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Items: 1 to 50 of 96

1.

Differential Protonation at the Catalytic Six-Iron Cofactor of [FeFe]-Hydrogenases Revealed by 57Fe Nuclear Resonance X-ray Scattering and Quantum Mechanics/Molecular Mechanics Analyses.

Mebs S, Duan J, Wittkamp F, Stripp ST, Happe T, Apfel UP, Winkler M, Haumann M.

Inorg Chem. 2019 Mar 18;58(6):4000-4013. doi: 10.1021/acs.inorgchem.9b00100. Epub 2019 Feb 25.

PMID:
30802044
2.

His-Ligation to the [4Fe-4S] Subcluster Tunes the Catalytic Bias of [FeFe] Hydrogenase.

Rodríguez-Maciá P, Kertess L, Burnik J, Birrell JA, Hofmann E, Lubitz W, Happe T, Rüdiger O.

J Am Chem Soc. 2019 Jan 9;141(1):472-481. doi: 10.1021/jacs.8b11149. Epub 2018 Dec 26.

PMID:
30545220
3.

[FeFe]-hydrogenases from green algae.

Engelbrecht V, Happe T.

Methods Enzymol. 2018;613:203-230. doi: 10.1016/bs.mie.2018.10.004. Epub 2018 Nov 24.

PMID:
30509467
4.

Crystallographic and spectroscopic assignment of the proton transfer pathway in [FeFe]-hydrogenases.

Duan J, Senger M, Esselborn J, Engelbrecht V, Wittkamp F, Apfel UP, Hofmann E, Stripp ST, Happe T, Winkler M.

Nat Commun. 2018 Nov 9;9(1):4726. doi: 10.1038/s41467-018-07140-x.

5.

Preventing the coffee-ring effect and aggregate sedimentation by in situ gelation of monodisperse materials.

Li H, Buesen D, Williams R, Henig J, Stapf S, Mukherjee K, Freier E, Lubitz W, Winkler M, Happe T, Plumeré N.

Chem Sci. 2018 Aug 23;9(39):7596-7605. doi: 10.1039/c8sc03302a. eCollection 2018 Oct 21.

6.

Iron-sulphur cluster biogenesis via the SUF pathway.

Bai Y, Chen T, Happe T, Lu Y, Sawyer A.

Metallomics. 2018 Aug 15;10(8):1038-1052. doi: 10.1039/c8mt00150b. Review.

PMID:
30019043
7.

Spectroscopical Investigations on the Redox Chemistry of [FeFe]-Hydrogenases in the Presence of Carbon Monoxide.

Laun K, Mebs S, Duan J, Wittkamp F, Apfel UP, Happe T, Winkler M, Haumann M, Stripp ST.

Molecules. 2018 Jul 9;23(7). pii: E1669. doi: 10.3390/molecules23071669.

8.

Flavodiiron-Mediated O2 Photoreduction Links H2 Production with CO2 Fixation during the Anaerobic Induction of Photosynthesis.

Burlacot A, Sawyer A, Cuiné S, Auroy-Tarrago P, Blangy S, Happe T, Peltier G.

Plant Physiol. 2018 Aug;177(4):1639-1649. doi: 10.1104/pp.18.00721. Epub 2018 Jul 5.

9.

In memory of Achim Trebst (1929-2017): a pioneer of photosynthesis research.

Bothe H, Happe T, Trebst S, Rögner M.

Photosynth Res. 2018 Sep;137(3):341-359. doi: 10.1007/s11120-018-0516-x. Epub 2018 May 16.

PMID:
29767344
10.

Influence of the [4Fe-4S] cluster coordinating cysteines on active site maturation and catalytic properties of C. reinhardtii [FeFe]-hydrogenase.

Kertess L, Adamska-Venkatesh A, Rodríguez-Maciá P, Rüdiger O, Lubitz W, Happe T.

Chem Sci. 2017 Dec 1;8(12):8127-8137. doi: 10.1039/c7sc03444j. Epub 2017 Oct 9.

11.

