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Items: 30


Step-Down Therapy for Asthma Well Controlled on Inhaled Corticosteroid and Long-Acting Beta-Agonist: A Randomized Clinical Trial.

Rogers L, Sugar EA, Blake K, Castro M, Dimango E, Hanania NA, Happel KI, Peters SP, Reibman J, Saams J, Teague WG, Wise RA, Holbrook JT; American Lung Association Airways Clinical Research Centers.

J Allergy Clin Immunol Pract. 2018 Mar - Apr;6(2):633-643.e1. doi: 10.1016/j.jaip.2017.07.030. Epub 2017 Sep 30.


Treatment with intranasal iloprost reduces disease manifestations in a murine model of previously established COPD.

Lammi MR, Ghonim MA, Pyakurel K, Naura AS, Ibba SV, Davis CJ, Okpechi SC, Happel KI, deBoisblanc BP, Shellito J, Boulares AH.

Am J Physiol Lung Cell Mol Physiol. 2016 Apr 1;310(7):L630-8. doi: 10.1152/ajplung.00297.2015. Epub 2016 Feb 5.


Serotonin 5-HT₂ receptor activation prevents allergic asthma in a mouse model.

Nau F Jr, Miller J, Saravia J, Ahlert T, Yu B, Happel KI, Cormier SA, Nichols CD.

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L191-8.


Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function.

Brown AO, Mann B, Gao G, Hankins JS, Humann J, Giardina J, Faverio P, Restrepo MI, Halade GV, Mortensen EM, Lindsey ML, Hanes M, Happel KI, Nelson S, Bagby GJ, Lorent JA, Cardinal P, Granados R, Esteban A, LeSaux CJ, Tuomanen EI, Orihuela CJ.

PLoS Pathog. 2014 Sep 18;10(9):e1004383. doi: 10.1371/journal.ppat.1004383. eCollection 2014 Sep.


Chronic alcohol induces M2 polarization enhancing pulmonary disease caused by exposure to particulate air pollution.

Thevenot P, Saravia J, Giaimo J, Happel KI, Dugas TR, Cormier SA.

Alcohol Clin Exp Res. 2013 Nov;37(11):1910-9. doi: 10.1111/acer.12184. Epub 2013 Jun 13.


Effect of bacterial pneumonia on lung simian immunodeficiency virus (SIV) replication in alcohol consuming SIV-infected rhesus macaques.

Nelson S, Happel KI, Zhang P, Myers L, Dufour JP, Bagby GJ.

Alcohol Clin Exp Res. 2013 Jun;37(6):969-77. doi: 10.1111/acer.12070. Epub 2013 Feb 15.


An eating disorder leading to wet beriberi heart failure in a 30-year-old woman.

Ward KE, Happel KI.

Am J Emerg Med. 2013 Feb;31(2):460.e5-6. doi: 10.1016/j.ajem.2012.08.007. Epub 2012 Nov 15. No abstract available.


The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathway.

Yano J, Kolls JK, Happel KI, Wormley F, Wozniak KL, Fidel PL Jr.

PLoS One. 2012;7(9):e46311. doi: 10.1371/journal.pone.0046311. Epub 2012 Sep 25.


Inhaled fluticasone propionate impairs pulmonary clearance of Klebsiella pneumoniae in mice.

Patterson CM, Morrison RL, D'Souza A, Teng XS, Happel KI.

Respir Res. 2012 May 31;13:40. doi: 10.1186/1465-9921-13-40.


The impact of alcohol on BCG-induced immunity against Mycobacterium tuberculosis.

Porretta E, Happel KI, Teng XS, Ramsay A, Mason CM.

Alcohol Clin Exp Res. 2012 Feb;36(2):310-7. doi: 10.1111/j.1530-0277.2011.01624.x. Epub 2011 Oct 20.


Alcohol's role in HIV transmission and disease progression.

Pandrea I, Happel KI, Amedee AM, Bagby GJ, Nelson S.

Alcohol Res Health. 2010;33(3):203-18. Review.


Focus on: Alcohol and the immune system.

Molina PE, Happel KI, Zhang P, Kolls JK, Nelson S.

Alcohol Res Health. 2010;33(1-2):97-108. Review.


Mechanisms of neutrophil accumulation in the lungs against bacteria.

Balamayooran G, Batra S, Fessler MB, Happel KI, Jeyaseelan S.

Am J Respir Cell Mol Biol. 2010 Jul;43(1):5-16. doi: 10.1165/rcmb.2009-0047TR. Epub 2009 Sep 8. Review.


