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Items: 1 to 50 of 277

1.

Selective Phenylimidazole-based Inhibitors of the Mycobacterium tuberculosis Proteasome.

Zhan W, Hsu HC, Morgan T, Ouellette T, Burns-Huang K, Hara R, Wright AG, Imaeda T, Okamoto R, Sato K, Michino M, Ramjee M, Aso K, Meinke P, Foley M, Nathan CF, Li H, Lin G.

J Med Chem. 2019 Sep 27. doi: 10.1021/acs.jmedchem.9b01187. [Epub ahead of print]

PMID:
31560200
2.

Tonic suppression of the mesolimbic dopaminergic system by enhanced corticotropin-releasing factor signaling within the bed nucleus of the stria terminalis in chronic pain model rats.

Takahashi D, Asaoka Y, Kimura K, Hara R, Arakaki S, Sakasai K, Suzuki H, Yamauchi N, Nomura H, Amano T, Minami M.

J Neurosci. 2019 Aug 26. pii: 3047-18. doi: 10.1523/JNEUROSCI.3047-18.2019. [Epub ahead of print]

PMID:
31451580
3.

Effect of ICRU report 90 recommendations on Monte Carlo calculated kQ for ionization chambers listed in the Addendum to AAPM's TG-51 protocol.

Kawachi T, Saitoh H, Katayose T, Tohyama N, Miyasaka R, Cho SY, Iwase T, Hara R.

Med Phys. 2019 Aug 6. doi: 10.1002/mp.13743. [Epub ahead of print]

PMID:
31386762
4.

Evaluation of gantry angle during respiratory-gated VMAT using triggered kilovoltage x-ray image.

Miyasaka R, Saitoh H, Kawachi T, Katayose T, Cho S, Yamauchi R, Hara R.

J Appl Clin Med Phys. 2019 Aug;20(8):98-104. doi: 10.1002/acm2.12683. Epub 2019 Jul 29.

5.

Highly efficient silencing of microRNA by heteroduplex oligonucleotides.

Yoshioka K, Kunieda T, Asami Y, Guo H, Miyata H, Yoshida-Tanaka K, Sujino Y, Piao W, Kuwahara H, Nishina K, Hara RI, Nagata T, Wada T, Obika S, Yokota T.

Nucleic Acids Res. 2019 Aug 22;47(14):7321-7332. doi: 10.1093/nar/gkz492.

6.

Intra-abdominal desmoid tumor mimicking local recurrence of renal cell carcinoma after laparoscopic partial nephrectomy.

Hara R, Fujii T, Ohira S, Kaifu M, Miyaji Y, Nagai A.

Urol Case Rep. 2019 Mar 15;24:100865. doi: 10.1016/j.eucr.2019.100865. eCollection 2019 May.

7.

Does Abatacept Increase Postoperative Adverse Events in Rheumatoid Arthritis Compared with Conventional Synthetic Disease-modifying Drugs?

Ito H, Tsuji S, Nakayama M, Mochida Y, Nishida K, Ishikawa H, Kojima T, Matsumoto T, Kubota A, Mochizuki T, Sakuraba K, Matsushita I, Nakajima A, Hara R, Haraguchi A, Matsubara T, Kanbe K, Nakagawa N, Hamaguchi M, Momohara S; JOSRA Consortium.

J Rheumatol. 2019 Jun 15. pii: jrheum.181100. doi: 10.3899/jrheum.181100. [Epub ahead of print]

PMID:
31203226
8.

Stereocontrolled Synthesis of Boranophosphate DNA by an Oxazaphospholidine Approach and Evaluation of Its Properties.

Hara RI, Saito T, Kogure T, Hamamura Y, Uchiyama N, Nukaga Y, Iwamoto N, Wada T.

J Org Chem. 2019 Jun 21;84(12):7971-7983. doi: 10.1021/acs.joc.9b00658. Epub 2019 Jun 6.

PMID:
31140804
9.