Rational redesign of the ferredoxin-NADP+-oxido-reductase/ferredoxin-interaction for photosynthesis-dependent H2-production.

Wiegand K, Winkler M, Rumpel S, Kannchen D, Rexroth S, Hase T, Farès C, Happe T, Lubitz W, Rögner M.

Biochim Biophys Acta Bioenerg. 2018 Apr;1859(4):253-262. doi: 10.1016/j.bbabio.2018.01.006. Epub 2018 Jan 31.

12.

Interplay between CN- Ligands and the Secondary Coordination Sphere of the H-Cluster in [FeFe]-Hydrogenases.

Lampret O, Adamska-Venkatesh A, Konegger H, Wittkamp F, Apfel UP, Reijerse EJ, Lubitz W, Rüdiger O, Happe T, Winkler M.

J Am Chem Soc. 2017 Dec 20;139(50):18222-18230. doi: 10.1021/jacs.7b08735. Epub 2017 Dec 7.

PMID:
29179539
13.

Chalcogenide substitution in the [2Fe] cluster of [FeFe]-hydrogenases conserves high enzymatic activity.

Kertess L, Wittkamp F, Sommer C, Esselborn J, Rüdiger O, Reijerse EJ, Hofmann E, Lubitz W, Winkler M, Happe T, Apfel UP.

Dalton Trans. 2017 Dec 12;46(48):16947-16958. doi: 10.1039/c7dt03785f.

PMID:
29177350
14.

Proton-Coupled Reduction of the Catalytic [4Fe-4S] Cluster in [FeFe]-Hydrogenases.

Senger M, Laun K, Wittkamp F, Duan J, Haumann M, Happe T, Winkler M, Apfel UP, Stripp ST.

Angew Chem Int Ed Engl. 2017 Dec 22;56(52):16503-16506. doi: 10.1002/anie.201709910. Epub 2017 Nov 30.

PMID:
29072356
15.

Hydrogen and oxygen trapping at the H-cluster of [FeFe]-hydrogenase revealed by site-selective spectroscopy and QM/MM calculations.

Mebs S, Kositzki R, Duan J, Kertess L, Senger M, Wittkamp F, Apfel UP, Happe T, Stripp ST, Winkler M, Haumann M.

Biochim Biophys Acta Bioenerg. 2018 Jan;1859(1):28-41. doi: 10.1016/j.bbabio.2017.09.003. Epub 2017 Sep 15.

16.

Protonation/reduction dynamics at the [4Fe-4S] cluster of the hydrogen-forming cofactor in [FeFe]-hydrogenases.

Senger M, Mebs S, Duan J, Shulenina O, Laun K, Kertess L, Wittkamp F, Apfel UP, Happe T, Winkler M, Haumann M, Stripp ST.

Phys Chem Chem Phys. 2018 Jan 31;20(5):3128-3140. doi: 10.1039/c7cp04757f.

PMID:
28884175
17.

Bridging Hydride at Reduced H-Cluster Species in [FeFe]-Hydrogenases Revealed by Infrared Spectroscopy, Isotope Editing, and Quantum Chemistry.

Mebs S, Senger M, Duan J, Wittkamp F, Apfel UP, Happe T, Winkler M, Stripp ST, Haumann M.

J Am Chem Soc. 2017 Sep 6;139(35):12157-12160. doi: 10.1021/jacs.7b07548. Epub 2017 Aug 25.

PMID:
28825810
18.

Accumulating the hydride state in the catalytic cycle of [FeFe]-hydrogenases.

Winkler M, Senger M, Duan J, Esselborn J, Wittkamp F, Hofmann E, Apfel UP, Stripp ST, Happe T.

Nat Commun. 2017 Jul 19;8:16115. doi: 10.1038/ncomms16115.

19.

The structurally unique photosynthetic Chlorella variabilis NC64A hydrogenase does not interact with plant-type ferredoxins.

Engelbrecht V, Rodríguez-Maciá P, Esselborn J, Sawyer A, Hemschemeier A, Rüdiger O, Lubitz W, Winkler M, Happe T.

