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Arctigenin induces apoptosis in human hepatoblastoma cells.

Naoe A, Tsuchiya T, Kondo Y, Uga N, Watanabe S, Yasui T, Hara F, Suzuki T.

Pediatr Surg Int. 2019 Jun;35(6):723-728. doi: 10.1007/s00383-019-04473-6. Epub 2019 Mar 19.


Current situation and challenges regarding biosimilars in Japan: an example of trastuzumab biosimilars for breast cancer.

Hara F, Tajima K, Tanabe K.

Future Oncol. 2019 Apr;15(12):1353-1361. doi: 10.2217/fon-2018-0957. Epub 2019 Feb 15.


Evaluation of Ki-67 as prognostic factor for pediatric neuroblastoma and the possibility of molecular-targeted drugs with vascular endothelial growth factor and platelet-derived growth factor receptor.

Watanabe S, Suzuki T, Kondo Y, Naoe A, Uga N, Yasui T, Hara F, Tsuchiya T.

Minerva Pediatr. 2019 Jan 2. doi: 10.23736/S0026-4946.18.05444-0. [Epub ahead of print]


Palbociclib in combination with fulvestrant in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: PALOMA-3 subgroup analysis of Japanese patients.

Masuda N, Inoue K, Nakamura R, Rai Y, Mukai H, Ohno S, Hara F, Mori Y, Hashigaki S, Muramatsu Y, Nagasawa T, Umeyama Y, Huang X, Iwata H.

Int J Clin Oncol. 2019 Mar;24(3):262-273. doi: 10.1007/s10147-018-1359-3. Epub 2018 Nov 3.


Effects of assisted reproductive technologies in neonates with indications for surgery (2007-2016).

Watanabe S, Kondo Y, Naoe A, Yasui T, Suzuki T, Hara F, Uga N, Miyata M, Boda H.

J Neonatal Perinatal Med. 2018;11(4):379-385. doi: 10.3233/NPM-17131.


A randomized, open-label, Phase III trial of pertuzumab retreatment in HER2-positive locally advanced/metastatic breast cancer patients previously treated with pertuzumab, trastuzumab and chemotherapy: the Japan Breast Cancer Research Group-M05 PRECIOUS study.

Yamamoto Y, Iwata H, Ueno T, Taira N, Kashiwaba M, Takahashi M, Tada H, Tsugawa K, Toyama T, Niikura N, Hara F, Fujisawa T, Yoshinami T, Saji S, Takano T, Masuda N, Morita S, Toi M, Ohno S.

Jpn J Clin Oncol. 2018 Sep 1;48(9):855-859. doi: 10.1093/jjco/hyy097.


The efficacy and feasibility of dose-dense sequential chemotherapy for Japanese patients with breast cancer.

Takabatake D, Kajiwara Y, Ohtani S, Itano Y, Yamamoto M, Kubo S, Ikeda M, Takahashi M, Hara F, Aogi K, Ohsumi S, Ogasawara Y, Nishiyama Y, Hikino H, Matsuoka K, Takahashi Y, Shien T, Taira N, Doihara H.

Breast Cancer. 2018 Nov;25(6):717-722. doi: 10.1007/s12282-018-0877-1. Epub 2018 Jun 11.


Clinical course of human herpesvirus 6 infection in pediatric living donor liver transplantation.

Yasui T, Suzuki T, Yoshikawa T, Yatsuya H, Kawamura Y, Miura H, Hara F, Watanabe S, Uga N, Naoe A.

Pediatr Transplant. 2018 Nov;22(7):e13239. doi: 10.1111/petr.13239. Epub 2018 Jun 3.


Tailored Predictive Formulas for Glomerular Filtration Rate for Early Detection of Deteriorating Renal Function After Pediatric Living-Donor Liver Transplant.

Yasui T, Suzuki T, Hara F, Watanabe S, Uga N, Naoe A, Kondo Y.

Exp Clin Transplant. 2018 Dec;16(6):708-713. doi: 10.6002/ect.2017.0159. Epub 2018 Mar 9.


Predictive value of genetic analysis for pathological complete response to preoperative treatment in HER2 positive, HR negative early breast cancer (PASSION trial).