Ectoine hydroxylase displays selective trans-3-hydroxylation activity towards L-proline.

Hara R, Nishikawa T, Okuhara T, Koketsu K, Kino K.

Appl Microbiol Biotechnol. 2019 Jul;103(14):5689-5698. doi: 10.1007/s00253-019-09868-y. Epub 2019 May 20.

PMID:
31106391
10.

Drug tolerability and reasons for discontinuation of seven biologics in elderly patients with rheumatoid arthritis -The ANSWER cohort study.

Ebina K, Hashimoto M, Yamamoto W, Hirano T, Hara R, Katayama M, Onishi A, Nagai K, Son Y, Amuro H, Yamamoto K, Maeda Y, Murata K, Jinno S, Takeuchi T, Hirao M, Kumanogoh A, Yoshikawa H.

PLoS One. 2019 May 8;14(5):e0216624. doi: 10.1371/journal.pone.0216624. eCollection 2019.

11.

Correction to: Drug tolerability and reasons for discontinuation of seven biologics in 4466 treatment courses of rheumatoid arthritis-the ANSWER cohort study.

Ebina K, Hashimoto M, Yamamoto W, Hirano T, Hara R, Katayama M, Onishi A, Nagai K, Son Y, Amuro H, Yamamoto K, Maeda Y, Murata K, Jinno S, Takeuchi T, Hirao M, Kumanogoh A, Yoshikawa H.

Arthritis Res Ther. 2019 May 6;21(1):114. doi: 10.1186/s13075-019-1897-8.

12.

Intravenous abatacept in Japanese patients with polyarticular-course juvenile idiopathic arthritis: results from a phase III open-label study.

Hara R, Umebayashi H, Takei S, Okamoto N, Iwata N, Yamasaki Y, Nakagishi Y, Kizawa T, Kobayashi I, Imagawa T, Kinjo N, Amano N, Takahashi Y, Mori M, Itoh Y, Yokota S.

Pediatr Rheumatol Online J. 2019 Apr 30;17(1):17. doi: 10.1186/s12969-019-0319-4.

13.

Synthesis of d-Amino Acid-Containing Dipeptides Using the Adenylation Domains of Nonribosomal Peptide Synthetase.

Kano S, Suzuki S, Hara R, Kino K.

Appl Environ Microbiol. 2019 Jun 17;85(13). pii: e00120-19. doi: 10.1128/AEM.00120-19. Print 2019 Jul 1.

PMID:
31003981
14.

Clinical features and characteristics of uveitis associated with juvenile idiopathic arthritis in Japan: first report of the pediatric rheumatology association of Japan (PRAJ).

Yasumura J, Yashiro M, Okamoto N, Shabana K, Umebayashi H, Iwata N, Okura Y, Kubota T, Shimizu M, Tomiita M, Nakagishi Y, Nishimura K, Hara R, Mizuta M, Yasumi T, Yamaide F, Wakiguchi H, Kobayashi M, Mori M.

Pediatr Rheumatol Online J. 2019 Apr 11;17(1):15. doi: 10.1186/s12969-019-0318-5.

15.

Drug tolerability and reasons for discontinuation of seven biologics in 4466 treatment courses of rheumatoid arthritis-the ANSWER cohort study.

Ebina K, Hashimoto M, Yamamoto W, Hirano T, Hara R, Katayama M, Onishi A, Nagai K, Son Y, Amuro H, Yamamoto K, Maeda Y, Murata K, Jinno S, Takeuchi T, Hirao M, Kumanogoh A, Yoshikawa H.

Arthritis Res Ther. 2019 Apr 11;21(1):91. doi: 10.1186/s13075-019-1880-4. Erratum in: Arthritis Res Ther. 2019 May 6;21(1):114.

16.

A Case of Composite Lymphoma with Extranodal NK/T-cell Lymphoma, Nasal-type and Diffuse Large B-cell Lymphoma.

