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Items: 1 to 50 of 2862

1.

Serum amyloid a as an indicator of impending xenograft failure: Experimental studies.

Zhang G, Hara H, Yamamoto T, Li Q, Jagdale A, Li Y, Cooper DKC, Iwase H.

Int J Surg. 2018 Dec 3;60:283-290. doi: 10.1016/j.ijsu.2018.11.027. [Epub ahead of print]

PMID:
30521954
2.

Multi-area lymphaticovenous anastomosis with multi-lymphosome injection in indocyanine green lymphography: A prospective study.

Hara H, Mihara M.

Microsurgery. 2018 Dec 3. doi: 10.1002/micr.30398. [Epub ahead of print]

PMID:
30508302
3.

Casein materials show different digestion patterns using an in vitro gastrointestinal model and different release of glucagon-like peptide-1 by enteroendocrine GLUTag cells.

Komatsu Y, Wada Y, Izumi H, Shimizu T, Takeda Y, Hira T, Hara H.

Food Chem. 2019 Mar 30;277:423-431. doi: 10.1016/j.foodchem.2018.10.123. Epub 2018 Oct 31.

PMID:
30502166
4.

Phase 1 trial of avelumab (anti-PD-L1) in Japanese patients with advanced solid tumors, including dose expansion in patients with gastric or gastroesophageal junction cancer: the JAVELIN Solid Tumor JPN trial.

Doi T, Iwasa S, Muro K, Satoh T, Hironaka S, Esaki T, Nishina T, Hara H, Machida N, Komatsu Y, Shimada Y, Otsu S, Shimizu S, Watanabe M.

Gastric Cancer. 2018 Dec 4. doi: 10.1007/s10120-018-0903-1. [Epub ahead of print]

PMID:
30515672
5.

Erratum to "Protective effect of an astaxanthin nanoemulsion against neomycin-induced hair-cell damage in zebrafish" [Auris Nasus Larynx 45 (2018) 20-25].

Takemoto Y, Hirose Y, Sugahara K, Hashimoto M, Hara H, Yamashita H.

Auris Nasus Larynx. 2018 Nov 22. pii: S0385-8146(18)30989-1. doi: 10.1016/j.anl.2018.11.010. [Epub ahead of print] No abstract available.

PMID:
30473273
6.

TAS-118 (S-1 plus leucovorin) versus S-1 in patients with gemcitabine-refractory advanced pancreatic cancer: a randomised, open-label, phase 3 study (GRAPE trial).

Ioka T, Ueno M, Ueno H, Park JO, Chang HM, Sasahira N, Kanai M, Chung IJ, Ikeda M, Nakamori S, Mizuno N, Omuro Y, Yamaguchi T, Hara H, Sugimori K, Furuse J, Maguchi H, Furukawa M, Fukuzawa K, Kim JS, Yukisawa S, Takeuchi M, Okusaka T, Boku N, Hyodo I.

Eur J Cancer. 2018 Nov 21;106:78-88. doi: 10.1016/j.ejca.2018.10.004. [Epub ahead of print]

PMID:
30471651
Free Article
7.

Intense water-window soft x-ray emission by spectral control using dual laser pulses.

Arai G, Hara H, Hatano T, Ejima T, Jiang W, Ohashi H, Namba S, Sunahara A, Sasaki A, Nishikino M, O'Sullivan G, Higashiguchi T.

Opt Express. 2018 Oct 15;26(21):27748-27756. doi: 10.1364/OE.26.027748.

PMID:
30469835
8.

Impaired Cerebellar Development in Mice Overexpressing VGF.

Mizoguchi T, Shimazawa M, Ohuchi K, Kuse Y, Nakamura S, Hara H.

Neurochem Res. 2018 Nov 20. doi: 10.1007/s11064-018-2684-7. [Epub ahead of print]

PMID:
30460640
9.

Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury.

Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Fujiwara T, Maemura S, Ito M, Naito AT, Harada M, Toko H, Nomura S, Kumagai H, Ikeda Y, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, Komuro I.