Yamaguchi T, Mukai H, Takahashi M, Hara F, Yamauchi C, Yamashita S, Ushijima T.

Jpn J Clin Oncol. 2018 Apr 1;48(4):388-391. doi: 10.1093/jjco/hyy024.


Bi-weekly eribulin therapy for metastatic breast cancer: a multicenter phase II prospective study (JUST-STUDY).

Ohtani S, Nakayama T, Yoshinami T, Watanabe KI, Hara F, Sagara Y, Kawaguchi H, Higaki K, Matsunami N, Hasegawa Y, Takahashi M, Mizutani M, Morimoto T, Sato M, Itoh M, Morita S, Masuda N.

Breast Cancer. 2018 Jul;25(4):438-446. doi: 10.1007/s12282-018-0843-y. Epub 2018 Feb 12.


[III. Indication of G-CSF in Advanced or Metastatic Breast Cancer].

Hara F.

Gan To Kagaku Ryoho. 2017 Dec;44(13):2082-2086. Japanese. No abstract available.


Comparison of Direct Oral Anticoagulants and Warfarin in the Treatment of Deep Venous Thrombosis in the Chronic Phase.

Wakakura S, Hara F, Fujino T, Hamai A, Ohara H, Kabuki T, Harada M, Ikeda T.

Int Heart J. 2018 Jan 27;59(1):126-135. doi: 10.1536/ihj.16-482. Epub 2017 Dec 27.


Correlation between plasma brain natriuretic peptide levels and left atrial appendage flow velocity in patients with non-valvular atrial fibrillation and normal left ventricular systolic function.

Harada M, Tabako S, Fujii Y, Takarada Y, Hayashi K, Ohara H, Hara F, Ikeda T.

J Echocardiogr. 2018 Jun;16(2):72-80. doi: 10.1007/s12574-017-0362-4. Epub 2017 Dec 18.


Liver Transplantation from Female Donors Provokes Higher Complement Component C5a Activity.

Hussein MH, Hashimoto T, Suzuki T, Abdel-Hamid Daoud G, Kato T, Hibi M, Tomishige H, Hara F, Ito T, Kato I, Kazuhiko K, Sobajima H, Tamura M, Togari H.

Ann Transplant. 2017 Nov 22 [revised 2017 Jan 1];22:694-700. doi: 10.12659/AOT.905464. No abstract available.


Omphalocele and Gastroschisis in Newborns: Over 16 Years of Experience from a Single Clinic.

Watanabe S, Suzuki T, Hara F, Yasui T, Uga N, Naoe A.

J Neonatal Surg. 2017 Apr 15;6(2):27. doi: 10.21699/jns.v6i2.530. eCollection 2017 Apr-Jun.


Polyphyllin D, a steroidal saponin in Paris polyphylla, induces apoptosis and necroptosis cell death of neuroblastoma cells.

Watanabe S, Suzuki T, Hara F, Yasui T, Uga N, Naoe A.

Pediatr Surg Int. 2017 Jun;33(6):713-719. doi: 10.1007/s00383-017-4069-4. Epub 2017 Mar 4.


Patritumab plus trastuzumab and paclitaxel in human epidermal growth factor receptor 2-overexpressing metastatic breast cancer.

Mukai H, Saeki T, Aogi K, Naito Y, Matsubara N, Shigekawa T, Ueda S, Takashima S, Hara F, Yamashita T, Ohwada S, Sasaki Y.

Cancer Sci. 2016 Oct;107(10):1465-1470. doi: 10.1111/cas.13017. Epub 2016 Sep 15.


Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells.

Hara F, Tatebe J, Watanabe I, Yamazaki J, Ikeda T, Morita T.

Circ J. 2016 Aug 25;80(9):2037-46. doi: 10.1253/circj.CJ-16-0227. Epub 2016 Jul 29.


Successful living donor liver transplantation for classical maple syrup urine disease.

Yasui T, Suzuki T, Hara F, Watanabe S, Uga N, Naoe A, Yoshikawa T, Ito T, Nakajima Y, Miura H, Sugioka A, Kato Y, Tokoro T, Tanahashi Y, Kasahara M, Fukuda A, Kurahashi H.