Kawai H, Matsushita H, Kawakami S, Furuya D, Shiraiwa-Hara S, Ichiki A, Hara R, Aoyama Y, Ogiya D, Suzuki R, Machida S, Onizuka M, Shirasugi Y, Ogawa Y, Kawada H, Nakamura N, Ando K.

J Clin Exp Hematop. 2019;59(1):34-39. doi: 10.3960/jslrt.18038.

17.

Synthesis of [Mo3S4] Clusters from Half-Sandwich Molybdenum(V) Chlorides and Their Application as Platforms for [Mo3S4Fe] Cubes.

Ohki Y, Hara R, Munakata K, Tada M, Takayama T, Sakai Y, Cramer RE.

Inorg Chem. 2019 Apr 15;58(8):5230-5240. doi: 10.1021/acs.inorgchem.9b00309. Epub 2019 Mar 22.

PMID:
30900879
18.

A multi-institutional observational study on the effects of three-dimensional radiotherapy and weekly 40-mg/m2 cisplatin on postoperative uterine cervical cancer patients with high-risk prognostic factors.

Isohashi F, Takano T, Onuki M, Arimoto T, Kawamura N, Hara R, Kawano Y, Ota Y, Inokuchi H, Shinjo H, Saito T, Fujiwara S, Sawasaki T, Ando K, Horie K, Okamoto H, Murakami N, Hasumi Y, Kasamatsu T, Toita T.

Int J Clin Oncol. 2019 May;24(5):575-582. doi: 10.1007/s10147-018-01380-z. Epub 2018 Dec 22.

19.

T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice.

Matsuda S, Baba R, Oki H, Morimoto S, Toyofuku M, Igaki S, Kamada Y, Iwasaki S, Matsumiya K, Hibino R, Kamada H, Hirakawa T, Iwatani M, Tsuchida K, Hara R, Ito M, Kimura H.

Neuropsychopharmacology. 2019 Jul;44(8):1505-1512. doi: 10.1038/s41386-018-0300-9. Epub 2018 Dec 22.

PMID:
30580376
20.

[A Case of Rheumatoid Arthritis Developed during Treatment with Nivolumab for Renal Cell Carcinoma].

Tomizawa M, Nakai Y, Maesaka F, Owari T, Hara R, Miyake M, Inoue T, Anai S, Tanaka N, Fujimoto K.

Hinyokika Kiyo. 2018 Oct;64(10):397-401. doi: 10.14989/ActaUrolJap_64_10_397. Review. Japanese.

PMID:
30543737
21.

Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection.

Fujiwara S, Hoshizaki M, Ichida Y, Lex D, Kuroda E, Ishii KJ, Magi S, Okada M, Takao H, Gandou M, Imai H, Hara R, Herzog H, Yoshimura A, Okamura H, Penninger JM, Slutsky AS, Uhlig S, Kuba K, Imai Y.

Nat Microbiol. 2019 Feb;4(2):258-268. doi: 10.1038/s41564-018-0289-1. Epub 2018 Nov 19.

PMID:
30455472
22.

Correction: Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides.

Hara RI, Maeda Y, Fujimaki H, Wada T.

Chem Commun (Camb). 2018 Oct 9;54(81):11499. doi: 10.1039/c8cc90436g.

PMID:
30264082
23.

Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath.

Kawamura T, Suzuki K, Takahashi M, Tomari M, Hara R, Gando Y, Muraoka I.

Antioxidants (Basel). 2018 Sep 25;7(10). pii: E127. doi: 10.3390/antiox7100127.

24.

Toxicological effects of fumonisin B1 in combination with other Fusarium toxins.

Feijó Corrêa JA, Orso PB, Bordin K, Hara RV, Luciano FB.

Food Chem Toxicol. 2018 Nov;121:483-494. doi: 10.1016/j.fct.2018.09.043. Epub 2018 Sep 21. Review.

PMID:
30248478
25.

Cubane-Type [Mo3 S4 M] Clusters with First-Row Groups 4-10 Transition-Metal Halides Supported by C5 Me5 Ligands on Molybdenum.

