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Items: 24


The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state.

Tavoulari S, Thangaratnarajah C, Mavridou V, Harbour ME, Martinou JC, Kunji ER.

EMBO J. 2019 May 15;38(10). pii: e100785. doi: 10.15252/embj.2018100785. Epub 2019 Apr 12.


The F1 -ATPase from Trypanosoma brucei is elaborated by three copies of an additional p18-subunit.

Gahura O, Šubrtová K, Váchová H, Panicucci B, Fearnley IM, Harbour ME, Walker JE, Zíková A.

FEBS J. 2018 Feb;285(3):614-628. doi: 10.1111/febs.14364. Epub 2017 Dec 30.


TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III.

Bottani E, Cerutti R, Harbour ME, Ravaglia S, Dogan SA, Giordano C, Fearnley IM, D'Amati G, Viscomi C, Fernandez-Vizarra E, Zeviani M.

Mol Cell. 2017 Jul 6;67(1):96-105.e4. doi: 10.1016/j.molcel.2017.06.001. Epub 2017 Jun 29.


MR-1S Interacts with PET100 and PET117 in Module-Based Assembly of Human Cytochrome c Oxidase.

Vidoni S, Harbour ME, Guerrero-Castillo S, Signes A, Ding S, Fearnley IM, Taylor RW, Tiranti V, Arnold S, Fernandez-Vizarra E, Zeviani M.

Cell Rep. 2017 Feb 14;18(7):1727-1738. doi: 10.1016/j.celrep.2017.01.044.


Subunit NDUFV3 is present in two distinct isoforms in mammalian complex I.

Bridges HR, Mohammed K, Harbour ME, Hirst J.

Biochim Biophys Acta Bioenerg. 2017 Mar;1858(3):197-207. doi: 10.1016/j.bbabio.2016.12.001. Epub 2016 Dec 8.


Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster.

Menger KE, James AM, Cochemé HM, Harbour ME, Chouchani ET, Ding S, Fearnley IM, Partridge L, Murphy MP.

Cell Rep. 2015 Nov 10;13(6):1285. doi: 10.1016/j.celrep.2015.10.048. Epub 2015 Nov 10. No abstract available.


Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster.

Menger KE, James AM, Cochemé HM, Harbour ME, Chouchani ET, Ding S, Fearnley IM, Partridge L, Murphy MP.

Cell Rep. 2015 Jun 30;11(12):1856-65. doi: 10.1016/j.celrep.2015.05.033. Epub 2015 Jun 18. Erratum in: Cell Rep. 2015 Nov 10;13(6):1285.


The purification and characterization of ATP synthase complexes from the mitochondria of four fungal species.

Liu S, Charlesworth TJ, Bason JV, Montgomery MG, Harbour ME, Fearnley IM, Walker JE.

Biochem J. 2015 May 15;468(1):167-75. doi: 10.1042/BJ20150197.


VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface.

Hesketh GG, Pérez-Dorado I, Jackson LP, Wartosch L, Schäfer IB, Gray SR, McCoy AJ, Zeldin OB, Garman EF, Harbour ME, Evans PR, Seaman MNJ, Luzio JP, Owen DJ.

Dev Cell. 2014 Jun 9;29(5):591-606. doi: 10.1016/j.devcel.2014.04.010. Epub 2014 May 22.


Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy.

Zavodszky E, Seaman MN, Moreau K, Jimenez-Sanchez M, Breusegem SY, Harbour ME, Rubinsztein DC.

Nat Commun. 2014 May 13;5:3828. doi: 10.1038/ncomms4828.


Tapasin-related protein TAPBPR is an additional component of the MHC class I presentation pathway.

Boyle LH, Hermann C, Boname JM, Porter KM, Patel PA, Burr ML, Duncan LM, Harbour ME, Rhodes DA, Skjødt K, Lehner PJ, Trowsdale J.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3465-70. doi: 10.1073/pnas.1222342110. Epub 2013 Feb 11.


Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer.

Helfer E, Harbour ME, Henriot V, Lakisic G, Sousa-Blin C, Volceanov L, Seaman MNJ, Gautreau A.

Biol Cell. 2013 May;105(5):191-207. doi: 10.1111/boc.201200038. Epub 2013 Mar 7.


Identification of Alzheimer disease-associated variants in genes that regulate retromer function.

Vardarajan BN, Bruesegem SY, Harbour ME, Inzelberg R, Friedland R, St George-Hyslop P, Seaman MN, Farrer LA.

Neurobiol Aging. 2012 Sep;33(9):2231.e15-2231.e30. doi: 10.1016/j.neurobiolaging.2012.04.020. Epub 2012 Jun 5. Erratum in: Neurobiol Aging. 2013 Jul;34(7):1923. Inzelberg, Rivka [added]; Friedland, Robert [added].


Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35.

Harbour ME, Breusegem SY, Seaman MN.

Biochem J. 2012 Feb 15;442(1):209-20. doi: 10.1042/BJ20111761.


Evolutionary variations of VPS29, and their implications for the heteropentameric model of retromer.

Harbour ME, Seaman MN.

Commun Integr Biol. 2011 Sep;4(5):619-22. doi: 10.4161/cib.4.5.16855. Epub 2011 Sep 1.


Actin and myosin contribute to mammalian mitochondrial DNA maintenance.

Reyes A, He J, Mao CC, Bailey LJ, Di Re M, Sembongi H, Kazak L, Dzionek K, Holmes JB, Cluett TJ, Harbour ME, Fearnley IM, Crouch RJ, Conti MA, Adelstein RS, Walker JE, Holt IJ.

Nucleic Acids Res. 2011 Jul;39(12):5098-108. doi: 10.1093/nar/gkr052. Epub 2011 Mar 11.


Evolution of respiratory complex I: "supernumerary" subunits are present in the alpha-proteobacterial enzyme.

Yip CY, Harbour ME, Jayawardena K, Fearnley IM, Sazanov LA.

J Biol Chem. 2011 Feb 18;286(7):5023-33. doi: 10.1074/jbc.M110.194993. Epub 2010 Nov 29.


The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics.

Harbour ME, Breusegem SY, Antrobus R, Freeman C, Reid E, Seaman MN.

J Cell Sci. 2010 Nov 1;123(Pt 21):3703-17. doi: 10.1242/jcs.071472. Epub 2010 Oct 5.


Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells.

Hirst J, Sahlender DA, Choma M, Sinka R, Harbour ME, Parkinson M, Robinson MS.

Traffic. 2009 Nov;10(11):1696-710.


Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.

Seaman MN, Harbour ME, Tattersall D, Read E, Bright N.

J Cell Sci. 2009 Jul 15;122(Pt 14):2371-82. doi: 10.1242/jcs.048686. Epub 2009 Jun 16.


The respiratory complexes I from the mitochondria of two Pichia species.

Bridges HR, Grgic L, Harbour ME, Hirst J.

Biochem J. 2009 Jul 29;422(1):151-9. doi: 10.1042/BJ20090492.


Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: implications for mitochondrial redox signaling.

Hurd TR, Prime TA, Harbour ME, Lilley KS, Murphy MP.

J Biol Chem. 2007 Jul 27;282(30):22040-51. Epub 2007 May 24.


The mimivirus genome encodes a mitochondrial carrier that transports dATP and dTTP.

Monné M, Robinson AJ, Boes C, Harbour ME, Fearnley IM, Kunji ER.

J Virol. 2007 Apr;81(7):3181-6. Epub 2007 Jan 17.


Proliferative response of different human osteoblast-like cell models to proinflammatory cytokines.

Harbour ME, Gregory JW, Jenkins HR, Evans BA.

Pediatr Res. 2000 Aug;48(2):163-8.


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