Pediatr Transplant. 2016 Aug;20(5):707-710. doi: 10.1111/petr.12738. Epub 2016 Jun 20.


The Japanese Breast Cancer Society Clinical Practice Guideline for systemic treatment of breast cancer, 2015 edition.

Aihara T, Toyama T, Takahashi M, Yamamoto Y, Hara F, Akabane H, Fujisawa T, Ishikawa T, Nagai S, Nakamura R, Tsurutani J, Ito Y, Mukai H.

Breast Cancer. 2016 May;23(3):329-42. doi: 10.1007/s12282-016-0670-y. Epub 2016 Feb 24. No abstract available.


Taxanes versus S-1 as the first-line chemotherapy for metastatic breast cancer (SELECT BC): an open-label, non-inferiority, randomised phase 3 trial.

Takashima T, Mukai H, Hara F, Matsubara N, Saito T, Takano T, Park Y, Toyama T, Hozumi Y, Tsurutani J, Imoto S, Watanabe T, Sagara Y, Nishimura R, Shimozuma K, Ohashi Y; SELECT BC Study Group.

Lancet Oncol. 2016 Jan;17(1):90-8. doi: 10.1016/S1470-2045(15)00411-8. Epub 2015 Nov 27.


Intensive vs. Standard Post-Operative Surveillance in High-Risk Breast Cancer Patients (INSPIRE): Japan Clinical Oncology Group Study JCOG1204.

Hojo T, Masuda N, Mizutani T, Shibata T, Kinoshita T, Tamura K, Hara F, Fujisawa T, Inoue K, Saji S, Nakamura K, Fukuda H, Iwata H.

Jpn J Clin Oncol. 2015 Oct;45(10):983-6. doi: 10.1093/jjco/hyv110. Epub 2015 Aug 5.


Clinical experience with nanoparticle albumin-bound paclitaxel, a novel taxane anticancer agent, and management of adverse events in females with breast cancer.

Takashima S, Kiyoto S, Takahashi M, Hara F, Aogi K, Ohsumi S, Mukai R, Fujita Y.

Oncol Lett. 2015 Apr;9(4):1822-1826. Epub 2015 Feb 10.


Impact of modifiable lifestyle factors on outcomes after breast cancer diagnosis: the Setouchi Breast Cancer Cohort Study.

Taira N, Akiyama I, Ishihara S, Ishibe Y, Kawasaki K, Saito M, Shien T, Nomura T, Hara F, Mizoo T, Mizota Y, Yamamoto S, Ohsumi S, Doihara H; Executive Committee for the Setouchi Breast Cancer Cohort Study.

Jpn J Clin Oncol. 2015 Jun;45(6):600-2. doi: 10.1093/jjco/hyv033. Epub 2015 Mar 13.


Phase I and pharmacokinetic study of trastuzumab emtansine in Japanese patients with HER2-positive metastatic breast cancer.

Yamamoto H, Ando M, Aogi K, Iwata H, Tamura K, Yonemori K, Shimizu C, Hara F, Takabatake D, Hattori M, Asakawa T, Fujiwara Y.

Jpn J Clin Oncol. 2015 Jan;45(1):12-8. doi: 10.1093/jjco/hyu160. Epub 2014 Oct 20.


The Japanese Breast Cancer Society Clinical Practice Guideline for systemic treatment of breast cancer.

Mukai H, Aihara T, Yamamoto Y, Takahashi M, Toyama T, Sagara Y, Yamaguchi H, Akabane H, Tsurutani J, Hara F, Fujisawa T, Yamamoto N, Ohsumi S; Japanese Breast Cancer Society.

Breast Cancer. 2015 Jan;22(1):5-15. doi: 10.1007/s12282-014-0563-x. Epub 2014 Sep 9. No abstract available.


X-ray diagnosis with a bloating agent for foreign object ingestion.

Tomishige H, Morise Z, Suzuki T, Hara F, Hibi M, Kato T, Hashimoto T.

World J Clin Cases. 2014 May 16;2(5):157-9. doi: 10.12998/wjcc.v2.i5.157.



Hara F, Yamazaki J.

Nihon Rinsho. 2013 Sep;71(9):1643-8. Review. Japanese.