Biochim Biophys Acta Bioenerg. 2017 Sep;1858(9):771-778. doi: 10.1016/j.bbabio.2017.06.004. Epub 2017 Jun 21.

20.

Association of Ferredoxin:NADP+ oxidoreductase with the photosynthetic apparatus modulates electron transfer in Chlamydomonas reinhardtii.

Mosebach L, Heilmann C, Mutoh R, Gäbelein P, Steinbeck J, Happe T, Ikegami T, Hanke G, Kurisu G, Hippler M.

Photosynth Res. 2017 Dec;134(3):291-306. doi: 10.1007/s11120-017-0408-5. Epub 2017 Jun 7.

21.

Transfer of photosynthetic NADP+/NADPH recycling activity to a porous metal oxide for highly specific, electrochemically-driven organic synthesis.

Siritanaratkul B, Megarity CF, Roberts TG, Samuels TOM, Winkler M, Warner JH, Happe T, Armstrong FA.

Chem Sci. 2017 Jun 1;8(6):4579-4586. doi: 10.1039/c7sc00850c. Epub 2017 May 5.

22.

Vibrational spectroscopy reveals the initial steps of biological hydrogen evolution.

Katz S, Noth J, Horch M, Shafaat HS, Happe T, Hildebrandt P, Zebger I.

Chem Sci. 2016 Nov 1;7(11):6746-6752. doi: 10.1039/c6sc01098a. Epub 2016 Jul 11.

23.

Frequency and potential dependence of reversible electrocatalytic hydrogen interconversion by [FeFe]-hydrogenases.

Pandey K, Islam ST, Happe T, Armstrong FA.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3843-3848. doi: 10.1073/pnas.1619961114. Epub 2017 Mar 27.

24.

Compartmentalisation of [FeFe]-hydrogenase maturation in Chlamydomonas reinhardtii.

Sawyer A, Bai Y, Lu Y, Hemschemeier A, Happe T.

Plant J. 2017 Jun;90(6):1134-1143. doi: 10.1111/tpj.13535. Epub 2017 Apr 26.

25.

Sunlight-Dependent Hydrogen Production by Photosensitizer/Hydrogenase Systems.

Adam D, Bösche L, Castañeda-Losada L, Winkler M, Apfel UP, Happe T.

ChemSusChem. 2017 Mar 9;10(5):894-902. doi: 10.1002/cssc.201601523. Epub 2017 Feb 9.

PMID:
27976835
26.

Electrochemical Investigations of the Mechanism of Assembly of the Active-Site H-Cluster of [FeFe]-Hydrogenases.

Megarity CF, Esselborn J, Hexter SV, Wittkamp F, Apfel UP, Happe T, Armstrong FA.

J Am Chem Soc. 2016 Nov 23;138(46):15227-15233. Epub 2016 Nov 14.

PMID:
27776209
27.

[FeFe]-Hydrogenase with Chalcogenide Substitutions at the H-Cluster Maintains Full H2 Evolution Activity.

Noth J, Esselborn J, Güldenhaupt J, Brünje A, Sawyer A, Apfel UP, Gerwert K, Hofmann E, Winkler M, Happe T.

Angew Chem Int Ed Engl. 2016 Jul 11;55(29):8396-400. doi: 10.1002/anie.201511896. Epub 2016 May 23.

PMID:
27214763
28.

A structural view of synthetic cofactor integration into [FeFe]-hydrogenases.

Esselborn J, Muraki N, Klein K, Engelbrecht V, Metzler-Nolte N, Apfel UP, Hofmann E, Kurisu G, Happe T.

Chem Sci. 2016 Feb 1;7(2):959-968. doi: 10.1039/c5sc03397g. Epub 2015 Oct 26.

29.

Lyophilization protects [FeFe]-hydrogenases against O2-induced H-cluster degradation.

Noth J, Kositzki R, Klein K, Winkler M, Haumann M, Happe T.

Sci Rep. 2015 Sep 14;5:13978. doi: 10.1038/srep13978.

30.

A redox hydrogel protects the O2 -sensitive [FeFe]-hydrogenase from Chlamydomonas reinhardtii from oxidative damage.