JACC Basic Transl Sci. 2018 Nov 12;3(5):639-653. doi: 10.1016/j.jacbts.2018.07.005. eCollection 2018 Oct.

10.

Author Correction: Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF.

Mizoguchi T, Minakuchi H, Ishisaka M, Tsuruma K, Shimazawa M, Hara H.

Sci Rep. 2018 Nov 20;8(1):17326. doi: 10.1038/s41598-018-35362-y.

11.

Clinical Validation of Newly Developed Multiplex Kit Using Luminex xMAP Technology for Detecting Simultaneous RAS and BRAF Mutations in Colorectal Cancer: Results of the RASKET-B Study.

Taniguchi H, Okamoto W, Muro K, Akagi K, Hara H, Nishina T, Kajiwara T, Denda T, Hironaka S, Kudo T, Satoh T, Yamanaka T, Abe Y, Fukushima Y, Yoshino T.

Neoplasia. 2018 Dec;20(12):1219-1226. doi: 10.1016/j.neo.2018.10.004. Epub 2018 Nov 6.

12.

VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush.

Takeuchi H, Inagaki S, Morozumi W, Nakano Y, Inoue Y, Kuse Y, Mizoguchi T, Nakamura S, Funato M, Kaneko H, Hara H, Shimazawa M.

Sci Rep. 2018 Nov 6;8(1):16443. doi: 10.1038/s41598-018-34585-3.

13.

The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection.

Hara H, Seregin SS, Yang D, Fukase K, Chamaillard M, Alnemri ES, Inohara N, Chen GY, Núñez G.

Cell. 2018 Nov 29;175(6):1651-1664.e14. doi: 10.1016/j.cell.2018.09.047. Epub 2018 Nov 1.

PMID:
30392956
14.

Reversible Multicolor Photochromism of Dihydroazulene Crystals.

Liepuoniute I, Commins P, Karothu DP, Schramm S, Hara H, Naumov P.

Chemistry. 2018 Nov 2. doi: 10.1002/chem.201804677. [Epub ahead of print]

PMID:
30388317
15.

Cohort study exploring the effect of lenvatinib on differentiated thyroid cancer.

Tahara M, Takami H, Ito Y, Sugino K, Takahashi S, Takeyama H, Tsutsui H, Hara H, Mitsuma A, Yamashita H, Okamoto T, Sugitani I, Ohashi Y, Imai T.

Endocr J. 2018 Nov 29;65(11):1071-1074. doi: 10.1507/endocrj.EJ18-0261. Epub 2018 Oct 24.

16.

An interspecies barrier to tetraploid complementation and chimera formation.

Yamaguchi T, Sato H, Kobayashi T, Kato-Itoh M, Goto T, Hara H, Mizuno N, Yanagida A, Umino A, Hamanaka S, Suchy F, Masaki H, Ota Y, Hirabayashi M, Nakauchi H.

Sci Rep. 2018 Oct 16;8(1):15289. doi: 10.1038/s41598-018-33690-7.

17.

Lymphaticovenous anastomosis and resection for genital acquired lymphangiectasia (GAL).

Hara H, Mihara M.

J Plast Reconstr Aesthet Surg. 2018 Nov;71(11):1625-1630. doi: 10.1016/j.bjps.2018.05.015. Epub 2018 Jun 8.

PMID:
30327121
18.

Evaluation of the host immune response to decellularized lung scaffolds derived from α-Gal knockout pigs in a non-human primate model.

Stahl EC, Bonvillain RW, Skillen CD, Burger BL, Hara H, Lee W, Trygg CB, Didier PJ, Grasperge BF, Pashos NC, Bunnell BA, Bianchi J, Ayares DL, Guthrie KI, Brown BN, Petersen TH.

Biomaterials. 2018 Dec;187:93-104. doi: 10.1016/j.biomaterials.2018.09.038. Epub 2018 Sep 28.

PMID:
30312852
19.