[Clinical experience with gemcitabine treatment for metastatic breast cancer].

Watanabe M, Hara F, Kiyoto S, Takahashi M, Takabatake D, Takashima S, Aogi K, Ohsumi S.

Gan To Kagaku Ryoho. 2013 Oct;40(10):1355-9. Japanese.


Children undergoing liver transplantation for treatment of inherited metabolic diseases are prone to higher oxidative stress, complement activity and transforming growth factor-β1.

Hussein MH, Hashimoto T, Suzuki T, Daoud GA, Goto T, Nakajima Y, Kato T, Hibi M, Tomishige H, Hara F, Kato S, Kakita H, Kamei M, Ito T, Kato I, Sugioka A, Togari H.

Ann Transplant. 2013 Feb 17;18:63-8. doi: 10.12659/AOT.883820.


Biliary atresia type I cyst and choledochal cyst [corrected]: can we differentiate or not?

Suzuki T, Hashimoto T, Hussein MH, Hara F, Hibi M, Kato T.

J Hepatobiliary Pancreat Sci. 2013 Jun;20(5):465-70. doi: 10.1007/s00534-013-0605-3. Erratum in: J Hepatobiliary Pancreat Sci. 2013 Jun;20(5):471.


Ght2⁺ is required for UDP-galactose synthesis from extracellular galactose by Schizosaccharomyces pombe.

Matsuzawa T, Hara F, Tanaka N, Tohda H, Takegawa K.

Appl Microbiol Biotechnol. 2013 Jun;97(11):4957-64. doi: 10.1007/s00253-012-4637-4. Epub 2012 Dec 20.


Transcatheter atrial septal defect closure in a patient with paradoxical brain emboli: who should treat it and who should be treated?

Hara H, Nakayama T, Matsuura H, Sato K, Hashimoto G, Yoshikawa H, Suzuki M, Hara F, Harada M, Wagatsuma K, Sugi K, Saji T, Nakamura M.

Cardiovasc Interv Ther. 2012 Sep;27(3):214-7. Epub 2012 Jul 10.


Breast biopsy for mammographically detected nonpalpable lesions using a vacuum-assisted biopsy device (Mammotome) and upright-type stereotactic mammography unit without a digital imaging system: experience of 500 biopsies.

Ohsumi S, Taira N, Takabatake D, Takashima S, Hara F, Takahashi M, Kiyoto S, Aogi K, Nishimura R.

Breast Cancer. 2014 Mar;21(2):123-7. doi: 10.1007/s12282-012-0360-3. Epub 2012 Apr 5.


Promotion of glycerol utilization using ethanol and 1-propanol in Schizosaccharomyces pombe.

Matsuzawa T, Hara F, Tohda H, Uemura H, Takegawa K.

Appl Microbiol Biotechnol. 2012 Jul;95(2):441-9. doi: 10.1007/s00253-012-3971-x. Epub 2012 Feb 29.


Spontaneous superficial temporal artery pseudoaneurysm in elderly women--three case reports.

Nii K, Tsutsumi M, Aikawa H, Onizuka M, Sakamoto K, Inoue R, Nakau H, Iko M, Haraoka S, Hara F, Kazekawa K.

Neurol Med Chir (Tokyo). 2011;51(10):713-5.


[Gastrointestinal hemorrhage associated with concurrent use of sorafenib and warfarin for hepatocellular carcinoma].

Shiozawa K, Watanabe M, Hirano N, Wakui N, Kikuchi Y, Hara F, Ishii K, Iida K, Sumino Y.

Gan To Kagaku Ryoho. 2011 Oct;38(10):1713-5. Japanese.


[Efficacy and safety of aprepitant in patients with breast cancer].

Tagashira H, Matsuhisa T, Oze I, Kiyoto S, Takahashi M, Hara F, Takabatake D, Takashima S, Aogi K, Osumi S, Eguchi H.

Gan To Kagaku Ryoho. 2011 Aug;38(8):1307-11. Japanese.


Thirty years' experience of open-repair surgery for pectus excavatum: development of a metal-free procedure.

Masaoka A, Kondo S, Sasaki S, Hara F, Mizuno T, Yamakawa Y, Kobayashi T, Fujii Y.