Oughli AA, Conzuelo F, Winkler M, Happe T, Lubitz W, Schuhmann W, Rüdiger O, Plumeré N.

Angew Chem Int Ed Engl. 2015 Oct 12;54(42):12329-33. doi: 10.1002/anie.201502776. Epub 2015 Jun 12.

PMID:
26073322
31.

How Formaldehyde Inhibits Hydrogen Evolution by [FeFe]-Hydrogenases: Determination by ¹³C ENDOR of Direct Fe-C Coordination and Order of Electron and Proton Transfers.

Bachmeier A, Esselborn J, Hexter SV, Krämer T, Klein K, Happe T, McGrady JE, Myers WK, Armstrong FA.

J Am Chem Soc. 2015 Apr 29;137(16):5381-9. doi: 10.1021/ja513074m. Epub 2015 Apr 14.

PMID:
25871921
32.

Quantum yield measurements of light-induced H₂ generation in a photosystem I-[FeFe]-H₂ase nanoconstruct.

Applegate AM, Lubner CE, Knörzer P, Happe T, Golbeck JH.

Photosynth Res. 2016 Jan;127(1):5-11. doi: 10.1007/s11120-014-0064-y. Epub 2014 Dec 20.

PMID:
25527460
33.

Hydride binding to the active site of [FeFe]-hydrogenase.

Chernev P, Lambertz C, Brünje A, Leidel N, Sigfridsson KG, Kositzki R, Hsieh CH, Yao S, Schiwon R, Driess M, Limberg C, Happe T, Haumann M.

Inorg Chem. 2014 Nov 17;53(22):12164-77. doi: 10.1021/ic502047q. Epub 2014 Nov 4.

PMID:
25369169
34.

New redox states observed in [FeFe] hydrogenases reveal redox coupling within the H-cluster.

Adamska-Venkatesh A, Krawietz D, Siebel J, Weber K, Happe T, Reijerse E, Lubitz W.

J Am Chem Soc. 2014 Aug 13;136(32):11339-46. doi: 10.1021/ja503390c. Epub 2014 Jul 29.

PMID:
25025613
35.

Metalloprotein mimics - old tools in a new light.

Happe T, Hemschemeier A.

Trends Biotechnol. 2014 Apr;32(4):170-6. doi: 10.1016/j.tibtech.2014.02.004. Epub 2014 Mar 11.

PMID:
24630475
36.

Copper response regulator1-dependent and -independent responses of the Chlamydomonas reinhardtii transcriptome to dark anoxia.

Hemschemeier A, Casero D, Liu B, Benning C, Pellegrini M, Happe T, Merchant SS.

Plant Cell. 2013 Sep;25(9):3186-211. doi: 10.1105/tpc.113.115741. Epub 2013 Sep 6.

37.

Spontaneous activation of [FeFe]-hydrogenases by an inorganic [2Fe] active site mimic.

Esselborn J, Lambertz C, Adamska-Venkates A, Simmons T, Berggren G, Noth J, Siebel J, Hemschemeier A, Artero V, Reijerse E, Fontecave M, Lubitz W, Happe T.

Nat Chem Biol. 2013 Oct;9(10):607-609. doi: 10.1038/nchembio.1311. Epub 2013 Aug 11.

38.

Biomimetic assembly and activation of [FeFe]-hydrogenases.

Berggren G, Adamska A, Lambertz C, Simmons TR, Esselborn J, Atta M, Gambarelli S, Mouesca JM, Reijerse E, Lubitz W, Happe T, Artero V, Fontecave M.

Nature. 2013 Jul 4;499(7456):66-69. doi: 10.1038/nature12239. Epub 2013 Jun 26.

39.

Hypoxic survival requires a 2-on-2 hemoglobin in a process involving nitric oxide.

Hemschemeier A, Düner M, Casero D, Merchant SS, Winkler M, Happe T.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10854-9. doi: 10.1073/pnas.1302592110. Epub 2013 Jun 10.

40.

Molecular basis of [FeFe]-hydrogenase function: an insight into the complex interplay between protein and catalytic cofactor.