Ohki Y, Uchida K, Hara R, Kachi M, Fujisawa M, Tada M, Sakai Y, Sameera WMC.

Chemistry. 2018 Nov 16;24(64):17138-17147. doi: 10.1002/chem.201804083. Epub 2018 Oct 31.

PMID:
30204282
26.

Phase I/II study of first-line combination therapy with sorafenib plus resminostat, an oral HDAC inhibitor, versus sorafenib monotherapy for advanced hepatocellular carcinoma in east Asian patients.

Tak WY, Ryoo BY, Lim HY, Kim DY, Okusaka T, Ikeda M, Hidaka H, Yeon JE, Mizukoshi E, Morimoto M, Lee MA, Yasui K, Kawaguchi Y, Heo J, Morita S, Kim TY, Furuse J, Katayama K, Aramaki T, Hara R, Kimura T, Nakamura O, Kudo M.

Invest New Drugs. 2018 Dec;36(6):1072-1084. doi: 10.1007/s10637-018-0658-x. Epub 2018 Sep 10.

PMID:
30198057
27.

Visualization of erythrocyte deformation induced by supraphysiological shear stress.

Watanabe N, Shimada T, Hakozaki M, Hara R.

Int J Artif Organs. 2018 Dec;41(12):838-844. doi: 10.1177/0391398818793387. Epub 2018 Aug 21.

PMID:
30126305
28.

An Aromatic Farnesyltransferase Functions in Biosynthesis of the Anti-HIV Meroterpenoid Daurichromenic Acid.

Saeki H, Hara R, Takahashi H, Iijima M, Munakata R, Kenmoku H, Fuku K, Sekihara A, Yasuno Y, Shinada T, Ueda D, Nishi T, Sato T, Asakawa Y, Kurosaki F, Yazaki K, Taura F.

Plant Physiol. 2018 Oct;178(2):535-551. doi: 10.1104/pp.18.00655. Epub 2018 Aug 10.

29.

Clinical significance of subcutaneous fat and fascial involvement in juvenile dermatomyositis.

Sakurai N, Hino-Shishikura A, Nozawa T, Kamide H, Ohara A, Nishimura K, Kikuchi M, Hara R, Mori M, Ito S.

Mod Rheumatol. 2019 Sep;29(5):808-813. doi: 10.1080/14397595.2018.1511026. Epub 2018 Oct 18.

PMID:
30092673
30.

Factors associated with the achievement of biological disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: the ANSWER cohort study.

Hashimoto M, Furu M, Yamamoto W, Fujimura T, Hara R, Katayama M, Ohnishi A, Akashi K, Yoshida S, Nagai K, Son Y, Amuro H, Hirano T, Ebina K, Uozumi R, Ito H, Tanaka M, Ohmura K, Fujii T, Mimori T.

Arthritis Res Ther. 2018 Aug 3;20(1):165. doi: 10.1186/s13075-018-1673-1.

31.

Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides.

Hara RI, Maeda Y, Fujimaki H, Wada T.

Chem Commun (Camb). 2018 Jul 26;54(61):8526-8529. doi: 10.1039/c8cc04082f. Erratum in: Chem Commun (Camb). 2018 Oct 9;54(81):11499.

PMID:
30009294
32.

Phase I study of resminostat, an HDAC inhibitor, combined with S-1 in patients with pre-treated biliary tract or pancreatic cancer.

Ikeda M, Ohno I, Ueno H, Mitsunaga S, Hashimoto Y, Okusaka T, Kondo S, Sasaki M, Sakamoto Y, Takahashi H, Hara R, Kobayashi S, Nakamura O, Morizane C.

Invest New Drugs. 2019 Feb;37(1):109-117. doi: 10.1007/s10637-018-0634-5. Epub 2018 Jul 11.

PMID:
29995287
33.

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.

Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M, Imaeda T, Okamoto R, Sato K, Michino M, Alvaro EF, Guiang LF, Sanz L, Mota DJ, Govindasamy K, Wang R, Ling Y, Tumwebaze PK, Sukenick G, Shi L, Vendome J, Bhanot P, Rosenthal PJ, Aso K, Foley MA, Cooper RA, Kafsack B, Doggett JS, Nathan CF, Lin G.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6863-E6870. doi: 10.1073/pnas.1806109115. Epub 2018 Jul 2.

34.

Solid-Phase Synthesis of Fluorinated Analogues of Glycosyl 1-Phosphate Repeating Structures from Leishmania using the Phosphoramidite Method.

Hara RI, Yaoita A, Takeda K, Ueki H, Ishii A, Imoto H, Kobayashi S, Sano M, Noro M, Sato K, Wada T.

ChemistryOpen. 2018 Apr 30;7(6):439-446. doi: 10.1002/open.201800030. eCollection 2018 Jun.

35.

Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes.

De Benedetti F, Gattorno M, Anton J, Ben-Chetrit E, Frenkel J, Hoffman HM, Koné-Paut I, Lachmann HJ, Ozen S, Simon A, Zeft A, Calvo Penades I, Moutschen M, Quartier P, Kasapcopur O, Shcherbina A, Hofer M, Hashkes PJ, Van der Hilst J, Hara R, Bujan-Rivas S, Constantin T, Gul A, Livneh A, Brogan P, Cattalini M, Obici L, Lheritier K, Speziale A, Junge G.

N Engl J Med. 2018 May 17;378(20):1908-1919. doi: 10.1056/NEJMoa1706314.

36.

Excitation wavelength selection for quantitative analysis of carotenoids in tomatoes using Raman spectroscopy.

Hara R, Ishigaki M, Kitahama Y, Ozaki Y, Genkawa T.

Food Chem. 2018 Aug 30;258:308-313. doi: 10.1016/j.foodchem.2018.03.089. Epub 2018 Mar 21.

PMID:
29655738
37.

Drug retention and discontinuation reasons between seven biologics in patients with rheumatoid arthritis -The ANSWER cohort study.

Ebina K, Hashimoto M, Yamamoto W, Ohnishi A, Kabata D, Hirano T, Hara R, Katayama M, Yoshida S, Nagai K, Son Y, Amuro H, Akashi K, Fujimura T, Hirao M, Yamamoto K, Shintani A, Kumanogoh A, Yoshikawa H.

PLoS One. 2018 Mar 15;13(3):e0194130. doi: 10.1371/journal.pone.0194130. eCollection 2018.

38.

Artificial cationic oligosaccharides for heteroduplex oligonucleotide-type drugs.

Hara RI, Hisada Y, Maeda Y, Yokota T, Wada T.

Sci Rep. 2018 Mar 12;8(1):4323. doi: 10.1038/s41598-018-22161-8.

39.

A chemoenzymatic process for amide bond formation by an adenylating enzyme-mediated mechanism.

Hara R, Hirai K, Suzuki S, Kino K.

Sci Rep. 2018 Feb 13;8(1):2950. doi: 10.1038/s41598-018-21408-8.

40.

The Comparison of the Surgical Outcome for the Full-Thickness Macular Hole with/without Lamellar Hole-Associated Epiretinal Proliferation.

Ubukata Y, Imai H, Otsuka K, Nishizaki M, Hara R, Uenishi M, Azumi A, Nakamura M.

J Ophthalmol. 2017;2017:9640756. doi: 10.1155/2017/9640756. Epub 2017 Dec 13.

41.

Production of aminoacyl prolines using the adenylation domain of nonribosomal peptide synthetase with class III polyphosphate kinase 2-mediated ATP regeneration.

Suzuki S, Hara R, Kino K.

J Biosci Bioeng. 2018 Jun;125(6):644-648. doi: 10.1016/j.jbiosc.2017.12.023. Epub 2018 Feb 1.

PMID:
29366718
42.
43.