Eur J Cardiothorac Surg. 2012 Feb;41(2):329-34. doi: 10.1016/j.ejcts.2011.06.022. Epub 2011 Dec 12.


Detection of isolated ipsilateral regional lymph node recurrences by F18-fluorodeoxyglucose positron emission tomography-CT in follow-up of postoperative breast cancer patients.

Ohsumi S, Inoue T, Kiyoto S, Hara F, Takahashi M, Takabatake D, Takashima S, Aogi K, Takashima S.

Breast Cancer Res Treat. 2011 Nov;130(1):267-72. doi: 10.1007/s10549-011-1561-8. Epub 2011 May 13.


Examination of the use of Exemestane in patients with metastatic breast cancer.

Takashima S, Kiyoto S, Takahashi M, Hara F, Takabatake D, Aogi K, Ohsumi S.

Breast Cancer. 2011 Jul;18(3):189-94. doi: 10.1007/s12282-011-0258-5. Epub 2011 Mar 25.


Efficacy and safety of S-1 in patients with metastatic breast cancer: retrospective review in a single institution.

Hara F, Kiyoto S, Takahashi M, Takabatake D, Takashima S, Aogi K, Ohsumi S, Takashima S.

Oncology. 2010;79(3-4):273-7. doi: 10.1159/000322371. Epub 2011 Mar 4.


Pediatric patients receiving ABO-incompatible living related liver transplantation exhibit higher serum transforming growth factor-β1, interferon-γ and interleukin-2 levels.

Hussein MH, Hashimoto T, AbdEl-Hamid Daoud G, Kato T, Hibi M, Tomishige H, Hara F, Suzuki T, Nakajima Y, Goto T, Ito T, Kato I, Sugioka A, Togari H.

Pediatr Surg Int. 2011 Mar;27(3):263-8. doi: 10.1007/s00383-010-2784-1.


Oxidative stress after living related liver transplantation subsides with time in pediatric patients.

Hussein MH, Hashimoto T, Daoud GA, Kakita H, Kato S, Goto T, Hibi M, Kato T, Okumura N, Tomishige H, Hara F, Ito T, Fukuda S, Kato I, Suzuki T, Suzuki S, Togari H.

Pediatr Surg Int. 2011 Jan;27(1):17-22. doi: 10.1007/s00383-010-2721-3.


Metastatic Breast Cancer to the Stomach Resembling Early Gastric Cancer.

Hara F, Kiyoto S, Takabatake D, Takashima S, Aogi K, Ohsumi S, Teramoto N, Nishimura R, Takashima S.

Case Rep Oncol. 2010 Apr 29;3(2):142-147.


Endometrial Metastasis from Breast Cancer during Adjuvant Endocrine Therapy.

Hara F, Kiyoto S, Takabatake D, Takashima S, Aogi K, Ohsumi S, Teramoto N, Nishimura R, Takashima S.

Case Rep Oncol. 2010 Apr 29;3(2):137-141.


The estrogen receptor influences microtubule-associated protein tau (MAPT) expression and the selective estrogen receptor inhibitor fulvestrant downregulates MAPT and increases the sensitivity to taxane in breast cancer cells.

Ikeda H, Taira N, Hara F, Fujita T, Yamamoto H, Soh J, Toyooka S, Nogami T, Shien T, Doihara H, Miyoshi S.

Breast Cancer Res. 2010;12(3):R43. doi: 10.1186/bcr2598. Epub 2010 Jun 28.


Correlation between plasma B-type natriuretic peptide levels and left ventricular diastolic function using color kinetic imaging.

Harada M, Hara F, Yamazaki J.

J Cardiol. 2010 Jul;56(1):91-6. doi: 10.1016/j.jjcc.2010.03.003. Epub 2010 May 5.


High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns.

Hussein MH, Daoud GA, Kakita H, Kato S, Goto T, Kamei M, Goto K, Nobata M, Ozaki Y, Ito T, Fukuda S, Kato I, Suzuki S, Sobajima H, Hara F, Hashimoto T, Togari H.

Free Radic Res. 2010 Apr;44(4):422-9. doi: 10.3109/10715760903548245.


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