The Case for Cardiac Xenotransplantation in Neonates: Is Now the Time to Reconsider Xenotransplantation for Hypoplastic Left Heart Syndrome?

Cleveland D, Adam Banks C, Hara H, Carlo WF, Mauchley DC, Cooper DKC.

Pediatr Cardiol. 2018 Oct 9. doi: 10.1007/s00246-018-1998-1. [Epub ahead of print]

PMID:
30302505
20.

Induction of Human-Lung-Cancer-A549-Cell Apoptosis by 4-Hydroperoxy-2-decenoic Acid Ethyl Ester through Intracellular ROS Accumulation and the Induction of Proapoptotic CHOP Expression.

Kamiya T, Watanabe M, Hara H, Mitsugi Y, Yamaguchi E, Itoh A, Adachi T.

J Agric Food Chem. 2018 Oct 17;66(41):10741-10747. doi: 10.1021/acs.jafc.8b04424. Epub 2018 Oct 8.

PMID:
30296076
21.

Data on B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy.

Yamamoto T, Li Q, Hara H, Wang L, Zhou H, Li J, Eckhoff DE, Tector AJ, Klein EC, Lovingood R, Ezzelarab M, Ayares D, Wang Y, Cooper DKC, Iwase H.

Data Brief. 2018 Sep 13;20:1965-1974. doi: 10.1016/j.dib.2018.08.213. eCollection 2018 Oct.

22.

Editorial: Drug Repositioning: Current Advances and Future Perspectives.

Nishimura Y, Hara H.

Front Pharmacol. 2018 Sep 20;9:1068. doi: 10.3389/fphar.2018.01068. eCollection 2018. No abstract available.

23.

Bilberry extract and anthocyanins suppress unfolded protein response induced by exposure to blue LED light of cells in photoreceptor cell line.

Ooe E, Kuse Y, Yako T, Sogon T, Nakamura S, Hara H, Shimazawa M.

Mol Vis. 2018 Sep 24;24:621-632. eCollection 2018.

24.

PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.

Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, Hosaka Y, Ichikawa A, Saito N, Kadota T, Yoshida M, Fujita Y, Utsumi H, Kobayashi K, Yanagisawa H, Hashimoto M, Wakui H, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K.

Autophagy. 2018 Oct 5:1-17. doi: 10.1080/15548627.2018.1532259. [Epub ahead of print]

PMID:
30290714
25.

Pacemaker malfunction after acute myocardial infarction in a patient with wrap-around left anterior descending artery supplying the right ventricular apex.

Umei TC, Awaya T, Okazaki O, Hara H, Hiroi Y.

J Cardiol Cases. 2018 Apr 4;18(1):9-12. doi: 10.1016/j.jccase.2018.03.001. eCollection 2018 Jul.

26.

Bilateral glomus tympanicum tumors: Human temporalbone study.

Fukushima H, Hara H, Paparella MM, Oktay MF, Schachern PA, Cureoglu S.

Clin Pract. 2018 Jul 12;8(3):1035. doi: 10.4081/cp.2018.1035. eCollection 2018 Jul 10.

27.

Activation of the unfolded protein response in canine degenerative myelopathy.

Yokota S, Kobatake Y, Noda Y, Nakata K, Yamato O, Hara H, Sakai H, Nishida H, Maeda S, Kamishina H.

Neurosci Lett. 2018 Nov 20;687:216-222. doi: 10.1016/j.neulet.2018.09.040. Epub 2018 Sep 29.

PMID:
30273700
28.
29.

Pathophysiological Role of VEGF on Retinal Edema and Nonperfused Areas in Mouse Eyes With Retinal Vein Occlusion.

Nishinaka A, Inoue Y, Fuma S, Hida Y, Nakamura S, Shimazawa M, Hara H.

Invest Ophthalmol Vis Sci. 2018 Sep 4;59(11):4701-4713. doi: 10.1167/iovs.18-23994.

PMID:
30267092
30.

Perspectives on the Optimal Genetically Engineered Pig in 2018 for Initial Clinical Trials of Kidney or Heart Xenotransplantation.

