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Genetic Inactivation of ZCCHC6 Suppresses Interleukin-6 Expression and Reduces the Severity of Experimental Osteoarthritis in Mice.

Ansari MY, Khan NM, Ahmad N, Green J, Novak K, Haqqi TM.

Arthritis Rheumatol. 2019 Apr;71(4):583-593. doi: 10.1002/art.40751. Epub 2019 Mar 6.


Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes.

Ansari MY, Ahmad N, Haqqi TM.

Cell Physiol Biochem. 2018;49(3):932-946. doi: 10.1159/000493225. Epub 2018 Sep 5.


Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis.

Khan NM, Ahmad I, Haqqi TM.

Free Radic Biol Med. 2018 Feb 20;116:159-171. doi: 10.1016/j.freeradbiomed.2018.01.013. Epub 2018 Jan 12.


Deep sequencing and analyses of miRNAs, isomiRs and miRNA induced silencing complex (miRISC)-associated miRNome in primary human chondrocytes.

Haseeb A, Makki MS, Khan NM, Ahmad I, Haqqi TM.

Sci Rep. 2017 Nov 9;7(1):15178. doi: 10.1038/s41598-017-15388-4.


Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics.

Khan NM, Haqqi TM.

Pharmacol Res. 2018 Feb;128:73-79. doi: 10.1016/j.phrs.2017.08.007. Epub 2017 Aug 18. Review.


Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes.

Ansari MY, Khan NM, Ahmad I, Haqqi TM.

Osteoarthritis Cartilage. 2018 Aug;26(8):1087-1097. doi: 10.1016/j.joca.2017.07.020. Epub 2017 Aug 8.


Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1β stimulated osteoarthritis chondrocytes.

Khan NM, Ahmad I, Ansari MY, Haqqi TM.

Chem Biol Interact. 2017 Aug 25;274:13-23. doi: 10.1016/j.cbi.2017.06.025. Epub 2017 Jul 5.


Dataset of effect of Wogonin, a natural flavonoid, on the viability and activation of NF-κB and MAPKs in IL-1β-stimulated human OA chondrocytes.

Khan NM, Haseeb A, Ansari MY, Devarapalli P, Haynie S, Haqqi TM.

Data Brief. 2017 Apr 9;12:150-155. doi: 10.1016/j.dib.2017.03.054. eCollection 2017 Jun.


An effective and efficient method of transfecting primary human chondrocytes in suspension.

Makki MS, Akhtar N, Haqqi TM.

Anal Biochem. 2017 Jun 1;526:29-32. doi: 10.1016/j.ab.2017.03.009. Epub 2017 Mar 14.


A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-κB and IL-6 Expression by Blocking the Activation of IKKβ and NIK in Primary Human Chondrocytes.

Haseeb A, Khan NM, Ashruf OS, Haqqi TM.

Phytother Res. 2017 May;31(5):778-782. doi: 10.1002/ptr.5799. Epub 2017 Mar 9.


Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes.

Khan NM, Haseeb A, Ansari MY, Devarapalli P, Haynie S, Haqqi TM.

Free Radic Biol Med. 2017 May;106:288-301. doi: 10.1016/j.freeradbiomed.2017.02.041. Epub 2017 Feb 22.


Inhibition of cartilage degradation and suppression of PGE2 and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis.

Akhtar N, Khan NM, Ashruf OS, Haqqi TM.

Nutrition. 2017 Jan;33:1-13. doi: 10.1016/j.nut.2016.08.004. Epub 2016 Sep 2.


Sucrose, But Not Glucose, Blocks IL1-β-Induced Inflammatory Response in Human Chondrocytes by Inducing Autophagy via AKT/mTOR Pathway.

Khan NM, Ansari MY, Haqqi TM.

J Cell Biochem. 2017 Mar;118(3):629-639. doi: 10.1002/jcb.25750. Epub 2016 Oct 12.


Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1β-induced IL-6 expression in human OA chondrocytes.

Makki MS, Haqqi TM.

Connect Tissue Res. 2017 Jan;58(1):64-75. doi: 10.1080/03008207.2016.1211113. Epub 2016 Jul 12.


The Role of MicroRNAs and Their Targets in Osteoarthritis.

Sondag GR, Haqqi TM.

Curr Rheumatol Rep. 2016 Aug;18(8):56. doi: 10.1007/s11926-016-0604-x. Review.


Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes.

Haseeb A, Ansari MY, Haqqi TM.

J Orthop Res. 2017 Feb;35(2):311-320. doi: 10.1002/jor.23262. Epub 2016 May 4.


miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes.

Makki MS, Haqqi TM.

Exp Mol Med. 2015 Oct 9;47:e189. doi: 10.1038/emm.2015.66.


MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes.

Akhtar N, Makki MS, Haqqi TM.

Arthritis Rheumatol. 2015 Feb;67(2):423-34. doi: 10.1002/art.38952.


Protective effects of C-type natriuretic peptide on linear growth and articular cartilage integrity in a mouse model of inflammatory arthritis.

Bükülmez H, Khan F, Bartels CF, Murakami S, Ortiz-Lopez A, Sattar A, Haqqi TM, Warman ML.

Arthritis Rheumatol. 2014 Jan;66(1):78-89. doi: 10.1002/art.38199.


Delphinidin inhibits IL-1β-induced activation of NF-κB by modulating the phosphorylation of IRAK-1(Ser376) in human articular chondrocytes.

Haseeb A, Chen D, Haqqi TM.

Rheumatology (Oxford). 2013 Jun;52(6):998-1008. doi: 10.1093/rheumatology/kes363. Epub 2013 Feb 7.


Immunopathogenesis of osteoarthritis.

Haseeb A, Haqqi TM.

Clin Immunol. 2013 Mar;146(3):185-96. doi: 10.1016/j.clim.2012.12.011. Epub 2013 Jan 6. Review.


Current nutraceuticals in the management of osteoarthritis: a review.

Akhtar N, Haqqi TM.

Ther Adv Musculoskelet Dis. 2012 Jun;4(3):181-207. doi: 10.1177/1759720X11436238.


MicroRNA-199a* regulates the expression of cyclooxygenase-2 in human chondrocytes.

Akhtar N, Haqqi TM.

Ann Rheum Dis. 2012 Jun;71(6):1073-80. doi: 10.1136/annrheumdis-2011-200519. Epub 2012 Jan 31.


Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes.

Akhtar N, Miller MJ, Haqqi TM.

BMC Complement Altern Med. 2011 Aug 19;11:66. doi: 10.1186/1472-6882-11-66.


Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected].

Singh R, Akhtar N, Haqqi TM.

Life Sci. 2010 Jun 19;86(25-26):907-18. doi: 10.1016/j.lfs.2010.04.013. Epub 2010 May 10. Review. Erratum in: Life Sci. 2010 Jul 31;87(5-6):196.


MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes.

Akhtar N, Rasheed Z, Ramamurthy S, Anbazhagan AN, Voss FR, Haqqi TM.

Arthritis Rheum. 2010 May;62(5):1361-71. doi: 10.1002/art.27329.


Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes.

Rasheed Z, Anbazhagan AN, Akhtar N, Ramamurthy S, Voss FR, Haqqi TM.

Arthritis Res Ther. 2009;11(3):R71. doi: 10.1186/ar2700. Epub 2009 May 15.


Update on Targets of Biologic Therapies for Rheumatoid Arthritis.

Rasheed Z, Haqqi TM.

Curr Rheumatol Rev. 2008 Nov 1;4(4):246.


Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis.

Shukla M, Gupta K, Rasheed Z, Khan KA, Haqqi TM.

Nutrition. 2008 Jul-Aug;24(7-8):733-43. doi: 10.1016/j.nut.2008.03.013. Epub 2008 May 19.


Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9.

Gupta K, Shukla M, Cowland JB, Malemud CJ, Haqqi TM.

Arthritis Rheum. 2007 Oct;56(10):3326-35.


Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB.

Hafeez BB, Ahmed S, Wang N, Gupta S, Zhang A, Haqqi TM.

Toxicol Appl Pharmacol. 2006 Oct 1;216(1):11-9. Epub 2006 May 17.


Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review.

Ahmed S, Anuntiyo J, Malemud CJ, Haqqi TM.

Evid Based Complement Alternat Med. 2005 Sep;2(3):301-8.


Expression and characterization of a novel CD6 ligand in cells derived from joint and epithelial tissues.

Saifullah MK, Fox DA, Sarkar S, Abidi SM, Endres J, Piktel J, Haqqi TM, Singer NG.

J Immunol. 2004 Nov 15;173(10):6125-33.

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