva S.

Radiat Oncol. 2014 Nov 26;9:253. doi: 10.1186/s13014-014-0253-z.

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