Cooper DKC, Ezzelarab M, Iwase H, Hara H.

Transplantation. 2018 Dec;102(12):1974-1982. doi: 10.1097/TP.0000000000002443.

PMID:
30247446
31.

The role and regulation of TMEM2 (transmembrane protein 2) in HYBID (hyaluronan (HA)-binding protein involved in HA depolymerization/ KIAA1199/CEMIP)-mediated HA depolymerization in human skin fibroblasts.

Yoshino Y, Goto M, Hara H, Inoue S.

Biochem Biophys Res Commun. 2018 Oct 20;505(1):74-80. doi: 10.1016/j.bbrc.2018.09.097. Epub 2018 Sep 18.

PMID:
30241936
32.

Development of a novel algorithm for metal artifact reduction in digital tomosynthesis using projection-based dual-energy material decomposition for arthroplasty: A phantom study.

Gomi T, Sakai R, Goto M, Hara H, Watanabe Y.

Phys Med. 2018 Sep;53:4-16. doi: 10.1016/j.ejmp.2018.07.011. Epub 2018 Aug 9.

PMID:
30241753
33.

Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival.

Saito Y, Kuse Y, Inoue Y, Nakamura S, Hara H, Shimazawa M.

Redox Biol. 2018 Oct;19:354-363. doi: 10.1016/j.redox.2018.09.004. Epub 2018 Sep 5.

34.

Clinical Usefulness of Magnetic Resonance Imaging in Four Children With Scleroderma.

Agata K, Kawashima H, Kumada A, Kashiwagi Y, Hara H.

Arch Rheumatol. 2017 Nov 2;33(2):230-235. doi: 10.5606/ArchRheumatol.2018.6498. eCollection 2018 Jun.

35.

Simultaneous collection of the portal and superior vena cava blood in conscious rats defined that intestinal epithelium is the major site of glucuronidation, but not sulfation and methylation, of quercetin.

Tanaka S, Oyama M, Nishikawa M, Ikushiro S, Hara H.

Biosci Biotechnol Biochem. 2018 Dec;82(12):2118-2129. doi: 10.1080/09168451.2018.1515615. Epub 2018 Sep 10.

PMID:
30200823
36.

The Effect of Repeated Botulinum Toxin A Therapy Combined with Intensive Rehabilitation on Lower Limb Spasticity in Post-Stroke Patients.

Hara T, Abo M, Hara H, Sasaki N, Yamada N, Niimi M, Shimamoto Y.

Toxins (Basel). 2018 Aug 31;10(9). pii: E349. doi: 10.3390/toxins10090349.

37.

[Establishment of retinal disease models using non-human primates and its strategy for drug discovery].

Shimazawa M, Hara H.

Nihon Yakurigaku Zasshi. 2018;152(3):139-146. doi: 10.1254/fpj.152.139. Japanese.

PMID:
30185732
38.

Marginal iron deficiency enhances liver triglyceride accumulation in rats fed a high-sucrose diet.

Hori S, Hara H, Ishizuka S.

Biosci Biotechnol Biochem. 2018 Dec;82(12):2140-2148. doi: 10.1080/09168451.2018.1515616. Epub 2018 Sep 5.

PMID:
30185127
39.

Huge chronic expanding hematoma of the iliac bone following multiple hip surgeries: a case report.

Morishita M, Hara H, Katayama E, Kawamoto T, Fukase N, Takemori T, Fujiwara S, Nishida K, Kuroda R, Akisue T.

J Med Case Rep. 2018 Sep 4;12(1):265. doi: 10.1186/s13256-018-1783-z.

40.

Ultrasonography for classifying lymphatic sclerosis types and deciding optimal sites for lymphatic-venous anastomosis in patients with lymphoedema.

Mihara M, Hara H, Kawakami Y.

J Plast Reconstr Aesthet Surg. 2018 Sep;71(9):1274-1281. doi: 10.1016/j.bjps.2018.05.012. Epub 2018 Jun 15.