Acute alcohol intoxication inhibits the lineage- c-kit+ Sca-1+ cell response to Escherichia coli bacteremia.

Zhang P, Welsh DA, Siggins RW 2nd, Bagby GJ, Raasch CE, Happel KI, Nelson S.

J Immunol. 2009 Feb 1;182(3):1568-76.


Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxication.

Walker JE Jr, Odden AR, Jeyaseelan S, Zhang P, Bagby GJ, Nelson S, Happel KI.

Alcohol Clin Exp Res. 2009 Feb;33(2):357-65. doi: 10.1111/j.1530-0277.2008.00844.x. Epub 2008 Nov 25.


The systemic and pulmonary LPS binding protein response to intratracheal lipopolysaccharide.

Gamble L, Bagby GJ, Quinton LJ, Happel KI, Mizgerd JP, Zhang P, Nelson S.

Shock. 2009 Feb;31(2):212-7. doi: 10.1097/SHK.0b013e31817c0d7d.


Alcohol abuse, immunosuppression, and pulmonary infection.

Zhang P, Bagby GJ, Happel KI, Raasch CE, Nelson S.

Curr Drug Abuse Rev. 2008 Jan;1(1):56-67. Review.


Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide.

Happel KI, Rudner X, Quinton LJ, Movassaghi JL, Clark C, Odden AR, Zhang P, Bagby GJ, Nelson S, Shellito JE.

Alcohol. 2007 Aug;41(5):325-33.


Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection.

Rudner XL, Happel KI, Young EA, Shellito JE.

Infect Immun. 2007 Jun;75(6):3055-61. Epub 2007 Apr 2.


Acute alcohol intoxication suppresses the interleukin 23 response to Klebsiella pneumoniae infection.

Happel KI, Odden AR, Zhang P, Shellito JE, Bagby GJ, Nelson S.

Alcohol Clin Exp Res. 2006 Jul;30(7):1200-7.


Alcohol, immunosuppression, and the lung.

Happel KI, Nelson S.

Proc Am Thorac Soc. 2005;2(5):428-32. Review.


RSA 2004: combined basic research satellite symposium-mechanisms of alcohol-mediated organ and tissue damage: inflammation and immunity and alcohol and mitochondrial metabolism: at the crossroads of life and death session one: alcohol, cellular and organ damage.

Hoek J, Thiele GM, Klassen LW, Mandrekar P, Zakhari S, Cook RT, Ray NB, Happel KI, Kolls JK, Kovacs EJ, Szab G.

Alcohol Clin Exp Res. 2005 Sep;29(9):1735-43. Erratum in: Alcohol Clin Exp Res. 2006 Feb;30(2):388. Klassen, Lynell W [added].


Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae.

Happel KI, Dubin PJ, Zheng M, Ghilardi N, Lockhart C, Quinton LJ, Odden AR, Shellito JE, Bagby GJ, Nelson S, Kolls JK.

J Exp Med. 2005 Sep 19;202(6):761-9. Epub 2005 Sep 12.


Pulmonary interleukin-23 gene delivery increases local T-cell immunity and controls growth of Mycobacterium tuberculosis in the lungs.

Happel KI, Lockhart EA, Mason CM, Porretta E, Keoshkerian E, Odden AR, Nelson S, Ramsay AJ.

Infect Immun. 2005 Sep;73(9):5782-8.


Host defense and bacterial pneumonia.

Happel KI, Bagby GJ, Nelson S.

Semin Respir Crit Care Med. 2004 Feb;25(1):43-52.


Effects of systemic and local CXC chemokine administration on the ethanol-induced suppression of pulmonary neutrophil recruitment.

Quinton LJ, Nelson S, Zhang P, Happel KI, Gamble L, Bagby GJ.

Alcohol Clin Exp Res. 2005 Jul;29(7):1198-205.


The lung in sepsis: fueling the fire.

Happel KI, Nelson S, Summer W.

Am J Med Sci. 2004 Oct;328(4):230-7. Review.


Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitment.

Quinton LJ, Nelson S, Zhang P, Boé DM, Happel KI, Pan W, Bagby GJ.

Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L465-72. Epub 2003 Nov 14.


Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection.

Happel KI, Zheng M, Young E, Quinton LJ, Lockhart E, Ramsay AJ, Shellito JE, Schurr JR, Bagby GJ, Nelson S, Kolls JK.

J Immunol. 2003 May 1;170(9):4432-6.


Pulmonary host defenses and alcohol.

Zhang P, Bagby GJ, Happel KI, Summer WR, Nelson S.

Front Biosci. 2002 May 1;7:d1314-30. Review.


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