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Items: 1 to 50 of 128

1.

Human oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket.

Lan L, Xing M, Douglas JT, Gao P, Hanzlik RP, Xu L.

Oncotarget. 2017 Nov 20;8(63):106587-106597. doi: 10.18632/oncotarget.22540. eCollection 2017 Dec 5.

2.

Comparative Toxicity and Metabolism of N-Acyl Homologues of Acetaminophen and Its Isomer 3'-Hydroxyacetanilide.

Koen YM, Liu K, Shinogle H, Williams TD, Hanzlik RP.

Chem Res Toxicol. 2016 Nov 21;29(11):1857-1864. Epub 2016 Oct 13.

PMID:
27680534
3.

Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes.

Goldman JL, Koen YM, Rogers SA, Li K, Leeder JS, Hanzlik RP.

Drug Metab Dispos. 2016 Oct;44(10):1603-7. doi: 10.1124/dmd.116.072041. Epub 2016 Jul 25.

4.

Protein Targets of Isoniazid-Reactive Metabolites in Mouse Liver in Vivo.

Koen YM, Galeva NA, Metushi IG, Uetrecht J, Hanzlik RP.

Chem Res Toxicol. 2016 Jun 20;29(6):1064-72. doi: 10.1021/acs.chemrestox.6b00098. Epub 2016 May 5.

PMID:
27097313
5.

Branched amphiphilic peptide capsules: cellular uptake and retention of encapsulated solutes.

Sukthankar P, Avila LA, Whitaker SK, Iwamoto T, Morgenstern A, Apostolidis C, Liu K, Hanzlik RP, Dadachova E, Tomich JM.

Biochim Biophys Acta. 2014 Sep;1838(9):2296-305. doi: 10.1016/j.bbamem.2014.02.005. Epub 2014 Feb 22.

6.

Bioinformatic analysis of 302 reactive metabolite target proteins. Which ones are important for cell death?

Hanzlik RP, Koen YM, Fang J.

Toxicol Sci. 2013 Oct;135(2):390-401. doi: 10.1093/toxsci/kft166. Epub 2013 Jul 28.

7.

Protein targets of thioacetamide metabolites in rat hepatocytes.

Koen YM, Sarma D, Hajovsky H, Galeva NA, Williams TD, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2013 Apr 15;26(4):564-74. doi: 10.1021/tx400001x. Epub 2013 Mar 20.

8.

Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes.

Hajovsky H, Hu G, Koen Y, Sarma D, Cui W, Moore DS, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2012 Sep 17;25(9):1955-63. doi: 10.1021/tx3002719. Epub 2012 Aug 17.

9.

Liver protein targets of hepatotoxic 4-bromophenol metabolites.

Koen YM, Hajovsky H, Liu K, Williams TD, Galeva NA, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2012 Aug 20;25(8):1777-86. doi: 10.1021/tx3002675. Epub 2012 Aug 3.

10.

Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites.

Sarma D, Hajovsky H, Koen YM, Galeva NA, Williams TD, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2012 Sep 17;25(9):1868-77. doi: 10.1021/tx3001658. Epub 2012 Jun 15.

11.

Identification of protein targets of reactive metabolites of tienilic acid in human hepatocytes.

Koen YM, Sarma D, Williams TD, Galeva NA, Obach RS, Hanzlik RP.

Chem Res Toxicol. 2012 May 21;25(5):1145-54. doi: 10.1021/tx300103j. Epub 2012 Apr 10.

12.
13.

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.

Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai G, Battaile KP, Thomas CJ, Simeonov A, Hanzlik RP, Inglese J.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4878-83. doi: 10.1073/pnas.0909141107. Epub 2010 Mar 1.

14.

Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners.

Fang J, Koen YM, Hanzlik RP.

BMC Chem Biol. 2009 Jun 12;9:5. doi: 10.1186/1472-6769-9-5.

15.

Ocular and systemic safety evaluation of calcium formate as a dietary supplement.

Altaweel MM, Hanzlik RP, Ver Hoeve JN, Eells J, Zhang B.