PMID:
30173714
41.

CYP3A but not P-gp plays a relevant role in the in vivo intestinal and hepatic clearance of the delta-specific phosphoinositide-3 kinase inhibitor leniolisib.

De Buck S, Kucher K, Hara H, Gray C, Woessner R.

Biopharm Drug Dispos. 2018 Sep;39(8):394-402. doi: 10.1002/bdd.2157.

PMID:
30171694
42.

Enhanced ability of plasma-activated lactated Ringer's solution to induce A549 cell injury.

Matsuzaki T, Kano A, Kamiya T, Hara H, Adachi T.

Arch Biochem Biophys. 2018 Oct 15;656:19-30. doi: 10.1016/j.abb.2018.08.011. Epub 2018 Aug 28.

PMID:
30170003
43.

Intravitreal aflibercept protects photoreceptors of mice against excessive light exposure.

Kuse Y, Takahashi K, Inoue Y, Izawa H, Nakamura S, Shimazawa M, Hara H.

J Pharmacol Sci. 2018 Aug;137(4):407-411. doi: 10.1016/j.jphs.2018.07.010. Epub 2018 Aug 4.

44.

A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase.

Sugiyama T, Imai T, Nakamura S, Yamauchi K, Sawada S, Shimazawa M, Hara H.

Brain Res. 2018 Dec 15;1701:137-145. doi: 10.1016/j.brainres.2018.08.021. Epub 2018 Aug 22.

PMID:
30142309
45.

An approach to induction of tolerance to pig cardiac xenografts in neonates.

Cooper DKC, Hara H, Iwase H, Banks CA, Cleveland DC.

Xenotransplantation. 2018 Aug 20:e12454. doi: 10.1111/xen.12454. [Epub ahead of print]

PMID:
30125392
46.

Phase II feasibility study of preoperative concurrent chemoradiotherapy with cisplatin plus 5-fluorouracil and elective lymph node irradiation for clinical stage II/III esophageal squamous cell carcinoma.

Hashimoto J, Kato K, Ito Y, Kojima T, Akimoto T, Daiko H, Hamamoto Y, Matsushita H, Katano S, Hara H, Tanaka Y, Saito Y, Nagashima K, Igaki H.

Int J Clin Oncol. 2018 Aug 14. doi: 10.1007/s10147-018-1336-x. [Epub ahead of print]

PMID:
30109544
47.

Phase I dose-escalation trial of Sym004, an anti-EGFR antibody mixture, in Japanese patients with advanced solid tumors.

Kojima T, Yamazaki K, Kato K, Muro K, Hara H, Chin K, Goddemeier T, Kuffel S, Watanabe M, Doi T.

Cancer Sci. 2018 Oct;109(10):3253-3262. doi: 10.1111/cas.13767. Epub 2018 Sep 25.

48.

Wheat gluten hydrolysate potently stimulates peptide-YY secretion and suppresses food intake in rats.

Chen W, Hira T, Nakajima S, Hara H.

Biosci Biotechnol Biochem. 2018 Nov;82(11):1992-1999. doi: 10.1080/09168451.2018.1505482. Epub 2018 Aug 10.

PMID:
30096043
49.

B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy.

Yamamoto T, Li Q, Hara H, Wang L, Zhou H, Li J, Eckhoff DE, Joseph Tector A, Klein EC, Lovingood R, Ezzelarab M, Ayares D, Wang Y, Cooper DKC, Iwase H.

Transpl Immunol. 2018 Dec;51:12-20. doi: 10.1016/j.trim.2018.08.005. Epub 2018 Aug 6.

PMID:
30092338
50.

Protective effects of the astaxanthin derivative, adonixanthin, on brain hemorrhagic injury.

Iwata S, Imai T, Shimazawa M, Ishibashi T, Hayashi M, Hara H, Nakamura S.

Brain Res. 2018 Nov 1;1698:130-138. doi: 10.1016/j.brainres.2018.08.009. Epub 2018 Aug 6.

PMID:
30092231

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