The expression of thymic stromal lymphopoietin in patients and animal models with eosinophilic otitis media.

Miura T, Matsubara A, Kudo N, Hara R, Takahata J, Sasaki A.

Acta Otolaryngol. 2018 May;138(5):447-451. doi: 10.1080/00016489.2017.1416170. Epub 2017 Dec 22.

PMID:
29272985
44.

Discovery of 3,5-Diphenyl-4-methyl-1,3-oxazolidin-2-ones as Novel, Potent, and Orally Available Δ-5 Desaturase (D5D) Inhibitors.

Fujimoto J, Okamoto R, Noguchi N, Hara R, Masada S, Kawamoto T, Nagase H, Tamura YO, Imanishi M, Takagahara S, Kubo K, Tohyama K, Iida K, Andou T, Miyahisa I, Matsui J, Hayashi R, Maekawa T, Matsunaga N.

J Med Chem. 2017 Nov 9;60(21):8963-8981. doi: 10.1021/acs.jmedchem.7b01210. Epub 2017 Oct 31.

PMID:
29023121
45.

Use of the product of mean intensity ratio (PMIR) technique for discriminant analysis of lycopene-rich vegetable juice using a portable NIR-excited Raman spectrometer.

Hara R, Ishigaki M, Kitahama Y, Ozaki Y, Genkawa T.

Food Chem. 2018 Feb 15;241:353-357. doi: 10.1016/j.foodchem.2017.08.094. Epub 2017 Aug 31.

PMID:
28958539
46.

NKG2D gene polymorphisms are associated with disease control of chronic myeloid leukemia by dasatinib.

Hara R, Onizuka M, Matsusita E, Kikkawa E, Nakamura Y, Matsushita H, Ohgiya D, Murayama H, Machida S, Ohmachi K, Shirasugi Y, Ogawa Y, Kawada H, Ando K.

Int J Hematol. 2017 Nov;106(5):666-674. doi: 10.1007/s12185-017-2294-1. Epub 2017 Aug 9.

PMID:
28795321
47.

Discovery of Lysine Hydroxylases in the Clavaminic Acid Synthase-Like Superfamily for Efficient Hydroxylysine Bioproduction.

Hara R, Yamagata K, Miyake R, Kawabata H, Uehara H, Kino K.

Appl Environ Microbiol. 2017 Aug 17;83(17). pii: e00693-17. doi: 10.1128/AEM.00693-17. Print 2017 Sep 1.

48.

Phase II study of induction gemcitabine and S-1 followed by chemoradiotherapy and systemic chemotherapy using S-1 for locally advanced pancreatic cancer.

Sudo K, Hara R, Nakamura K, Kita E, Tsujimoto A, Yamaguchi T.

Cancer Chemother Pharmacol. 2017 Jul;80(1):195-202. doi: 10.1007/s00280-017-3350-5. Epub 2017 Jun 8.

PMID:
28597040
49.

Refined Internal Limiting Membrane Inverted Flap Technique for Intractable Macular Detachment with Optic Disc Pit.

Hara R, Tsukahara Y, Simoyama T, Mori S.

Case Rep Ophthalmol. 2017 Apr 4;8(1):208-213. doi: 10.1159/000462956. eCollection 2017 Jan-Apr.

50.

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.

Funnell T, Tasaki S, Oloumi A, Araki S, Kong E, Yap D, Nakayama Y, Hughes CS, Cheng SG, Tozaki H, Iwatani M, Sasaki S, Ohashi T, Miyazaki T, Morishita N, Morishita D, Ogasawara-Shimizu M, Ohori M, Nakao S, Karashima M, Sano M, Murai A, Nomura T, Uchiyama N, Kawamoto T, Hara R, Nakanishi O, Shumansky K, Rosner J, Wan A, McKinney S, Morin GB, Nakanishi A, Shah S, Toyoshiba H, Aparicio S.

Nat Commun. 2017 Feb 23;8(1):7. doi: 10.1038/s41467-016-0008-7.

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