Winkler M, Esselborn J, Happe T.

Biochim Biophys Acta. 2013 Aug-Sep;1827(8-9):974-85. doi: 10.1016/j.bbabio.2013.03.004. Epub 2013 Mar 16.

41.

Pyruvate:ferredoxin oxidoreductase is coupled to light-independent hydrogen production in Chlamydomonas reinhardtii.

Noth J, Krawietz D, Hemschemeier A, Happe T.

J Biol Chem. 2013 Feb 8;288(6):4368-77. doi: 10.1074/jbc.M112.429985. Epub 2012 Dec 20.

42.

Identification and characterization of the "super-reduced" state of the H-cluster in [FeFe] hydrogenase: a new building block for the catalytic cycle?

Adamska A, Silakov A, Lambertz C, Rüdiger O, Happe T, Reijerse E, Lubitz W.

Angew Chem Int Ed Engl. 2012 Nov 12;51(46):11458-62. doi: 10.1002/anie.201204800. Epub 2012 Oct 26. No abstract available.

PMID:
23109267
43.

Electrocatalytic mechanism of reversible hydrogen cycling by enzymes and distinctions between the major classes of hydrogenases.

Hexter SV, Grey F, Happe T, Climent V, Armstrong FA.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11516-21. doi: 10.1073/pnas.1204770109. Epub 2012 Jul 16. Erratum in: Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18232-3.

44.

Differential expression of the Chlamydomonas [FeFe]-hydrogenase-encoding HYDA1 gene is regulated by the copper response regulator1.

Pape M, Lambertz C, Happe T, Hemschemeier A.

Plant Physiol. 2012 Aug;159(4):1700-12. doi: 10.1104/pp.112.200162. Epub 2012 Jun 5.

45.

Inhibition of [FeFe]-hydrogenases by formaldehyde and wider mechanistic implications for biohydrogen activation.

Foster CE, Krämer T, Wait AF, Parkin A, Jennings DP, Happe T, McGrady JE, Armstrong FA.

J Am Chem Soc. 2012 May 2;134(17):7553-7. doi: 10.1021/ja302096r. Epub 2012 Apr 18.

PMID:
22512303
46.

Solar hydrogen-producing bionanodevice outperforms natural photosynthesis.

Lubner CE, Applegate AM, Knörzer P, Ganago A, Bryant DA, Happe T, Golbeck JH.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20988-91. doi: 10.1073/pnas.1114660108. Epub 2011 Dec 12.

47.

Importance of the protein framework for catalytic activity of [FeFe]-hydrogenases.

Knörzer P, Silakov A, Foster CE, Armstrong FA, Lubitz W, Happe T.

J Biol Chem. 2012 Jan 6;287(2):1489-99. doi: 10.1074/jbc.M111.305797. Epub 2011 Nov 22.

48.

Nitrogen deprivation results in photosynthetic hydrogen production in Chlamydomonas reinhardtii.

Philipps G, Happe T, Hemschemeier A.

Planta. 2012 Apr;235(4):729-45. doi: 10.1007/s00425-011-1537-2. Epub 2011 Oct 22.

PMID:
22020754
49.

O2 reactions at the six-iron active site (H-cluster) in [FeFe]-hydrogenase.

Lambertz C, Leidel N, Havelius KG, Noth J, Chernev P, Winkler M, Happe T, Haumann M.

J Biol Chem. 2011 Nov 25;286(47):40614-23. doi: 10.1074/jbc.M111.283648. Epub 2011 Sep 19.

50.

Control of hydrogen photoproduction by the proton gradient generated by cyclic electron flow in Chlamydomonas reinhardtii.

Tolleter D, Ghysels B, Alric J, Petroutsos D, Tolstygina I, Krawietz D, Happe T, Auroy P, Adriano JM, Beyly A, Cuiné S, Plet J, Reiter IM, Genty B, Cournac L, Hippler M, Peltier G.

Plant Cell. 2011 Jul;23(7):2619-30. doi: 10.1105/tpc.111.086876. Epub 2011 Jul 15.

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