J Ocul Pharmacol Ther. 2009 Jun;25(3):223-30. doi: 10.1089/jop.2008.0128.

PMID:
19456257
16.

Eulogy to Mathias P. Mertes, 1932-1989.

Bowman-James K, Grunewald GL, Hanzlik RP.

Med Res Rev. 2009 Jan;29(1):1-2. doi: 10.1002/med.20147. No abstract available.

PMID:
19058131
17.

Filling and mining the reactive metabolite target protein database.

Hanzlik RP, Fang J, Koen YM.

Chem Biol Interact. 2009 Apr 15;179(1):38-44. doi: 10.1016/j.cbi.2008.08.016. Epub 2008 Sep 6. Review.

18.

Protein targets of reactive metabolites of thiobenzamide in rat liver in vivo.

Ikehata K, Duzhak TG, Galeva NA, Ji T, Koen YM, Hanzlik RP.

Chem Res Toxicol. 2008 Jul;21(7):1432-42. doi: 10.1021/tx800093k. Epub 2008 Jun 12.

19.

X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives.

Huang W, Yamamoto Y, Li Y, Dou D, Alliston KR, Hanzlik RP, Williams TD, Groutas WC.

J Med Chem. 2008 Apr 10;51(7):2003-8. doi: 10.1021/jm700966p. Epub 2008 Mar 5.

20.

Covalent modification of microsomal lipids by thiobenzamide metabolites in vivo.

Ji T, Ikehata K, Koen YM, Esch SW, Williams TD, Hanzlik RP.

Chem Res Toxicol. 2007 Apr;20(4):701-8. Epub 2007 Mar 24.

21.

The reactive metabolite target protein database (TPDB)--a web-accessible resource.

Hanzlik RP, Koen YM, Theertham B, Dong Y, Fang J.

BMC Bioinformatics. 2007 Mar 16;8:95.

22.

A proteomic analysis of bromobenzene reactive metabolite targets in rat liver cytosol in vivo.

Koen YM, Gogichaeva NV, Alterman MA, Hanzlik RP.

Chem Res Toxicol. 2007 Mar;20(3):511-9. Epub 2007 Feb 17.

PMID:
17305373
23.

Site-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivo.

Koen YM, Yue W, Galeva NA, Williams TD, Hanzlik RP.

Chem Res Toxicol. 2006 Nov;19(11):1426-34.

24.

Structural basis of catalysis by monometalated methionine aminopeptidase.

Ye QZ, Xie SX, Ma ZQ, Huang M, Hanzlik RP.

Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9470-5. Epub 2006 Jun 12.

25.

Structural analysis of metalloform-selective inhibition of methionine aminopeptidase.

Xie SX, Huang WJ, Ma ZQ, Huang M, Hanzlik RP, Ye QZ.

Acta Crystallogr D Biol Crystallogr. 2006 Apr;62(Pt 4):425-32. Epub 2006 Mar 18.

PMID:
16552144
27.

Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core.

Li Q, Hanzlik RP, Weaver RF, Schönbrunn E.

Biochemistry. 2006 Jan 24;45(3):701-8.

PMID:
16411745
28.

Metal mediated inhibition of methionine aminopeptidase by quinolinyl sulfonamides.

Huang M, Xie SX, Ma ZQ, Hanzlik RP, Ye QZ.

Biochem Biophys Res Commun. 2006 Jan 13;339(2):506-13. Epub 2005 Nov 15.

PMID:
16300729
29.
30.

Towards the creation of an international toxicology information centre.

Judson PN, Cooke PA, Doerrer NG, Greene N, Hanzlik RP, Hardy C, Hartmann A, Hinchliffe D, Holder J, Müller L, Steger-Hartmann T, Rothfuss A, Smith M, Thomas K, Vessey JD, Zeiger E.

Toxicology. 2005 Sep 15;213(1-2):117-28.

PMID:
16084005
31.

Synthesis of a small library of diketopiperazines as potential inhibitors of calpain.

Zeng Y, Li Q, Hanzlik RP, Aubé J.

Bioorg Med Chem Lett. 2005 Jun 15;15(12):3034-8.

PMID:
15896956
32.

Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes.

Cerny MA, Hanzlik RP.

Arch Biochem Biophys. 2005 Apr 15;436(2):265-75.

PMID:
15797239
33.

Relative bioavailability of calcium from calcium formate, calcium citrate, and calcium carbonate.

Hanzlik RP, Fowler SC, Fisher DH.

J Pharmacol Exp Ther. 2005 Jun;313(3):1217-22. Epub 2005 Feb 25.

PMID:
15734899
34.

Absorption and elimination of formate following oral administration of calcium formate in female human subjects.

Hanzlik RP, Fowler SC, Eells JT.

Drug Metab Dispos. 2005 Feb;33(2):282-6. Epub 2004 Nov 16.

PMID:
15547050
35.

1H high-resolution magic-angle spinning (HR-MAS) NMR analysis of ligand density on resins using a resin internal standard.

Lucas LH, Cerny MA, Koen YM, Hanzlik RP, Larive CK.

Anal Bioanal Chem. 2004 Oct;380(4):627-31. Epub 2004 Oct 7.

PMID:
15480583
37.

Synthesis of N tau-arylhistidine derivatives via direct N-arylation.

Yue W, Lewis SI, Koen YM, Hanzlik RP.

Bioorg Med Chem Lett. 2004 Apr 5;14(7):1637-40.

PMID:
15026040
38.

Non-oxidative decarboxylation of glycine derivatives by a peroxidase.

Totah RA, Hanzlik RP.

J Am Chem Soc. 2002 Aug 28;124(34):10000-1.

PMID:
12188659
39.

Formation of cyclopropanone during cytochrome P450-catalyzed N-dealkylation of a cyclopropylamine.

Shaffer CL, Harriman S, Koen YM, Hanzlik RP.

J Am Chem Soc. 2002 Jul 17;124(28):8268-74.

PMID:
12105905
40.
41.

Hydroxylation of fatty acids by microsomal and reconstituted cytochrome P450 2B1.

Alterman MA, Hanzlik RP.

FEBS Lett. 2002 Feb 13;512(1-3):319-22.

42.
43.

Detection of aminium ion intermediates: N-cyclopropyl versus N-carboxymethyl groups as reporters.

Totah RA, Hanzlik RP.

J Am Chem Soc. 2001 Oct 17;123(41):10107-8. No abstract available.

PMID:
11592894
44.

N-dealkylation of an N-cyclopropylamine by horseradish peroxidase. Fate of the cyclopropyl group.

Shaffer CL, Morton MD, Hanzlik RP.

J Am Chem Soc. 2001 Sep 5;123(35):8502-8.

PMID:
11525657
45.

Enzymatic N-dealkylation of an N-cyclopropylamine: an unusual fate for the cyclopropyl group.

Shaffer CL, Morton MD, Hanzlik RP.

J Am Chem Soc. 2001 Jan 17;123(2):349-50. No abstract available.

PMID:
11456529
46.

Identification of three protein targets for reactive metabolites of bromobenzene in rat liver cytosol.

Koen YM, Williams TD, Hanzlik RP.

Chem Res Toxicol. 2000 Dec;13(12):1326-35.

PMID:
11123975
47.

Roles of key active-site residues in flavocytochrome P450 BM3.

Noble MA, Miles CS, Chapman SK, Lysek DA, MacKay AC, Reid GA, Hanzlik RP, Munro AW.

Biochem J. 1999 Apr 15;339 ( Pt 2):371-9.

48.

Design, synthesis, and evaluation of azapeptides as substrates and inhibitors for human rhinovirus 3C protease.

Venkatraman S, Kong J, Nimkar S, Wang QM, Aubé J, Hanzlik RP.

Bioorg Med Chem Lett. 1999 Feb 22;9(4):577-80.

PMID:
10098667
49.
50.

Imidazolyl carboxylic acids as mechanistic probes of flavocytochrome P-450 BM3.

Noble MA, Quaroni L, Chumanov GD, Turner KL, Chapman SK, Hanzlik RP, Munro AW.

Biochemistry. 1998 Nov 10;37(45):15799-807.

PMID:
9843385

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